Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | Pten 3-phosphoinositide phosphatase, putative | 0.0160904 | 0.0956908 | 0.5 |
Echinococcus granulosus | defective proboscis extension response | 0.00605202 | 0.0297038 | 0.0297038 |
Loa Loa (eye worm) | hypothetical protein | 0.00605202 | 0.0297038 | 0.0297038 |
Loa Loa (eye worm) | hypothetical protein | 0.00605202 | 0.0297038 | 0.0297038 |
Echinococcus multilocularis | 0.00699065 | 0.0358738 | 0.0358738 | |
Echinococcus multilocularis | Immunoglobulin | 0.00605202 | 0.0297038 | 0.0297038 |
Loa Loa (eye worm) | hypothetical protein | 0.136981 | 0.890361 | 0.890361 |
Loa Loa (eye worm) | hypothetical protein | 0.00605202 | 0.0297038 | 0.0297038 |
Brugia malayi | Protein kinase domain containing protein | 0.15366 | 1 | 1 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.00756116 | 0.0396241 | 0.0396241 |
Brugia malayi | Fibronectin type III domain containing protein | 0.00605202 | 0.0297038 | 0.0297038 |
Schistosoma mansoni | tyrosine kinase | 0.00224732 | 0.00469379 | 0.00469379 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.00756116 | 0.0396241 | 0.0396241 |
Trypanosoma cruzi | tyrosine phosphatase isoform, putative | 0.0160904 | 0.0956908 | 1 |
Trypanosoma cruzi | tyrosine phosphatase isoform, putative | 0.0160904 | 0.0956908 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.00757923 | 0.0397428 | 0.0397428 |
Echinococcus granulosus | hypothetical protein | 0.00699065 | 0.0358738 | 0.0358738 |
Echinococcus granulosus | Immunoglobulin | 0.00605202 | 0.0297038 | 0.0297038 |
Echinococcus granulosus | roundabout 2 | 0.00758529 | 0.0397827 | 0.0397827 |
Entamoeba histolytica | hypothetical protein | 0.0160904 | 0.0956908 | 0.5 |
Echinococcus multilocularis | neuroglian | 0.0067902 | 0.0345562 | 0.0345562 |
Loa Loa (eye worm) | CAMK/MLCK protein kinase | 0.00212185 | 0.00386898 | 0.00386898 |
Echinococcus multilocularis | phosphatase and tensin | 0.0160904 | 0.0956908 | 0.0956908 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.00684711 | 0.0349303 | 0.0349303 |
Loa Loa (eye worm) | hypothetical protein | 0.00699065 | 0.0358738 | 0.0358738 |
Echinococcus multilocularis | basement membrane specific heparan sulfate | 0.00605202 | 0.0297038 | 0.0297038 |
Echinococcus multilocularis | dual specificity protein kinase clk2 | 0.00757923 | 0.0397428 | 0.0397428 |
Schistosoma mansoni | pten | 0.0160904 | 0.0956908 | 0.0956908 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.00605202 | 0.0297038 | 0.0297038 |
Loa Loa (eye worm) | CMGC/CLK protein kinase | 0.00757923 | 0.0397428 | 0.0397428 |
Trypanosoma brucei | kinetoplastid kinetochore protein 10 | 0.00757923 | 0.0397428 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.00186588 | 0.00218639 | 0.00218639 |
Loa Loa (eye worm) | hypothetical protein | 0.00758529 | 0.0397827 | 0.0397827 |
Echinococcus granulosus | phosphatase and tensin | 0.0160904 | 0.0956908 | 0.0956908 |
Entamoeba histolytica | phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase, putative | 0.0160904 | 0.0956908 | 0.5 |
Trichomonas vaginalis | pten, drome, putative | 0.0160904 | 0.0956908 | 1 |
Echinococcus multilocularis | Immunoglobulin | 0.00605202 | 0.0297038 | 0.0297038 |
Plasmodium vivax | formin 2, putative | 0.0160904 | 0.0956908 | 1 |
Trypanosoma brucei | kinetoplastid kinetochore protein 19 | 0.00757923 | 0.0397428 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.15366 | 1 | 1 |
Schistosoma mansoni | Neurotrimin precursor (hNT) | 0.00605202 | 0.0297038 | 0.0297038 |
Loa Loa (eye worm) | hypothetical protein | 0.0160904 | 0.0956908 | 0.0956908 |
Loa Loa (eye worm) | hypothetical protein | 0.00605202 | 0.0297038 | 0.0297038 |
Echinococcus granulosus | cyclin g associated kinase | 0.15366 | 1 | 1 |
Loa Loa (eye worm) | STE/STE11/MEKK2 protein kinase | 0.00186588 | 0.00218639 | 0.00218639 |
Schistosoma mansoni | atypical protein kinase C | 0.00186588 | 0.00218639 | 0.00218639 |
Schistosoma mansoni | defective proboscis extension response (dpr)-related | 0.00605202 | 0.0297038 | 0.0297038 |
Toxoplasma gondii | cell-cycle-associated protein kinase CLK, putative | 0.00757923 | 0.0397428 | 0.5 |
Echinococcus multilocularis | roundabout 2 | 0.00758529 | 0.0397827 | 0.0397827 |
Plasmodium falciparum | protein serine/threonine kinase-1 | 0.00757923 | 0.0397428 | 0.5 |
Echinococcus multilocularis | cyclin g associated kinase | 0.15366 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.00684711 | 0.0349303 | 0.0349303 |
Schistosoma mansoni | cell adhesion molecule | 0.00684711 | 0.0349303 | 0.0349303 |
Brugia malayi | Protein kinase domain containing protein | 0.00757923 | 0.0397428 | 0.0397428 |
Loa Loa (eye worm) | NAK/GAK protein kinase | 0.15366 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.00605202 | 0.0297038 | 0.0297038 |
Echinococcus granulosus | dual specificity protein kinase clk2 | 0.00757923 | 0.0397428 | 0.0397428 |
Schistosoma mansoni | tensin | 0.0160904 | 0.0956908 | 0.0956908 |
Giardia lamblia | Kinase, CMGC CLK | 0.00757923 | 0.0397428 | 0.5 |
Trypanosoma cruzi | tyrosine phosphatase, putative | 0.0160904 | 0.0956908 | 1 |
Brugia malayi | daf-18 protein | 0.0160904 | 0.0956908 | 0.0956908 |
Onchocerca volvulus | 0.00186588 | 0.00218639 | 1 | |
Echinococcus granulosus | twitchin | 0.00737878 | 0.0384252 | 0.0384252 |
Schistosoma mansoni | nephrin | 0.0067902 | 0.0345562 | 0.0345562 |
Schistosoma mansoni | serine/threonine protein kinase | 0.00757923 | 0.0397428 | 0.0397428 |
Echinococcus granulosus | neuroglian | 0.0067902 | 0.0345562 | 0.0345562 |
Schistosoma mansoni | vesicular amine transporter | 0.00605202 | 0.0297038 | 0.0297038 |
Loa Loa (eye worm) | AGC/PKC/IOTA protein kinase | 0.00186588 | 0.00218639 | 0.00218639 |
Loa Loa (eye worm) | hypothetical protein | 0.00605202 | 0.0297038 | 0.0297038 |
Leishmania major | tyrosine phosphatase isoform, putative | 0.0160904 | 0.0956908 | 1 |
Echinococcus granulosus | macrophage colony stimulating factor 1 receptor | 0.113264 | 0.734454 | 0.734454 |
Loa Loa (eye worm) | hypothetical protein | 0.00758529 | 0.0397827 | 0.0397827 |
Brugia malayi | hypothetical protein | 0.00605202 | 0.0297038 | 0.0297038 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 3.0642 uM | Antimalarial activity against chloroquine-resistant Plasmodium falciparum 3D7 incubated for 72 hrs by DNA staining based MARK1 growth inhibition assay | ChEMBL. | 22727641 |
EC50 (ADMET) | > 13.0208 uM | Cytotoxicity against human HepG2 cells after 72 hrs by resazurin dye based CellTiterGlo reagent assay | ChEMBL. | 22727641 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | 22727641 | |
Homo sapiens | ChEMBL23 | 22727641 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.