Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0404 | 0.0444 |
Plasmodium falciparum | protein serine/threonine kinase-1 | 0.0069 | 0.0537 | 0.5 |
Schistosoma mansoni | cell adhesion molecule | 0.0063 | 0.0476 | 0.0522 |
Brugia malayi | Protein kinase domain containing protein | 0.0069 | 0.0537 | 0.0589 |
Echinococcus granulosus | cyclin g associated kinase | 0.0952 | 0.9113 | 0.9113 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.0476 | 0.0522 |
Echinococcus granulosus | roundabout 2 | 0.007 | 0.0542 | 0.0542 |
Echinococcus granulosus | dual specificity protein kinase clk2 | 0.0069 | 0.0537 | 0.0537 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0952 | 0.9113 | 1 |
Trypanosoma brucei | kinetoplastid kinetochore protein 19 | 0.0069 | 0.0537 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0404 | 0.0444 |
Loa Loa (eye worm) | STE/STE11/MEKK2 protein kinase | 0.0016 | 0.0016 | 0.0018 |
Onchocerca volvulus | 0.0016 | 0.0016 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0404 | 0.0444 |
Loa Loa (eye worm) | NAK/GAK protein kinase | 0.0952 | 0.9113 | 1 |
Echinococcus multilocularis | cyclin g associated kinase | 0.0952 | 0.9113 | 1 |
Trichomonas vaginalis | pten, drome, putative | 0.0095 | 0.0782 | 1 |
Brugia malayi | Fibronectin type III domain containing protein | 0.0056 | 0.0404 | 0.0444 |
Loa Loa (eye worm) | CMGC/CLK protein kinase | 0.0069 | 0.0537 | 0.0589 |
Trypanosoma cruzi | tyrosine phosphatase, putative | 0.0095 | 0.0782 | 1 |
Schistosoma mansoni | pten | 0.0095 | 0.0782 | 0.0859 |
Plasmodium vivax | formin 2, putative | 0.0095 | 0.0782 | 1 |
Schistosoma mansoni | vesicular amine transporter | 0.0056 | 0.0404 | 0.0444 |
Echinococcus multilocularis | Immunoglobulin | 0.0056 | 0.0404 | 0.0444 |
Schistosoma mansoni | tensin | 0.0095 | 0.0782 | 0.0859 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.007 | 0.054 | 0.0592 |
Schistosoma mansoni | Neurotrimin precursor (hNT) | 0.0056 | 0.0404 | 0.0444 |
Trypanosoma cruzi | tyrosine phosphatase isoform, putative | 0.0095 | 0.0782 | 1 |
Echinococcus granulosus | neuroglian | 0.0063 | 0.0471 | 0.0471 |
Loa Loa (eye worm) | AGC/PKC/IOTA protein kinase | 0.0016 | 0.0016 | 0.0018 |
Echinococcus multilocularis | basement membrane specific heparan sulfate | 0.0056 | 0.0404 | 0.0444 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0069 | 0.0537 | 0.0589 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0404 | 0.0444 |
Echinococcus granulosus | hypothetical protein | 0.0064 | 0.0488 | 0.0488 |
Brugia malayi | daf-18 protein | 0.0095 | 0.0782 | 0.0859 |
Trypanosoma cruzi | tyrosine phosphatase isoform, putative | 0.0095 | 0.0782 | 1 |
Trypanosoma brucei | kinetoplastid kinetochore protein 10 | 0.0069 | 0.0537 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.0782 | 0.0859 |
Leishmania major | tyrosine phosphatase isoform, putative | 0.0095 | 0.0782 | 1 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0063 | 0.0476 | 0.0476 |
Brugia malayi | Protein kinase domain containing protein | 0.0016 | 0.0016 | 0.0018 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.007 | 0.054 | 0.0592 |
Schistosoma mansoni | nephrin | 0.0063 | 0.0471 | 0.0516 |
Echinococcus granulosus | phosphatase and tensin | 0.0095 | 0.0782 | 0.0782 |
Schistosoma mansoni | defective proboscis extension response (dpr)-related | 0.0056 | 0.0404 | 0.0444 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.0542 | 0.0594 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.0542 | 0.0594 |
Echinococcus multilocularis | phosphatase and tensin | 0.0095 | 0.0782 | 0.0859 |
Echinococcus multilocularis | 0.0064 | 0.0488 | 0.0536 | |
Loa Loa (eye worm) | CAMK/MLCK protein kinase | 0.0019 | 0.0048 | 0.0053 |
Echinococcus multilocularis | Immunoglobulin | 0.0056 | 0.0404 | 0.0444 |
Echinococcus granulosus | twitchin | 0.0068 | 0.0519 | 0.0519 |
Brugia malayi | Protein kinase domain containing protein | 0.0952 | 0.9113 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0069 | 0.0537 | 0.0589 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0404 | 0.0444 |
Loa Loa (eye worm) | hypothetical protein | 0.0853 | 0.8145 | 0.8938 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.0488 | 0.0536 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0056 | 0.0404 | 0.0444 |
Echinococcus granulosus | Immunoglobulin | 0.0056 | 0.0404 | 0.0404 |
Echinococcus granulosus | defective proboscis extension response | 0.0056 | 0.0404 | 0.0404 |
Entamoeba histolytica | hypothetical protein | 0.0095 | 0.0782 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0021 | 0.0064 | 0.007 |
Echinococcus multilocularis | roundabout 2 | 0.007 | 0.0542 | 0.0594 |
Entamoeba histolytica | Pten 3-phosphoinositide phosphatase, putative | 0.0095 | 0.0782 | 0.5 |
Schistosoma mansoni | atypical protein kinase C | 0.0016 | 0.0016 | 0.0018 |
Toxoplasma gondii | cell-cycle-associated protein kinase CLK, putative | 0.0069 | 0.0537 | 0.5 |
Echinococcus multilocularis | dual specificity protein kinase clk2 | 0.0069 | 0.0537 | 0.0589 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0404 | 0.0444 |
Entamoeba histolytica | phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase, putative | 0.0095 | 0.0782 | 0.5 |
Giardia lamblia | Kinase, CMGC CLK | 0.0069 | 0.0537 | 0.5 |
Brugia malayi | hypothetical protein | 0.0056 | 0.0404 | 0.0444 |
Echinococcus multilocularis | neuroglian | 0.0063 | 0.0471 | 0.0516 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.