Detailed information for compound 1690262

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 767.886 | Formula: C43H41N15
  • H donors: 6 H acceptors: 9 LogP: 9.62 Rotable bonds: 15
    Rule of 5 violations (Lipinski): 3
  • SMILES: N#C/C=C/c1cc(C)c(c(c1)C)Nc1nc(NCCCNc2nc(Nc3ccc(cc3)C#N)nc(n2)Nc2c(C)cc(cc2C)C)nc(n1)Nc1ccc(cc1)C#N
  • InChi: 1S/C43H41N15/c1-26-20-27(2)36(28(3)21-26)51-42-55-38(53-40(57-42)49-34-13-9-31(24-45)10-14-34)47-18-7-19-48-39-54-41(50-35-15-11-32(25-46)12-16-35)58-43(56-39)52-37-29(4)22-33(8-6-17-44)23-30(37)5/h6,8-16,20-23H,7,18-19H2,1-5H3,(H3,47,49,51,53,55,57)(H3,48,50,52,54,56,58)/b8-6+
  • InChiKey: XJDYEVCZSZERAQ-SOFGYWHQSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0205 0.3167
Schistosoma mansoni hypothetical protein 0.0033 0.0444 0.092
Loa Loa (eye worm) hypothetical protein 0.0031 0.0388 0.091
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0021 0.0153 0.1569
Giardia lamblia Lysyl-tRNA synthetase 0.0023 0.0201 0.1932
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0077 0.1488 0.3087
Plasmodium vivax lysine--tRNA ligase, putative 0.0023 0.0201 0.0201
Trichomonas vaginalis CAMK family protein kinase 0.0031 0.0404 0.1653
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0205 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0056 0.0978 0.4007
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0153 0.0629
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.0404 0.0837
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0018 0.009 0.0367
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0018 0.009 0.0186
Brugia malayi Sugar transporter family protein 0.0103 0.2094 0.858
Brugia malayi MH2 domain containing protein 0.0116 0.2413 0.9884
Schistosoma mansoni protein kinase 0.0031 0.0404 0.0837
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0077 0.1488 0.6098
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.007 0.0288
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0036 0.051 0.2088
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0077 0.1488 0.3087
Brugia malayi Cam kinase protein 1 0.0031 0.0404 0.1653
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0413 0.1692
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0014 0 0.5
Trypanosoma brucei glucose transporter, putative 0.0032 0.0413 0.4224
Entamoeba histolytica hypothetical protein 0.0023 0.0201 0.0475
Trypanosoma brucei glucose transporter, putative 0.0032 0.0413 0.4224
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0413 0.1692
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0205 0.2091
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0724 0.2967
Entamoeba histolytica hypothetical protein 0.0035 0.0488 0.1693
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0056 0.0978 0.3778
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0031 0.0404 0.0617
Loa Loa (eye worm) phosphatidylinositol 3 0.0056 0.0978 0.229
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0021 0.0044
Plasmodium falciparum lysine--tRNA ligase 0.0023 0.0201 0.0201
Plasmodium vivax hexose transporter 0.0103 0.2094 0.2094
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0488 0.1011
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0031 0.0388 0.1591
Plasmodium vivax calcium-dependent protein kinase, putative 0.0031 0.0404 0.0404
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0205 1
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0021 0.0153 0.0318
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0021 0.0153 0.1569
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0103 0.2094 0.4343
Loa Loa (eye worm) hypothetical protein 0.0023 0.0201 0.0471
Loa Loa (eye worm) hypothetical protein 0.0017 0.0066 0.0155
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0479 0.1961
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0021 0.0153 0.0318
Loa Loa (eye worm) phosphatidylinositol 3 0.0035 0.0482 0.1128
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0018 0.009 0.0916
Schistosoma mansoni hypothetical protein 0.0015 0.0021 0.0044
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0028 0.0324 0.3314
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0031 0.0404 0.0617
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.066 0.2704
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0021 0.0153 0.0318
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0201 0.0417
Giardia lamblia GTOR 0.0056 0.0978 0.9385
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0021 0.005
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0021 0.0088
Leishmania major glucose transporter, lmgt3 0.0032 0.0413 0.4224
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0023 0.0201 0.3046
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0404 0.0837
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.01 0.2039 0.8352
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0023 0.0201 0.2058
Trypanosoma brucei glucose transporter, putative 0.0032 0.0413 0.4224
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0045 0.0725 0.7415
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0045 0.0725 0.7415
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0117 0.2441 1
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0018 0.009 0.0367
Leishmania major phosphatidylinositol 3-kinase, putative 0.0018 0.009 0.0916
Loa Loa (eye worm) hypothetical protein 0.004 0.061 0.1428
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0031 0.0404 0.0404
Trypanosoma brucei glucose transporter, putative 0.0032 0.0413 0.4224
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0413 0.1692
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0023 0.0201 0.0825
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0031 0.0404 0.0617
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.066 0.2704
Plasmodium falciparum calcium-dependent protein kinase 2 0.0031 0.0404 0.0404
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0018 0.009 0.0367
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.051 0.5211
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0413 0.4224
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.051 0.5211
Loa Loa (eye worm) hypothetical protein 0.0017 0.0066 0.0155
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0413 0.1692
Trypanosoma cruzi hexose transporter, putative 0.0017 0.007 0.0289
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0023 0.0201 0.0825
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.057 0.2333
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0205 0.0489
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0021 0.0044
Brugia malayi hypothetical protein 0.0035 0.0488 0.1998
Leishmania major glucose transporter/membrane transporter D2, putative 0.0032 0.0413 0.4224
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0018 0.009 0.0186
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0808 0.331
Echinococcus granulosus calcium dependent protein kinase 0.003 0.0357 0.0741
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0413 0.1692
Leishmania major glucose transporter, lmgt2 0.0032 0.0413 0.4224
Mycobacterium ulcerans hypothetical protein 0.0023 0.0205 1
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0205 1
Entamoeba histolytica hypothetical protein 0.0035 0.0488 0.1693
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0056 0.0978 0.2028
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0054 0.0936 0.3601
Schistosoma mansoni hypothetical protein 0.0165 0.3568 0.74
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0021 0.0044
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0056 0.0978 0.2028
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.066 0.2704
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0205 0.0489
Trichomonas vaginalis glucose transporter, putative 0.0032 0.0413 0.1692
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0117 0.2441 1
Trypanosoma brucei glucose transporter, putative 0.0032 0.0413 0.4224
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0444 0.1818
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0388 0.0806
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0056 0.0978 0.4007
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0201 0.9841
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0205 0.0838
Echinococcus granulosus GPCR family 2 0.0015 0.0021 0.0044
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0031 0.0388 0.0806
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0407 0.1669
Schistosoma mansoni glucose transport protein 0.0103 0.2094 0.4343
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0205 0.2091
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0021 0.0153 0.0629
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0205 0.3167
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0056 0.0978 1
Echinococcus multilocularis geminin 0.0165 0.3568 0.74
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.051 0.5211
Plasmodium falciparum calcium-dependent protein kinase 5 0.0031 0.0404 0.0404
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0031 0.0404 0.0404
Loa Loa (eye worm) hypothetical protein 0.0015 0.0021 0.005
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0166 0.3595 0.5495
Toxoplasma gondii protein kinase, putative 0.029 0.6542 1
Echinococcus multilocularis General substrate transporter 0.0088 0.1752 0.3632
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0058 0.1042 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0094 0.1889 0.7652
Schistosoma mansoni hypothetical protein 0.0015 0.0021 0.0044
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0205 0.0489
Plasmodium falciparum acyl-CoA synthetase 0.0017 0.0066 0.0066
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0103 0.2094 0.4343
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0056 0.0978 1
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0166 0.3595 0.3595
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0117 0.2441 1
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.0066 0.0066
Schistosoma mansoni protein kinase 0.0031 0.0404 0.0837
Loa Loa (eye worm) sugar transporter 0.0103 0.2094 0.4905
Echinococcus granulosus lysyl tRNA synthetase 0.0023 0.0201 0.0417
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0488 0.1011
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0724 0.2967
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0042 0.0642 0.6562
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0056 0.0978 1
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0103 0.2094 0.4343
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0017 0.0066 0.3237
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0036 0.051 0.0779
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.066 0.2704
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0042 0.0642 0.2348
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0056 0.0978 0.2028
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0021 0.0044
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.2413 0.565
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.066 0.2704
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0042 0.0642 0.1331
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0018 0.009 0.0186
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0031 0.0388 0.0806
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0103 0.2094 0.4343
Trypanosoma brucei glucose transporter, putative 0.0032 0.0413 0.4224
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0205 1
Giardia lamblia Prolyl-tRNA synthetase 0.0031 0.0388 0.3728
Plasmodium falciparum proline--tRNA ligase 0.0036 0.051 0.051
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0479 0.1961
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0153 0.0629
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0031 0.0404 0.0945
Leishmania major lysyl-tRNA synthetase, putative 0.0023 0.0201 0.2058
Schistosoma mansoni hypothetical protein 0.0015 0.0021 0.0044
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0117 0.2441 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0066 0.0155
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0018 0.009 0.021
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.2413 0.565
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0018 0.009 0.009
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0044 0.2145
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0082 0.1594 0.6531
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0406 0.1664
Entamoeba histolytica hypothetical protein 0.0035 0.0488 0.1693
Loa Loa (eye worm) phosphatidylinositol 3 0.0195 0.427 1
Entamoeba histolytica hypothetical protein 0.0094 0.1889 0.7652
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0042 0.0642 0.2629
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0201 0.0417
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0205 1
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0404 0.0837
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0019 0.0119 0.5833
Loa Loa (eye worm) hypothetical protein 0.0017 0.0066 0.0155
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0407 0.1669
Leishmania major glucose transporter, lmgt1 0.0032 0.0413 0.4224
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0031 0.0404 0.4126
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0201 0.9841
Loa Loa (eye worm) hypothetical protein 0.0025 0.0251 0.0589
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0413 0.1692
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0218 0.4822 1
Brugia malayi lysyl-tRNA synthetase 0.0023 0.0201 0.0825
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.066 0.2704
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0021 0.0153 0.0629
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0724 0.2967
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0205 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0056 0.0978 0.4007
Trypanosoma brucei glucose transporter, putative 0.0032 0.0413 0.4224
Loa Loa (eye worm) hypothetical protein 0.0017 0.0066 0.0155
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0797 0.3263
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0066 0.3237
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0205 1
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0031 0.0388 0.1591
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0044 0.2145
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0117 0.2441 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0044 0.2145
Plasmodium falciparum calcium-dependent protein kinase 3 0.0031 0.0404 0.0404
Schistosoma mansoni hypothetical protein 0.0103 0.2094 0.4343
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0025 0.0253 0.2584
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0404 0.0837
Plasmodium vivax CDK-related protein kinase 6, putative 0.0436 1 1
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0018 0.009 0.0916
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0205 0.2091
Schistosoma mansoni hypothetical protein 0.0165 0.3568 0.74
Loa Loa (eye worm) hypothetical protein 0.0023 0.0205 0.0479
Entamoeba histolytica protein kinase, putative 0.0031 0.0404 0.1335
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0111 0.2281 0.9319
Trichomonas vaginalis PIKK family atypical protein kinase 0.0056 0.0978 0.4007
Onchocerca volvulus 0.0023 0.0205 1
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0205 0.0838
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0153 0.0629
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0031 0.0404 0.0404
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0205 1
Echinococcus granulosus geminin 0.0165 0.3568 0.74
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0479 0.1961
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0543 0.2224
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.0404 0.0837
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0056 0.0978 0.4007
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0406 0.1664
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0018 0.009 0.0186
Leishmania major protein kinase, putative 0.0031 0.0404 0.4126
Loa Loa (eye worm) hypothetical protein 0.0031 0.0404 0.0945
Echinococcus granulosus General substrate transporter 0.0088 0.1752 0.3632
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0018 0.009 0.0137
Loa Loa (eye worm) hypothetical protein 0.0077 0.1488 0.3486
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0407 0.1669
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0021 0.0088
Entamoeba histolytica hypothetical protein 0.0035 0.0488 0.1693
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0031 0.0404 0.1653
Echinococcus multilocularis lysyl tRNA synthetase 0.0023 0.0201 0.0417
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0042 0.0642 0.2629
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0036 0.051 0.2088
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0018 0.009 0.0367
Chlamydia trachomatis lysine--tRNA ligase 0.0023 0.0201 1
Schistosoma mansoni protein kinase 0.0031 0.0404 0.0837
Entamoeba histolytica protein kinase, putative 0.0031 0.0404 0.1335
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0035 0.0482 0.1973
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0056 0.0978 1
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0042 0.0642 0.2629
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.003 0.037 0.3547
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0388 0.0806
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0018 0.009 0.0137
Plasmodium vivax proline--tRNA ligase, putative 0.0036 0.051 0.051
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0042 0.0642 0.2629
Toxoplasma gondii target of rapamycin (TOR), putative 0.0042 0.066 0.1009
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0103 0.2094 0.4343
Echinococcus multilocularis calcium dependent protein kinase 0.003 0.0357 0.0741
Echinococcus multilocularis Zinc finger, PHD finger 0.0018 0.009 0.0186
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0031 0.0388 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.066 0.2704
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0413 0.4224
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0031 0.0388 0.1271
Trypanosoma cruzi target of rapamycin kinase 3 0.0045 0.0725 0.2971
Loa Loa (eye worm) hypothetical protein 0.0023 0.0205 0.0479
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0153 0.0629
Trichomonas vaginalis conserved hypothetical protein 0.0103 0.2094 0.858
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0406 0.1664
Schistosoma mansoni glucose transport protein 0.0103 0.2094 0.4343
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0205 1
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0413 0.4224
Schistosoma mansoni serine/threonine protein kinase 0.0031 0.0404 0.0837
Plasmodium falciparum protein kinase 7 0.029 0.6542 0.6542
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0724 0.2967
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0044 0.2145
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0404 0.0837
Loa Loa (eye worm) phosphatidylinositol 3 0.0021 0.0153 0.0359
Loa Loa (eye worm) hypothetical protein 0.0049 0.0808 0.1892
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0471 0.1931
Trypanosoma cruzi hexose transporter 0.0032 0.0413 0.1692
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0018 0.009 0.0367
Plasmodium falciparum calcium-dependent protein kinase 1 0.0031 0.0404 0.0404
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0488 0.1011
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0413 0.1692
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0117 0.2441 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.0404 0.0837
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0018 0.009 0.0367
Loa Loa (eye worm) hypothetical protein 0.0023 0.0205 0.0479
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0018 0.009 0.0186
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0218 0.4822 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0056 0.0978 0.4007
Schistosoma mansoni glucose transport protein 0.0103 0.2094 0.4343
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0042 0.0642 0.2629
Leishmania major phosphatidylinositol 3-kinase, putative 0.0021 0.0153 0.1569
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0031 0.0388 0.1591
Schistosoma mansoni hypothetical protein 0.0015 0.0021 0.0044
Trypanosoma brucei glucose transporter, putative 0.0032 0.0413 0.4224
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0413 0.1692
Toxoplasma gondii facilitative glucose transporter GT1 0.0103 0.2094 0.3201
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0031 0.0404 0.0945
Plasmodium falciparum mitogen-activated protein kinase 2 0.0166 0.3595 0.3595
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0471 0.1931
Schistosoma mansoni hypothetical protein 0.0035 0.0488 0.1011
Echinococcus multilocularis GPCR, family 2 0.0015 0.0021 0.0044
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0103 0.2094 0.4343
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0056 0.0978 0.3778
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0018 0.009 0.009
Loa Loa (eye worm) hypothetical protein 0.0033 0.0444 0.1039
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0103 0.2094 0.4343
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0031 0.0404 0.0837
Trypanosoma brucei glucose transporter 1E 0.0032 0.0413 0.4224
Trichomonas vaginalis glucose transporter, putative 0.0032 0.0413 0.1692
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0042 0.0642 0.2348
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0153 0.0629
Plasmodium falciparum hexose transporter 0.0103 0.2094 0.2094
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0019 0.0119 0.5833
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0407 0.1669
Toxoplasma gondii lysine-tRNA ligase 0.0023 0.0201 0.0308
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0808 0.331
Loa Loa (eye worm) hypothetical protein 0.0031 0.0388 0.091
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0218 0.4822 1
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0082 0.1594 0.6531
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0103 0.2094 0.4343
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0724 0.2967
Plasmodium falciparum calcium-dependent protein kinase 4 0.0031 0.0404 0.0404
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0021 0.0153 0.1569
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0117 0.2441 1
Trypanosoma brucei glucose transporter 2A 0.0032 0.0413 0.4224
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.002 0.0134 0.055
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0021 0.0153 0.0629
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0205 0.0838
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0808 0.1892

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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