Detailed information for compound 1684507

Basic information

Technical information
  • TDR Targets ID: 1684507
  • Name: N-[4-(5-cyano-1-methylpyrrol-2-yl)-2-fluoroph enyl]ethanesulfonamide
  • MW: 307.343 | Formula: C14H14FN3O2S
  • H donors: 1 H acceptors: 3 LogP: 1.81 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#Cc1ccc(n1C)c1ccc(c(c1)F)NS(=O)(=O)CC
  • InChi: 1S/C14H14FN3O2S/c1-3-21(19,20)17-13-6-4-10(8-12(13)15)14-7-5-11(9-16)18(14)2/h4-8,17H,3H2,1-2H3
  • InChiKey: PALDPPQXEQQEEN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-[4-(5-cyano-1-methyl-pyrrol-2-yl)-2-fluoro-phenyl]ethanesulfonamide
  • N-[4-(5-cyano-1-methyl-2-pyrrolyl)-2-fluorophenyl]ethanesulfonamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens progesterone receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0062 0.0622 0.2733
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0202 0.2274 1
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0062 0.0622 0.2733
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0045 0.0424 0.6932
Trichomonas vaginalis sugar transporter, putative 0.0028 0.0227 0.0956
Brugia malayi Major Facilitator Superfamily protein 0.0028 0.0227 0.0999
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0227 0.0956
Echinococcus granulosus solute carrier family 22 0.0028 0.0227 0.0999
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0028 0.0227 0.303
Entamoeba histolytica protein kinase, putative 0.0062 0.0622 1
Loa Loa (eye worm) glycyl-tRNA synthetase 0.0011 0.0026 0.0116
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0038 0.0344 1
Brugia malayi hypothetical protein 0.0028 0.0227 0.0999
Echinococcus multilocularis solute carrier family 22 0.0028 0.0227 0.0999
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0062 0.0622 0.2733
Loa Loa (eye worm) major facilitator superfamily transporter 0.0028 0.0227 0.0999
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0202 0.2274 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0227 0.0999
Trichomonas vaginalis sugar transporter, putative 0.0028 0.0227 0.0956
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0061 0.0607 0.2668
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0631 0.274
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0202 0.2274 1
Echinococcus multilocularis calcium dependent protein kinase 0.0058 0.0576 0.2535
Entamoeba histolytica protein kinase, putative 0.0062 0.0622 1
Trichomonas vaginalis sugar transporter, putative 0.0028 0.0227 0.0956
Brugia malayi Major Facilitator Superfamily protein 0.0028 0.0227 0.0999
Toxoplasma gondii glycyl-tRNA synthetase 0.0011 0.0026 0.0024
Loa Loa (eye worm) hypothetical protein 0.0028 0.0227 0.0999
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0071 0.0725 0.1081
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0025 0.0186 0.0816
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0028 0.0227 0.5239
Trichomonas vaginalis sugar transporter, putative 0.0028 0.0227 0.0956
Trypanosoma brucei glucose transporter 2A 0.0063 0.0631 0.868
Echinococcus multilocularis synaptic vesicle 2 protein 0.0028 0.0227 0.0999
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0062 0.0622 0.0597
Trypanosoma brucei glucose transporter, putative 0.0063 0.0631 0.868
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0202 0.2274 1
Loa Loa (eye worm) sugar transporter 0.0202 0.2274 1
Trichomonas vaginalis sugar transporter, putative 0.0028 0.0227 0.0956
Trichomonas vaginalis conserved hypothetical protein 0.0063 0.0631 0.274
Trichomonas vaginalis glucose transporter, putative 0.0063 0.0631 0.274
Schistosoma mansoni glucose transport protein 0.0202 0.2274 1
Toxoplasma gondii protein kinase, putative 0.0572 0.6621 1
Leishmania major glucose transporter, lmgt2 0.0063 0.0631 0.868
Trypanosoma cruzi glucose transporter, putative 0.0028 0.0227 0.303
Echinococcus granulosus solute carrier family 22 0.0028 0.0227 0.0999
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0061 0.0607 0.2668
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0061 0.0607 0.2668
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0061 0.0607 0.2668
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0062 0.0622 0.2733
Plasmodium vivax proline--tRNA ligase, putative 0.0071 0.0725 0.0701
Entamoeba histolytica hypothetical protein 0.0045 0.0424 0.6679
Schistosoma mansoni protein kinase 0.0062 0.0622 0.2733
Giardia lamblia Prolyl-tRNA synthetase 0.0061 0.0607 1
Trichomonas vaginalis myo-inositol transporter, putative 0.0028 0.0227 0.0956
Loa Loa (eye worm) hypothetical protein 0.0028 0.0227 0.0999
Loa Loa (eye worm) hypothetical protein 0.0028 0.0227 0.0999
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0011 0.0026 0.0218
Plasmodium falciparum proline--tRNA ligase 0.0071 0.0725 0.0701
Trichomonas vaginalis sugar transporter, putative 0.0028 0.0227 0.0956
Plasmodium falciparum calcium-dependent protein kinase 3 0.0062 0.0622 0.0597
Plasmodium falciparum calcium-dependent protein kinase 4 0.0062 0.0622 0.0597
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0062 0.0622 0.2733
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0202 0.2274 1
Trypanosoma brucei sugar transporter, putative 0.0028 0.0227 0.303
Trichomonas vaginalis conserved hypothetical protein 0.0063 0.0631 0.274
Plasmodium falciparum lysine--tRNA ligase 0.0045 0.0424 0.0399
Echinococcus granulosus glycyl tRNA synthetase 0.0011 0.0026 0.0116
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0202 0.2274 1
Plasmodium vivax hexose transporter 0.0202 0.2274 0.2253
Trichomonas vaginalis sugar transporter, putative 0.0028 0.0227 0.0956
Loa Loa (eye worm) hypothetical protein 0.0011 0.0026 0.0116
Loa Loa (eye worm) hypothetical protein 0.0028 0.0227 0.0999
Schistosoma mansoni lysyl-tRNA synthetase 0.0045 0.0424 0.1864
Echinococcus granulosus calcium dependent protein kinase 0.0058 0.0576 0.2535
Brugia malayi glycyl-tRNA synthetase 0.0011 0.0026 0.0116
Trichomonas vaginalis sugar transporter, putative 0.0028 0.0227 0.0956
Onchocerca volvulus 0.0028 0.0227 1
Trichomonas vaginalis sugar transporter, putative 0.0028 0.0227 0.0956
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0061 0.0607 0.9752
Schistosoma mansoni glucose transport protein 0.0202 0.2274 1
Leishmania major glucose transporter, lmgt3 0.0063 0.0631 0.868
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0227 0.0956
Trichomonas vaginalis threonyl-tRNA synthetase, putative 0.0011 0.0026 0.0069
Loa Loa (eye worm) threonyl-tRNA synthetase 0.0011 0.0026 0.0116
Onchocerca volvulus 0.0028 0.0227 1
Trichomonas vaginalis glucose transporter, putative 0.0063 0.0631 0.274
Trichomonas vaginalis sugar transporter, putative 0.0028 0.0227 0.0956
Trichomonas vaginalis sugar transporter, putative 0.0028 0.0227 0.0956
Trypanosoma brucei glucose transporter, putative 0.0063 0.0631 0.868
Trichomonas vaginalis glucose transporter, putative 0.0028 0.0227 0.0956
Mycobacterium ulcerans threonyl-tRNA synthetase 0.0011 0.0026 0.0377
Echinococcus multilocularis solute carrier family 22 0.0028 0.0227 0.0999
Trichomonas vaginalis sugar transporter, putative 0.0028 0.0227 0.0956
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.004 0.0358 0.1536
Trypanosoma cruzi hexose transporter, putative 0.0034 0.0296 0.3994
Loa Loa (eye worm) hypothetical protein 0.0028 0.0227 0.0999
Brugia malayi hypothetical protein 0.0028 0.0227 0.0999
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0062 0.0622 0.2733
Onchocerca volvulus 0.0028 0.0227 1
Onchocerca volvulus 0.0028 0.0227 1
Trichomonas vaginalis sugar transport protein, putative 0.0028 0.0227 0.0956
Trichomonas vaginalis sugar transporter, putative 0.0028 0.0227 0.0956
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0045 0.0424 1
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0631 0.274
Mycobacterium ulcerans sugar transporter 0.0028 0.0227 0.5239
Trypanosoma brucei glucose transporter, putative 0.0063 0.0631 0.868
Plasmodium falciparum hexose transporter 0.0202 0.2274 0.2253
Trypanosoma brucei glucose transporter, putative 0.0063 0.0631 0.868
Mycobacterium leprae Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase) 0.0011 0.0026 0.0262
Trichomonas vaginalis sugar transporter, putative 0.0028 0.0227 0.0956
Chlamydia trachomatis lysine--tRNA ligase 0.0045 0.0424 1
Trypanosoma brucei glucose transporter, putative 0.0063 0.0631 0.868
Brugia malayi major facilitator superfamily protein 0.0028 0.0227 0.0999
Trypanosoma cruzi hexose transporter, putative 0.0028 0.0227 0.303
Trichomonas vaginalis sugar transporter, putative 0.0028 0.0227 0.0956
Echinococcus granulosus solute carrier family 22 0.0028 0.0227 0.0999
Schistosoma mansoni protein kinase 0.0062 0.0622 0.2733
Trypanosoma cruzi hexose transporter, putative 0.0063 0.0631 0.868
Echinococcus granulosus lysyl tRNA synthetase 0.0045 0.0424 0.1864
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0045 0.0424 0.5783
Mycobacterium ulcerans glycyl-tRNA synthetase 0.0011 0.0026 0.0377
Echinococcus multilocularis lysyl tRNA synthetase 0.0045 0.0424 0.1864
Trypanosoma brucei THT1 - hexose transporter, putative 0.0063 0.0631 0.868
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0028 0.0227 0.0999
Chlamydia trachomatis proline--tRNA ligase 0.0021 0.0145 0.2978
Trypanosoma brucei THT1 - hexose transporter, putative 0.0063 0.0631 0.868
Onchocerca volvulus 0.0028 0.0227 1
Leishmania major hypothetical protein, conserved 0.0028 0.0227 0.303
Loa Loa (eye worm) hypothetical protein 0.0028 0.0227 0.0999
Trichomonas vaginalis sugar transporter, putative 0.0028 0.0227 0.0956
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0062 0.0622 0.0597
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0021 0.0145 0.3243
Loa Loa (eye worm) hypothetical protein 0.0061 0.0607 0.2668
Echinococcus granulosus synaptic vesicle 2 protein 0.0028 0.0227 0.0999
Toxoplasma gondii transporter, major facilitator family protein 0.0028 0.0227 0.0327
Trichomonas vaginalis sugar transporter, putative 0.0028 0.0227 0.0956
Trichomonas vaginalis sugar transporter, putative 0.0028 0.0227 0.0956
Schistosoma mansoni sugar transporter 0.0028 0.0227 0.0999
Brugia malayi hypothetical protein 0.0028 0.0227 0.0999
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0028 0.0227 0.6499
Loa Loa (eye worm) hypothetical protein 0.0061 0.0607 0.2668
Schistosoma mansoni hypothetical protein 0.0202 0.2274 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0062 0.0622 0.2733
Brugia malayi Cam kinase protein 1 0.0062 0.0622 0.2733
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0227 0.0956
Onchocerca volvulus 0.0028 0.0227 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0227 0.0999
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0045 0.0424 0.1826
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0061 0.0607 1
Onchocerca volvulus 0.0028 0.0227 1
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0061 0.0607 0.2634
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0038 0.0344 0.5587
Leishmania major lysyl-tRNA synthetase, putative 0.0045 0.0424 0.5783
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0061 0.0607 0.2668
Schistosoma mansoni glucose transporter 0.0028 0.0227 0.0999
Trichomonas vaginalis sugar transporter, putative 0.0028 0.0227 0.0956
Trichomonas vaginalis sugar transporter, putative 0.0028 0.0227 0.0956
Plasmodium vivax calcium-dependent protein kinase, putative 0.0062 0.0622 0.0597
Plasmodium falciparum protein kinase 7 0.0572 0.6621 0.6612
Echinococcus multilocularis solute carrier family 22 0.0028 0.0227 0.0999
Trichomonas vaginalis sugar transporter, putative 0.0028 0.0227 0.0956
Loa Loa (eye worm) hypothetical protein 0.0028 0.0227 0.0999
Trypanosoma brucei glucose transporter, putative 0.0063 0.0631 0.868
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0062 0.0622 0.2733
Onchocerca volvulus 0.0028 0.0227 1
Leishmania major threonyl-tRNA synthetase, putative 0.0011 0.0026 0.0218
Schistosoma mansoni sugar transporter 0.0028 0.0227 0.0999
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0202 0.2274 1
Giardia lamblia Hexose transporter 0.0028 0.0227 0.346
Trichomonas vaginalis sugar transporter, putative 0.0028 0.0227 0.0956
Giardia lamblia Sugar-proton symporter 0.0028 0.0227 0.346
Plasmodium vivax lysine--tRNA ligase, putative 0.0045 0.0424 0.0399
Loa Loa (eye worm) hypothetical protein 0.0028 0.0227 0.0999
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0045 0.0424 0.5783
Brugia malayi Sugar transporter family protein 0.0202 0.2274 1
Mycobacterium ulcerans integral membrane transport protein 0.0028 0.0227 0.5239
Echinococcus granulosus General substrate transporter 0.0174 0.1939 0.8527
Onchocerca volvulus 0.0028 0.0227 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0227 0.0999
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0028 0.0227 0.0201
Toxoplasma gondii threonyl-tRNA synthetase family protein 0.0011 0.0026 0.0024
Plasmodium falciparum calcium-dependent protein kinase 5 0.0062 0.0622 0.0597
Loa Loa (eye worm) hypothetical protein 0.0062 0.0622 0.2733
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0071 0.0725 1
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0327 0.3741 0.5643
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0038 0.0344 1
Trypanosoma brucei glucose transporter, putative 0.0063 0.0631 0.868
Trypanosoma brucei glucose transporter 1E 0.0063 0.0631 0.868
Leishmania major glucose transporter, lmgt1 0.0063 0.0631 0.868
Loa Loa (eye worm) hypothetical protein 0.0045 0.0424 0.1864
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0045 0.0424 1
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0071 0.0725 1
Echinococcus multilocularis glycyl tRNA synthetase 0.0011 0.0026 0.0116
Treponema pallidum prolyl-tRNA synthetase 0.0021 0.0145 1
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0062 0.0622 0.0925
Loa Loa (eye worm) hypothetical protein 0.0028 0.0227 0.0999
Onchocerca volvulus 0.0028 0.0227 1
Trichomonas vaginalis sugar transporter, putative 0.0028 0.0227 0.0956
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0631 0.274
Trypanosoma brucei glucose transporter, putative 0.0063 0.0631 0.868
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0062 0.0622 0.2733
Trichomonas vaginalis sugar transporter, putative 0.0028 0.0227 0.0956
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0327 0.3741 0.3724
Onchocerca volvulus 0.0028 0.0227 1
Trichomonas vaginalis CAMK family protein kinase 0.0062 0.0622 0.2699
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0227 0.0956
Loa Loa (eye worm) hypothetical protein 0.0028 0.0227 0.0999
Plasmodium falciparum calcium-dependent protein kinase 2 0.0062 0.0622 0.0597
Schistosoma mansoni sugar transporter 0.0028 0.0227 0.0999
Echinococcus multilocularis Threonyl tRNA synthetase, C 0.0011 0.0026 0.0116
Mycobacterium tuberculosis Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase) 0.0011 0.0026 0.0468
Loa Loa (eye worm) major facilitator superfamily transporter 0.0028 0.0227 0.0999
Trypanosoma brucei threonyl-tRNA synthetase, putative 0.0011 0.0026 0.0218
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0202 0.2274 1
Plasmodium falciparum mitogen-activated protein kinase 2 0.0327 0.3741 0.3724
Schistosoma mansoni sugar transporter 0.0028 0.0227 0.0999
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0227 0.0956
Toxoplasma gondii sugar transporter ST3 0.0028 0.0227 0.0327
Brugia malayi Sugar transporter family protein 0.0028 0.0227 0.0999
Echinococcus granulosus Sugar transporter ERD6 protein 0.0028 0.0227 0.0999
Loa Loa (eye worm) hypothetical protein 0.0028 0.0227 0.0999
Loa Loa (eye worm) hypothetical protein 0.0028 0.0227 0.0999
Schistosoma mansoni glucose transport protein 0.0202 0.2274 1
Loa Loa (eye worm) sugar transporter 0.0028 0.0227 0.0999
Trichomonas vaginalis sugar transporter, putative 0.0028 0.0227 0.0956
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0062 0.0622 0.2733
Onchocerca volvulus Putative transporter 0.0028 0.0227 1
Leishmania major myo-inositol/proton symporter (MIT) 0.0028 0.0227 0.303
Trypanosoma cruzi hexose transporter, putative 0.0063 0.0631 0.868
Brugia malayi probable proline-trna synthetase - fission yeast, putative 0.0011 0.0026 0.0116
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0062 0.0622 0.2733
Schistosoma mansoni protein kinase 0.0062 0.0622 0.2733
Echinococcus granulosus solute carrier family 22 0.0028 0.0227 0.0999
Echinococcus multilocularis General substrate transporter 0.0174 0.1939 0.8527
Trypanosoma cruzi hexose transporter, putative 0.0063 0.0631 0.868
Trichomonas vaginalis sugar transporter, putative 0.0028 0.0227 0.0956
Trichomonas vaginalis sugar transporter, putative 0.0028 0.0227 0.0956
Toxoplasma gondii facilitative glucose transporter GT1 0.0202 0.2274 0.3424
Echinococcus granulosus Threonyl tRNA synthetase C 0.0011 0.0026 0.0116
Onchocerca volvulus 0.0028 0.0227 1
Plasmodium vivax CDK-related protein kinase 6, putative 0.0859 1 1
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0028 0.0227 1
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0071 0.0725 1
Plasmodium vivax sugar transporter, putative 0.0028 0.0227 0.0201
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0061 0.0607 0.2668
Toxoplasma gondii lysine-tRNA ligase 0.0045 0.0424 0.0625
Trichomonas vaginalis conserved hypothetical protein 0.0202 0.2274 1
Trichomonas vaginalis sugar transporter, putative 0.0028 0.0227 0.0956
Trypanosoma cruzi sugar transporter, putative 0.0028 0.0227 0.303
Schistosoma mansoni glycyl-tRNA synthetase 0.0011 0.0026 0.0116
Trichomonas vaginalis sugar transporter, putative 0.0028 0.0227 0.0956
Trichomonas vaginalis sugar transporter, putative 0.0028 0.0227 0.0956
Brugia malayi lysyl-tRNA synthetase 0.0045 0.0424 0.1864
Toxoplasma gondii sugar transporter ST1 0.0028 0.0227 0.0327
Brugia malayi Sugar transporter family protein 0.0028 0.0227 0.0999
Trichomonas vaginalis sugar transporter, putative 0.0028 0.0227 0.0956
Trypanosoma brucei THT1 - hexose transporter, putative 0.0063 0.0631 0.868
Onchocerca volvulus 0.0028 0.0227 1
Leishmania major glucose transporter/membrane transporter D2, putative 0.0063 0.0631 0.868
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0011 0.0026 0.0218
Onchocerca volvulus 0.0028 0.0227 1
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0028 0.0227 0.0999
Trypanosoma cruzi hexose transporter 0.0063 0.0631 0.868
Trichomonas vaginalis sugar transporter, putative 0.0028 0.0227 0.0956
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0062 0.0622 0.0597
Schistosoma mansoni lysyl-tRNA synthetase 0.0045 0.0424 0.1864
Brugia malayi Major Facilitator Superfamily protein 0.0028 0.0227 0.0999
Onchocerca volvulus 0.0028 0.0227 1
Trichomonas vaginalis sugar transporter, putative 0.0028 0.0227 0.0956
Plasmodium falciparum calcium-dependent protein kinase 1 0.0062 0.0622 0.0597
Giardia lamblia Lysyl-tRNA synthetase 0.0045 0.0424 0.6849
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0062 0.0622 0.0925
Leishmania major protein kinase, putative 0.0062 0.0622 0.855
Loa Loa (eye worm) hypothetical protein 0.0049 0.0473 0.2079
Echinococcus multilocularis solute carrier family 22 0.0028 0.0227 0.0999
Brugia malayi major facilitator superfamily protein 0.0028 0.0227 0.0999
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0062 0.0622 0.0925
Trichomonas vaginalis sugar transporter, putative 0.0028 0.0227 0.0956
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0071 0.0725 1
Brugia malayi threonyl-tRNA synthetase, cytoplasmic 0.0011 0.0026 0.0116
Trichomonas vaginalis sugar transporter, putative 0.0028 0.0227 0.0956
Onchocerca volvulus 0.0028 0.0227 1
Schistosoma mansoni serine/threonine protein kinase 0.0062 0.0622 0.2733
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0028 0.0227 0.5239
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0062 0.0622 0.855
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0028 0.0227 0.6499
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0071 0.0725 1
Toxoplasma gondii sugar transporter ST2 0.0028 0.0227 0.0327
Trypanosoma brucei glycyl-tRNA synthetase, putative 0.0011 0.0026 0.0218

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 30 nM Antagonist activity against progesterone receptor in human T47D cells by alkaline phosphatase assay ChEMBL. 23079530

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.