Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Staphylococcus aureus | Phospho-N-acetylmuramoyl-pentapeptide-transferase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Mycobacterium tuberculosis | Probable phospho-N-acetylmuramoyl-pentappeptidetransferase MurX | Get druggable targets OG5_131597 | All targets in OG5_131597 |
Mycobacterium leprae | Probable phospho-N-acetylmuramoyl-pentappeptidetransferase MurX | Get druggable targets OG5_131597 | All targets in OG5_131597 |
Treponema pallidum | phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) | Get druggable targets OG5_131597 | All targets in OG5_131597 |
Wolbachia endosymbiont of Brugia malayi | phospho-N-acetylmuramoyl-pentapeptide-transferase | Get druggable targets OG5_131597 | All targets in OG5_131597 |
Mycobacterium ulcerans | phospho-N-acetylmuramoyl-pentapeptide-transferase | Get druggable targets OG5_131597 | All targets in OG5_131597 |
Chlamydia trachomatis | phospho-N-acetylmuramoyl-pentapeptide-transferase | Get druggable targets OG5_131597 | All targets in OG5_131597 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | Neurotrimin precursor (hNT) | 0.0053 | 0.0322 | 0.0322 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1166 | 1 | 1 |
Treponema pallidum | phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) | 0.0511 | 0.4305 | 0.5 |
Echinococcus granulosus | hypothetical protein | 0.0061 | 0.0393 | 0.0074 |
Loa Loa (eye worm) | NAK/GAK protein kinase | 0.1166 | 1 | 1 |
Echinococcus granulosus | neuroglian | 0.006 | 0.0378 | 0.0058 |
Schistosoma mansoni | pten | 0.0116 | 0.0868 | 0.0868 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0439 | 0.0439 |
Echinococcus multilocularis | phosphatase and tensin | 0.0116 | 0.0868 | 0.0564 |
Mycobacterium leprae | Probable phospho-N-acetylmuramoyl-pentappeptidetransferase MurX | 0.0511 | 0.4305 | 0.5 |
Trypanosoma cruzi | kinetoplastid kinetochore protein 19, putative | 0.0067 | 0.0444 | 0.1815 |
Schistosoma mansoni | UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase | 0.0056 | 0.035 | 0.035 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0067 | 0.0444 | 0.1815 |
Giardia lamblia | Kinase, CMGC CLK | 0.0067 | 0.0444 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1044 | 0.8941 | 0.8941 |
Plasmodium vivax | serine/threonine kinase-1, putative | 0.0067 | 0.0444 | 0.1815 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0439 | 0.0439 |
Brugia malayi | daf-18 protein | 0.0116 | 0.0868 | 0.0868 |
Echinococcus granulosus | cyclin g associated kinase | 0.1166 | 1 | 1 |
Schistosoma mansoni | vesicular amine transporter | 0.0053 | 0.0322 | 0.0322 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0067 | 0.0444 | 0.0444 |
Schistosoma mansoni | nephrin | 0.006 | 0.0378 | 0.0378 |
Brugia malayi | hypothetical protein | 0.0053 | 0.0322 | 0.0322 |
Trypanosoma cruzi | kinetoplastid kinetochore protein 19, putative | 0.0067 | 0.0444 | 0.1815 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0322 | 0.0322 |
Toxoplasma gondii | cell-cycle-associated protein kinase CLK, putative | 0.0067 | 0.0444 | 1 |
Entamoeba histolytica | phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase, putative | 0.0116 | 0.0868 | 1 |
Brugia malayi | Fibronectin type III domain containing protein | 0.0053 | 0.0322 | 0.0322 |
Trypanosoma brucei | kinetoplastid kinetochore protein 10 | 0.0067 | 0.0444 | 1 |
Echinococcus granulosus | phosphatase and tensin | 0.0116 | 0.0868 | 0.0564 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0322 | 0.0322 |
Leishmania major | protein kinase, putative | 0.0067 | 0.0444 | 0.1815 |
Mycobacterium tuberculosis | Probable phospho-N-acetylmuramoyl-pentappeptidetransferase MurX | 0.0511 | 0.4305 | 0.5 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0066 | 0.0437 | 0.0437 |
Entamoeba histolytica | hypothetical protein | 0.0116 | 0.0868 | 1 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0066 | 0.0437 | 0.0437 |
Wolbachia endosymbiont of Brugia malayi | phospho-N-acetylmuramoyl-pentapeptide-transferase | 0.0511 | 0.4305 | 0.5 |
Leishmania major | tyrosine phosphatase isoform, putative | 0.0116 | 0.0868 | 1 |
Loa Loa (eye worm) | CMGC/CLK protein kinase | 0.0067 | 0.0444 | 0.0444 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0322 | 0.0322 |
Echinococcus multilocularis | 0.0061 | 0.0393 | 0.0074 | |
Schistosoma mansoni | tyrosine kinase | 0.002 | 0.0031 | 0.0031 |
Trypanosoma cruzi | kinetoplastid kinetochore protein 10, putative | 0.0067 | 0.0444 | 0.1815 |
Echinococcus granulosus | macrophage colony stimulating factor 1 receptor | 0.0995 | 0.8511 | 0.8462 |
Schistosoma mansoni | cell adhesion molecule | 0.006 | 0.0382 | 0.0382 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.035 | 0.035 |
Echinococcus multilocularis | roundabout 2 | 0.0067 | 0.0439 | 0.0121 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0382 | 0.0382 |
Echinococcus granulosus | UDP N acetylglucosamine dolichyl phosphate | 0.0056 | 0.035 | 0.003 |
Plasmodium vivax | formin 2, putative | 0.0116 | 0.0868 | 1 |
Trypanosoma cruzi | tyrosine phosphatase, putative | 0.0116 | 0.0868 | 1 |
Chlamydia trachomatis | phospho-N-acetylmuramoyl-pentapeptide-transferase | 0.0511 | 0.4305 | 0.5 |
Echinococcus multilocularis | UDP N acetylglucosamine dolichyl phosphate | 0.0056 | 0.035 | 0.003 |
Trypanosoma brucei | kinetoplastid kinetochore protein 19 | 0.0067 | 0.0444 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0116 | 0.0868 | 0.0868 |
Plasmodium falciparum | protein serine/threonine kinase-1 | 0.0067 | 0.0444 | 1 |
Brugia malayi | UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase | 0.0056 | 0.035 | 0.035 |
Schistosoma mansoni | UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase | 0.0056 | 0.035 | 0.035 |
Echinococcus granulosus | twitchin | 0.0065 | 0.0429 | 0.0111 |
Leishmania major | protein kinase, putative | 0.0067 | 0.0444 | 0.1815 |
Schistosoma mansoni | defective proboscis extension response (dpr)-related | 0.0053 | 0.0322 | 0.0322 |
Entamoeba histolytica | Pten 3-phosphoinositide phosphatase, putative | 0.0116 | 0.0868 | 1 |
Trypanosoma cruzi | tyrosine phosphatase isoform, putative | 0.0116 | 0.0868 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0067 | 0.0444 | 0.0444 |
Trichomonas vaginalis | pten, drome, putative | 0.0116 | 0.0868 | 1 |
Echinococcus multilocularis | neuroglian | 0.006 | 0.0378 | 0.0058 |
Echinococcus granulosus | dual specificity protein kinase clk2 | 0.0067 | 0.0444 | 0.0127 |
Echinococcus multilocularis | cyclin g associated kinase | 0.1166 | 1 | 1 |
Echinococcus granulosus | roundabout 2 | 0.0067 | 0.0439 | 0.0121 |
Loa Loa (eye worm) | CAMK/MLCK protein kinase | 0.0019 | 0.0027 | 0.0027 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0322 | 0.0322 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.0393 | 0.0393 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0322 | 0.0322 |
Echinococcus multilocularis | dual specificity protein kinase clk2 | 0.0067 | 0.0444 | 0.0127 |
Trypanosoma cruzi | tyrosine phosphatase isoform, putative | 0.0116 | 0.0868 | 1 |
Schistosoma mansoni | tensin | 0.0116 | 0.0868 | 0.0868 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0053 | 0.0322 | 0.0322 |
Trypanosoma cruzi | kinetoplastid kinetochore protein 10, putative | 0.0067 | 0.0444 | 0.1815 |
Onchocerca volvulus | 0.0056 | 0.035 | 1 | |
Brugia malayi | Protein kinase domain containing protein | 0.0067 | 0.0444 | 0.0444 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.006 | 0.0382 | 0.0063 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0322 | 0.0322 |
Mycobacterium ulcerans | phospho-N-acetylmuramoyl-pentapeptide-transferase | 0.0511 | 0.4305 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 65 nM | Inhibition of Staphylococcus aureus MraY using UDP-MurNAc-dansylpentapeptide substrate assessed as formation of dansylated lipid I incubated for 3 to 4 hrs by fluorometric assay | ChEMBL. | 22677318 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.