Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glycogen synthase kinase 3 beta | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.0278 | 0.0278 |
Brugia malayi | hypothetical protein | 0.0112 | 0.1508 | 0.3067 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0058 | 0 | 0.5 |
Brugia malayi | metalloprotease disintegrin 16 with thrombospondin type I motif | 0.0093 | 0.099 | 0.2014 |
Echinococcus multilocularis | a disintegrin and metalloproteinase with | 0.0178 | 0.3347 | 0.8563 |
Schistosoma mansoni | subfamily M12B unassigned peptidase (M12 family) | 0.0068 | 0.0278 | 0.0711 |
Plasmodium falciparum | glycogen synthase kinase 3 | 0.0058 | 0 | 0.5 |
Trypanosoma brucei | protein kinase, putative | 0.0058 | 0 | 0.5 |
Schistosoma mansoni | adam (A disintegrin and metalloprotease | 0.0112 | 0.1508 | 0.3858 |
Plasmodium vivax | glycogen synthase kinase 3, putative | 0.0058 | 0 | 0.5 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0085 | 0.0753 | 0.1925 |
Giardia lamblia | Kinase, CMGC GSK | 0.0058 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0092 | 0.0957 | 0.0957 |
Echinococcus multilocularis | Blood coagulation inhibitor, Disintegrin | 0.0124 | 0.1849 | 0.473 |
Onchocerca volvulus | Papilin homolog | 0.0065 | 0.0182 | 1 |
Echinococcus granulosus | adam | 0.0112 | 0.1508 | 0.3381 |
Schistosoma mansoni | subfamily M12B unassigned peptidase (M12 family) | 0.0068 | 0.0278 | 0.0711 |
Entamoeba histolytica | protein kinase, putative | 0.0058 | 0 | 0.5 |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | 0.0085 | 0.0753 | 0.1687 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0058 | 0 | 0.5 |
Echinococcus multilocularis | adam 17 protease | 0.0198 | 0.3909 | 1 |
Echinococcus granulosus | subfamily M12B unassigned peptidase | 0.0068 | 0.0278 | 0.0623 |
Leishmania major | glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 | 0.0058 | 0 | 0.5 |
Trypanosoma cruzi | glycogen synthase kinase 3, putative | 0.0058 | 0 | 0.5 |
Echinococcus granulosus | adam 17 protease | 0.0218 | 0.4461 | 1 |
Loa Loa (eye worm) | reprolysin | 0.0068 | 0.0278 | 0.0278 |
Echinococcus multilocularis | subfamily M12B unassigned peptidase | 0.0068 | 0.0278 | 0.0711 |
Loa Loa (eye worm) | hypothetical protein | 0.0065 | 0.0182 | 0.0182 |
Brugia malayi | ADAM-TS Spacer 1 family protein | 0.0234 | 0.4918 | 1 |
Giardia lamblia | Kinase, CMGC GSK | 0.0058 | 0 | 0.5 |
Toxoplasma gondii | cell-cycle-associated protein kinase GSK, putative | 0.0058 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0234 | 0.4918 | 0.4918 |
Schistosoma mansoni | ADAMTS5 peptidase (M12 family) | 0.0178 | 0.3347 | 0.8563 |
Schistosoma mansoni | ADAM17 peptidase (M12 family) | 0.0198 | 0.3909 | 1 |
Echinococcus granulosus | a disintegrin and metalloproteinase with | 0.0178 | 0.3347 | 0.7504 |
Brugia malayi | ADAMTS-like protease | 0.0099 | 0.1156 | 0.2351 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0058 | 0 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0058 | 0 | 0.5 |
Brugia malayi | angiogenesis inhibito | 0.0099 | 0.1156 | 0.2351 |
Echinococcus granulosus | Blood coagulation inhibitor Disintegrin | 0.0124 | 0.1849 | 0.4145 |
Echinococcus multilocularis | adam | 0.0112 | 0.1508 | 0.3858 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.