TDR Targets

Basic information

Technical information

TDR Targets ID: 16786
Name: 1H-indazol-7-ol
MW: 134.135 | Formula: C7H6N2O
H donors: 2 H acceptors: 2 LogP: 1.2 Rotable bonds: 0
Rule of 5 violations (Lipinski): 1
SMILES: Oc1cccc2c1[nH]nc2
InChi: 1S/C7H6N2O/c10-6-3-1-2-5-4-8-9-7(5)6/h1-4,10H,(H,8,9)
InChiKey: VEDLFQPHHBOHIR-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	hypothetical protein	0.0208	0.1341	0.1957
Brugia malayi	Protein kinase domain containing protein	0.0436	0.3128	0.9108
Loa Loa (eye worm)	D-ets-4 DNA binding domain-containing protein	0.0073	0.0285	0.0831
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0059	0.0178	0.026
Loa Loa (eye worm)	hypoxia-induced factor 1	0.0174	0.1079	0.314
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0203	0.059
Mycobacterium tuberculosis	3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III)	0.0318	0.2209	0.3719
Plasmodium vivax	bifunctional dihydrofolate reductase-thymidylate synthase, putative	0.0475	0.3435	1
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0057	0.0161	0.0469
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0059	0.0178	0.026
Trichomonas vaginalis	set domain proteins, putative	0.047	0.34	1
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0053	0.0128	0.0373
Loa Loa (eye worm)	thymidylate synthase	0.0475	0.3435	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0053	0.0128	0.0373
Plasmodium falciparum	beta-ketoacyl-ACP synthase III	0.0318	0.2209	0.6432
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0053	0.0128	0.0187
Onchocerca volvulus		0.0475	0.3435	0.3826
Loa Loa (eye worm)	orotate phosphoribosyltransferase	0.013	0.0736	0.2143
Echinococcus granulosus	uridine 5' monophosphate synthase	0.013	0.0736	0.2143
Schistosoma mansoni	aryl hydrocarbon receptor	0.0056	0.0155	0.0226
Brugia malayi	hypothetical protein	0.0042	0.004	0.0115
Brugia malayi	Pre-SET motif family protein	0.0059	0.0178	0.0518
Brugia malayi	follicle stimulating hormone receptor	0.0229	0.1507	0.4387
Brugia malayi	hypoxia-induced factor 1	0.0174	0.1079	0.314
Echinococcus granulosus	GA binding protein alpha chain	0.0073	0.0285	0.0831
Plasmodium falciparum	orotidine 5'-phosphate decarboxylase	0.013	0.0736	0.2143
Echinococcus multilocularis	transfer RNA-Lys	0.0042	0.004	0.0116
Mycobacterium ulcerans	thymidylate synthase	0.0475	0.3435	1
Echinococcus multilocularis	Alpha N acetylgalactosaminidase	0.01	0.0498	0.1451
Schistosoma mansoni	memapsin-2 (A01 family)	0.091	0.6849	1
Mycobacterium leprae	PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE)	0.0475	0.3435	1
Echinococcus multilocularis	uridine 5' monophosphate synthase	0.013	0.0736	0.2143
Brugia malayi	Ets-domain containing protein	0.0073	0.0285	0.0831
Entamoeba histolytica	hypothetical protein	0.0042	0.004	1
Schistosoma mansoni	bifunctional dihydrofolate reductase-thymidylate synthase	0.0475	0.3435	0.5015
Echinococcus granulosus	thymidylate synthase	0.0475	0.3435	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0053	0.0128	0.0187
Brugia malayi	bHLH-PAS transcription factor	0.0042	0.004	0.0116
Mycobacterium ulcerans	orotidine 5'-phosphate decarboxylase	0.013	0.0736	0.205
Mycobacterium ulcerans	3-oxoacyl-ACP synthase	0.0318	0.2209	0.639
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0042	0.004	0.0115
Plasmodium falciparum	bifunctional dihydrofolate reductase-thymidylate synthase	0.0475	0.3435	1
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0059	0.0178	0.0518
Schistosoma mansoni	hypothetical protein	0.0196	0.125	0.1825
Toxoplasma gondii	bifunctional dihydrofolate reductase-thymidylate synthase	0.0475	0.3435	1
Echinococcus granulosus	histone lysine methyltransferase setb	0.0059	0.0178	0.0518
Trichomonas vaginalis	conserved hypothetical protein	0.0226	0.1484	0.4364
Loa Loa (eye worm)	fli-1 protein	0.0222	0.145	0.4222
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.01	0.0498	0.0728
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0053	0.0128	0.0187
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0059	0.0178	0.0518
Chlamydia trachomatis	oxoacyl-ACP synthase III	0.0318	0.2209	0.5
Schistosoma mansoni	gabp alpha	0.0073	0.0285	0.0417
Brugia malayi	hypothetical protein	0.0123	0.0681	0.1982
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0042	0.004	0.0115
Echinococcus granulosus	geminin	0.0196	0.125	0.3639
Trichomonas vaginalis	alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative	0.0067	0.0237	0.0697
Loa Loa (eye worm)	hypothetical protein	0.0322	0.2235	0.6507
Onchocerca volvulus		0.0059	0.0178	0.0198
Brugia malayi	hypothetical protein	0.0226	0.1484	0.432
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase	0.0475	0.3435	1
Entamoeba histolytica	hypothetical protein	0.0042	0.004	1
Schistosoma mansoni	transcription factor LCR-F1	0.0042	0.004	0.0058
Plasmodium vivax	SET domain protein, putative	0.0059	0.0178	0.0518
Mycobacterium ulcerans	beta-ketoacyl synthase-like protein	0.0318	0.2209	0.639
Entamoeba histolytica	hypothetical protein	0.0042	0.004	1
Echinococcus multilocularis	geminin	0.0196	0.125	0.3639
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0067	0.0237	0.0346
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0237	0.069
Brugia malayi	orotate phosphoribosyltransferase family protein	0.013	0.0736	0.2143
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0053	0.0128	0.0373
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0067	0.0237	0.0346
Schistosoma mansoni	hypothetical protein	0.0042	0.004	0.0058
Brugia malayi	Ets-domain containing protein	0.0073	0.0285	0.0831
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0229	0.1507	0.4387
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0053	0.0128	0.0373
Plasmodium vivax	beta-ketoacyl-acyl carrier protein synthase III precursor, putative	0.0318	0.2209	0.6432
Leishmania major	dihydrofolate reductase-thymidylate synthase	0.0475	0.3435	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0053	0.0128	0.0373
Mycobacterium tuberculosis	Probable thymidylate synthase ThyA (ts) (TSASE)	0.0475	0.3435	1
Brugia malayi	PAS domain containing protein	0.0056	0.0155	0.045
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0178	0.0518
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0059	0.0178	0.0518
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0053	0.0128	0.0373
Echinococcus granulosus	Alpha N acetylgalactosaminidase	0.01	0.0498	0.1451
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase, putative	0.0226	0.1484	0.2771
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0059	0.0178	0.026
Brugia malayi	thymidylate synthase	0.0475	0.3435	1
Echinococcus granulosus	single minded 2	0.0042	0.004	0.0116
Echinococcus multilocularis	Glycoside hydrolase, family 27	0.01	0.0498	0.1451
Trypanosoma brucei	dihydrofolate reductase-thymidylate synthase	0.0475	0.3435	1
Schistosoma mansoni	single-minded	0.0056	0.0155	0.0226
Trypanosoma brucei	RNA helicase, putative	0.0208	0.1341	0.2241
Toxoplasma gondii	orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase	0.013	0.0736	0.2143
Toxoplasma gondii	melibiase subfamily protein	0.01	0.0498	0.1451
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.01	0.0498	0.0728
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.01	0.0498	0.0728
Entamoeba histolytica	hypothetical protein	0.0042	0.004	1
Onchocerca volvulus		0.047	0.34	0.3787
Brugia malayi	hypothetical protein	0.0189	0.1193	0.3474
Schistosoma mansoni	hypothetical protein	0.0051	0.011	0.016
Echinococcus multilocularis	thymidylate synthase	0.0475	0.3435	1
Brugia malayi	Pre-SET motif family protein	0.0413	0.2953	0.8596
Loa Loa (eye worm)	hypothetical protein	0.0189	0.1193	0.3474
Echinococcus multilocularis	GA binding protein alpha chain	0.0073	0.0285	0.0831
Onchocerca volvulus		0.1182	0.8978	1
Onchocerca volvulus		0.0042	0.004	0.0044
Brugia malayi	Fli-1 protein	0.0222	0.145	0.4222
Plasmodium vivax	orotidine 5'-phosphate decarboxylase, putative	0.013	0.0736	0.2143
Mycobacterium ulcerans	3-oxoacyl-ACP synthase	0.0318	0.2209	0.639
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0413	0.2953	0.8596
Loa Loa (eye worm)	camk/mapkapk/mnk protein kinase	0.0436	0.3128	0.9108
Brugia malayi	Melibiase family protein	0.0067	0.0237	0.069
Schistosoma mansoni	hypothetical protein	0.0196	0.125	0.1825
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.01	0.0498	0.0728
Schistosoma mansoni	orotidine 5'-phosphate decarboxylase	0.013	0.0736	0.1074
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0059	0.0178	0.026
Schistosoma mansoni	ets-related	0.0222	0.145	0.2117

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	> 100 uM	In vitro inhibitory concentration against rat cerebellar neuronal nitric oxide synthase	ChEMBL.	11354365
IC50 (binding)	> 100 uM	In vitro inhibitory concentration against rat cerebellar neuronal nitric oxide synthase	ChEMBL.	11354365
IC50 (binding)	= 650 uM	Inhibition of mouse recombinant iNOS	ChEMBL.	18502134
IC50 (binding)	= 700 uM	Inhibition of rat brain recombinant nNOS	ChEMBL.	18502134
IC50 (binding)	= 700 uM	Inhibition of bovine recombinant eNOS	ChEMBL.	18502134
Inhibition (binding)	= 7 %	In vitro percent inhibition of rat cerebellar neuronal nitric oxide synthase at a concentration of 100 uM	ChEMBL.	11354365
Inhibition (binding)	= 7 %	In vitro percent inhibition of rat cerebellar neuronal nitric oxide synthase at a concentration of 100 uM	ChEMBL.	11354365

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL278175
PubChem: 21453601

Bibliographic References

2 literature references were collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 16786