Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.0898 | 0.0898 |
Echinococcus granulosus | neuroglian | 0.0068 | 0.0366 | 0.0366 |
Trypanosoma brucei | kinetoplastid kinetochore protein 10 | 0.0078 | 0.043 | 0.5 |
Brugia malayi | daf-18 protein | 0.0145 | 0.0898 | 0.0898 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.0421 | 0.0421 |
Plasmodium vivax | formin 2, putative | 0.0145 | 0.0898 | 1 |
Trypanosoma cruzi | tyrosine phosphatase isoform, putative | 0.0145 | 0.0898 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0078 | 0.043 | 0.043 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.037 | 0.037 |
Entamoeba histolytica | Pten 3-phosphoinositide phosphatase, putative | 0.0145 | 0.0898 | 0.5 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0076 | 0.042 | 0.042 |
Schistosoma mansoni | pten | 0.0145 | 0.0898 | 0.0898 |
Loa Loa (eye worm) | NAK/GAK protein kinase | 0.146 | 1 | 1 |
Echinococcus multilocularis | Immunoglobulin | 0.0061 | 0.0315 | 0.0315 |
Schistosoma mansoni | tyrosine kinase | 0.0023 | 0.005 | 0.005 |
Schistosoma mansoni | cell adhesion molecule | 0.0069 | 0.037 | 0.037 |
Echinococcus multilocularis | phosphatase and tensin | 0.0145 | 0.0898 | 0.0898 |
Echinococcus multilocularis | neuroglian | 0.0068 | 0.0366 | 0.0366 |
Echinococcus multilocularis | roundabout 2 | 0.0076 | 0.0421 | 0.0421 |
Echinococcus granulosus | Immunoglobulin | 0.0061 | 0.0315 | 0.0315 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.0315 | 0.0315 |
Brugia malayi | hypothetical protein | 0.0061 | 0.0315 | 0.0315 |
Brugia malayi | Protein kinase domain containing protein | 0.0078 | 0.043 | 0.043 |
Trypanosoma cruzi | tyrosine phosphatase, putative | 0.0145 | 0.0898 | 1 |
Echinococcus multilocularis | basement membrane specific heparan sulfate | 0.0061 | 0.0315 | 0.0315 |
Loa Loa (eye worm) | AGC/PKC/IOTA protein kinase | 0.0019 | 0.0025 | 0.0025 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0078 | 0.043 | 0.043 |
Echinococcus multilocularis | Immunoglobulin | 0.0061 | 0.0315 | 0.0315 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.0421 | 0.0421 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.0315 | 0.0315 |
Schistosoma mansoni | defective proboscis extension response (dpr)-related | 0.0061 | 0.0315 | 0.0315 |
Echinococcus granulosus | cyclin g associated kinase | 0.146 | 1 | 1 |
Schistosoma mansoni | Neurotrimin precursor (hNT) | 0.0061 | 0.0315 | 0.0315 |
Plasmodium falciparum | protein serine/threonine kinase-1 | 0.0078 | 0.043 | 0.5 |
Echinococcus granulosus | defective proboscis extension response | 0.0061 | 0.0315 | 0.0315 |
Trypanosoma brucei | kinetoplastid kinetochore protein 19 | 0.0078 | 0.043 | 0.5 |
Onchocerca volvulus | 0.0019 | 0.0025 | 1 | |
Brugia malayi | Protein kinase domain containing protein | 0.0019 | 0.0025 | 0.0025 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.0315 | 0.0315 |
Entamoeba histolytica | phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase, putative | 0.0145 | 0.0898 | 0.5 |
Echinococcus multilocularis | dual specificity protein kinase clk2 | 0.0078 | 0.043 | 0.043 |
Schistosoma mansoni | atypical protein kinase C | 0.0019 | 0.0025 | 0.0025 |
Loa Loa (eye worm) | hypothetical protein | 0.1308 | 0.8945 | 0.8945 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.0315 | 0.0315 |
Echinococcus granulosus | macrophage colony stimulating factor 1 receptor | 0.114 | 0.778 | 0.778 |
Leishmania major | tyrosine phosphatase isoform, putative | 0.0145 | 0.0898 | 1 |
Echinococcus multilocularis | 0.007 | 0.038 | 0.038 | |
Loa Loa (eye worm) | CMGC/CLK protein kinase | 0.0078 | 0.043 | 0.043 |
Echinococcus granulosus | roundabout 2 | 0.0076 | 0.0421 | 0.0421 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.038 | 0.038 |
Loa Loa (eye worm) | STE/STE11/MEKK2 protein kinase | 0.0019 | 0.0025 | 0.0025 |
Giardia lamblia | Kinase, CMGC CLK | 0.0078 | 0.043 | 0.5 |
Echinococcus granulosus | dual specificity protein kinase clk2 | 0.0078 | 0.043 | 0.043 |
Echinococcus granulosus | phosphatase and tensin | 0.0145 | 0.0898 | 0.0898 |
Trichomonas vaginalis | pten, drome, putative | 0.0145 | 0.0898 | 1 |
Trypanosoma cruzi | tyrosine phosphatase isoform, putative | 0.0145 | 0.0898 | 1 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0076 | 0.042 | 0.042 |
Echinococcus multilocularis | cyclin g associated kinase | 0.146 | 1 | 1 |
Brugia malayi | Fibronectin type III domain containing protein | 0.0061 | 0.0315 | 0.0315 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.0315 | 0.0315 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.0315 | 0.0315 |
Loa Loa (eye worm) | CAMK/MLCK protein kinase | 0.0023 | 0.005 | 0.005 |
Schistosoma mansoni | tensin | 0.0145 | 0.0898 | 0.0898 |
Schistosoma mansoni | serine/threonine protein kinase | 0.146 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0145 | 0.0898 | 0.5 |
Schistosoma mansoni | nephrin | 0.0068 | 0.0366 | 0.0366 |
Echinococcus granulosus | twitchin | 0.0076 | 0.0416 | 0.0416 |
Schistosoma mansoni | vesicular amine transporter | 0.0061 | 0.0315 | 0.0315 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0061 | 0.0315 | 0.0315 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0069 | 0.037 | 0.037 |
Echinococcus granulosus | hypothetical protein | 0.007 | 0.038 | 0.038 |
Toxoplasma gondii | cell-cycle-associated protein kinase CLK, putative | 0.0078 | 0.043 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.