Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | ribosomal protein S6 kinase alpha 3 | 0.0614 | 0.1814 | 1 |
Echinococcus multilocularis | ribosomal protein s6 kinase beta 1 | 0.0089 | 0.0236 | 0.13 |
Loa Loa (eye worm) | AGC/RSK/MSK protein kinase | 0.0089 | 0.0236 | 0.13 |
Brugia malayi | p70 ribosomal S6 kinase beta | 0.0089 | 0.0236 | 0.1521 |
Echinococcus multilocularis | tyrosine protein kinase Fgr | 0.0015 | 0.0012 | 0.0065 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0522 | 0.1537 | 0.8473 |
Echinococcus multilocularis | tyrosine protein kinase Src64B | 0.0015 | 0.0012 | 0.0065 |
Echinococcus granulosus | tyrosine protein kinase Btk29A | 0.0309 | 0.0895 | 0.4931 |
Mycobacterium leprae | PROBABLE CONSERVED LIPOPROTEIN LPQF | 0.0924 | 0.2745 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0614 | 0.1814 | 1 |
Mycobacterium ulcerans | class a beta-lactamase, BlaC | 0.1925 | 0.5755 | 1 |
Brugia malayi | SRC-1 | 0.0015 | 0.0012 | 0.0076 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0089 | 0.0236 | 0.13 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0522 | 0.1537 | 0.1357 |
Echinococcus granulosus | tyrosine protein kinase Src42A | 0.0015 | 0.0012 | 0.0065 |
Schistosoma mansoni | tyrosine kinase | 0.013 | 0.0357 | 0.1965 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0522 | 0.1537 | 0.1357 |
Echinococcus granulosus | tyrosine protein kinase Src64B | 0.0015 | 0.0012 | 0.0065 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0522 | 0.1537 | 0.5 |
Trypanosoma brucei | beta lactamase | 0.0924 | 0.2745 | 1 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0522 | 0.1537 | 0.2395 |
Trichomonas vaginalis | AGC family protein kinase | 0.0092 | 0.0245 | 0.0271 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0522 | 0.1537 | 1 |
Loa Loa (eye worm) | AGC/AKT protein kinase | 0.0092 | 0.0245 | 0.135 |
Mycobacterium ulcerans | lipase LipD | 0.0522 | 0.1537 | 0.2395 |
Mycobacterium tuberculosis | Probable conserved lipoprotein LpqF | 0.0924 | 0.2745 | 0.259 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0522 | 0.1537 | 0.5 |
Echinococcus multilocularis | Protein kinase C, brain isozyme | 0.0089 | 0.0236 | 0.13 |
Schistosoma mansoni | tyrosine kinase | 0.0303 | 0.0878 | 0.4841 |
Onchocerca volvulus | 0.0522 | 0.1537 | 0.5 | |
Echinococcus multilocularis | ribosomal protein S6 kinase alpha 3 | 0.0614 | 0.1814 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0089 | 0.0236 | 0.13 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0522 | 0.1537 | 0.8473 |
Loa Loa (eye worm) | SRC-1 | 0.0015 | 0.0012 | 0.0065 |
Brugia malayi | Protein kinase domain containing protein | 0.0092 | 0.0245 | 0.1579 |
Schistosoma mansoni | tyrosine kinase | 0.0015 | 0.0012 | 0.0065 |
Trichomonas vaginalis | esterase, putative | 0.0522 | 0.1537 | 1 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0133 | 0.0368 | 0.203 |
Mycobacterium leprae | conserved hypothetical protein | 0.0522 | 0.1537 | 0.5237 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0089 | 0.0236 | 0.13 |
Echinococcus granulosus | ribosomal protein s6 kinase beta 1 | 0.0089 | 0.0236 | 0.13 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0015 | 0.0012 | 0.0065 |
Schistosoma mansoni | atypical protein kinase C | 0.0089 | 0.0236 | 0.13 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0522 | 0.1537 | 1 |
Mycobacterium leprae | Probable lipase LipE | 0.0522 | 0.1537 | 0.5237 |
Echinococcus multilocularis | tyrosine protein kinase Src42A | 0.0015 | 0.0012 | 0.0065 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0015 | 0.0012 | 0.0065 |
Trichomonas vaginalis | AGC family protein kinase | 0.0092 | 0.0245 | 0.0271 |
Loa Loa (eye worm) | TK/INSR protein kinase | 0.0291 | 0.0843 | 0.4649 |
Echinococcus granulosus | Ribosomal protein S6 kinase beta 2 | 0.0089 | 0.0236 | 0.13 |
Mycobacterium tuberculosis | Conserved protein | 0.0522 | 0.1537 | 0.1357 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0291 | 0.0843 | 0.4649 |
Echinococcus multilocularis | tyrosine protein kinase Btk29A | 0.0309 | 0.0895 | 0.4931 |
Mycobacterium ulcerans | lipoprotein LpqF | 0.0924 | 0.2745 | 0.4573 |
Schistosoma mansoni | serine/threonine kinase | 0.0089 | 0.0236 | 0.13 |
Echinococcus granulosus | protein kinase c epsilon type | 0.0089 | 0.0236 | 0.13 |
Trichomonas vaginalis | serine/threonine-protein kinase sgk, putative | 0.0087 | 0.023 | 0.0158 |
Schistosoma mansoni | tyrosine kinase | 0.0015 | 0.0012 | 0.0065 |
Echinococcus granulosus | proto oncogene tyrosine protein kinase LCK | 0.0015 | 0.0012 | 0.0065 |
Mycobacterium tuberculosis | Class a beta-lactamase BlaC | 0.1925 | 0.5755 | 0.5665 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0522 | 0.1537 | 0.1357 |
Onchocerca volvulus | 0.0522 | 0.1537 | 0.5 | |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0522 | 0.1537 | 1 |
Treponema pallidum | penicillin-binding protein (pbp-2) | 0.008 | 0.0209 | 0.5 |
Onchocerca volvulus | 0.0522 | 0.1537 | 0.5 | |
Mycobacterium tuberculosis | Probable hydrolase | 0.0522 | 0.1537 | 0.1357 |
Schistosoma mansoni | tyrosine kinase | 0.0291 | 0.0843 | 0.4649 |
Echinococcus granulosus | insulin growth factor 1 receptor beta | 0.0291 | 0.0843 | 0.4649 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0522 | 0.1537 | 0.991 |
Echinococcus granulosus | 3'partial|tyrosine protein kinase Fgr | 0.0015 | 0.0012 | 0.0065 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0522 | 0.1537 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Abl | 0.0015 | 0.0012 | 0.0065 |
Schistosoma mansoni | tyrosine kinase | 0.0291 | 0.0843 | 0.4649 |
Brugia malayi | beta-lactamase family protein | 0.0522 | 0.1537 | 0.991 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0522 | 0.1537 | 1 |
Brugia malayi | beta-lactamase family protein | 0.0522 | 0.1537 | 0.991 |
Schistosoma mansoni | tyrosine kinase | 0.0133 | 0.0368 | 0.203 |
Entamoeba histolytica | protein kinase, putative | 0.0092 | 0.0245 | 1 |
Loa Loa (eye worm) | AGC/PKC/ETA protein kinase | 0.0089 | 0.0236 | 0.13 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0133 | 0.0368 | 0.203 |
Brugia malayi | protein kinase C II. | 0.0089 | 0.0236 | 0.1521 |
Mycobacterium tuberculosis | Conserved protein | 0.0522 | 0.1537 | 0.1357 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0089 | 0.0236 | 0.13 |
Echinococcus multilocularis | protein kinase c iota type | 0.0089 | 0.0236 | 0.13 |
Mycobacterium ulcerans | beta-lactamase | 0.0522 | 0.1537 | 0.2395 |
Echinococcus granulosus | serine:threonine protein kinase N2 | 0.0089 | 0.0236 | 0.13 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0015 | 0.0012 | 0.0065 |
Echinococcus multilocularis | insulin receptor | 0.0291 | 0.0843 | 0.4649 |
Brugia malayi | Furin-like cysteine rich region family protein | 0.0133 | 0.0368 | 0.2374 |
Echinococcus granulosus | NDR protein kinase | 0.0089 | 0.0236 | 0.13 |
Brugia malayi | Protein kinase domain containing protein | 0.0089 | 0.0236 | 0.1521 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0522 | 0.1537 | 0.8473 |
Loa Loa (eye worm) | hypothetical protein | 0.0522 | 0.1537 | 0.8473 |
Trichomonas vaginalis | AGC family protein kinase | 0.0089 | 0.0236 | 0.0202 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0015 | 0.0012 | 0.0065 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0522 | 0.1537 | 0.1357 |
Loa Loa (eye worm) | hypothetical protein | 0.0089 | 0.0236 | 0.13 |
Mycobacterium tuberculosis | Conserved protein | 0.0522 | 0.1537 | 0.1357 |
Echinococcus multilocularis | 0.0038 | 0.0081 | 0.0446 | |
Brugia malayi | Protein kinase domain containing protein | 0.0162 | 0.0454 | 0.2926 |
Schistosoma mansoni | tyrosine kinase | 0.0015 | 0.0012 | 0.0065 |
Trichomonas vaginalis | AGC family protein kinase | 0.0089 | 0.0236 | 0.0202 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0089 | 0.0236 | 0.13 |
Echinococcus granulosus | insulin receptor | 0.0291 | 0.0843 | 0.4649 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0133 | 0.0368 | 0.203 |
Chlamydia trachomatis | transglycolase/transpeptidase | 0.008 | 0.0209 | 0.5 |
Loa Loa (eye worm) | AGC/RSK/P70 protein kinase | 0.0089 | 0.0236 | 0.13 |
Trichomonas vaginalis | AGC family protein kinase | 0.0092 | 0.0245 | 0.0271 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0522 | 0.1537 | 0.2395 |
Echinococcus granulosus | c src tyrosine kinase | 0.0015 | 0.0012 | 0.0065 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0015 | 0.0012 | 0.0065 |
Echinococcus multilocularis | c src tyrosine kinase | 0.0015 | 0.0012 | 0.0065 |
Trichomonas vaginalis | AGC family protein kinase | 0.0092 | 0.0245 | 0.0271 |
Echinococcus multilocularis | tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase | 0.0015 | 0.0012 | 0.0065 |
Schistosoma mansoni | tyrosine kinase | 0.0133 | 0.0368 | 0.203 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.0089 | 0.0236 | 0.13 |
Loa Loa (eye worm) | hypothetical protein | 0.0522 | 0.1537 | 0.8473 |
Loa Loa (eye worm) | hypothetical protein | 0.0158 | 0.0442 | 0.2437 |
Chlamydia trachomatis | transglycolase/transpeptidase | 0.008 | 0.0209 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.0089 | 0.0236 | 0.0202 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.0089 | 0.0236 | 0.13 |
Mycobacterium ulcerans | hypothetical protein | 0.0522 | 0.1537 | 0.2395 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0015 | 0.0012 | 0.0065 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.0133 | 0.0368 | 0.203 |
Brugia malayi | Protein kinase domain containing protein | 0.0291 | 0.0843 | 0.5437 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0522 | 0.1537 | 0.5169 |
Toxoplasma gondii | ABC1 family protein | 0.0522 | 0.1537 | 1 |
Echinococcus multilocularis | protein kinase c epsilon type | 0.0089 | 0.0236 | 0.13 |
Loa Loa (eye worm) | AGC/RSK/RSK protein kinase | 0.0614 | 0.1814 | 1 |
Loa Loa (eye worm) | beta-lactamase | 0.0522 | 0.1537 | 0.8473 |
Loa Loa (eye worm) | AGC/NDR protein kinase | 0.0089 | 0.0236 | 0.13 |
Plasmodium vivax | hypothetical protein, conserved | 0.0522 | 0.1537 | 0.5 |
Treponema pallidum | penicillin-binding protein (pbp-3) | 0.008 | 0.0209 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0089 | 0.0236 | 0.13 |
Giardia lamblia | Kinase, AGC AKT | 0.0527 | 0.1551 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.0092 | 0.0245 | 0.0271 |
Loa Loa (eye worm) | hypothetical protein | 0.0522 | 0.1537 | 0.8473 |
Echinococcus multilocularis | proto oncogene tyrosine protein kinase LCK | 0.0015 | 0.0012 | 0.0065 |
Schistosoma mansoni | tyrosine kinase | 0.013 | 0.0357 | 0.1965 |
Loa Loa (eye worm) | AGC/PKN protein kinase | 0.0089 | 0.0236 | 0.13 |
Echinococcus granulosus | protein kinase C gamma type | 0.0089 | 0.0236 | 0.13 |
Wolbachia endosymbiont of Brugia malayi | cell division protein FtsI | 0.008 | 0.0209 | 0.5 |
Echinococcus multilocularis | serine threonine protein kinase | 0.0089 | 0.0236 | 0.13 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0522 | 0.1537 | 0.8473 |
Echinococcus multilocularis | tyrosine protein kinase lyn tyrosine protein kinase blk | 0.0015 | 0.0012 | 0.0065 |
Echinococcus granulosus | tyrosine protein kinase Lyn | 0.0017 | 0.0018 | 0.0097 |
Brugia malayi | Tyrosine-protein kinase abl-1 | 0.0015 | 0.0012 | 0.0076 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0133 | 0.0368 | 0.203 |
Loa Loa (eye worm) | hypothetical protein | 0.0522 | 0.1537 | 0.8473 |
Schistosoma mansoni | tyrosine kinase | 0.013 | 0.0357 | 0.1965 |
Brugia malayi | beta-lactamase | 0.0522 | 0.1537 | 0.991 |
Echinococcus multilocularis | Ribosomal protein S6 kinase beta 2 | 0.0089 | 0.0236 | 0.13 |
Echinococcus granulosus | protein kinase c iota type | 0.0089 | 0.0236 | 0.13 |
Schistosoma mansoni | tyrosine kinase | 0.0015 | 0.0012 | 0.0065 |
Echinococcus multilocularis | serine:threonine protein kinase 38 | 0.0089 | 0.0236 | 0.13 |
Leishmania major | rac serine-threonine kinase, putative,protein kinase, putative | 0.053 | 0.156 | 1 |
Brugia malayi | Hr1 repeat family protein | 0.0089 | 0.0236 | 0.1521 |
Schistosoma mansoni | tyrosine kinase | 0.0133 | 0.0368 | 0.203 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0522 | 0.1537 | 0.1357 |
Schistosoma mansoni | proto-oncogene tyrosine-protein kinase src | 0.0015 | 0.0012 | 0.0065 |
Brugia malayi | Protein kinase domain containing protein | 0.0089 | 0.0236 | 0.1521 |
Treponema pallidum | penicillin-binding protein (pbp-1) | 0.008 | 0.0209 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.0092 | 0.0245 | 0.0271 |
Brugia malayi | ribosomal protein S6 kinase alpha 3 | 0.0527 | 0.1551 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0092 | 0.0245 | 0.0271 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0133 | 0.0368 | 0.203 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0522 | 0.1537 | 0.1357 |
Loa Loa (eye worm) | AGC/DMPK/GEK protein kinase | 0.0089 | 0.0236 | 0.13 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0522 | 0.1537 | 0.8473 |
Trichomonas vaginalis | AGC family protein kinase | 0.0092 | 0.0245 | 0.0271 |
Echinococcus granulosus | Protein kinase C brain isozyme | 0.0089 | 0.0236 | 0.13 |
Loa Loa (eye worm) | hypothetical protein | 0.0522 | 0.1537 | 0.8473 |
Entamoeba histolytica | protein kinase, putative | 0.0092 | 0.0245 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0522 | 0.1537 | 0.8473 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.