Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0072917 | 0.0364827 | 0.0364827 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.00581777 | 0.0272399 | 0.0272399 |
Schistosoma mansoni | pten | 0.0168536 | 0.0964444 | 0.0964444 |
Echinococcus granulosus | phosphatase and tensin | 0.0168536 | 0.0964444 | 0.0964444 |
Giardia lamblia | Kinase, CMGC CLK | 0.00732885 | 0.0367157 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.00183665 | 0.0022746 | 0.0022746 |
Loa Loa (eye worm) | CMGC/CLK protein kinase | 0.00732885 | 0.0367157 | 0.0367157 |
Echinococcus multilocularis | basement membrane specific heparan sulfate | 0.00581777 | 0.0272399 | 0.0272399 |
Echinococcus granulosus | hypothetical protein | 0.00672007 | 0.0328981 | 0.0328981 |
Schistosoma mansoni | serine/threonine protein kinase | 0.00732885 | 0.0367157 | 0.0367157 |
Trypanosoma cruzi | tyrosine phosphatase, putative | 0.0168536 | 0.0964444 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.00672007 | 0.0328981 | 0.0328981 |
Trypanosoma cruzi | tyrosine phosphatase isoform, putative | 0.0168536 | 0.0964444 | 1 |
Trypanosoma brucei | kinetoplastid kinetochore protein 19 | 0.00732885 | 0.0367157 | 0.5 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0072685 | 0.0363372 | 0.0363372 |
Brugia malayi | Fibronectin type III domain containing protein | 0.00581777 | 0.0272399 | 0.0272399 |
Schistosoma mansoni | tyrosine kinase | 0.00216034 | 0.00430444 | 0.00430444 |
Brugia malayi | Protein kinase domain containing protein | 0.16094 | 1 | 1 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0072685 | 0.0363372 | 0.0363372 |
Loa Loa (eye worm) | hypothetical protein | 0.00581777 | 0.0272399 | 0.0272399 |
Schistosoma mansoni | cell adhesion molecule | 0.00658209 | 0.0320328 | 0.0320328 |
Brugia malayi | daf-18 protein | 0.0168536 | 0.0964444 | 0.0964444 |
Entamoeba histolytica | hypothetical protein | 0.0168536 | 0.0964444 | 0.5 |
Trypanosoma brucei | kinetoplastid kinetochore protein 10 | 0.00732885 | 0.0367157 | 0.5 |
Loa Loa (eye worm) | CAMK/MLCK protein kinase | 0.00208271 | 0.00381761 | 0.00381761 |
Echinococcus multilocularis | neuroglian | 0.00652738 | 0.0316897 | 0.0316897 |
Echinococcus granulosus | Immunoglobulin | 0.00581777 | 0.0272399 | 0.0272399 |
Echinococcus multilocularis | Immunoglobulin | 0.00581777 | 0.0272399 | 0.0272399 |
Echinococcus multilocularis | 0.00672007 | 0.0328981 | 0.0328981 | |
Loa Loa (eye worm) | hypothetical protein | 0.00581777 | 0.0272399 | 0.0272399 |
Loa Loa (eye worm) | hypothetical protein | 0.00581777 | 0.0272399 | 0.0272399 |
Echinococcus granulosus | defective proboscis extension response | 0.00581777 | 0.0272399 | 0.0272399 |
Entamoeba histolytica | Pten 3-phosphoinositide phosphatase, putative | 0.0168536 | 0.0964444 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.143478 | 0.890495 | 0.890495 |
Schistosoma mansoni | vesicular amine transporter | 0.00581777 | 0.0272399 | 0.0272399 |
Loa Loa (eye worm) | AGC/PKC/IOTA protein kinase | 0.00183665 | 0.0022746 | 0.0022746 |
Echinococcus granulosus | neuroglian | 0.00652738 | 0.0316897 | 0.0316897 |
Schistosoma mansoni | serine/threonine protein kinase | 0.00732885 | 0.0367157 | 0.0367157 |
Brugia malayi | hypothetical protein | 0.00581777 | 0.0272399 | 0.0272399 |
Toxoplasma gondii | cell-cycle-associated protein kinase CLK, putative | 0.00732885 | 0.0367157 | 0.5 |
Echinococcus granulosus | macrophage colony stimulating factor 1 receptor | 0.10888 | 0.673531 | 0.673531 |
Loa Loa (eye worm) | hypothetical protein | 0.00581777 | 0.0272399 | 0.0272399 |
Trypanosoma cruzi | tyrosine phosphatase isoform, putative | 0.0168536 | 0.0964444 | 1 |
Echinococcus multilocularis | phosphatase and tensin | 0.0168536 | 0.0964444 | 0.0964444 |
Schistosoma mansoni | tensin | 0.0168536 | 0.0964444 | 0.0964444 |
Echinococcus granulosus | dual specificity protein kinase clk2 | 0.00732885 | 0.0367157 | 0.0367157 |
Schistosoma mansoni | nephrin | 0.00652738 | 0.0316897 | 0.0316897 |
Echinococcus granulosus | twitchin | 0.00713616 | 0.0355074 | 0.0355074 |
Onchocerca volvulus | 0.00183665 | 0.0022746 | 1 | |
Leishmania major | tyrosine phosphatase isoform, putative | 0.0168536 | 0.0964444 | 1 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.00658209 | 0.0320328 | 0.0320328 |
Echinococcus multilocularis | cyclin g associated kinase | 0.16094 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0072917 | 0.0364827 | 0.0364827 |
Echinococcus multilocularis | dual specificity protein kinase clk2 | 0.00732885 | 0.0367157 | 0.0367157 |
Brugia malayi | Protein kinase domain containing protein | 0.00732885 | 0.0367157 | 0.0367157 |
Schistosoma mansoni | defective proboscis extension response (dpr)-related | 0.00581777 | 0.0272399 | 0.0272399 |
Schistosoma mansoni | atypical protein kinase C | 0.00183665 | 0.0022746 | 0.0022746 |
Echinococcus granulosus | roundabout 2 | 0.0072917 | 0.0364827 | 0.0364827 |
Loa Loa (eye worm) | hypothetical protein | 0.00581777 | 0.0272399 | 0.0272399 |
Echinococcus multilocularis | roundabout 2 | 0.0072917 | 0.0364827 | 0.0364827 |
Loa Loa (eye worm) | NAK/GAK protein kinase | 0.16094 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.00658209 | 0.0320328 | 0.0320328 |
Plasmodium falciparum | protein serine/threonine kinase-1 | 0.00732885 | 0.0367157 | 0.5 |
Plasmodium vivax | formin 2, putative | 0.0168536 | 0.0964444 | 1 |
Echinococcus multilocularis | Immunoglobulin | 0.00581777 | 0.0272399 | 0.0272399 |
Entamoeba histolytica | phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase, putative | 0.0168536 | 0.0964444 | 0.5 |
Trichomonas vaginalis | pten, drome, putative | 0.0168536 | 0.0964444 | 1 |
Loa Loa (eye worm) | STE/STE11/MEKK2 protein kinase | 0.00183665 | 0.0022746 | 0.0022746 |
Echinococcus granulosus | cyclin g associated kinase | 0.16094 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.00581777 | 0.0272399 | 0.0272399 |
Schistosoma mansoni | Neurotrimin precursor (hNT) | 0.00581777 | 0.0272399 | 0.0272399 |
Loa Loa (eye worm) | hypothetical protein | 0.0168536 | 0.0964444 | 0.0964444 |
Schistosoma mansoni | serine/threonine protein kinase | 0.16094 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | > 7.5075 uM | Antimalarial activity against chloroquine-resistant Plasmodium falciparum 3D7 incubated for 72 hrs by DNA staining based MARK1 growth inhibition assay | ChEMBL. | 22727641 |
EC50 (ADMET) | > 13.0208 uM | Cytotoxicity against human HepG2 cells after 72 hrs by resazurin dye based CellTiterGlo reagent assay | ChEMBL. | 22727641 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 22727641 | |
Plasmodium falciparum | ChEMBL23 | 22727641 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.