TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 411.362 | Formula: C22H28Cl2O3
H donors: 1 H acceptors: 3 LogP: 3.96 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: OCC(=O)C1[C@H](C)CC2C1(C)CC(Cl)[C@]1(C2CCC2=CC(=O)C=CC12C)Cl
InChi: 1S/C22H28Cl2O3/c1-12-8-16-15-5-4-13-9-14(26)6-7-21(13,3)22(15,24)18(23)10-20(16,2)19(12)17(27)11-25/h6-7,9,12,15-16,18-19,25H,4-5,8,10-11H2,1-3H3/t12-,15?,16?,18?,19?,20?,21?,22+/m1/s1
InChiKey: FKRMBGXNTOTQDI-OKPPOTDYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	TK/FER protein kinase	0.0024	0.0127	0.0169
Brugia malayi	Protein kinase domain containing protein	0.0024	0.0127	0.0169
Schistosoma mansoni	tyrosine kinase	0.0024	0.0127	0.0141
Loa Loa (eye worm)	metabotropic GABA-B receptor subtype 2	0.0096	0.1236	0.1642
Trichomonas vaginalis	TKL family protein kinase	0.0024	0.0127	1
Schistosoma mansoni	tyrosine kinase	0.0024	0.0127	0.0141
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0024	0.0127	1
Brugia malayi	metabotropic GABA-B receptor subtype 2	0.0096	0.1236	0.1642
Trichomonas vaginalis	TKL family protein kinase	0.0024	0.0127	1
Loa Loa (eye worm)	TK/EPH protein kinase	0.0024	0.0127	0.0169
Loa Loa (eye worm)	TK/FAK protein kinase	0.0024	0.0127	0.0169
Schistosoma mansoni	tyrosine kinase	0.0024	0.0127	0.0141
Entamoeba histolytica	protein kinase domain containing protein	0.0024	0.0127	0.092
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.0024	0.0127	0.0169
Loa Loa (eye worm)	hypothetical protein	0.0096	0.1236	0.1642
Entamoeba histolytica	protein kinase, putative	0.0024	0.0127	0.092
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0024	0.0127	0.0169
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.06	0.8999	0.8999
Echinococcus multilocularis	ephrin type A receptor 4 A	0.0024	0.0127	0.0127
Brugia malayi	hypothetical protein	0.0096	0.1236	0.1642
Trypanosoma cruzi	cysteine peptidase, putative	0.0062	0.072	0.5778
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0024	0.0127	0.0127
Entamoeba histolytica	tyrosine kinase, putative	0.0024	0.0127	0.092
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0024	0.0127	0.0127
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0057	0.0637	0.5098
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.072	1
Onchocerca volvulus	Tyrosine kinase homolog	0.0024	0.0127	0.0709
Entamoeba histolytica	protein kinase, putative	0.0024	0.0127	0.092
Schistosoma mansoni	tyrosine kinase	0.0024	0.0127	0.0141
Entamoeba histolytica	protein kinase, putative	0.0024	0.0127	0.092
Echinococcus granulosus	glutamate receptor 2	0.06	0.8999	0.8999
Loa Loa (eye worm)	SRC-1	0.0024	0.0127	0.0169
Loa Loa (eye worm)	TK/RYK protein kinase	0.0024	0.0127	0.0169
Schistosoma mansoni	cellular tumor antigen P53	0.0048	0.0505	0.0561
Brugia malayi	hypothetical protein	0.0024	0.0127	0.0169
Trichomonas vaginalis	conserved hypothetical protein	0.0024	0.0127	1
Echinococcus granulosus	lamin dm0	0.0026	0.0168	0.0168
Echinococcus multilocularis	musashi	0.0026	0.0168	0.0168
Schistosoma mansoni	tyrosine kinase	0.0024	0.0127	0.0141
Entamoeba histolytica	protein kinase domain containing protein	0.0024	0.0127	0.092
Trypanosoma cruzi	cysteine peptidase, putative	0.0062	0.072	0.5778
Trichomonas vaginalis	TKL family protein kinase	0.0024	0.0127	1
Trichomonas vaginalis	TKL family protein kinase	0.0024	0.0127	1
Echinococcus granulosus	glutamate receptor ionotrophic AMPA 3	0.06	0.8999	0.8999
Echinococcus multilocularis	FL cytokine receptor	0.0024	0.0127	0.0127
Loa Loa (eye worm)	TK/ABL protein kinase	0.0024	0.0127	0.0169
Echinococcus granulosus	raf serine:threonine protein kinase	0.0024	0.0127	0.0127
Loa Loa (eye worm)	TK/FER protein kinase	0.0024	0.0127	0.0169
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0127	0.0169
Loa Loa (eye worm)	ctsf protein	0.0016	0.0015	0.0019
Entamoeba histolytica	tyrosine kinase, putative	0.0024	0.0127	0.092
Trichomonas vaginalis	TKL family protein kinase	0.0024	0.0127	1
Onchocerca volvulus		0.0024	0.0127	0.0709
Loa Loa (eye worm)	hypothetical protein	0.0096	0.1236	0.1642
Loa Loa (eye worm)	TK/ALK protein kinase	0.0024	0.0127	0.0169
Schistosoma mansoni	cathepsin F (C01 family)	0.0016	0.0015	0.0016
Echinococcus multilocularis	natriuretic peptide receptor 1	0.0024	0.0127	0.0127
Echinococcus multilocularis	glutamate receptor ionotropic kainate	0.0187	0.2636	0.2636
Loa Loa (eye worm)	TK protein kinase	0.0024	0.0127	0.0169
Entamoeba histolytica	hypothetical protein	0.0024	0.0127	0.092
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0024	0.0127	0.0127
Brugia malayi	Glutamate receptor 1 precursor	0.0505	0.7527	1
Trichomonas vaginalis	TKL family protein kinase	0.0024	0.0127	1
Entamoeba histolytica	protein kinase, putative	0.0024	0.0127	0.092
Entamoeba histolytica	serine/threonine kinase, putative	0.0024	0.0127	0.092
Trichomonas vaginalis	conserved hypothetical protein	0.0024	0.0127	1
Entamoeba histolytica	protein kinase, putative	0.0024	0.0127	0.092
Entamoeba histolytica	cysteine surface protein, putative	0.0024	0.0127	0.092
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.072	1
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0127	0.0169
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0024	0.0127	0.0169
Echinococcus granulosus	epidermal growth factor receptor	0.0024	0.0127	0.0127
Entamoeba histolytica	tyrosine kinase, putative	0.0024	0.0127	0.092
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.06	0.8999	0.8999
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0024	0.0127	0.0127
Plasmodium vivax	protein kinase, putative	0.0024	0.0127	1
Echinococcus granulosus	tyrosine protein kinase Srms	0.0024	0.0127	0.0127
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0024	0.0127	0.092
Trichomonas vaginalis	TKL family protein kinase	0.0024	0.0127	1
Entamoeba histolytica	serine/threonine kinase, putative	0.0024	0.0127	0.092
Echinococcus granulosus	tyrosine protein kinase csk	0.0024	0.0127	0.0127
Echinococcus multilocularis	glutamate receptor subunit protein glur	0.0187	0.2636	0.2636
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.072	1
Echinococcus granulosus	metabotropic glutamate receptor 5	0.0096	0.1236	0.1236
Echinococcus multilocularis	protein kinase	0.0024	0.0127	0.0127
Trichomonas vaginalis	TKL family protein kinase	0.0024	0.0127	1
Entamoeba histolytica	protein kinase domain containing protein	0.0024	0.0127	0.092
Schistosoma mansoni	protein kinase	0.0024	0.0127	0.0141
Brugia malayi	Furin-like cysteine rich region family protein	0.0024	0.0127	0.0169
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0024	0.0127	1
Entamoeba histolytica	protein kinase, putative	0.0024	0.0127	0.092
Brugia malayi	Protein kinase domain containing protein	0.0024	0.0127	0.0169
Trichomonas vaginalis	TKL family protein kinase	0.0024	0.0127	1
Schistosoma mansoni	protein kinase	0.0024	0.0127	0.0141
Trichomonas vaginalis	TKL family protein kinase	0.0024	0.0127	1
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0024	0.0127	0.0127
Trypanosoma cruzi	protein kinase, putative	0.0024	0.0127	0.092
Schistosoma mansoni	protein kinase	0.0024	0.0127	0.0141
Toxoplasma gondii	STE kinase	0.0024	0.0127	1
Loa Loa (eye worm)	TK protein kinase	0.0024	0.0127	0.0169
Schistosoma mansoni	hypothetical protein	0.0187	0.2636	0.2929
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0024	0.0127	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0024	0.0127	0.0169
Trichomonas vaginalis	TKL family protein kinase	0.0024	0.0127	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.0016	0.0015	0.0015
Giardia lamblia	Protein 21.1	0.0024	0.0127	0.5
Echinococcus multilocularis	transfer RNA-Thr	0.0024	0.0127	0.0127
Onchocerca volvulus		0.0024	0.0127	0.0709
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.0024	0.0127	0.0127
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0049	0.0511	0.0679
Entamoeba histolytica	protein kinase, putative	0.0024	0.0127	0.092
Entamoeba histolytica	protein kinase, putative	0.0024	0.0127	0.092
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.0024	0.0127	0.0169
Schistosoma mansoni	tyrosine kinase	0.0119	0.16	0.1778
Onchocerca volvulus		0.0026	0.0168	0.0967
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.0024	0.0127	0.0127
Trichomonas vaginalis	TKL family protein kinase	0.0024	0.0127	1
Brugia malayi	Cathepsin L-like precursor	0.0016	0.0015	0.0019
Loa Loa (eye worm)	TK/Met protein kinase	0.0024	0.0127	0.0169
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.0024	0.0127	0.0127
Echinococcus multilocularis	epidermal growth factor receptor	0.0024	0.0127	0.0127
Trichomonas vaginalis	TKL family protein kinase	0.0024	0.0127	1
Schistosoma mansoni	protein kinase	0.0024	0.0127	0.0141
Echinococcus granulosus	cathepsin l1	0.0016	0.0015	0.0015
Brugia malayi	SH2 domain containing protein	0.0024	0.0127	0.0169
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0024	0.0127	0.0127
Entamoeba histolytica	tyrosin kinase, putative	0.0024	0.0127	0.092
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0024	0.0127	0.0127
Trichomonas vaginalis	conserved hypothetical protein	0.0024	0.0127	1
Echinococcus multilocularis	tumor protein p63	0.0329	0.4832	0.4832
Brugia malayi	protein-tyrosine kinase	0.0024	0.0127	0.0169
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0161	0.0213
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.072	1
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0024	0.0127	0.0141
Loa Loa (eye worm)	hypothetical protein	0.0096	0.1236	0.1642
Schistosoma mansoni	serine/threonine protein kinase	0.0024	0.0127	0.0141
Echinococcus granulosus	protein kinase	0.0024	0.0127	0.0127
Echinococcus granulosus	tyrosine protein kinase shark	0.0024	0.0127	0.0127
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0024	0.0127	0.0169
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0016	0.0015	0.0015
Echinococcus multilocularis	activated cdc42 kinase 1	0.0024	0.0127	0.0127
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0024	0.0127	0.092
Echinococcus multilocularis	lamin dm0	0.0026	0.0168	0.0168
Entamoeba histolytica	protein kinase domain containing protein	0.0024	0.0127	0.092
Schistosoma mansoni	tyrosine kinase	0.0024	0.0127	0.0141
Entamoeba histolytica	tyrosine kinase, putative	0.0024	0.0127	0.092
Schistosoma mansoni	lamin	0.0026	0.0168	0.0187
Brugia malayi	Cathepsin L-like precursor	0.0016	0.0015	0.0019
Plasmodium falciparum	tyrosine kinase-like protein	0.0024	0.0127	1
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0024	0.0127	0.0169
Entamoeba histolytica	protein kinase domain containing protein	0.0024	0.0127	0.092
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0024	0.0127	0.0127
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0024	0.0127	0.0127
Entamoeba histolytica	protein kinase, putative	0.0024	0.0127	0.092
Echinococcus granulosus	activin receptor type	0.0024	0.0127	0.0127
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0024	0.0127	0.092
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0127	0.0169
Loa Loa (eye worm)	metabotropic glutamate receptor 8	0.0096	0.1236	0.1642
Loa Loa (eye worm)	hypothetical protein	0.0096	0.1236	0.1642
Entamoeba histolytica	protein kinase domain containing protein	0.0024	0.0127	0.092
Entamoeba histolytica	hypothetical protein	0.0026	0.0168	0.1259
Trichomonas vaginalis	TKL family protein kinase	0.0024	0.0127	1
Trichomonas vaginalis	TKL family protein kinase	0.0024	0.0127	1
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0024	0.0127	0.0127
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.0024	0.0127	0.0169
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.06	0.8999	0.8999
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0024	0.0127	0.0127
Trichomonas vaginalis	TKL family protein kinase	0.0024	0.0127	1
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0024	0.0127	0.0141
Entamoeba histolytica	protein kinase with ankyrin repeats, putative	0.0024	0.0127	0.092
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0024	0.0127	0.092
Schistosoma mansoni	serine/threonine protein kinase	0.0024	0.0127	0.0141
Entamoeba histolytica	protein kinase domain containing protein	0.0024	0.0127	0.092
Brugia malayi	Cathepsin L-like precursor	0.0016	0.0015	0.0019
Onchocerca volvulus		0.0024	0.0127	0.0709
Loa Loa (eye worm)	TK protein kinase	0.0024	0.0127	0.0169
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0024	0.0127	0.0127
Brugia malayi	Tyrosine-protein kinase PR2	0.0024	0.0127	0.0169
Echinococcus granulosus	glutamate receptor ionotropic kainate	0.0187	0.2636	0.2636
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0049	0.0511	0.0679
Loa Loa (eye worm)	TK/DDR protein kinase	0.0024	0.0127	0.0169
Schistosoma mansoni	tyrosine kinase	0.0024	0.0127	0.0141
Brugia malayi	Protein kinase domain containing protein	0.0024	0.0127	0.0169
Schistosoma mansoni	tyrosine kinase	0.0024	0.0127	0.0141
Echinococcus granulosus	intermediate filament protein	0.0026	0.0168	0.0168
Entamoeba histolytica	protein kinase domain containing protein	0.0024	0.0127	0.092
Schistosoma mansoni	tyrosine kinase	0.0119	0.16	0.1778
Entamoeba histolytica	tyrosine- protein kinase 2, putative	0.0024	0.0127	0.092
Brugia malayi	Protein kinase domain containing protein	0.0024	0.0127	0.0169
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.0024	0.0127	0.0127
Echinococcus granulosus	tyrosine protein kinase csk	0.0024	0.0127	0.0127
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0024	0.0127	1
Entamoeba histolytica	tyrosine kinase, putative	0.0024	0.0127	0.092
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0024	0.0127	0.0127
Loa Loa (eye worm)	fibroinase	0.0016	0.0015	0.0019
Entamoeba histolytica	tyrosin kinase, putative	0.0024	0.0127	0.092
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.06	0.8999	0.8999
Trichomonas vaginalis	TKL family protein kinase	0.0024	0.0127	1
Mycobacterium tuberculosis	Probable glutamine-binding lipoprotein GlnH (GLNBP)	0.0479	0.7127	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0024	0.0127	1
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.0024	0.0127	0.0127
Trichomonas vaginalis	conserved hypothetical protein	0.0024	0.0127	1
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0024	0.0127	0.092
Entamoeba histolytica	hypothetical protein, conserved	0.0024	0.0127	0.092
Echinococcus multilocularis	lamin	0.0026	0.0168	0.0168
Echinococcus granulosus	lamin	0.0026	0.0168	0.0168
Entamoeba histolytica	protein kinase domain containing protein	0.0024	0.0127	0.092
Loa Loa (eye worm)	TK/FER protein kinase	0.0024	0.0127	0.0169
Schistosoma mansoni	protein kinase	0.0119	0.16	0.1778
Echinococcus granulosus	glutamate NMDA receptor subunit	0.0505	0.7527	0.7527
Loa Loa (eye worm)	TK/FER protein kinase	0.0024	0.0127	0.0169
Onchocerca volvulus		0.0024	0.0127	0.0709
Echinococcus granulosus	tyrosine protein kinase csk	0.0024	0.0127	0.0127
Brugia malayi	Protein kinase domain containing protein	0.0024	0.0127	0.0169
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0127	0.0169
Entamoeba histolytica	tyrosine kinase, putative	0.0024	0.0127	0.092
Brugia malayi	Protein kinase domain containing protein	0.0024	0.0127	0.0169
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0024	0.0127	0.092
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0024	0.0127	0.0127
Leishmania major	protein kinase, putative	0.0024	0.0127	0.092
Trichomonas vaginalis	TKL family protein kinase	0.0024	0.0127	1
Trichomonas vaginalis	TKL family protein kinase	0.0024	0.0127	1
Onchocerca volvulus		0.0024	0.0127	0.0709
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.0024	0.0127	0.0169
Onchocerca volvulus		0.0024	0.0127	0.0709
Schistosoma mansoni	protein kinase	0.0024	0.0127	0.0141
Entamoeba histolytica	protein kinase domain containing protein	0.0024	0.0127	0.092
Schistosoma mansoni	protein kinase	0.0024	0.0127	0.0141
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0026	0.0168	0.0223
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0024	0.0127	1
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0016	0.0015	0.0015
Entamoeba histolytica	hypothetical protein	0.0026	0.0168	0.1259
Loa Loa (eye worm)	TK/INSR protein kinase	0.0024	0.0127	0.0169
Loa Loa (eye worm)	hypothetical protein	0.0119	0.16	0.2125
Entamoeba histolytica	hypothetical protein	0.0026	0.0168	0.1259
Schistosoma mansoni	tyrosine kinase	0.0024	0.0127	0.0141
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0119	0.16	0.16
Echinococcus granulosus	kinase suppressor of Ras 1	0.0024	0.0127	0.0127
Trichomonas vaginalis	TKL family protein kinase	0.0024	0.0127	1
Trichomonas vaginalis	TKL family protein kinase	0.0024	0.0127	1
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0024	0.0127	0.0127
Trichomonas vaginalis	TKL family protein kinase	0.0024	0.0127	1
Giardia lamblia	Kinase, NEK	0.0024	0.0127	0.5
Giardia lamblia	Kinase	0.0024	0.0127	0.5
Brugia malayi	Protein kinase domain containing protein	0.0024	0.0127	0.0169
Loa Loa (eye worm)	serine/threonine protein kinase	0.0024	0.0127	0.0169
Brugia malayi	Protein kinase domain containing protein	0.0024	0.0127	0.0169
Trichomonas vaginalis	TKL family protein kinase	0.0024	0.0127	1
Echinococcus multilocularis	tyrosine protein kinase csk	0.0024	0.0127	0.0127
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0024	0.0127	0.0127
Plasmodium falciparum	tyrosine kinase-like protein	0.0024	0.0127	1
Entamoeba histolytica	protein kinase, putative	0.0024	0.0127	0.092
Echinococcus multilocularis	tyrosine kinase	0.0024	0.0127	0.0127
Schistosoma mansoni	tyrosine kinase	0.0024	0.0127	0.0141
Brugia malayi	SRC-1	0.0024	0.0127	0.0169
Entamoeba histolytica	hypothetical protein	0.0024	0.0127	0.092
Echinococcus multilocularis	c src tyrosine kinase	0.0024	0.0127	0.0127
Entamoeba histolytica	protein kinase, putative	0.0024	0.0127	0.092
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.072	1
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0168	0.0223
Entamoeba histolytica	tyrosine kinase, putative	0.0024	0.0127	0.092
Loa Loa (eye worm)	glutamate receptor 2	0.0505	0.7527	1
Echinococcus multilocularis	glutamate receptor, ionotrophic, AMPA 3	0.06	0.8999	0.8999
Schistosoma mansoni	tyrosine kinase	0.0024	0.0127	0.0141
Chlamydia trachomatis	arginine ABC transporter substrate-binding protein ArtJ	0.0479	0.7127	0.5
Entamoeba histolytica	hypothetical protein	0.0096	0.1236	1
Echinococcus granulosus	tyrosine kinase	0.0024	0.0127	0.0127
Brugia malayi	Tyrosine-protein kinase abl-1	0.0024	0.0127	0.0169
Brugia malayi	Guanylyl cyclase protein 23	0.0119	0.16	0.2125
Trichomonas vaginalis	TKL family protein kinase	0.0024	0.0127	1
Loa Loa (eye worm)	receptor family ligand binding region containing protein	0.0096	0.1236	0.1642
Onchocerca volvulus		0.0024	0.0127	0.0709
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.072	1
Echinococcus multilocularis	tyrosine protein kinase	0.0024	0.0127	0.0127
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0024	0.0127	0.0127
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0024	0.0127	0.0127
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0275	0.0365
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0024	0.0127	0.0127
Trichomonas vaginalis	TKL family protein kinase	0.0024	0.0127	1
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.0024	0.0127	0.0169
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0024	0.0127	0.0127
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0505	0.0671
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0024	0.0127	0.092
Entamoeba histolytica	protein kinase domain containing protein	0.0024	0.0127	0.092
Echinococcus granulosus	glutamate receptor subunit protein glur	0.0187	0.2636	0.2636
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0024	0.0127	1
Trypanosoma cruzi	major cysteine proteinase, putative	0.0049	0.0516	0.4101
Echinococcus granulosus	insulin receptor	0.0024	0.0127	0.0127
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.0024	0.0127	0.0127
Loa Loa (eye worm)	TK/FER protein kinase	0.0024	0.0127	0.0169
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0024	0.0127	1
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0127	0.0169
Echinococcus multilocularis	protein KINase family member (kin 25)	0.0024	0.0127	0.0127
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0024	0.0127	0.0127
Trichomonas vaginalis	TKL family protein kinase	0.0024	0.0127	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0062	0.072	0.5778
Schistosoma mansoni	glutamate receptor kainate	0.0505	0.7527	0.8364
Echinococcus granulosus	natriuretic peptide receptor 1	0.0024	0.0127	0.0127
Plasmodium falciparum	protein kinase, putative	0.0024	0.0127	1
Trichomonas vaginalis	TKL family protein kinase	0.0024	0.0127	1
Echinococcus granulosus	tyrosine kinase	0.0024	0.0127	0.0127
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0024	0.0127	0.092
Echinococcus granulosus	tyrosine protein kinase Blk	0.0024	0.0127	0.0127
Echinococcus granulosus	tyrosine protein kinase	0.0024	0.0127	0.0127
Brugia malayi	intermediate filament protein	0.0026	0.0168	0.0223
Brugia malayi	Cathepsin L-like precursor	0.0016	0.0015	0.0019
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.072	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0024	0.0127	0.092
Loa Loa (eye worm)	TK/FER protein kinase	0.0024	0.0127	0.0169
Brugia malayi	Protein kinase domain containing protein	0.0024	0.0127	0.0169
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0024	0.0127	0.092
Loa Loa (eye worm)	TK/FER protein kinase	0.0024	0.0127	0.0169
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0024	0.0127	0.092
Echinococcus multilocularis	glutamate receptor 2	0.0414	0.6127	0.6127
Trichomonas vaginalis	TKL family protein kinase	0.0024	0.0127	1
Echinococcus multilocularis	metabotropic glutamate receptor 2	0.0096	0.1236	0.1236
Schistosoma mansoni	tyrosine protein kinase	0.0024	0.0127	0.0141
Trypanosoma cruzi	extracellular receptor, putative	0.0096	0.1236	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.072	1
Leishmania major	cathepsin L-like protease	0.0062	0.072	0.5778
Entamoeba histolytica	protein kinase domain containing protein	0.0024	0.0127	0.092
Entamoeba histolytica	protein kinase, putative	0.0024	0.0127	0.092
Echinococcus multilocularis	epidermal growth factor receptor	0.0024	0.0127	0.0127
Onchocerca volvulus		0.0119	0.16	1
Leishmania major	extracellular receptor, putative	0.0096	0.1236	1
Trichomonas vaginalis	TKL family protein kinase	0.0024	0.0127	1
Schistosoma mansoni	tyrosine kinase	0.0024	0.0127	0.0141
Trichomonas vaginalis	TKL family protein kinase	0.0024	0.0127	1
Loa Loa (eye worm)	TK protein kinase	0.0024	0.0127	0.0169
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0024	0.0127	0.0169
Loa Loa (eye worm)	glutamate receptor	0.0096	0.1236	0.1642
Echinococcus multilocularis	kinase suppressor of Ras 1	0.0024	0.0127	0.0127
Schistosoma mansoni	protein tyrosine kinase	0.0024	0.0127	0.0141
Leishmania major	protein kinase, putative	0.0024	0.0127	0.092
Echinococcus multilocularis	cathepsin L cysteine protease	0.0016	0.0015	0.0015
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0024	0.0127	0.0127
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.0024	0.0127	0.0169
Schistosoma mansoni	tyrosine kinase	0.0024	0.0127	0.0141
Schistosoma mansoni	glutamate receptor kainate	0.0505	0.7527	0.8364
Brugia malayi	Protein kinase domain containing protein	0.0024	0.0127	0.0169
Loa Loa (eye worm)	TK/ROR protein kinase	0.0024	0.0127	0.0169
Loa Loa (eye worm)	hypothetical protein	0.0096	0.1236	0.1642
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0127	0.0169
Trichomonas vaginalis	TKL family protein kinase	0.0024	0.0127	1
Brugia malayi	SH2 domain containing protein	0.0024	0.0127	0.0169
Trichomonas vaginalis	TKL family protein kinase	0.0024	0.0127	1
Echinococcus multilocularis	protein tyrosine kinase	0.0024	0.0127	0.0127
Echinococcus granulosus	atrial natriuretic peptide receptor	0.0096	0.1236	0.1236
Schistosoma mansoni	tyrosine kinase	0.0024	0.0127	0.0141
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0024	0.0127	0.0127
Entamoeba histolytica	ankyrin repeat protein	0.0024	0.0127	0.092
Loa Loa (eye worm)	TK protein kinase	0.0024	0.0127	0.0169
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0511	0.0679
Echinococcus granulosus	receptor type guanylyl cyclase	0.0119	0.16	0.16
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0024	0.0127	0.0127
Trichomonas vaginalis	TKL family protein kinase	0.0024	0.0127	1
Trichomonas vaginalis	TKL family protein kinase	0.0024	0.0127	1
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0119	0.16	0.2125
Echinococcus multilocularis	glutamate receptor 2	0.0505	0.7527	0.7527
Trichomonas vaginalis	conserved hypothetical protein	0.0024	0.0127	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.072	1
Brugia malayi	Protein kinase domain containing protein	0.0024	0.0127	0.0169
Onchocerca volvulus		0.0024	0.0127	0.0709
Trichomonas vaginalis	TKL family protein kinase	0.0024	0.0127	1
Echinococcus granulosus	tyrosine kinase	0.0119	0.16	0.16
Trypanosoma cruzi	cruzipain precursor, putative	0.0062	0.072	0.5778
Loa Loa (eye worm)	TK/ACK protein kinase	0.0024	0.0127	0.0169
Echinococcus multilocularis	cysteine protease	0.0016	0.0015	0.0015
Trichomonas vaginalis	TKL family protein kinase	0.0024	0.0127	1
Entamoeba histolytica	tyrosine kinase, putative	0.0024	0.0127	0.092
Schistosoma mansoni	tyrosine kinase	0.0024	0.0127	0.0141
Echinococcus multilocularis	activin receptor type	0.0024	0.0127	0.0127
Echinococcus multilocularis	tyrosine protein kinase csk	0.0024	0.0127	0.0127
Onchocerca volvulus	Atrial natriuretic peptide receptor 3 homolog	0.0119	0.16	1
Loa Loa (eye worm)	TK protein kinase	0.0024	0.0127	0.0169
Loa Loa (eye worm)	TK protein kinase	0.0024	0.0127	0.0169
Schistosoma mansoni	glutamate receptor NMDA	0.0505	0.7527	0.8364
Onchocerca volvulus		0.0024	0.0127	0.0709
Brugia malayi	Metabotropic glutamate receptor precursor.	0.0096	0.1236	0.1642
Trichomonas vaginalis	TKL family protein kinase	0.0024	0.0127	1
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0024	0.0127	0.0127
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0024	0.0127	1
Loa Loa (eye worm)	hypothetical protein	0.0096	0.1236	0.1642
Loa Loa (eye worm)	TK protein kinase	0.0024	0.0127	0.0169
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0024	0.0127	0.0127
Echinococcus multilocularis	tyrosine protein kinase pr2	0.0024	0.0127	0.0127
Schistosoma mansoni	glutamate receptor kainate	0.0505	0.7527	0.8364
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0024	0.0127	0.0127
Echinococcus multilocularis	nmda type glutamate receptor	0.0096	0.1236	0.1236
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0016	0.0015	0.0019
Trichomonas vaginalis	TKL family protein kinase	0.0024	0.0127	1
Schistosoma mansoni	protein kinase	0.0024	0.0127	0.0141
Entamoeba histolytica	ankyrin repeat protein	0.0024	0.0127	0.092
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0024	0.0127	0.0127
Trypanosoma cruzi	protein kinase, putative	0.0024	0.0127	0.092
Loa Loa (eye worm)	protein kinase domain-containing protein	0.0024	0.0127	0.0169
Brugia malayi	Receptor family ligand binding region containing protein	0.0096	0.1236	0.1642
Echinococcus granulosus	nmda type glutamate receptor	0.0096	0.1236	0.1236
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0024	0.0127	0.0127
Schistosoma mansoni	tyrosine kinase	0.0024	0.0127	0.0141
Echinococcus granulosus	protein tyrosine kinase	0.0024	0.0127	0.0127
Loa Loa (eye worm)	TK protein kinase	0.0024	0.0127	0.0169
Trichomonas vaginalis	TKL family protein kinase	0.0024	0.0127	1
Schistosoma mansoni	serine/threonine RGC	0.0024	0.0127	0.0141
Schistosoma mansoni	tyrosine kinase	0.0024	0.0127	0.0141
Entamoeba histolytica	protein kinase domain containing protein	0.0024	0.0127	0.092
Schistosoma mansoni	tyrosine kinase	0.0024	0.0127	0.0141
Trichomonas vaginalis	TKL family protein kinase	0.0024	0.0127	1
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0024	0.0127	0.0127
Onchocerca volvulus		0.0024	0.0127	0.0709
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0024	0.0127	0.0127
Trichomonas vaginalis	TKL family protein kinase	0.0024	0.0127	1
Treponema pallidum	amino acid ABC transporter, periplasmic binding protein (hisJ)	0.0479	0.7127	0.5
Brugia malayi	Protein kinase domain containing protein	0.0024	0.0127	0.0169
Echinococcus granulosus	tyrosine protein kinase pr2	0.0024	0.0127	0.0127
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 3	0.0665	1	1
Entamoeba histolytica	receptor protein kinase, putative	0.0024	0.0127	0.092
Loa Loa (eye worm)	hypothetical protein	0.0096	0.1236	0.1642
Echinococcus multilocularis	cysteine protease	0.0016	0.0015	0.0015
Echinococcus multilocularis	atrial natriuretic peptide receptor	0.0096	0.1236	0.1236
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0049	0.0511	0.0679
Plasmodium falciparum	protein kinase, putative	0.0024	0.0127	1
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0024	0.0127	1
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0024	0.0127	0.0169
Trichomonas vaginalis	TKL family protein kinase	0.0024	0.0127	1
Trichomonas vaginalis	STE family protein kinase	0.0024	0.0127	1
Trichomonas vaginalis	conserved hypothetical protein	0.0024	0.0127	1
Schistosoma mansoni	lamin	0.0026	0.0168	0.0187
Schistosoma mansoni	serine/threonine protein kinase	0.0024	0.0127	0.0141
Echinococcus multilocularis	glutamate (NMDA) receptor subunit	0.0505	0.7527	0.7527
Brugia malayi	Protein kinase domain containing protein	0.0024	0.0127	0.0169
Entamoeba histolytica	protein kinase, putative	0.0024	0.0127	0.092
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0127	0.0169
Schistosoma mansoni	tyrosine kinase	0.0024	0.0127	0.0141
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0024	0.0127	0.0127
Echinococcus granulosus	ephrin type A receptor 4 A	0.0024	0.0127	0.0127
Loa Loa (eye worm)	glutamate receptor 1	0.0505	0.7527	1
Trichomonas vaginalis	TKL family protein kinase	0.0024	0.0127	1
Brugia malayi	Protein kinase domain containing protein	0.0024	0.0127	0.0169
Brugia malayi	metabotropic glutamate receptor type 2	0.0096	0.1236	0.1642
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0024	0.0127	0.0127
Entamoeba histolytica	protein kinase domain containing protein	0.0024	0.0127	0.092
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0127	0.0169
Echinococcus multilocularis	metabotropic glutamate receptor 5	0.0096	0.1236	0.1236
Trichomonas vaginalis	TKL family protein kinase	0.0024	0.0127	1
Brugia malayi	Papain family cysteine protease containing protein	0.0016	0.0015	0.0019
Schistosoma mansoni	protein kinase	0.0024	0.0127	0.0141
Echinococcus multilocularis	tyrosine kinase	0.0119	0.16	0.16
Entamoeba histolytica	protein kinase, putative	0.0024	0.0127	0.092
Schistosoma mansoni	serine/threonine protein kinase	0.0024	0.0127	0.0141
Schistosoma mansoni	ephrin receptor	0.0024	0.0127	0.0141
Schistosoma mansoni	tyrosine kinase	0.0024	0.0127	0.0141
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0024	0.0127	0.0169
Echinococcus granulosus	integrin linked protein kinase	0.0024	0.0127	0.0127
Schistosoma mansoni	tyrosine kinase	0.0024	0.0127	0.0141
Trichomonas vaginalis	TKL family protein kinase	0.0024	0.0127	1
Trichomonas vaginalis	TKL family protein kinase	0.0024	0.0127	1
Mycobacterium ulcerans	glutamine-binding lipoprotein GlnH	0.0479	0.7127	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0024	0.0127	0.092
Loa Loa (eye worm)	TK/FER protein kinase	0.0024	0.0127	0.0169
Loa Loa (eye worm)	cysteine protease	0.0016	0.0015	0.0019
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.0024	0.0127	0.0127
Loa Loa (eye worm)	TK/FER protein kinase	0.0024	0.0127	0.0169
Entamoeba histolytica	hypothetical protein	0.0024	0.0127	0.092
Trichomonas vaginalis	TKL family protein kinase	0.0024	0.0127	1
Brugia malayi	Receptor family ligand binding region containing protein	0.0119	0.16	0.2125
Echinococcus multilocularis	protein kinase	0.0024	0.0127	0.0127
Echinococcus multilocularis	tyrosine protein kinase shark	0.0024	0.0127	0.0127
Echinococcus granulosus	metabotropic glutamate receptor 2	0.0096	0.1236	0.1236
Brugia malayi	Glutamate receptor 2 precursor	0.0505	0.7527	1
Echinococcus multilocularis	integrin linked protein kinase	0.0024	0.0127	0.0127
Trichomonas vaginalis	TKL family protein kinase	0.0024	0.0127	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0024	0.0127	0.092
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0024	0.0127	0.092
Trichomonas vaginalis	TKL family protein kinase	0.0024	0.0127	1
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0024	0.0127	0.0127
Trichomonas vaginalis	protein kinase atn1, putative	0.0024	0.0127	1
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0127	0.0169
Trichomonas vaginalis	TKL family protein kinase	0.0024	0.0127	1
Brugia malayi	Protein kinase domain containing protein	0.0024	0.0127	0.0169
Brugia malayi	Protein kinase domain containing protein	0.0024	0.0127	0.0169
Onchocerca volvulus		0.0024	0.0127	0.0709
Schistosoma mansoni	metabotropic glutamate receptor	0.0096	0.1236	0.1374
Entamoeba histolytica	tyrosine kinase, putative	0.0024	0.0127	0.092
Loa Loa (eye worm)	TK/FER protein kinase	0.0024	0.0127	0.0169
Entamoeba histolytica	hypothetical protein	0.0024	0.0127	0.092
Entamoeba histolytica	protein kinase, putative	0.0026	0.0168	0.1259
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0016	0.0015	0.0019
Trichomonas vaginalis	TKL family protein kinase	0.0024	0.0127	1
Entamoeba histolytica	tyrosine kinase, putative	0.0024	0.0127	0.092
Trichomonas vaginalis	TKL family protein kinase	0.0024	0.0127	1
Brugia malayi	Cathepsin L-like precursor	0.0016	0.0015	0.0019
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0024	0.0127	0.0141
Entamoeba histolytica	protein kinase domain containing protein	0.0024	0.0127	0.092
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0024	0.0127	1
Schistosoma mansoni	tyrosine kinase	0.0024	0.0127	0.0141
Echinococcus granulosus	glutamate receptor 2	0.0414	0.6127	0.6127
Treponema pallidum	amino acid ABC transporter, periplasmic binding protein	0.0479	0.7127	0.5
Brugia malayi	C-terminal src kinase protein 1	0.0024	0.0127	0.0169
Schistosoma mansoni	intermediate filament proteins	0.0026	0.0168	0.0187
Brugia malayi	hypothetical protein	0.0024	0.0127	0.0169
Schistosoma mansoni	tyrosine kinase	0.0024	0.0127	0.0141
Schistosoma mansoni	protein kinase	0.0024	0.0127	0.0141
Leishmania major	hypothetical protein, conserved	0.0024	0.0127	0.092
Trichomonas vaginalis	TKL family protein kinase	0.0024	0.0127	1
Echinococcus multilocularis	glutamate receptor 2	0.06	0.8999	0.8999
Schistosoma mansoni	ATP-binding cassette transporter	0.0505	0.7527	0.8364
Leishmania major	cathepsin L-like protease	0.0062	0.072	0.5778
Echinococcus granulosus	fibroblast growth factor receptor 4	0.0024	0.0127	0.0127
Echinococcus multilocularis	Ribosomal protein S1, RNA binding domain	0.0187	0.2636	0.2636
Schistosoma mansoni	hypothetical protein	0.0033	0.0275	0.0305
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.0024	0.0127	0.0169
Entamoeba histolytica	serine/threonine kinase, putative	0.0024	0.0127	0.092
Giardia lamblia	Kinase, NEK	0.0024	0.0127	0.5
Brugia malayi	Protein kinase domain containing protein	0.0024	0.0127	0.0169
Brugia malayi	integrin-linked kinase	0.0024	0.0127	0.0169
Echinococcus granulosus	activated cdc42 kinase 1	0.0024	0.0127	0.0127
Brugia malayi	Protein kinase domain containing protein	0.0024	0.0127	0.0169
Entamoeba histolytica	hypothetical protein	0.0024	0.0127	0.092
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0119	0.16	0.2125
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0024	0.0127	0.0127
Entamoeba histolytica	protein kinase domain containing protein	0.0024	0.0127	0.092
Trichomonas vaginalis	conserved hypothetical protein	0.0024	0.0127	1
Echinococcus granulosus	Ribosomal protein S1 RNA binding domain	0.0187	0.2636	0.2636
Trichomonas vaginalis	TKL family protein kinase	0.0024	0.0127	1
Echinococcus granulosus	c src tyrosine kinase	0.0024	0.0127	0.0127
Entamoeba histolytica	hypothetical protein	0.0024	0.0127	0.092
Schistosoma mansoni	tyrosine kinase	0.0024	0.0127	0.0141
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.0024	0.0127	0.0127
Trichomonas vaginalis	TKL family protein kinase	0.0024	0.0127	1
Trichomonas vaginalis	TK family protein kinase	0.0024	0.0127	1
Onchocerca volvulus		0.0024	0.0127	0.0709
Schistosoma mansoni	hypothetical protein	0.0024	0.0127	0.0141
Schistosoma mansoni	tyrosine kinase	0.0024	0.0127	0.0141
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.06	0.8999	0.8999
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.0024	0.0127	0.0127
Loa Loa (eye worm)	TK/FER protein kinase	0.0024	0.0127	0.0169
Echinococcus multilocularis	nmda type glutamate receptor	0.0665	1	1
Onchocerca volvulus		0.0024	0.0127	0.0709
Brugia malayi	Protein kinase domain containing protein	0.0024	0.0127	0.0169
Trichomonas vaginalis	TKL family protein kinase	0.0024	0.0127	1
Brugia malayi	Intermediate filament tail domain containing protein	0.0026	0.0168	0.0223
Schistosoma mansoni	ephrin receptor	0.0024	0.0127	0.0141
Brugia malayi	Raf kinase	0.0024	0.0127	0.0169
Entamoeba histolytica	protein kinase domain containing protein	0.0024	0.0127	0.092
Trichomonas vaginalis	AGC family protein kinase	0.0024	0.0127	1
Schistosoma mansoni	protein kinase	0.0024	0.0127	0.0141
Onchocerca volvulus		0.0026	0.0168	0.0967
Brugia malayi	Protein kinase domain containing protein	0.0024	0.0127	0.0169
Entamoeba histolytica	tyrosine kinase, putative	0.0024	0.0127	0.092
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.0024	0.0127	0.0127
Entamoeba histolytica	hypothetical protein	0.0024	0.0127	0.092
Entamoeba histolytica	protein kinase domain containing protein	0.0024	0.0127	0.092
Brugia malayi	Protein kinase domain containing protein	0.0024	0.0127	0.0169
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0127	0.0169
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0016	0.0015	0.0015
Brugia malayi	ephrin receptor 1 precursor	0.0024	0.0127	0.0169
Onchocerca volvulus		0.0048	0.0505	0.3096
Schistosoma mansoni	tyrosine kinase	0.0024	0.0127	0.0141
Entamoeba histolytica	tyrosine kinase, putative	0.0024	0.0127	0.092
Loa Loa (eye worm)	TK protein kinase	0.0024	0.0127	0.0169
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0024	0.0127	0.0141
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0024	0.0127	0.092
Entamoeba histolytica	tyrosine kinase, putative	0.0024	0.0127	0.092
Brugia malayi	Protein kinase domain containing protein	0.0024	0.0127	0.0169
Entamoeba histolytica	tyrosine kinase, putative	0.0024	0.0127	0.092
Echinococcus granulosus	tumor protein p63	0.0329	0.4832	0.4832
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0024	0.0127	0.0127
Echinococcus multilocularis	insulin receptor	0.0024	0.0127	0.0127
Brugia malayi	Protein kinase domain containing protein	0.0024	0.0127	0.0169
Schistosoma mansoni	tyrosine kinase	0.0024	0.0127	0.0141
Trichomonas vaginalis	TKL family protein kinase	0.0024	0.0127	1
Brugia malayi	Protein kinase domain containing protein	0.0024	0.0127	0.0169
Onchocerca volvulus	Tyrosine kinase receptor Cad96Ca homolog	0.0024	0.0127	0.0709
Brugia malayi	Protein kinase domain containing protein	0.0024	0.0127	0.0169
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0024	0.0127	0.0127
Toxoplasma gondii	protein kinase domain-containing protein	0.0024	0.0127	1
Trichomonas vaginalis	TKL family protein kinase	0.0024	0.0127	1
Brugia malayi	Protein kinase domain containing protein	0.0024	0.0127	0.0169
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0016	0.0015	0.0015
Entamoeba histolytica	tyrosine kinase, putative	0.0024	0.0127	0.092
Brugia malayi	Protein kinase domain containing protein	0.0024	0.0127	0.0169
Trichomonas vaginalis	TKL family protein kinase	0.0024	0.0127	1
Echinococcus granulosus	activated cdc42 kinase 1	0.0024	0.0127	0.0127
Echinococcus multilocularis	heat shock protein 70	0.0024	0.0127	0.0127
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0024	0.0127	0.0127
Entamoeba histolytica	serine/threonine kinase, putative	0.0024	0.0127	0.092
Schistosoma mansoni	glutamate receptor AMPA	0.0505	0.7527	0.8364
Entamoeba histolytica	serine/threonine kinase, putative	0.0024	0.0127	0.092
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0024	0.0127	0.0127
Trichomonas vaginalis	TKL family protein kinase	0.0024	0.0127	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0024	0.0127	0.0169
Plasmodium falciparum	protein kinase, putative	0.0024	0.0127	1
Brugia malayi	Cathepsin L-like precursor	0.0016	0.0015	0.0019
Loa Loa (eye worm)	TK/FER protein kinase	0.0024	0.0127	0.0169
Loa Loa (eye worm)	TK/CSK protein kinase	0.0024	0.0127	0.0169
Loa Loa (eye worm)	TK/FER protein kinase	0.0024	0.0127	0.0169
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0024	0.0127	0.0169
Entamoeba histolytica	protein kinase domain containing protein	0.0024	0.0127	0.092
Entamoeba histolytica	protein kinase, putative	0.0024	0.0127	0.092
Entamoeba histolytica	protein kinase, putative	0.0024	0.0127	0.092
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0024	0.0127	0.0169
Schistosoma mansoni	tyrosine kinase	0.0024	0.0127	0.0141
Schistosoma mansoni	glutamate receptor AMPA	0.0505	0.7527	0.8364
Onchocerca volvulus		0.0096	0.1236	0.7706
Loa Loa (eye worm)	hypothetical protein	0.0096	0.1236	0.1642
Trichomonas vaginalis	TKL family protein kinase	0.0024	0.0127	1
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0024	0.0127	0.0127
Echinococcus granulosus	glutamate receptor ionotropic kainate 3	0.0187	0.2636	0.2636
Schistosoma mansoni	tyrosine kinase	0.0024	0.0127	0.0141
Echinococcus granulosus	epidermal growth factor receptor	0.0024	0.0127	0.0127
Trichomonas vaginalis	CAMK family protein kinase	0.0024	0.0127	1
Entamoeba histolytica	protein kinase, putative	0.0024	0.0127	0.092
Entamoeba histolytica	protein kinase domain containing protein	0.0024	0.0127	0.092
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0127	0.0169
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0024	0.0127	0.0127
Loa Loa (eye worm)	TK/FER protein kinase	0.0024	0.0127	0.0169
Brugia malayi	bone morphogenetic protein type 1 receptor	0.0024	0.0127	0.0169
Entamoeba histolytica	receptor protein kinase, putative	0.0024	0.0127	0.092
Entamoeba histolytica	serine/threonine kinase, putative	0.0024	0.0127	0.092
Echinococcus multilocularis	tyrosine protein kinase csk	0.0024	0.0127	0.0127
Schistosoma mansoni	metabotropic glutamate receptor	0.0096	0.1236	0.1374
Loa Loa (eye worm)	TK/FER protein kinase	0.0024	0.0127	0.0169
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0024	0.0127	0.092
Entamoeba histolytica	tyrosine kinase, putative	0.0024	0.0127	0.092
Chlamydia trachomatis	glutamine binding protein	0.0479	0.7127	0.5
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0127	0.0169
Entamoeba histolytica	protein kinase, putative	0.0024	0.0127	0.092
Brugia malayi	Protein kinase domain containing protein	0.0024	0.0127	0.0169
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0024	0.0127	0.0141
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0024	0.0127	0.0127
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.0024	0.0127	0.0169
Echinococcus multilocularis	tyrosine protein kinase csk	0.0024	0.0127	0.0127
Brugia malayi	Protein kinase domain containing protein	0.0024	0.0127	0.0169
Loa Loa (eye worm)	intermediate filament protein	0.0026	0.0168	0.0223
Trichomonas vaginalis	TKL family protein kinase	0.0024	0.0127	1
Trichomonas vaginalis	TKL family protein kinase	0.0024	0.0127	1
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0024	0.0127	0.0127
Toxoplasma gondii	protein kinase	0.0024	0.0127	1
Entamoeba histolytica	hypothetical protein	0.0024	0.0127	0.092
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0119	0.16	0.2125
Echinococcus granulosus	tyrosine protein kinase HCK	0.0024	0.0127	0.0127
Trichomonas vaginalis	TKL family protein kinase	0.0024	0.0127	1
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0024	0.0127	0.0127
Onchocerca volvulus		0.0024	0.0127	0.0709
Brugia malayi	hypothetical protein	0.0024	0.0127	0.0169
Trichomonas vaginalis	TKL family protein kinase	0.0024	0.0127	1
Entamoeba histolytica	tyrosin kinase, putative	0.0024	0.0127	0.092
Leishmania major	cathepsin L-like protease	0.0062	0.072	0.5778
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.06	0.8999	0.8999
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0024	0.0127	0.092
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.0024	0.0127	0.0127
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.0024	0.0127	0.0169
Brugia malayi	Protein kinase domain containing protein	0.0024	0.0127	0.0169
Entamoeba histolytica	leucine-rich repeat domain-containing protein	0.0026	0.0168	0.1259
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.072	1
Entamoeba histolytica	protein kinase domain containing protein	0.0024	0.0127	0.092
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0024	0.0127	0.0127
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0024	0.0127	0.0141
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.0024	0.0127	0.0127
Brugia malayi	latrophilin 2 splice variant baaae	0.0033	0.0275	0.0365
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0015	0.0019
Schistosoma mansoni	src-type protein tyrosine kinase-related	0.0024	0.0127	0.0141
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0024	0.0127	0.0127
Entamoeba histolytica	tyrosine kinase, putative	0.0024	0.0127	0.092
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0024	0.0127	0.0127
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0024	0.0127	0.0127
Schistosoma mansoni	cathepsin F (C01 family)	0.0016	0.0015	0.0016
Schistosoma mansoni	glutamate receptor NMDA	0.06	0.8999	1
Echinococcus multilocularis	NMDA receptor	0.0187	0.2636	0.2636
Entamoeba histolytica	tyrosin kinase, putative	0.0024	0.0127	0.092
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.072	1

Activities

Activity type	Activity value	Assay description	Source	Reference
RBA (binding)	= 1.1	Relative binding affinity for mineralocorticoid receptor of rat kidney at 24 hr	ChEMBL.	2897467
RBA (binding)	= 4.1	Relative binding affinity for androgen receptor of prostate of rat at 2 hr	ChEMBL.	2897467
RBA (binding)	= 91	Relative binding affinity for progestin receptor of uterus of rabbit at 24 hr	ChEMBL.	2897467
RBA (binding)	= 1.1	Relative binding affinity for mineralocorticoid receptor of rat kidney at 24 hr	ChEMBL.	2897467
RBA (binding)	= 4.1	Relative binding affinity for androgen receptor of prostate of rat at 2 hr	ChEMBL.	2897467
RBA (binding)	= 91	Relative binding affinity to glucocorticoid receptor on cytosol from liver at 4 hr	ChEMBL.	2897467
RBA (binding)	= 91	Relative binding affinity for progestin receptor of uterus of rabbit at 24 hr	ChEMBL.	2897467
RBA (binding)	= 99	Relative binding affinity to glucocorticoid receptor on cytosol from liver at 24 hr	ChEMBL.	2897467
RBA (binding)	= 209	Relative binding affinity to glucocorticoid receptor on cytosol from thymus at 24 hr	ChEMBL.	2897467
RBA (binding)	= 228	Relative binding affinity to glucocorticoid receptor on cytosol from thymus at 4 hr	ChEMBL.	2897467
RBA (binding)	= 435	Relative binding affinity to glucocorticoid receptor on cytosol from hepatoma tissue cells at 24 hr	ChEMBL.	2897467
RBA (binding)	= 450	Relative binding affinity to glucocorticoid receptor on cytosol from hepatoma tissue cells at 4 hr	ChEMBL.	2897467
Relative activity (functional)	= 95 %	Glucocorticoid induced Tyrosine Aminotransferase activity relative to dexamethasone	ChEMBL.	2897467
Relative activity (functional)	= 95 %	Glucocorticoid induced Tyrosine Aminotransferase activity relative to dexamethasone	ChEMBL.	2897467

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL16418

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 16988