pI: 7.1488 |
Length (AA): 106 |
MW (Da): 12135 |
Paralog Number:
21
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 4 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
2 | 53 | 5fma (A) | 200 | 248 | 49.00 | 0.00000026 | 0.83 | 1.00817 | -0.11 |
2 | 53 | 4xbm (B) | 310 | 357 | 48.00 | 0.0000015 | 0.93 | 0.976166 | 0.01 |
2 | 51 | 2gl1 (A) | 8 | 44 | 30.00 | 0 | 0.81 | 0.513498 | -0.47 |
3 | 63 | 4d90 (A) | 45 | 121 | 46.00 | 0.0000063 | 0.99 | 0.774072 | 0.94 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_126619)
Species | Accession | Gene Product |
---|---|---|
Brugia malayi | Bm1_34120 | Calcium binding EGF domain containing protein |
Brugia malayi | Bm1_14430 | Transmembrane cell adhesion receptor mua-3 precursor, putative |
Brugia malayi | Bm1_32035 | Calcium binding EGF domain containing protein |
Brugia malayi | Bm1_32030 | notch-like transmembrane receptor |
Brugia malayi | Bm1_42270 | EGF-like domain containing protein |
Brugia malayi | Bm1_45425 | Calcium binding EGF domain containing protein |
Brugia malayi | Bm1_15155 | Transmembrane cell adhesion receptor mua-3 precursor, putative |
Caenorhabditis elegans | CELE_K07D8.1 | Protein MUP-4 |
Caenorhabditis elegans | CELE_F02A9.6 | Protein GLP-1 |
Caenorhabditis elegans | CELE_F11C7.4 | Protein CRB-1 |
Caenorhabditis elegans | CELE_ZK783.1 | Protein FBN-1, isoform J |
Caenorhabditis elegans | CELE_K08E5.3 | Protein MUA-3, isoform A |
Caenorhabditis elegans | CELE_R107.8 | Protein LIN-12 |
Cryptosporidium hominis | Chro.30220 | ENSANGP00000004359 |
Cryptosporidium parvum | cgd3_1860 | extracellular protein with a signal peptide and 9 EGF domains |
Dictyostelium discoideum | DDB_G0295485 | EGF-like domain-containing protein |
Dictyostelium discoideum | DDB_G0272434 | hypothetical protein |
Dictyostelium discoideum | DDB_G0270488 | hypothetical protein |
Drosophila melanogaster | Dmel_CG7526 | faulty attraction |
Drosophila melanogaster | Dmel_CG6383 | crumbs |
Drosophila melanogaster | Dmel_CG3936 | Notch |
Echinococcus granulosus | EgrG_001024500 | hypothetical protein |
Echinococcus granulosus | EgrG_000851400 | neurogenic locus notch protein 4 |
Echinococcus granulosus | EgrG_000338500 | crumbs 1 |
Echinococcus granulosus | EgrG_000164900 | expressed conserved protein |
Echinococcus granulosus | EgrG_000208200 | neurogenic locus notch protein |
Echinococcus multilocularis | EmuJ_000164900 | expressed conserved protein |
Echinococcus multilocularis | EmuJ_000208200 | neurogenic locus notch protein |
Echinococcus multilocularis | EmuJ_001024500 | conserved hypothetical protein |
Echinococcus multilocularis | EmuJ_001147600 | glioma pathogenesis protein |
Echinococcus multilocularis | EmuJ_000338500 | crumbs 1 |
Echinococcus multilocularis | EmuJ_000851400 | neurogenic locus notch protein 4 |
Giardia lamblia | GL50803_114161 | High cysteine protein |
Giardia lamblia | GL50803_137727 | High cysteine membrane protein EGF-like |
Giardia lamblia | GL50803_114991 | High cysteine membrane protein EGF-like |
Giardia lamblia | GL50803_6509 | Neurogenic locus notch-like protein |
Giardia lamblia | GL50803_114626 | High cysteine membrane protein EGF-like |
Giardia lamblia | GL50803_113268 | Notch 2, putative |
Giardia lamblia | GL50803_103983 | Hypothetical protein |
Giardia lamblia | GL50803_112633 | High cysteine membrane protein EGF-like |
Giardia lamblia | GL50803_16936 | High cysteine membrane protein EGF-like |
Giardia lamblia | GL50803_91099 | High cysteine membrane protein Group 2 |
Giardia lamblia | GL50803_113836 | High cysteine membrane protein EGF-like |
Giardia lamblia | GL50803_15317 | High cysteine membrane protein Group 1 |
Giardia lamblia | GL50803_113213 | High cysteine membrane protein EGF-like |
Giardia lamblia | GL50803_16318 | High cysteine membrane protein Group 1 |
Giardia lamblia | GL50803_137732 | High cysteine protein |
Giardia lamblia | GL50803_113531 | High cysteine membrane protein EGF-like |
Homo sapiens | ENSG00000188107 | eyes shut homolog (Drosophila) |
Homo sapiens | ENSG00000134376 | crumbs family member 1, photoreceptor morphogenesis associated |
Homo sapiens | ENSG00000134250 | notch 2 |
Homo sapiens | ENSG00000138829 | fibrillin 2 |
Homo sapiens | ENSG00000148204 | crumbs family member 2 |
Homo sapiens | ENSG00000166147 | fibrillin 1 |
Homo sapiens | ENSG00000204301 | notch 4 |
Homo sapiens | ENSG00000074181 | notch 3 |
Homo sapiens | ENSG00000142449 | fibrillin 3 |
Homo sapiens | ENSG00000148400 | notch 1 |
Loa Loa (eye worm) | LOAG_14713 | hypothetical protein |
Loa Loa (eye worm) | LOAG_15109 | hypothetical protein |
Loa Loa (eye worm) | LOAG_13518 | hypothetical protein |
Loa Loa (eye worm) | LOAG_13275 | hypothetical protein |
Loa Loa (eye worm) | LOAG_04811 | hypothetical protein |
Loa Loa (eye worm) | LOAG_04813 | notch protein |
Loa Loa (eye worm) | LOAG_07606 | transmembrane cell adhesion receptor mua-3 |
Loa Loa (eye worm) | LOAG_13342 | hypothetical protein |
Loa Loa (eye worm) | LOAG_05481 | hypothetical protein |
Loa Loa (eye worm) | LOAG_13894 | hypothetical protein |
Loa Loa (eye worm) | LOAG_07160 | hypothetical protein |
Loa Loa (eye worm) | LOAG_11919 | hypothetical protein |
Loa Loa (eye worm) | LOAG_13801 | hypothetical protein |
Loa Loa (eye worm) | LOAG_01945 | Notch2 |
Loa Loa (eye worm) | LOAG_01102 | hypothetical protein |
Loa Loa (eye worm) | LOAG_15508 | hypothetical protein |
Loa Loa (eye worm) | LOAG_16077 | hypothetical protein |
Loa Loa (eye worm) | LOAG_11373 | hypothetical protein |
Loa Loa (eye worm) | LOAG_15990 | hypothetical protein |
Loa Loa (eye worm) | LOAG_10972 | hypothetical protein |
Loa Loa (eye worm) | LOAG_13327 | hypothetical protein |
Loa Loa (eye worm) | LOAG_13602 | hypothetical protein |
Mus musculus | ENSMUSG00000026923 | notch 1 |
Mus musculus | ENSMUSG00000063681 | crumbs homolog 1 (Drosophila) |
Mus musculus | ENSMUSG00000035403 | crumbs homolog 2 (Drosophila) |
Mus musculus | 102642295 | fibrillin-2-like |
Mus musculus | ENSMUSG00000027878 | notch 2 |
Mus musculus | ENSMUSG00000027204 | fibrillin 1 |
Mus musculus | ENSMUSG00000038146 | notch 3 |
Mus musculus | ensembl-mmu:ENSMUSG00000024598 | fibrillin 2 |
Mus musculus | ENSMUSG00000015468 | notch 4 |
Neospora caninum | NCLIV_022530 | fibrillin-2 precursor, putative |
Neospora caninum | NCLIV_069310 | microneme protein, putative |
Onchocerca volvulus | OVOC3374 | Neurogenic locus notch homolog |
Onchocerca volvulus | OVOC7745 |
|
Onchocerca volvulus | OVOC10015 | Neurogenic locus notch protein homolog |
Plasmodium berghei | PBANKA_1215100 | Rh5 interacting protein, putative |
Plasmodium falciparum | PF3D7_0323400 | Rh5 interacting protein |
Plasmodium vivax | PVX_095055 | Rh5 interacting protein, putative |
Plasmodium yoelii | PY00357 | hypothetical protein |
Schistosoma japonicum | Sjp_0054940 | expressed protein |
Schistosoma japonicum | Sjp_0068990 | expressed protein |
Schmidtea mediterranea | mk4.000311.08 | BCL3-1 |
Schmidtea mediterranea | mk4.008776.00 | |
Schmidtea mediterranea | mk4.066546.00 | |
Schmidtea mediterranea | mk4.000702.02 | |
Schmidtea mediterranea | mk4.043054.00 | |
Schmidtea mediterranea | mk4.017201.00 | |
Schmidtea mediterranea | mk4.001395.06 | FBN-1A.1 |
Schmidtea mediterranea | mk4.002074.00 | |
Schmidtea mediterranea | mk4.009580.03 | |
Schmidtea mediterranea | mk4.017494.00 | |
Schmidtea mediterranea | mk4.030687.00 | |
Schmidtea mediterranea | mk4.004747.03 | Notch |
Schmidtea mediterranea | mk4.025817.01 | |
Schmidtea mediterranea | mk4.004747.02 | |
Schmidtea mediterranea | mk4.000256.02 | |
Schmidtea mediterranea | mk4.001395.05 | |
Schmidtea mediterranea | mk4.004747.04 | Delta and Notch-like epidermal growth factor-related receptor |
Schmidtea mediterranea | mk4.005691.00 | |
Toxoplasma gondii | TGME49_202400 | calcium binding egf domain-containing protein |
Toxoplasma gondii | TGME49_267680 | microneme protein MIC12 |
Trichomonas vaginalis | TVAG_RG_DS113230_20 | nucleolar phosphoprotein p130, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
CELE_F11C7.4 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_F02A9.6 | Caenorhabditis elegans | embryonic arrest | wormbase |
CELE_F02A9.6 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_F02A9.6 | Caenorhabditis elegans | larval lethal | wormbase |
CELE_F02A9.6 | Caenorhabditis elegans | slow growth | wormbase |
CELE_F02A9.6 | Caenorhabditis elegans | sterile | wormbase |
CELE_R107.8 | Caenorhabditis elegans | embryonic arrest | wormbase |
CELE_R107.8 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_R107.8 | Caenorhabditis elegans | sterile | wormbase |
CELE_K08E5.3 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_K08E5.3 | Caenorhabditis elegans | larval lethal | wormbase |
CELE_K07D8.1 | Caenorhabditis elegans | adult lethal | wormbase |
CELE_K07D8.1 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_K07D8.1 | Caenorhabditis elegans | sterile | wormbase |
CELE_ZK783.1 | Caenorhabditis elegans | larval lethal | wormbase |
CELE_ZK783.1 | Caenorhabditis elegans | slow growth | wormbase |
CELE_ZK783.1 | Caenorhabditis elegans | sterile | wormbase |
PBANKA_1215100 | Plasmodium berghei | Essential | plasmo |
TGME49_267680 | Toxoplasma gondii | Essentiality uncertain | sidik |
TGME49_202400 | Toxoplasma gondii | Essentiality uncertain | sidik |
TGME49_267680 | Toxoplasma gondii | Probably non-essential | sidik |
TGME49_202400 | Toxoplasma gondii | Probably non-essential | sidik |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Homo sapiens | notch 3 | Compounds | References |
Homo sapiens | notch 4 | Compounds | References |
Homo sapiens | notch 1 | Compounds | References |
Homo sapiens | notch 2 | Compounds | References |