Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | carnitine palmitoyltransferase 2 | Starlite/ChEMBL | References |
Rattus norvegicus | Carnitine palmitoyltransferase 1A | Starlite/ChEMBL | No references |
Rattus norvegicus | Carnitine palmitoyltransferase 1B | Starlite/ChEMBL | References |
Homo sapiens | carnitine palmitoyltransferase 1A (liver) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Onchocerca volvulus | Carnitine palmitoyltransferase 1A | 773 aa | 758 aa | 43.8 % | |
Trypanosoma brucei | carnitine O-acetyltransferase, putative | carnitine palmitoyltransferase 2 | 658 aa | 629 aa | 30.7 % |
Candida albicans | similar to S. cerevisiae YAT2 putative carnitine O-acetyltransferase | Carnitine palmitoyltransferase 1A | 773 aa | 645 aa | 25.6 % |
Candida albicans | similar to S. cerevisiae YAT2 putative carnitine O-acetyltransferase | Carnitine palmitoyltransferase 1A | 773 aa | 645 aa | 25.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.0459 | 0.5548 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0664 | 1 | 1 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.0459 | 0.5548 | 1 |
Echinococcus granulosus | carnitine O palmitoyltransferase 1 liver | 0.0459 | 0.5548 | 1 |
Leishmania major | choline/Carnitine o-acyltransferase-like protein | 0.0459 | 0.5548 | 1 |
Trypanosoma brucei | carnitine O-palmitoyltransferase II, putative | 0.0205 | 0 | 0.5 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 1, liver | 0.0459 | 0.5548 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.0196 uM | SUPPLEMENTARY: Inhibition of Carnitine palmitoyltransferase 1, liver isoform | ChEMBL. | No reference |
IC50 (binding) | = 0.02 uM | Inhibition of human CPT1A | ChEMBL. | 21504156 |
IC50 (binding) | = 0.1276 uM | SUPPLEMENTARY | SUPPLEMENTARY. | No reference |
IC50 (binding) | = 0.13 uM | Maximal inhibition of rat CPT1A | ChEMBL. | 21504156 |
IC50 (functional) | = 0.41 uM | Cytotoxicity in human KB cells | ChEMBL. | 21504156 |
IC50 (binding) | = 4.8 uM | Inhibition of human CPT2 | ChEMBL. | 21504156 |
IC50 (binding) | = 4.8301 uM | SUPPLEMENTARY | SUPPLEMENTARY. | No reference |
IC50 (binding) | = 30.6972 uM | SUPPLEMENTARY: Inhibition of Carnitine palmitoyltransferase 2 | ChEMBL. | No reference |
IC50 (binding) | = 30.7 uM | Inhibition of rat CPT2 | ChEMBL. | 21504156 |
IC50 (binding) | > 100 uM | Inhibition of human CPT1B | ChEMBL. | 21504156 |
IC50 (binding) | > 100 uM | SUPPLEMENTARY: Inhibition of Carnitine palmitoyltransferase 1, muscle isoform | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 21504156 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.