Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | neurogenic locus notch protein 4 | 0.0202 | 0.0276 | 0.0276 |
Brugia malayi | gamma-secretase subunit aph-1 | 0.024 | 0.041 | 0.0356 |
Schistosoma mansoni | slit | 0.0181 | 0.0204 | 0.054 |
Brugia malayi | EGF-like domain containing protein | 0.0281 | 0.0552 | 0.0506 |
Toxoplasma gondii | sushi domain (scr repeat) domain-containing protein | 0.0281 | 0.0552 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.03 | 0.0619 | 0.0577 |
Loa Loa (eye worm) | hypothetical protein | 0.0226 | 0.0361 | 0.0304 |
Loa Loa (eye worm) | hypothetical protein | 0.0202 | 0.0276 | 0.0215 |
Loa Loa (eye worm) | hypothetical protein | 0.0324 | 0.0704 | 0.0666 |
Onchocerca volvulus | Neurogenic locus notch protein homolog | 0.0507 | 0.1341 | 0.1161 |
Loa Loa (eye worm) | hypothetical protein | 0.0226 | 0.0361 | 0.0304 |
Echinococcus granulosus | neurogenic locus notch protein | 0.2986 | 1 | 1 |
Toxoplasma gondii | sushi domain (scr repeat) domain-containing protein | 0.0281 | 0.0552 | 1 |
Toxoplasma gondii | notch (dsl) domain-containing protein | 0.0281 | 0.0552 | 1 |
Loa Loa (eye worm) | gamma-secretase subunit aph-1 | 0.024 | 0.041 | 0.0356 |
Onchocerca volvulus | 0.0226 | 0.0361 | 0.016 | |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0324 | 0.0704 | 0.0666 |
Loa Loa (eye worm) | transmembrane cell adhesion receptor mua-3 | 0.0241 | 0.0415 | 0.0362 |
Onchocerca volvulus | 0.0281 | 0.0552 | 0.0355 | |
Schistosoma mansoni | notch | 0.0364 | 0.0841 | 0.2223 |
Loa Loa (eye worm) | hypothetical protein | 0.0181 | 0.0204 | 0.014 |
Onchocerca volvulus | 0.0281 | 0.0552 | 0.0355 | |
Echinococcus multilocularis | neurogenic locus protein delta | 0.0181 | 0.0204 | 0.0204 |
Schistosoma mansoni | hypothetical protein | 0.0281 | 0.0552 | 0.1459 |
Loa Loa (eye worm) | hypothetical protein | 0.0324 | 0.0704 | 0.0666 |
Echinococcus multilocularis | notch | 0.0364 | 0.0841 | 0.0841 |
Schistosoma mansoni | notch | 0.1206 | 0.3784 | 1 |
Echinococcus granulosus | slit 2 protein | 0.0181 | 0.0204 | 0.0204 |
Schistosoma mansoni | notch | 0.0181 | 0.0204 | 0.054 |
Loa Loa (eye worm) | hypothetical protein | 0.0202 | 0.0276 | 0.0215 |
Loa Loa (eye worm) | hypothetical protein | 0.0226 | 0.0361 | 0.0304 |
Brugia malayi | EGF-like domain containing protein | 0.1581 | 0.5094 | 0.5288 |
Echinococcus multilocularis | slit 2 protein | 0.0181 | 0.0204 | 0.0204 |
Brugia malayi | EGF-like domain containing protein | 0.0181 | 0.0204 | 0.014 |
Loa Loa (eye worm) | notch protein | 0.0324 | 0.0704 | 0.0666 |
Loa Loa (eye worm) | hypothetical protein | 0.0181 | 0.0204 | 0.014 |
Loa Loa (eye worm) | hypothetical protein | 0.0202 | 0.0276 | 0.0215 |
Loa Loa (eye worm) | Notch2 | 0.1887 | 0.6161 | 0.6411 |
Loa Loa (eye worm) | hypothetical protein | 0.2863 | 0.9571 | 1 |
Echinococcus multilocularis | neurogenic locus notch protein 4 | 0.0202 | 0.0276 | 0.0276 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0324 | 0.0704 | 0.0666 |
Onchocerca volvulus | Neurogenic locus notch homolog | 0.0281 | 0.0552 | 0.0355 |
Echinococcus granulosus | gamma secretase subunit aph 1 | 0.024 | 0.041 | 0.041 |
Loa Loa (eye worm) | hypothetical protein | 0.0281 | 0.0552 | 0.0506 |
Brugia malayi | notch-like transmembrane receptor | 0.2863 | 0.9571 | 1 |
Toxoplasma gondii | microneme protein MIC12 | 0.0241 | 0.0415 | 0.7147 |
Brugia malayi | Transmembrane cell adhesion receptor mua-3 precursor, putative | 0.0226 | 0.0361 | 0.0304 |
Schistosoma mansoni | gamma-secretase subunit aph-1 | 0.024 | 0.041 | 0.1083 |
Echinococcus granulosus | notch | 0.0364 | 0.0841 | 0.0841 |
Echinococcus granulosus | neurogenic locus protein delta | 0.0181 | 0.0204 | 0.0204 |
Echinococcus multilocularis | neurogenic locus notch protein | 0.2986 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0181 | 0.0204 | 0.014 |
Echinococcus multilocularis | gamma secretase subunit aph 1 | 0.024 | 0.041 | 0.041 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.