Detailed information for compound 1685459

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 255.312 | Formula: C16H17NO2
  • H donors: 3 H acceptors: 2 LogP: 3.83 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCNc1ccc(cc1)/C=C/c1cc(O)cc(c1)O
  • InChi: 1S/C16H17NO2/c1-2-17-14-7-5-12(6-8-14)3-4-13-9-15(18)11-16(19)10-13/h3-11,17-19H,2H2,1H3/b4-3+
  • InChiKey: BWSASFADJXCNNP-ONEGZZNKSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium leprae PROBABLE GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE HEML (GSA) (GLUTAMATE-1-SEMIALDEHYDE AMINOTRANSFERASE) (GSA-AT) 0.0036 0.0213 0.0705
Schistosoma mansoni nuclear hormone receptor 0.0026 0.0104 0.056
Brugia malayi Nuclear hormone receptor E75 0.0026 0.0104 0.0104
Entamoeba histolytica hypothetical protein 0.0055 0.0412 1
Wolbachia endosymbiont of Brugia malayi acetylornithine transaminase protein 0.0036 0.0213 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.014 0.1329 0.5081
Loa Loa (eye worm) hypothetical protein 0.0944 1 1
Onchocerca volvulus 0.0056 0.0422 0.7309
Brugia malayi MAP kinase sur-1 0.0043 0.0285 0.0285
Schistosoma mansoni nuclear hormone receptor 0.0026 0.0104 0.056
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0146 0.1398 0.1398
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0084 0.0725 0.2713
Schistosoma mansoni aldehyde dehydrogenase 0.014 0.1329 0.7125
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0056 0.0422 0.0422
Schistosoma mansoni hypothetical protein 0.019 0.1865 1
Echinococcus multilocularis GPCR, family 2 0.0018 0.0011 0.0011
Brugia malayi Nuclear hormone receptor E75 0.0026 0.0104 0.0104
Schistosoma mansoni hypothetical protein 0.0018 0.0011 0.0057
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.014 0.1329 0.1329
Echinococcus multilocularis geminin 0.019 0.1865 0.1865
Brugia malayi Steroid receptor seven-up type 2 0.0056 0.0422 0.0422
Plasmodium falciparum thioredoxin reductase 0.0037 0.0217 1
Loa Loa (eye worm) hypothetical protein 0.0056 0.0422 0.0422
Schistosoma mansoni retinoic acid receptor RXR 0.0056 0.0422 0.2265
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0026 0.0104 0.0104
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0043 0.0285 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0056 0.0422 0.0422
Onchocerca volvulus 0.007 0.0578 1
Brugia malayi nuclear hormone receptor family member odr-7 0.0026 0.0104 0.0104
Mycobacterium ulcerans hypothetical protein 0.0256 0.2583 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0056 0.0422 0.0422
Echinococcus multilocularis thyroid hormone receptor alpha 0.0056 0.0422 0.0422
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0056 0.0422 0.2265
Echinococcus multilocularis muscleblind protein 0.0944 1 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0056 0.0422 0.0422
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0056 0.0422 0.0422
Schistosoma mansoni nuclear receptor 0.0026 0.0104 0.056
Entamoeba histolytica hypothetical protein 0.0055 0.0412 1
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0043 0.0285 0.194
Loa Loa (eye worm) hypothetical protein 0.0026 0.0104 0.0104
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0056 0.0422 0.0422
Brugia malayi nuclear receptor RXR 0.0026 0.0104 0.0104
Brugia malayi 4-aminobutyrate aminotransferase, mitochondrial precursor 0.0036 0.0213 0.0213
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0146 0.1398 0.7497
Echinococcus granulosus tyrosine protein kinase ABL1 0.0095 0.0848 0.0848
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0026 0.0104 0.056
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0056 0.0422 0.0422
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0146 0.1398 0.1398
Loa Loa (eye worm) hypothetical protein 0.0026 0.0104 0.0104
Brugia malayi hypothetical protein 0.0026 0.0104 0.0104
Loa Loa (eye worm) hypothetical protein 0.0056 0.0422 0.0422
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0056 0.0422 0.2265
Echinococcus multilocularis ornithine aminotransferase 0.0036 0.0213 0.0213
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0056 0.0422 0.0422
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0093 0.0826 0.3109
Giardia lamblia Kinase, CMGC MAPK 0.0043 0.0285 0.5
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0036 0.0213 0.0705
Schistosoma mansoni tyrosine kinase 0.0094 0.0833 0.4467
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.007 0.0578 0.0578
Mycobacterium tuberculosis Probable aminotransferase 0.0256 0.2583 1
Mycobacterium tuberculosis Probable ornithine aminotransferase (N-terminus part) RocD1 (ornithine--oxo-acid aminotransferase) 0.0036 0.0213 0.0705
Schistosoma mansoni nuclear hormone receptor 0.0056 0.0422 0.2265
Mycobacterium tuberculosis Probable glutamate-1-semialdehyde 2,1-aminomutase HemL (GSA) (glutamate-1-semialdehyde aminotransferase) (GSA-at) 0.0036 0.0213 0.0705
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0029 0.0138 0.0742
Loa Loa (eye worm) DR-78 0.0026 0.0104 0.0104
Trichomonas vaginalis acetylornithine aminotransferase, putative 0.0256 0.2583 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0146 0.1398 0.7497
Brugia malayi orphan nuclear receptor NR2E1 0.0026 0.0104 0.0104
Echinococcus granulosus potassium channel KvQLT family member kqt 1 0.0151 0.1446 0.1446
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0043 0.0285 0.0285
Loa Loa (eye worm) steroid hormone receptor 0.0056 0.0422 0.0422
Plasmodium vivax ornithine aminotransferase, putative 0.0036 0.0213 0.9822
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0084 0.0725 0.2713
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.007 0.0578 0.31
Brugia malayi nuclear hormone receptor 0.0026 0.0104 0.0104
Echinococcus multilocularis thioredoxin glutathione reductase 0.0037 0.0217 0.0217
Brugia malayi nuclear receptor RXR 0.0029 0.0138 0.0138
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0056 0.0422 0.2265
Echinococcus granulosus mitogen activated protein kinase 3 0.0043 0.0285 0.0285
Brugia malayi nuclear receptor NHR-67 0.0026 0.0104 0.0104
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0146 0.1398 0.1398
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0056 0.0422 0.0422
Schistosoma mansoni nuclear receptor 0.0026 0.0104 0.056
Toxoplasma gondii ornithine aminotransferase, mitochondrial precursor, putative 0.0036 0.0213 0.1387
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0907 0.9605 0.9605
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0084 0.0725 0.2713
Schistosoma mansoni hypothetical protein 0.019 0.1865 1
Echinococcus multilocularis FTZ F1 alpha 0.0056 0.0422 0.0422
Onchocerca volvulus 0.0026 0.0104 0.1805
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0056 0.0422 0.2265
Schistosoma mansoni coup transcription factor 0.0056 0.0422 0.2265
Mycobacterium leprae PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA 0.0256 0.2583 1
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0026 0.0104 0.0104
Loa Loa (eye worm) voltage-gated potassium channel 0.0148 0.1418 0.1418
Loa Loa (eye worm) hypothetical protein 0.0026 0.0104 0.0104
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0056 0.0422 0.0422
Schistosoma mansoni hypothetical protein 0.0038 0.0231 0.1241
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.014 0.1329 0.1329
Echinococcus granulosus potassium voltage gated channel subfamily KQT 0.0068 0.0552 0.0552
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0056 0.0422 0.0422
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0056 0.0422 0.0422
Brugia malayi Nuclear hormone receptor-like 1 0.0029 0.0138 0.0138
Loa Loa (eye worm) hypothetical protein 0.0029 0.0138 0.0138
Echinococcus granulosus thyroid hormone receptor alpha 0.0026 0.0104 0.0104
Loa Loa (eye worm) hypothetical protein 0.0036 0.021 0.021
Brugia malayi nuclear receptor NHR-88 0.0026 0.0104 0.0104
Schistosoma mansoni thyroid hormone receptor 0.0056 0.0422 0.2265
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0146 0.1398 0.7497
Loa Loa (eye worm) hypothetical protein 0.0038 0.0231 0.0231
Loa Loa (eye worm) hypothetical protein 0.0029 0.0138 0.0138
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0029 0.0138 0.0138
Loa Loa (eye worm) hypothetical protein 0.0068 0.0552 0.0552
Schistosoma mansoni serine/threonine protein kinase 0.0043 0.0285 0.1527
Loa Loa (eye worm) thioredoxin reductase 0.0037 0.0217 0.0217
Echinococcus granulosus L aminoadipate semialdehyde 0.007 0.0578 0.0578
Plasmodium falciparum glutathione reductase 0.0037 0.0217 1
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0043 0.0285 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0029 0.0138 0.0742
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.014 0.1329 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0056 0.0422 0.0422
Echinococcus granulosus ornithine aminotransferase 0.0036 0.0213 0.0213
Echinococcus multilocularis potassium voltage gated channel subfamily KQT 0.0151 0.1446 0.1446
Chlamydia trachomatis glutamate-1-semialdehyde-2,1-aminomutase 0.0036 0.0213 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0018 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0026 0.0104 0.0104
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0146 0.1398 0.1398
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0011
Brugia malayi Tyrosine-protein kinase abl-1 0.0058 0.0443 0.0443
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0056 0.0422 0.0422
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0146 0.1398 0.1398
Echinococcus multilocularis ornithine aminotransferase 0.0036 0.0213 0.0213
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0056 0.0422 0.0422
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0026 0.0104 0.1805
Brugia malayi steroid hormone receptor 0.0056 0.0422 0.0422
Brugia malayi tailless protein 0.0026 0.0104 0.0104
Brugia malayi Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog 0.0151 0.1446 0.1446
Echinococcus multilocularis Aminotransferase class III 0.0036 0.0213 0.0213
Echinococcus multilocularis L aminoadipate semialdehyde 0.007 0.0578 0.0578
Loa Loa (eye worm) hypothetical protein 0.0056 0.0422 0.0422
Brugia malayi hypothetical protein 0.0029 0.0138 0.0138
Echinococcus granulosus FTZ F1 alpha 0.0056 0.0422 0.0422
Treponema pallidum 4'-phosphopantetheinyl transferase 0.002 0.0033 0.5
Trypanosoma brucei trypanothione reductase 0.0037 0.0217 0.7302
Mycobacterium leprae Probable 4-aminobutyrate aminotransferase GabT (GAMMA-AMINO-N-BUTYRATE TRANSAMINASE) (GABA TRANSAMINASE) (GLUTAMATE:SUCCINIC SEM 0.0036 0.0213 0.0705
Mycobacterium tuberculosis Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA 0.0256 0.2583 1
Echinococcus granulosus ecdysone induced protein 78C 0.0056 0.0422 0.0422
Mycobacterium tuberculosis Probable acetylornithine aminotransferase ArgD 0.0036 0.0213 0.0705
Mycobacterium ulcerans L-lysine aminotransferase 0.0036 0.0213 0.0705
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0043 0.0285 1
Toxoplasma gondii thioredoxin reductase 0.0037 0.0217 0.1416
Loa Loa (eye worm) hypothetical protein 0.0056 0.0422 0.0422
Loa Loa (eye worm) hypothetical protein 0.0026 0.0104 0.0104
Schistosoma mansoni steroid hormone receptor ad4bp 0.0056 0.0422 0.2265
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0056 0.0422 0.0422
Brugia malayi ecdysteroid receptor 0.0056 0.0422 0.0422
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0056 0.0422 0.0422
Schistosoma mansoni hypothetical protein 0.0018 0.0011 0.0057
Brugia malayi nuclear hormone receptor family member nhr-6 0.0026 0.0104 0.0104
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0043 0.0285 0.194
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0056 0.0422 0.0422
Mycobacterium leprae Probable Acetylornithine aminotransferase ArgD 0.0036 0.0213 0.0705
Brugia malayi Tyrosine-protein kinase abl-1 0.0039 0.0239 0.0239
Schistosoma mansoni ornithine--oxo-acid transaminase 0.0036 0.0213 0.1142
Echinococcus multilocularis mitogen activated protein kinase 3 0.0043 0.0285 0.0285
Loa Loa (eye worm) hypothetical protein 0.0056 0.0422 0.0422
Loa Loa (eye worm) TK/ABL protein kinase 0.0095 0.0848 0.0848
Echinococcus granulosus nuclear receptor nhr 48 0.0026 0.0104 0.0104
Loa Loa (eye worm) hypothetical protein 0.0026 0.0104 0.0104
Mycobacterium ulcerans aldehyde dehydrogenase 0.014 0.1329 0.5081
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0026 0.0104 0.0104
Schistosoma mansoni transcription factor LCR-F1 0.0055 0.0412 0.2211
Loa Loa (eye worm) potassium voltage-gated channel subfamily Q member 5 0.0068 0.0552 0.0552
Loa Loa (eye worm) hypothetical protein 0.0029 0.0138 0.0138
Echinococcus multilocularis muscleblind protein 1 0.0944 1 1
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0026 0.0104 0.1805
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0056 0.0422 0.0422
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0029 0.0138 0.0138
Mycobacterium tuberculosis Probable dehydrogenase 0.0084 0.0725 0.2713
Trypanosoma brucei protein kinase, putative 0.0043 0.0285 1
Echinococcus granulosus muscleblind protein 0.0944 1 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0138 0.0138
Loa Loa (eye worm) hypothetical protein 0.0068 0.0552 0.0552
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.01 0.0895 0.0895
Schistosoma mansoni aldehyde dehydrogenase 0.014 0.1329 0.7125
Brugia malayi Calcitonin receptor-like protein seb-1 0.0056 0.0422 0.0422
Loa Loa (eye worm) glutathione reductase 0.0037 0.0217 0.0217
Mycobacterium ulcerans acetylornithine aminotransferase 0.0036 0.0213 0.0705
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0043 0.0285 1
Echinococcus granulosus GPCR family 2 0.0018 0.0011 0.0011
Entamoeba histolytica hypothetical protein 0.0055 0.0412 1
Loa Loa (eye worm) hypothetical protein 0.0056 0.0422 0.0422
Brugia malayi glutathione reductase 0.0037 0.0217 0.0217
Onchocerca volvulus Bile acid receptor homolog 0.0056 0.0422 0.7309
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0018 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0026 0.0104 0.0104
Echinococcus multilocularis potassium voltage gated channel subfamily KQT 0.0068 0.0552 0.0552
Loa Loa (eye worm) hypothetical protein 0.0944 1 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0056 0.0422 0.2265
Loa Loa (eye worm) hypothetical protein 0.0026 0.0104 0.0104
Brugia malayi Thioredoxin reductase 0.0037 0.0217 0.0217
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.002 0.0033 0.1541
Mycobacterium ulcerans aldehyde dehydrogenase 0.014 0.1329 0.5081
Onchocerca volvulus 0.0026 0.0104 0.1805
Mycobacterium ulcerans glutamate-1-semialdehyde aminotransferase 0.0036 0.0213 0.0705
Mycobacterium tuberculosis Probable oxidoreductase 0.0093 0.0826 0.3109
Loa Loa (eye worm) hypothetical protein 0.0026 0.0104 0.0104
Loa Loa (eye worm) hypothetical protein 0.0056 0.0422 0.0422
Schistosoma mansoni hypothetical protein 0.0055 0.0412 0.2211
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0026 0.0104 0.056
Brugia malayi hypothetical protein 0.0029 0.0138 0.0138
Echinococcus granulosus mitogen activated protein kinase 0.0043 0.0285 0.0285
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0026 0.0104 0.0104
Schistosoma mansoni hypothetical protein 0.0018 0.0011 0.0057
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0026 0.0104 0.0104
Loa Loa (eye worm) latrophilin receptor protein 2 0.0018 0.0011 0.0011
Plasmodium vivax glutathione reductase, putative 0.0037 0.0217 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0056 0.0422 0.0422
Loa Loa (eye worm) hypothetical protein 0.0026 0.0104 0.0104
Loa Loa (eye worm) hypothetical protein 0.0026 0.0104 0.0104
Mycobacterium ulcerans adenosylmethionine-8-amino-7-oxononanoate aminotransferase 0.0256 0.2583 1
Brugia malayi nuclear receptor NHR-88 0.0056 0.0422 0.0422
Echinococcus multilocularis mitogen activated protein kinase 0.0043 0.0285 0.0285
Brugia malayi Nuclear hormone receptor-like 1 0.0056 0.0422 0.0422
Brugia malayi hypothetical protein 0.0055 0.0412 0.0412
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0056 0.0422 0.0422
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0056 0.0422 0.0422
Echinococcus granulosus Nuclear hormone receptor HR96 0.0026 0.0104 0.0104
Loa Loa (eye worm) hypothetical protein 0.0026 0.0104 0.0104
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0056 0.0422 0.2265
Leishmania major trypanothione reductase 0.0037 0.0217 0.1416
Mycobacterium ulcerans ornithine aminotransferase RocD1 and RocD2 0.0036 0.0213 0.0705
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0037 0.0217 0.072
Loa Loa (eye worm) hypothetical protein 0.0056 0.0422 0.0422
Echinococcus granulosus thioredoxin glutathione reductase 0.0037 0.0217 0.0217
Echinococcus multilocularis nuclear receptor nhr 48 0.0026 0.0104 0.0104
Loa Loa (eye worm) nuclear hormone receptor 0.0026 0.0104 0.0104
Schistosoma mansoni lipoxygenase 0.01 0.0895 0.48
Schistosoma mansoni thyroid hormone receptor 0.0056 0.0422 0.2265
Brugia malayi latrophilin 2 splice variant baaae 0.0038 0.0231 0.0231
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0055 0.0412 0.0412
Brugia malayi ecdysone receptor 0.0026 0.0104 0.0104
Echinococcus multilocularis tyrosine protein kinase Abl 0.0039 0.0239 0.0239
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0095 0.0848 0.0848
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0043 0.0285 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0056 0.0422 0.0422
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0056 0.0422 0.0422
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.002 0.0033 0.1541
Echinococcus granulosus Aminotransferase class III 0.0036 0.0213 0.0213
Mycobacterium tuberculosis Probable reductase 0.0084 0.0725 0.2713
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0056 0.0422 0.0422
Schistosoma mansoni lipoxygenase 0.007 0.0572 0.3066
Brugia malayi Nuclear hormone receptor-like 1 0.0029 0.0138 0.0138
Entamoeba histolytica hypothetical protein 0.0055 0.0412 1
Schistosoma mansoni nuclear receptor nhr-48 0.0026 0.0104 0.056
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0146 0.1398 0.1398
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0026 0.0104 0.0104
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0056 0.0422 0.0422
Brugia malayi nuclear hormone receptor 0.0056 0.0422 0.0422
Loa Loa (eye worm) hypothetical protein 0.007 0.0578 0.0578
Schistosoma mansoni voltage-gated potassium channel KCNQ 0.0151 0.1446 0.7752
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0036 0.0213 0.0705
Onchocerca volvulus Protein ultraspiracle homolog 0.0056 0.0422 0.7309
Brugia malayi Latrophilin receptor protein 2 0.0018 0.0011 0.0011
Mycobacterium tuberculosis Probable L-lysine-epsilon aminotransferase Lat (L-lysine aminotransferase) (lysine 6-aminotransferase) 0.0036 0.0213 0.0705
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0043 0.0285 0.194
Echinococcus multilocularis ecdysone induced protein 78C 0.0056 0.0422 0.0422
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0056 0.0422 0.0422
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0056 0.0422 0.0422
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0056 0.0422 0.0422
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0056 0.0422 0.0422
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0026 0.0104 0.0104
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0056 0.0422 0.0422
Loa Loa (eye worm) nuclear receptor NHR-67 0.0026 0.0104 0.0104
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0093 0.0826 0.3109
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0084 0.0725 0.2713
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0018 0.0011 0.0011
Echinococcus granulosus arachidonate 5 lipoxygenase 0.01 0.0895 0.0895
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0056 0.0422 0.0422
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0026 0.0104 0.0104
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0029 0.0138 0.0138
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0026 0.0104 0.0104
Toxoplasma gondii aldehyde dehydrogenase 0.014 0.1329 1
Brugia malayi conserved hypotetical protein 0.0026 0.0104 0.0104
Echinococcus granulosus geminin 0.019 0.1865 0.1865
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0093 0.0826 0.3109
Plasmodium vivax thioredoxin reductase, putative 0.0037 0.0217 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0056 0.0422 0.0422
Loa Loa (eye worm) hypothetical protein 0.0056 0.0422 0.0422
Plasmodium falciparum ornithine aminotransferase 0.0036 0.0213 0.9822
Brugia malayi photoreceptor-specific nuclear receptor 0.0056 0.0422 0.0422
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0055 0.0412 0.0412
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0056 0.0422 0.7309
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.014 0.1329 0.5081
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0018 0.0011 0.0011
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0084 0.0725 0.2713
Loa Loa (eye worm) hypothetical protein 0.0029 0.0138 0.0138
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0056 0.0422 0.0422
Brugia malayi hypothetical protein 0.0026 0.0104 0.0104
Echinococcus granulosus Nuclear hormone receptor HR96 0.0026 0.0104 0.0104
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0018 0.0011 0.0011
Schistosoma mansoni RAR-like nuclear receptor 0.0056 0.0422 0.2265
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0056 0.0422 0.0422
Schistosoma mansoni hypothetical protein 0.0018 0.0011 0.0057
Loa Loa (eye worm) hypothetical protein 0.0026 0.0104 0.0104
Schistosoma mansoni zinc finger protein 0.0026 0.0104 0.056

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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