Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Human immunodeficiency virus 1 | Protease | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma mansoni | intracisternal A-particle retropepsin (A02 family) | Get druggable targets OG5_131408 | All targets in OG5_131408 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Entamoeba histolytica | retroviral aspartyl protease domain-containing protein | Protease | 99 aa | 102 aa | 32.4 % |
Entamoeba histolytica | retroviral aspartyl protease domain-containing protein | Protease | 99 aa | 102 aa | 32.4 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | polycomb protein SCMH1 | 0.5614 | 0.2886 | 0.483 |
Echinococcus granulosus | histone acetyltransferase myst3 | 0.0861 | 0.0182 | 0.0277 |
Echinococcus granulosus | histone acetyltransferase MYST2 | 0.2025 | 0.0844 | 0.1392 |
Loa Loa (eye worm) | mbt repeat family protein | 0.5842 | 0.3016 | 0.58 |
Schistosoma mansoni | sex comb on midleg homolog | 0.5614 | 0.2886 | 0.2874 |
Schistosoma mansoni | hypothetical protein | 0.6914 | 0.3626 | 0.3615 |
Schistosoma mansoni | scm-relatedprotein containing 4 mbt domains (sfmbt) | 0.813 | 0.4318 | 0.4308 |
Echinococcus granulosus | endonuclease exonuclease phosphatase | 1.1013 | 0.5958 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.9658 | 0.5187 | 1 |
Echinococcus granulosus | SAM and MBT domain containing protein | 0.813 | 0.4318 | 0.7239 |
Onchocerca volvulus | Polycomb protein Sfmbt homolog | 0.9658 | 0.5187 | 1 |
Echinococcus multilocularis | histone acetyltransferase myst3 | 0.0861 | 0.0182 | 0.0277 |
Echinococcus multilocularis | Jumonji, AT rich interactive domain 1B | 0.2411 | 0.1064 | 0.1762 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.1966 | 0.0811 | 0.0795 |
Plasmodium vivax | JmjC domain containing protein | 0.0614 | 0.0042 | 0.5 |
Loa Loa (eye worm) | MBCTL1 | 0.2025 | 0.0844 | 0.16 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.2894 | 0.1339 | 0.2556 |
Toxoplasma gondii | histone lysine demethylase JMJC1/KDM5D/JARID1D | 0.0684 | 0.0081 | 0.3694 |
Brugia malayi | jmjC domain containing protein | 0.2894 | 0.1339 | 0.2556 |
Brugia malayi | C2-HC type zinc finger protein C.e-MyT1 | 0.2025 | 0.0844 | 0.16 |
Toxoplasma gondii | PLU-1 family protein | 0.0928 | 0.0221 | 1 |
Echinococcus multilocularis | endonuclease exonuclease phosphatase | 1.1013 | 0.5958 | 1 |
Echinococcus granulosus | Jumonji AT rich interactive domain 1B | 0.2411 | 0.1064 | 0.1762 |
Echinococcus granulosus | tumor suppressor p53 binding protein 1 | 0.6914 | 0.3626 | 0.6074 |
Schistosoma mansoni | intracisternal A-particle retropepsin (A02 family) | 0.1528 | 0.0562 | 0.0545 |
Echinococcus granulosus | chromobox protein 2 | 0.4163 | 0.2061 | 0.3441 |
Brugia malayi | mbt repeat family protein | 0.9658 | 0.5187 | 1 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.1638 | 0.0624 | 0.1022 |
Echinococcus multilocularis | chromobox protein 2 | 0.4163 | 0.2061 | 0.3441 |
Echinococcus multilocularis | tumor suppressor p53 binding protein 1 | 0.6914 | 0.3626 | 0.6074 |
Echinococcus multilocularis | suppression of tumorigenicity 18 protein | 0.2025 | 0.0844 | 0.1392 |
Plasmodium falciparum | JmjC domain-containing protein, putative | 0.0614 | 0.0042 | 0.5 |
Echinococcus granulosus | suppression of tumorigenicity 18 protein | 0.2025 | 0.0844 | 0.1392 |
Schistosoma mansoni | chromobox protein | 0.4163 | 0.2061 | 0.2047 |
Schistosoma mansoni | phd finger protein | 0.0861 | 0.0182 | 0.0165 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.1966 | 0.0811 | 0.1336 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.1966 | 0.0811 | 0.0795 |
Brugia malayi | mbt repeat family protein | 0.5842 | 0.3016 | 0.58 |
Echinococcus granulosus | polycomb protein SCMH1 | 0.5614 | 0.2886 | 0.483 |
Echinococcus multilocularis | histone acetyltransferase MYST2 | 0.2025 | 0.0844 | 0.1392 |
Schistosoma mansoni | myelin transcription factor 1 myt1 | 0.2025 | 0.0844 | 0.0828 |
Schistosoma mansoni | sex comb on midleg homolog | 0.5614 | 0.2886 | 0.2874 |
Loa Loa (eye worm) | hypothetical protein | 0.2025 | 0.0844 | 0.16 |
Echinococcus multilocularis | SAM and MBT domain containing protein | 0.813 | 0.4318 | 0.7239 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | Inhibition of recombinant renin using Arg-Glu(EDANS)-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Thr-Lys-(DABCYL)-Arg as substrate at 10 uM by fluorimetric analysis | ChEMBL. | 22800535 | |
Inhibition (binding) | Inhibition of HIV1 protease dimerization expressed in Escherichia coli Rosetta(DE3) at 5 uM by 1-Anilino-8-naphthalene sulfonate-based fluorescent probe binding assay | ChEMBL. | 22800535 | |
Ki (binding) | = 50 nM | Inhibition of HIV1 protease dimerization expressed in Escherichia coli Rosetta(DE3) using DABCYL-gamma-abu-Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln-EDANS as substrate by Zhang-Poorman kinetic analysis | ChEMBL. | 22800535 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.