Detailed information for compound 1682517

Basic information

Technical information
  • TDR Targets ID: 1682517
  • Name: [2-(4-methoxyphenyl)-3-(4-phenylphenyl)-1,2-o xazolidin-5-yl]methanol
  • MW: 361.434 | Formula: C23H23NO3
  • H donors: 1 H acceptors: 1 LogP: 4.73 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCC1CC(N(O1)c1ccc(cc1)OC)c1ccc(cc1)c1ccccc1
  • InChi: 1S/C23H23NO3/c1-26-21-13-11-20(12-14-21)24-23(15-22(16-25)27-24)19-9-7-18(8-10-19)17-5-3-2-4-6-17/h2-14,22-23,25H,15-16H2,1H3
  • InChiKey: LEVMIUWXDINKKO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [2-(4-methoxyphenyl)-3-(4-phenylphenyl)isoxazolidin-5-yl]methanol
  • [2-(4-methoxyphenyl)-3-(4-phenylphenyl)-5-isoxazolidinyl]methanol

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus protein kinase shaggy 0.0175 0.012 0.0389
Echinococcus granulosus hypothetical protein 0.0202 0.0313 0.1017
Plasmodium vivax glycogen synthase kinase 3, putative 0.0175 0.012 0.2833
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0175 0.012 0.0389
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0217 0.0423 1
Brugia malayi Protein kinase domain containing protein 0.0205 0.0337 0.0337
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0217 0.0423 1
Brugia malayi Protein kinase domain containing protein 0.055 0.284 0.284
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.0217 0.0423 1
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0175 0.012 0.0389
Giardia lamblia Kinase, CMGC GSK 0.0175 0.012 0.2833
Echinococcus granulosus dual specificity protein kinase clk2 0.0217 0.0423 0.1374
Echinococcus multilocularis 0.0216 0.0417 0.1355
Plasmodium falciparum glycogen synthase kinase 3 0.0175 0.012 0.2833
Brugia malayi probable protein kinase 0.0301 0.103 0.103
Trichomonas vaginalis CMGC family protein kinase 0.0175 0.012 0.2833
Schistosoma mansoni serine/threonine protein kinase 0.055 0.284 0.9222
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0217 0.0423 1
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0175 0.012 0.2833
Echinococcus multilocularis rho associated protein kinase 0.0504 0.2507 0.814
Giardia lamblia Kinase, CMGC CLK 0.0217 0.0423 1
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.0217 0.0423 1
Loa Loa (eye worm) CAMK/PIM protein kinase 0.055 0.284 0.284
Loa Loa (eye worm) CDC7 protein kinase 0.0205 0.0337 0.0337
Trichomonas vaginalis CMGC family protein kinase 0.0217 0.0423 1
Trypanosoma brucei protein kinase, putative 0.0175 0.012 0.2833
Entamoeba histolytica protein kinase domain containing protein 0.0175 0.012 0.0389
Echinococcus multilocularis dual specificity protein kinase clk2 0.0217 0.0423 0.1374
Schistosoma mansoni serine/threonine protein kinase 0.0583 0.308 1
Onchocerca volvulus 0.0205 0.0337 0.0799
Brugia malayi Protein kinase domain containing protein 0.0217 0.0423 0.0423
Schistosoma mansoni serine/threonine protein kinase 0.0205 0.0337 0.1095
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0217 0.0423 1
Giardia lamblia Kinase, CMGC GSK 0.0175 0.012 0.2833
Entamoeba histolytica protein kinase, putative 0.0175 0.012 0.0389
Echinococcus multilocularis 0.0202 0.0313 0.1017
Schistosoma mansoni serine/threonine protein kinase 0.0445 0.208 0.6755
Brugia malayi Serine/threonine-protein kinase Pim-3 0.055 0.284 0.284
Loa Loa (eye worm) STE/STE20/MSN protein kinase 0.0216 0.0417 0.0417
Schistosoma mansoni serine/threonine protein kinase 0.0504 0.2507 0.814
Echinococcus granulosus protein kinase 0.0216 0.0417 0.1355
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.0217 0.0423 1
Trichomonas vaginalis CMGC family protein kinase 0.0205 0.0337 0.797
Brugia malayi Protein kinase domain containing protein 0.0445 0.208 0.208
Loa Loa (eye worm) CAMK/PIM protein kinase 0.055 0.284 0.284
Loa Loa (eye worm) camk/mapkapk/mnk protein kinase 0.0937 0.5646 0.5646
Echinococcus granulosus homeodomain interacting protein kinase 3 0.0583 0.308 1
Loa Loa (eye worm) CMGC/DYRK/HIPK protein kinase 0.0583 0.308 0.308
Brugia malayi Homeodomain interacting protein kinase protein 1 0.0583 0.308 0.308
Trichomonas vaginalis CMGC family protein kinase 0.0205 0.0337 0.797
Plasmodium falciparum protein serine/threonine kinase-1 0.0217 0.0423 1
Schistosoma mansoni protein kinase 0.0301 0.103 0.3346
Leishmania major protein kinase, putative 0.0217 0.0423 1
Onchocerca volvulus 0.0504 0.2507 0.8775
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.055 0.284 0.9222
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.055 0.284 0.9222
Onchocerca volvulus 0.0489 0.2397 0.837
Loa Loa (eye worm) CMGC/CLK protein kinase 0.0217 0.0423 0.0423
Giardia lamblia Kinase, CDC7 0.0205 0.0337 0.797
Brugia malayi intracellular kinase 0.0175 0.012 0.012
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0175 0.012 0.2833
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase 0.1537 1 1
Trichomonas vaginalis CMGC family protein kinase 0.0205 0.0337 0.797
Brugia malayi Protein kinase domain containing protein 0.0937 0.5646 0.5646
Echinococcus multilocularis homeodomain interacting protein kinase 3 0.0583 0.308 1
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.0445 0.208 0.208
Onchocerca volvulus 0.0205 0.0337 0.0799
Echinococcus granulosus serine:threonine protein kinase mig 15 0.0286 0.092 0.2989
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0175 0.012 0.012
Entamoeba histolytica protein kinase domain containing protein 0.0175 0.012 0.0389
Echinococcus multilocularis CDC7 cell division cycle 7 0.0205 0.0337 0.1095
Loa Loa (eye worm) hypothetical protein 0.0286 0.092 0.092
Trichomonas vaginalis CMGC family protein kinase 0.0175 0.012 0.2833
Leishmania major protein kinase, putative 0.0217 0.0423 1
Entamoeba histolytica protein kinase domain containing protein 0.0583 0.308 1
Schistosoma mansoni serine/threonine protein kinase 0.0217 0.0423 0.1374
Loa Loa (eye worm) hypothetical protein 0.0202 0.0313 0.0313
Echinococcus multilocularis protein kinase shaggy 0.0175 0.012 0.0389
Plasmodium vivax serine/threonine kinase-1, putative 0.0217 0.0423 1
Echinococcus granulosus CDC7 cell division cycle 7 0.0205 0.0337 0.1095
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.055 0.284 1
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0175 0.012 0.0389
Schistosoma mansoni serine/threonine protein kinase 0.0217 0.0423 0.1374
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0175 0.012 0.012
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0175 0.012 0.2833
Schistosoma mansoni protein kinase 0.0216 0.0417 0.1355
Echinococcus granulosus rho-associated protein kinase 1 0.0504 0.2507 0.814

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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