TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 476.591 | Formula: C26H28N4O3S
H donors: 4 H acceptors: 2 LogP: 5.31 Rotable bonds: 10
Rule of 5 violations (Lipinski): 1
SMILES: COc1cc(ccc1NC(=O)c1ccc(cc1)N)NC(=S)NC(=O)c1ccc(cc1)C(C)(C)C
InChi: 1S/C26H28N4O3S/c1-26(2,3)18-9-5-16(6-10-18)24(32)30-25(34)28-20-13-14-21(22(15-20)33-4)29-23(31)17-7-11-19(27)12-8-17/h5-15H,27H2,1-4H3,(H,29,31)(H2,28,30,32,34)
InChiKey: JESGYMUPRAVZRP-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma cruzi	hexose transporter, putative	0.0016	0.0201	0.0211
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0065	0.1269	0.1556
Trichomonas vaginalis	prolyl-tRNA synthetase, putative	0.0033	0.0582	0.0609
Brugia malayi	hypothetical protein	0.0016	0.0201	0.0399
Mycobacterium leprae	conserved hypothetical protein	0.0139	0.2876	1
Mycobacterium tuberculosis	Probable conserved integral membrane transport protein	0.0016	0.0201	0.07
Echinococcus multilocularis	solute carrier family 22	0.0016	0.0201	0.0211
Brugia malayi	Major Facilitator Superfamily protein	0.0016	0.0201	0.0399
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0448	0.9557	1
Toxoplasma gondii	sugar transporter ST2	0.0016	0.0201	0.0247
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.011	0.2253	0.2358
Trichomonas vaginalis	conserved hypothetical protein	0.0383	0.8154	0.8532
Plasmodium falciparum	cGMP-specific phosphodiesterase	0.0065	0.1269	0.1269
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0201	0.0211
Trypanosoma brucei	glucose transporter 2A	0.0034	0.0606	0.0634
Plasmodium vivax	cyclic nucleotide phosphodiesterase, putative	0.0065	0.1269	0.1269
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0065	0.1269	0.1556
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0201	0.0399
Schistosoma mansoni	calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase	0.0065	0.1269	0.1327
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0448	0.9557	1
Plasmodium vivax	3',5'-cyclic nucleotide phosphodiesterase, putative	0.0065	0.1269	0.1269
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	0.0448	0.9557	1
Toxoplasma gondii	hypothetical protein	0.0139	0.2876	0.3527
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0399	0.079
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0448	0.9557	1
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0448	0.9557	1
Trichomonas vaginalis	conserved hypothetical protein	0.011	0.2253	0.2358
Plasmodium falciparum	phosphodiesterase delta, putative	0.0065	0.1269	0.1269
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0582	0.1154
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0201	0.0211
Giardia lamblia	Hypothetical protein	0.0065	0.1269	0.4216
Trichomonas vaginalis	conserved hypothetical protein	0.0016	0.0201	0.0211
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0448	0.9557	1
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0201	0.0211
Trichomonas vaginalis	sugar transporter, putative	0.0034	0.0606	0.0634
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0016	0.0205	0.0215
Plasmodium falciparum	lysine--tRNA ligase	0.0025	0.0399	0.0399
Brugia malayi	major facilitator superfamily protein	0.0016	0.0201	0.0399
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0034	0.0606	0.0634
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0065	0.1269	0.1327
Plasmodium vivax	3',5'-cyclic nucleotide phosphodiesterase, putative	0.0065	0.1269	0.1269
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0022	0.0333	0.0348
Trichomonas vaginalis	glucose transporter, putative	0.0016	0.0201	0.0211
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0201	0.0211
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0034	0.0597	0.0625
Loa Loa (eye worm)	calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase	0.0065	0.1269	0.2515
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.011	0.2253	0.2358
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0016	0.0205	0.0215
Trichomonas vaginalis	conserved hypothetical protein	0.0016	0.0201	0.0211
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0034	0.0597	0.0625
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0448	0.0888
Trypanosoma brucei	cAMP-specific phosphodiesterase	0.0448	0.9557	1
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0201	0.0211
Leishmania major	glucose transporter, lmgt1	0.0034	0.0606	0.0634
Giardia lamblia	Sugar-proton symporter	0.0016	0.0201	0.0669
Trypanosoma cruzi	hypothetical protein, conserved	0.0065	0.1269	0.1327
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0065	0.1269	0.1556
Toxoplasma gondii	cell-cycle-associated protein kinase MAPK, putative	0.0178	0.3724	0.4567
Echinococcus multilocularis	dual 3',5' cyclic AMP and GMP phosphodiesterase	0.0448	0.9557	1
Giardia lamblia	Lysyl-tRNA synthetase	0.0025	0.0399	0.1325
Trypanosoma brucei	cAMP-specific phosphodiesterase	0.0448	0.9557	1
Echinococcus granulosus	calcium:calmodulin dependent 3'5' cyclic	0.0065	0.1269	0.1327
Leishmania major	myo-inositol/proton symporter (MIT)	0.0016	0.0201	0.0211
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0201	0.0211
Trichomonas vaginalis	calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative	0.0065	0.1269	0.1327
Leishmania major	hypothetical protein, conserved	0.0065	0.1269	0.1327
Schistosoma mansoni	sugar transporter	0.0016	0.0201	0.0211
Mycobacterium ulcerans	sugar-transport integral membrane protein SugI	0.0016	0.0201	0.07
Echinococcus granulosus	glutamyl tRNA synthetase cytoplasmic	0.0033	0.0582	0.0609
Chlamydia trachomatis	proline--tRNA ligase	0.0012	0.0119	0.2978
Echinococcus granulosus	calcium dependent protein kinase	0.0032	0.0552	0.0577
Trypanosoma cruzi	hexose transporter, putative	0.0034	0.0606	0.0634
Mycobacterium ulcerans	putative regulatory protein	0.0139	0.2876	1
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0448	0.9557	1
Brugia malayi	hypothetical protein	0.0016	0.0201	0.0399
Brugia malayi	Bifunctional aminoacyl-tRNA synthetase	0.0033	0.0582	0.1154
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0065	0.1269	0.1327
Plasmodium vivax	sugar transporter, putative	0.0016	0.0201	0.0201
Toxoplasma gondii	sugar transporter ST1	0.0016	0.0201	0.0247
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0448	0.9557	1
Trichomonas vaginalis	glucose transporter, putative	0.0034	0.0606	0.0634
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.011	0.2253	0.2358
Trichomonas vaginalis	conserved hypothetical protein	0.0383	0.8154	0.8532
Loa Loa (eye worm)	pax transcription factor protein 2	0.0239	0.5043	1
Trypanosoma cruzi	cyclic nucleotide phosphodiesterase	0.0065	0.1269	0.1327
Trypanosoma brucei	glucose transporter, putative	0.0034	0.0606	0.0634
Toxoplasma gondii	GAF domain-containing protein	0.0139	0.2876	0.3527
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0201	0.0211
Echinococcus multilocularis	high affinity cAMP specific 3',5' cyclic	0.0065	0.1269	0.1327
Brugia malayi	Cam kinase protein 1	0.0034	0.0597	0.1183
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0065	0.1269	0.1556
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0201	0.0399
Schistosoma mansoni	hypothetical protein	0.0016	0.0205	0.0215
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0448	0.9557	1
Plasmodium falciparum	GAF domain-related protein, putative	0.0139	0.2876	0.2876
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0205	0.0406
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0033	0.0582	0.0609
Schistosoma mansoni	hypothetical protein	0.011	0.2253	0.2358
Echinococcus granulosus	synaptic vesicle 2 protein	0.0016	0.0201	0.0211
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0204	0.4279	0.4478
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	0.0034	0.0597	0.0732
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0201	0.0211
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0065	0.1269	0.1556
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 2 LysX	0.0021	0.0318	0.1107
Trypanosoma cruzi	hexose transporter, putative	0.0019	0.027	0.0283
Loa Loa (eye worm)	hypothetical protein	0.0139	0.2876	0.5703
Plasmodium falciparum	3',5'-cyclic nucleotide phosphodiesterase, putative	0.0065	0.1269	0.1269
Schistosoma mansoni	sugar transporter	0.0016	0.0201	0.0211
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0448	0.9557	1
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0034	0.0597	0.0597
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0065	0.1269	0.1556
Trypanosoma brucei	3', 5'-cyclic nucleotide phosphodiesterase, putative	0.0065	0.1269	0.1327
Schistosoma mansoni	hypothetical protein	0.0016	0.0205	0.0215
Mycobacterium ulcerans	prolyl-tRNA synthetase	0.0012	0.0119	0.0413
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0039	0.0701	0.0733
Echinococcus granulosus	solute carrier family 22	0.0016	0.0201	0.0211
Schistosoma mansoni	protein kinase	0.0034	0.0597	0.0625
Echinococcus multilocularis	GPCR, family 2	0.0016	0.0205	0.0215
Echinococcus multilocularis	Sugar transporter ERD6 protein	0.0016	0.0201	0.0211
Trypanosoma cruzi	hexose transporter, putative	0.0034	0.0606	0.0634
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0016	0.0205	0.0215
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.008	0.1606	0.1681
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.0065	0.1269	0.2515
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0201	0.0211
Trypanosoma brucei	glucose transporter, putative	0.0034	0.0606	0.0634
Mycobacterium ulcerans	sugar transporter	0.0016	0.0201	0.07
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0034	0.0597	0.0625
Schistosoma mansoni	hypothetical protein	0.0034	0.0599	0.0627
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0597	0.1183
Trypanosoma cruzi	hexose transporter	0.0034	0.0606	0.0634
Trypanosoma cruzi	glucose transporter, putative	0.0016	0.0201	0.0211
Brugia malayi	Latrophilin receptor protein 2	0.0016	0.0205	0.0406
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0448	0.9557	1
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0448	0.9557	1
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative	0.0204	0.4279	0.8485
Leishmania major	hypothetical protein, conserved	0.0016	0.0201	0.0211
Leishmania major	glucose transporter, lmgt2	0.0034	0.0606	0.0634
Entamoeba histolytica	protein kinase, putative	0.0034	0.0597	1
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0448	0.9557	1
Entamoeba histolytica	protein kinase, putative	0.0034	0.0597	1
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0201	0.0211
Plasmodium vivax	CDK-related protein kinase 6, putative	0.0469	1	1
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0065	0.1269	0.1327
Entamoeba histolytica	hypothetical protein	0.0025	0.0399	0.6679
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0448	0.9557	1
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	0.0034	0.0597	0.0732
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0599	0.1187
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0201	0.0399
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0201	0.0399
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0039	0.0701	0.0733
Plasmodium falciparum	phosphodiesterase gamma, putative	0.0065	0.1269	0.1269
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.0034	0.0597	0.0597
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0201	0.0211
Loa Loa (eye worm)	PDE1B protein	0.0065	0.1269	0.2515
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0201	0.0211
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0145	0.3009	0.3149
Leishmania major	cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100	0.0065	0.1269	0.1327
Loa Loa (eye worm)	sugar transporter	0.011	0.2253	0.4468
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0201	0.0211
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0025	0.0399	0.0417
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0201	0.0211
Echinococcus granulosus	high affinity cgmp specific 3' 5' cyclic	0.0065	0.1269	0.1327
Brugia malayi	Sugar transporter family protein	0.0016	0.0201	0.0399
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0201	0.0211
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0201	0.0399
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0034	0.0606	0.0634
Echinococcus multilocularis	solute carrier family 22	0.0016	0.0201	0.0211
Leishmania major	cAMP-specific phosphodiesterase, putative	0.0065	0.1269	0.1327
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0039	0.0701	0.0733
Giardia lamblia	hypothetical protein	0.0065	0.1269	0.4216
Trypanosoma cruzi	cAMP phosphodiesterase A, putative	0.0065	0.1269	0.1327
Loa Loa (eye worm)	hypothetical protein	0.0204	0.4279	0.8485
Giardia lamblia	Hexose transporter	0.0016	0.0201	0.0669
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0025	0.0399	0.1386
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.005	0.0938	0.186
Toxoplasma gondii	lysine-tRNA ligase	0.0025	0.0399	0.0489
Onchocerca volvulus		0.0239	0.5043	1
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase R153.1, putative	0.0065	0.1269	0.2515
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0204	0.4279	0.4478
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0448	0.9557	1
Echinococcus granulosus	GPCR family 2	0.0016	0.0205	0.0215
Trypanosoma brucei	hypothetical protein, conserved	0.0065	0.1269	0.1327
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0201	0.0211
Loa Loa (eye worm)	bifunctional aminoacyl-tRNA synthetase	0.0014	0.016	0.0317
Plasmodium vivax	lysine--tRNA ligase, putative	0.0025	0.0399	0.0399
Leishmania major	glucose transporter, lmgt3	0.0034	0.0606	0.0634
Trichomonas vaginalis	conserved hypothetical protein	0.0448	0.9557	1
Brugia malayi	Calcitonin receptor-like protein seb-1	0.005	0.0938	0.186
Schistosoma mansoni	glucose transport protein	0.011	0.2253	0.2358
Brugia malayi	Major Facilitator Superfamily protein	0.0016	0.0201	0.0399
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0065	0.1269	0.1556
Trichomonas vaginalis	conserved hypothetical protein	0.0139	0.2876	0.301
Trypanosoma cruzi	hypothetical protein, conserved	0.0065	0.1269	0.1327
Entamoeba histolytica	prolyl-tRNA synthetase, putative	0.0033	0.0582	0.9752
Plasmodium falciparum	calcium-dependent protein kinase 5	0.0034	0.0597	0.0597
Schistosoma mansoni	lysyl-tRNA synthetase	0.0025	0.0399	0.0417
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0065	0.1269	0.1556
Echinococcus granulosus	solute carrier family 22	0.0016	0.0201	0.0211
Trypanosoma cruzi	cAMP-specific phosphodiesterase, putative	0.0065	0.1269	0.1327
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.011	0.2253	0.2358
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.011	0.2253	0.2358
Schistosoma mansoni	glucose transport protein	0.011	0.2253	0.2358
Trichomonas vaginalis	conserved hypothetical protein	0.0034	0.0606	0.0634
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0448	0.9557	1
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0065	0.1269	0.1327
Echinococcus granulosus	solute carrier family 22	0.0016	0.0201	0.0211
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0201	0.0211
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0145	0.3009	0.3149
Loa Loa (eye worm)	hypothetical protein	0.005	0.0938	0.186
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	0.0034	0.0597	0.0625
Trypanosoma cruzi	hypothetical protein, conserved	0.0065	0.1269	0.1327
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0201	0.0211
Plasmodium vivax	mitogen-activated protein kinase 2, putative	0.0178	0.3724	0.3724
Trypanosoma brucei	myo-inositol/proton symporter (MIT)	0.0016	0.0201	0.0211
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.011	0.2253	0.2358
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.0034	0.0597	0.0625
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0201	0.0211
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0065	0.1269	0.1556
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0201	0.0211
Loa Loa (eye worm)	hypothetical protein	0.0145	0.3009	0.5967
Trichomonas vaginalis	cGMP-inhibited 3,5-cyclic phosphodiesterase, putative	0.0448	0.9557	1
Toxoplasma gondii	hypothetical protein	0.0139	0.2876	0.3527
Schistosoma mansoni	sugar transporter	0.0016	0.0201	0.0211
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0016	0.0205	0.0406
Mycobacterium tuberculosis	Two component sensor histidine kinase DevS	0.0139	0.2876	1
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.0025	0.0399	0.0417
Trypanosoma brucei	sugar transporter, putative	0.0016	0.0201	0.0211
Trichomonas vaginalis	conserved hypothetical protein	0.0065	0.1269	0.1327
Trichomonas vaginalis	glucose transporter, putative	0.0034	0.0606	0.0634
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0034	0.0597	0.0625
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.0034	0.0597	0.1183
Trichomonas vaginalis	conserved hypothetical protein	0.0065	0.1269	0.1327
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0065	0.1269	0.1327
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0201	0.0399
Toxoplasma gondii	transporter, major facilitator family protein	0.0016	0.0201	0.0247
Trypanosoma brucei	glucose transporter, putative	0.0034	0.0606	0.0634
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0448	0.9557	1
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0448	0.9557	1
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0201	0.0399
Toxoplasma gondii	hypothetical protein	0.0383	0.8154	1
Giardia lamblia	CAMP-specific 3,5-cyclic phosphodiesterase 4B	0.0145	0.3009	1
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.005	0.0938	0.186
Trypanosoma brucei	glucose transporter 1E	0.0034	0.0606	0.0634
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0448	0.9557	1
Loa Loa (eye worm)	sugar transporter	0.0016	0.0201	0.0399
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0039	0.0701	0.0733
Brugia malayi	Sugar transporter family protein	0.0016	0.0201	0.0399
Plasmodium falciparum	calcium-dependent protein kinase 2	0.0034	0.0597	0.0597
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0309	0.6546	0.685
Echinococcus granulosus	dual 3'5' cyclic AMP and GMP phosphodiesterase	0.0448	0.9557	1
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0448	0.9557	1
Trichomonas vaginalis	cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative	0.0309	0.6546	0.685
Echinococcus multilocularis	solute carrier family 22	0.0016	0.0201	0.0211
Wolbachia endosymbiont of Brugia malayi	major facilitator superfamily permease	0.0016	0.0201	1
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0204	0.4279	0.4478
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0201	0.0211
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0034	0.0597	0.0625
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0145	0.3009	0.3149
Mycobacterium ulcerans	integral membrane transport protein	0.0016	0.0201	0.07
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0448	0.9557	1
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0065	0.1269	0.1327
Treponema pallidum	prolyl-tRNA synthetase	0.0012	0.0119	1
Plasmodium vivax	phosphodiesterase gamma, putative	0.0065	0.1269	0.1269
Trypanosoma brucei	glucose transporter, putative	0.0034	0.0606	0.0634
Brugia malayi	major facilitator superfamily protein	0.0016	0.0201	0.0399
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0448	0.9557	1
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0201	0.0211
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0065	0.1269	0.1327
Mycobacterium leprae	Probable prolyl tRNA synthetase ProS	0.0033	0.0582	0.2024
Plasmodium falciparum	calcium-dependent protein kinase 3	0.0034	0.0597	0.0597
Trypanosoma cruzi	hexose transporter, putative	0.0034	0.0606	0.0634
Echinococcus multilocularis	solute carrier family 22	0.0016	0.0201	0.0211
Trichomonas vaginalis	cAMP/cGMP cyclic nucleotide phosphodiesterase, putative	0.0448	0.9557	1
Schistosoma mansoni	lysyl-tRNA synthetase	0.0025	0.0399	0.0417
Plasmodium falciparum	major facilitator superfamily domain-containing protein, putative	0.0016	0.0201	0.0201
Trypanosoma cruzi	hypothetical protein, conserved	0.0065	0.1269	0.1327
Echinococcus multilocularis	calcium:calmodulin dependent 3',5' cyclic	0.0065	0.1269	0.1327
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	0.0034	0.0597	0.0732
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0448	0.9557	1
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0201	0.0211
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0145	0.3009	0.3149
Schistosoma mansoni	glucose transporter	0.0016	0.0201	0.0211
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0016	0.0205	0.0215
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.011	0.2253	0.2358
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0201	0.0211
Toxoplasma gondii	sugar transporter ST3	0.0016	0.0201	0.0247
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0201	0.0399
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.011	0.2253	0.2358
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0068	0.1345	0.165
Trichomonas vaginalis	sugar transport protein, putative	0.0016	0.0201	0.0211
Plasmodium vivax	hexose transporter	0.011	0.2253	0.2253
Brugia malayi	Sugar transporter family protein	0.011	0.2253	0.4468
Plasmodium falciparum	hexose transporter	0.011	0.2253	0.2253
Mycobacterium ulcerans	putative regulatory protein	0.0139	0.2876	1
Schistosoma mansoni	camp-specific cyclic nucleotide phosphodiesterase	0.0065	0.1269	0.1327
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0448	0.9557	1
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0149	0.3086	0.3785
Mycobacterium tuberculosis	Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter)	0.0016	0.0201	0.07
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0201	0.0399
Schistosoma mansoni	protein kinase	0.0034	0.0597	0.0625
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0065	0.1269	0.1327
Echinococcus multilocularis	calcium dependent protein kinase	0.0032	0.0552	0.0577
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0309	0.6546	0.685
Schistosoma mansoni	camp/cgmp cyclic nucleotide phosphodiesterase	0.0448	0.9557	1
Echinococcus multilocularis	General substrate transporter	0.0095	0.1918	0.2007
Brugia malayi	Major Facilitator Superfamily protein	0.0016	0.0201	0.0399
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0201	0.0211
Trypanosoma brucei	glucose transporter, putative	0.0034	0.0606	0.0634
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0448	0.9557	1
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0201	0.0399
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0448	0.9557	1
Brugia malayi	lysyl-tRNA synthetase	0.0025	0.0399	0.079
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0025	0.0399	0.1386
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0201	0.0399
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0201	0.0399
Schistosoma mansoni	high-affinity cgmp-specific 35-cyclic phosphodiesterase	0.0065	0.1269	0.1327
Brugia malayi	Pax transcription factor protein 2	0.0239	0.5043	1
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0065	0.1269	0.1556
Loa Loa (eye worm)	hypothetical protein	0.0065	0.1269	0.2515
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0065	0.1269	0.1327
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0065	0.1269	0.1327
Echinococcus multilocularis	synaptic vesicle 2 protein	0.0016	0.0201	0.0211
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0201	0.0211
Echinococcus multilocularis	glutamyl tRNA synthetase cytoplasmic	0.0033	0.0582	0.0609
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0201	0.0211
Echinococcus granulosus	solute carrier family 22	0.0016	0.0201	0.0211
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0034	0.0597	0.0625
Trichomonas vaginalis	CAMK family protein kinase	0.0034	0.0597	0.0625
Schistosoma mansoni	protein kinase	0.0034	0.0597	0.0625
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0016	0.0205	0.0406
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0065	0.1269	0.1556
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0065	0.1269	0.1556
Schistosoma mansoni	serine/threonine protein kinase	0.0034	0.0597	0.0625
Mycobacterium ulcerans	two component sensor histidine kinase DevS	0.0139	0.2876	1
Echinococcus granulosus	calcium:calmodulin dependent 3'5' cyclic	0.0065	0.1269	0.1327
Trichomonas vaginalis	cGMP-inhibited 3,5-cyclic phosphodiesterase, putative	0.0065	0.1269	0.1327
Toxoplasma gondii	protein kinase, putative	0.0312	0.6612	0.8109
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0448	0.9557	1
Mycobacterium ulcerans	fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT	0.0016	0.0201	0.07
Echinococcus granulosus	cAMP and cAMP inhibited cGMP 3'5' cyclic	0.0204	0.4279	0.4478
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0065	0.1269	0.1556
Echinococcus multilocularis	cAMP and cAMP inhibited cGMP 3',5' cyclic	0.0204	0.4279	0.4478
Trichomonas vaginalis	cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative	0.0065	0.1269	0.1327
Mycobacterium leprae	Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0021	0.0318	0.1107
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0065	0.1269	0.1556
Schistosoma mansoni	cgmp-dependent 35-cyclic phosphodiesterase	0.0204	0.4279	0.4478
Plasmodium vivax	calcium-dependent protein kinase, putative	0.0034	0.0597	0.0597
Brugia malayi	hypothetical protein	0.0016	0.0201	0.0399
Giardia lamblia	Prolyl-tRNA synthetase	0.0033	0.0582	0.1934
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0025	0.0399	0.0417
Trichomonas vaginalis	sugar transporter, putative	0.0034	0.0606	0.0634
Mycobacterium leprae	Possible lysyl-tRNA synthetase 2 LysX	0.0025	0.0399	0.1386
Trypanosoma brucei	cAMP-specific phosphodiesterase, putative	0.0065	0.1269	0.1327
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0034	0.0606	0.0634
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0033	0.0582	0.0609
Trypanosoma cruzi	hypothetical protein, conserved	0.0065	0.1269	0.1327
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0034	0.0606	0.0634
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.0204	0.4279	0.8485
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0034	0.0597	0.0625
Trichomonas vaginalis	conserved hypothetical protein	0.0016	0.0201	0.0211
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0201	0.0399
Schistosoma mansoni	high-affinity cgmp-specific 35-cyclic phosphodiesterase	0.0065	0.1269	0.1327
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0582	0.1154
Schistosoma mansoni	hypothetical protein	0.0016	0.0205	0.0215
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.0065	0.1269	0.2515
Chlamydia trachomatis	lysine--tRNA ligase	0.0025	0.0399	1
Trypanosoma brucei	glucose transporter, putative	0.0034	0.0606	0.0634
Leishmania major	protein kinase, putative	0.0034	0.0597	0.0625
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	0.0448	0.9557	1
Brugia malayi	latrophilin 2 splice variant baaae	0.0034	0.0599	0.1187
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0201	0.0399
Toxoplasma gondii	prolyl-tRNA synthetase (ProRS)	0.0039	0.0701	0.0859
Echinococcus multilocularis	calcium:calmodulin dependent 3',5' cyclic	0.0065	0.1269	0.1327
Trichomonas vaginalis	conserved hypothetical protein	0.0383	0.8154	0.8532
Schistosoma mansoni	high-affinity cgmp-specific 35-cyclic phosphodiesterase	0.0065	0.1269	0.1327
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.0033	0.0582	0.1154
Plasmodium falciparum	calcium-dependent protein kinase 4	0.0034	0.0597	0.0597
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0201	0.0211
Loa Loa (eye worm)	hypothetical protein	0.0065	0.1269	0.2515
Plasmodium falciparum	mitogen-activated protein kinase 2	0.0178	0.3724	0.3724
Plasmodium vivax	hypothetical protein, conserved	0.0139	0.2876	0.2876
Plasmodium vivax	proline--tRNA ligase, putative	0.0039	0.0701	0.0701
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase R153.1, putative	0.008	0.1606	0.3185
Echinococcus granulosus	lysyl tRNA synthetase	0.0025	0.0399	0.0417
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0201	0.0211
Echinococcus multilocularis	high affinity cgmp specific 3' 5' cyclic	0.0065	0.1269	0.1327
Plasmodium falciparum	proline--tRNA ligase	0.0039	0.0701	0.0701
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative	0.0065	0.1269	0.2515
Leishmania major	hypothetical protein, conserved	0.0065	0.1269	0.1327
Plasmodium falciparum	calcium-dependent protein kinase 1	0.0034	0.0597	0.0597
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0065	0.1269	0.1556
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.0034	0.0597	0.0597
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0448	0.9557	1
Toxoplasma gondii	facilitative glucose transporter GT1	0.011	0.2253	0.2764
Mycobacterium tuberculosis	Two component sensor histidine kinase DosT	0.0139	0.2876	1
Leishmania major	lysyl-tRNA synthetase, putative	0.0025	0.0399	0.0417
Trichomonas vaginalis	conserved hypothetical protein	0.0016	0.0201	0.0211
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0145	0.3009	0.3149
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0016	0.0201	0.0399
Trypanosoma brucei	glucose transporter, putative	0.0034	0.0606	0.0634
Trypanosoma brucei	3', 5'-cyclic nucleotide phosphodiesterase, putative	0.0065	0.1269	0.1327
Schistosoma mansoni	sugar transporter	0.0016	0.0201	0.0211
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0016	0.0201	0.0399
Trypanosoma brucei	glucose transporter, putative	0.0034	0.0606	0.0634
Plasmodium falciparum	3',5'-cyclic nucleotide phosphodiesterase, putative	0.0065	0.1269	0.1269
Plasmodium falciparum	protein kinase 7	0.0312	0.6612	0.6612
Trichomonas vaginalis	conserved hypothetical protein	0.0034	0.0606	0.0634
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0201	0.0211
Trypanosoma brucei	bifunctional aminoacyl-tRNA synthetase, putative	0.0039	0.0701	0.0733
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0201	0.0399
Echinococcus granulosus	General substrate transporter	0.0095	0.1918	0.2007
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.0034	0.0597	0.1183
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0201	0.0211
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0201	0.0211
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0201	0.0211
Schistosoma mansoni	nuclear transcription factor X-box binding 1 (nfx1)	0.0016	0.0201	0.0211
Trichomonas vaginalis	myo-inositol transporter, putative	0.0016	0.0201	0.0211
Trichomonas vaginalis	conserved hypothetical protein	0.0016	0.0201	0.0211
Plasmodium falciparum	cGMP-specific phosphodiesterase	0.0065	0.1269	0.1269
Trypanosoma cruzi	hypothetical protein, conserved	0.0065	0.1269	0.1327
Schistosoma mansoni	hypothetical protein	0.0016	0.0205	0.0215
Trypanosoma brucei	cAMP phosphodiesterase A, putative	0.0065	0.1269	0.1327
Echinococcus granulosus	Sugar transporter ERD6 protein	0.0016	0.0201	0.0211
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0021	0.0318	0.1107
Trichomonas vaginalis	sugar transporter, putative	0.0034	0.0606	0.0634
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0034	0.0597	0.1183
Loa Loa (eye worm)	cyclic AMP specific phosphodiesterase PDE4D5A	0.008	0.1606	0.3185
Echinococcus granulosus	high affinity cAMP specific 3'5' cyclic	0.0065	0.1269	0.1327
Trypanosoma cruzi	cAMP phosphodiesterase A, putative	0.0065	0.1269	0.1327
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0201	0.0211
Schistosoma mansoni	glucose transport protein	0.011	0.2253	0.2358
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0065	0.1269	0.1556
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0201	0.0211
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.008	0.1606	0.1681
Echinococcus multilocularis	lysyl tRNA synthetase	0.0025	0.0399	0.0417
Trypanosoma cruzi	sugar transporter, putative	0.0016	0.0201	0.0211

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL2078939

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1658715