Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Steroid 5-alpha-reductase | Starlite/ChEMBL | References |
Homo sapiens | adrenoceptor alpha 1A | Starlite/ChEMBL | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.17 uM | Inhibitory activity against prostatic 5-alpha reductase in Sprague-Dawley rat | ChEMBL. | 9873656 |
IC50 (binding) | = 0.17 uM | Inhibitory activity against prostatic 5-alpha reductase in Sprague-Dawley rat | ChEMBL. | 9873656 |
Kd (binding) | = 6.7 | Inhibition of phenylephrine-induced contractions in white rabbit prostate. | ChEMBL. | 9873656 |
pA2 (binding) | = 6.7 | Inhibition of phenylephrine-induced contractions in white rabbit prostate. | ChEMBL. | 9873656 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.