Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | Notch2 | 0.0162 | 0.26 | 0.258 |
Schistosoma mansoni | hypothetical protein | 0.0024 | 0.0251 | 0.0251 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0107 | 0.008 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0274 | 0.0247 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0107 | 0.008 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0274 | 0.0247 |
Echinococcus multilocularis | slit 2 protein | 0.0014 | 0.0079 | 0.0079 |
Toxoplasma gondii | notch (dsl) domain-containing protein | 0.0024 | 0.0251 | 1 |
Schistosoma mansoni | notch | 0.0104 | 0.1615 | 0.1615 |
Toxoplasma gondii | microneme protein MIC12 | 0.0019 | 0.0161 | 0.5983 |
Brugia malayi | Transmembrane cell adhesion receptor mua-3 precursor, putative | 0.0018 | 0.014 | 0.0113 |
Echinococcus multilocularis | neurogenic locus protein delta | 0.0014 | 0.0079 | 0.0079 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0241 | 0.0214 |
Echinococcus multilocularis | neurogenic locus notch protein | 0.0258 | 0.4236 | 0.4236 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0079 | 0.0052 |
Loa Loa (eye worm) | transmembrane cell adhesion receptor mua-3 | 0.0019 | 0.0161 | 0.0134 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0026 | 0.0274 | 0.0247 |
Schistosoma mansoni | notch | 0.0014 | 0.0079 | 0.0079 |
Echinococcus granulosus | notch | 0.0031 | 0.0364 | 0.0364 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0251 | 0.0224 |
Onchocerca volvulus | Neurogenic locus notch protein homolog | 0.0042 | 0.0558 | 0.1152 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0079 | 0.0052 |
Schistosoma mansoni | notch | 0.0031 | 0.0364 | 0.0364 |
Loa Loa (eye worm) | hypothetical protein | 0.0248 | 0.4069 | 0.4053 |
Echinococcus multilocularis | neurogenic locus notch protein 4 | 0.0016 | 0.0107 | 0.0107 |
Brugia malayi | EGF-like domain containing protein | 0.0024 | 0.0251 | 0.0224 |
Echinococcus multilocularis | notch | 0.0031 | 0.0364 | 0.0364 |
Echinococcus granulosus | histone lysine N methyltransferase Ez | 0.0596 | 1 | 1 |
Echinococcus granulosus | neurogenic locus notch protein | 0.0258 | 0.4236 | 0.4236 |
Brugia malayi | notch-like transmembrane receptor | 0.0248 | 0.4069 | 0.4053 |
Schistosoma mansoni | enhancer of zeste ezh | 0.0596 | 1 | 1 |
Toxoplasma gondii | sushi domain (scr repeat) domain-containing protein | 0.0024 | 0.0251 | 1 |
Echinococcus multilocularis | histone lysine N methyltransferase E(z) | 0.0596 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.014 | 0.0113 |
Echinococcus granulosus | neurogenic locus notch protein 4 | 0.0016 | 0.0107 | 0.0107 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0026 | 0.0274 | 0.0247 |
Toxoplasma gondii | sushi domain (scr repeat) domain-containing protein | 0.0024 | 0.0251 | 1 |
Echinococcus granulosus | slit 2 protein | 0.0014 | 0.0079 | 0.0079 |
Onchocerca volvulus | 0.0024 | 0.0251 | 0.0413 | |
Loa Loa (eye worm) | SET domain-containing protein | 0.0596 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0107 | 0.008 |
Onchocerca volvulus | 0.0018 | 0.014 | 0.0146 | |
Brugia malayi | EGF-like domain containing protein | 0.0014 | 0.0079 | 0.0052 |
Onchocerca volvulus | 0.0024 | 0.0251 | 0.0413 | |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.014 | 0.0113 |
Echinococcus granulosus | neurogenic locus protein delta | 0.0014 | 0.0079 | 0.0079 |
Onchocerca volvulus | Neurogenic locus notch homolog | 0.0258 | 0.4236 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0079 | 0.0052 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.014 | 0.0113 |
Loa Loa (eye worm) | notch protein | 0.0026 | 0.0274 | 0.0247 |
Schistosoma mansoni | slit | 0.0014 | 0.0079 | 0.0079 |
Brugia malayi | EGF-like domain containing protein | 0.0136 | 0.2161 | 0.2139 |
Onchocerca volvulus | Neurogenic locus notch homolog | 0.0024 | 0.0251 | 0.0413 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -6.686 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -6.474 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -6.285 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -6.261 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.895 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.853 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.726 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.653 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.394 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.