Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | carbon catabolite repressor protein, putative | 0.0004 | 0.0013 | 0.0013 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.001 | 0.0232 | 0.0219 |
Echinococcus granulosus | Smad4 | 0.0008 | 0.0166 | 0.0153 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.013 | 0.013 |
Trichomonas vaginalis | carbon catabolite repressor protein, putative | 0.0004 | 0.0013 | 0.0013 |
Brugia malayi | MH1 domain containing protein | 0.0004 | 0.0024 | 0.0011 |
Onchocerca volvulus | 0.0031 | 0.1085 | 1 | |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.013 | 0.013 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0058 | 0.219 | 0.218 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.013 | 0.013 |
Schistosoma mansoni | hypothetical protein | 0.0182 | 0.7138 | 0.7134 |
Brugia malayi | Smad1 | 0.0008 | 0.0166 | 0.0153 |
Loa Loa (eye worm) | nuclear factor I | 0.0004 | 0.0024 | 0.0011 |
Leishmania major | ubiquitin-conjugating enzyme e2, putative | 0.0253 | 1 | 1 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0004 | 0.0027 | 0.0014 |
Brugia malayi | MH2 domain containing protein | 0.0008 | 0.0166 | 0.0153 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.013 | 0.013 |
Echinococcus multilocularis | geminin | 0.0182 | 0.7138 | 0.7134 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.002 | 0.0659 | 0.0646 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0031 | 0.1085 | 0.1073 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.002 | 0.0659 | 0.0646 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.002 | 0.0659 | 0.0646 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.002 | 0.0659 | 0.0646 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.013 | 0.013 |
Brugia malayi | MH2 domain containing protein | 0.0008 | 0.0166 | 0.0153 |
Loa Loa (eye worm) | hypothetical protein | 0.0004 | 0.0024 | 0.0011 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0007 | 0.013 | 0.013 |
Echinococcus multilocularis | cpg binding protein | 0.0033 | 0.1156 | 0.1144 |
Trichomonas vaginalis | type II inositol 5-phosphatase, putative | 0.0004 | 0.0013 | 0.0013 |
Trichomonas vaginalis | ocrl type II inositol 5-phosphatase, putative | 0.0004 | 0.0013 | 0.0013 |
Schistosoma mansoni | ubiquitin conjugating enzyme 13 | 0.0253 | 1 | 1 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.002 | 0.0659 | 1 |
Brugia malayi | ubiquitin conjugating enzyme protein 13 | 0.0253 | 1 | 1 |
Echinococcus granulosus | smad | 0.0008 | 0.0166 | 0.0153 |
Echinococcus granulosus | cpg binding protein | 0.0033 | 0.1156 | 0.1144 |
Brugia malayi | MH1 domain containing protein | 0.0008 | 0.0166 | 0.0153 |
Schistosoma mansoni | smad | 0.0008 | 0.0166 | 0.0153 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.013 | 0.013 |
Echinococcus granulosus | mixed lineage leukemia protein mll | 0.0008 | 0.0157 | 0.0144 |
Echinococcus multilocularis | mothers against decapentaplegic 5 | 0.0008 | 0.0166 | 0.0153 |
Schistosoma mansoni | ap endonuclease | 0.002 | 0.0659 | 0.0646 |
Echinococcus multilocularis | smad | 0.0008 | 0.0166 | 0.0153 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.013 | 0.013 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.013 | 0.013 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0116 | 0.4484 | 0.4477 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0008 | 0.0157 | 0.0144 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.002 | 0.0659 | 0.5 |
Brugia malayi | F/Y-rich N-terminus family protein | 0.0009 | 0.0227 | 0.0214 |
Loa Loa (eye worm) | Smad1 | 0.0008 | 0.0166 | 0.0153 |
Loa Loa (eye worm) | histone methyltransferase | 0.001 | 0.0232 | 0.0219 |
Trichomonas vaginalis | carbon catabolite repressor protein, putative | 0.0004 | 0.0013 | 0.0013 |
Trichomonas vaginalis | ubiquitin-conjugating enzyme E2, putative | 0.0253 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.013 | 0.013 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0065 | 0.247 | 0.246 |
Schistosoma mansoni | ap endonuclease | 0.002 | 0.0659 | 0.0646 |
Trichomonas vaginalis | skeletal muscle/kidney enriched inositol 5-phosphatase, putative | 0.0004 | 0.0013 | 0.0013 |
Toxoplasma gondii | exonuclease III APE | 0.002 | 0.0659 | 0.0646 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.002 | 0.0659 | 1 |
Schistosoma mansoni | smad1 5 8 and | 0.0008 | 0.0166 | 0.0153 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.001 | 0.0232 | 0.0219 |
Schistosoma mansoni | Smad4 | 0.0008 | 0.0166 | 0.0153 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0116 | 0.4484 | 0.4477 |
Trichomonas vaginalis | sphingomyelinase C 2 precursor, putative | 0.0004 | 0.0013 | 0.0013 |
Trichomonas vaginalis | ap endonuclease, putative | 0.002 | 0.0659 | 0.0659 |
Trichomonas vaginalis | type IV inositol 5-phosphatase, putative | 0.0004 | 0.0013 | 0.0013 |
Schistosoma mansoni | cpg binding protein | 0.0033 | 0.1156 | 0.1144 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.002 | 0.0659 | 0.0646 |
Plasmodium falciparum | ubiquitin-conjugating enzyme E2 N, putative | 0.0253 | 1 | 1 |
Plasmodium vivax | ubiquitin-conjugating enzyme E2 N, putative | 0.0253 | 1 | 1 |
Brugia malayi | CXXC zinc finger family protein | 0.0031 | 0.1085 | 0.1073 |
Echinococcus granulosus | geminin | 0.0182 | 0.7138 | 0.7134 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.013 | 0.013 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0008 | 0.0157 | 0.0144 |
Echinococcus multilocularis | muscleblind protein 1 | 0.016 | 0.6275 | 0.627 |
Loa Loa (eye worm) | hypothetical protein | 0.016 | 0.6275 | 0.627 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.002 | 0.0659 | 0.0646 |
Schistosoma mansoni | cpg binding protein | 0.0031 | 0.1085 | 0.1073 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.002 | 0.0659 | 0.0646 |
Brugia malayi | MH1 domain containing protein | 0.0008 | 0.0166 | 0.0153 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0007 | 0.013 | 0.013 |
Trichomonas vaginalis | helicase, putative | 0.0007 | 0.013 | 0.013 |
Echinococcus multilocularis | mixed lineage leukemia protein mll | 0.0008 | 0.0157 | 0.0144 |
Trichomonas vaginalis | ubiquitin-conjugating enzyme E2, putative | 0.0253 | 1 | 1 |
Loa Loa (eye worm) | ubiquitin conjugating enzyme protein 13 | 0.0253 | 1 | 1 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0008 | 0.0166 | 0.0153 |
Echinococcus multilocularis | TGF beta signal transducer SmadC | 0.0008 | 0.0166 | 0.0153 |
Brugia malayi | MH1 domain containing protein | 0.0004 | 0.0024 | 0.0011 |
Schistosoma mansoni | smad1 5 8 and | 0.0008 | 0.0166 | 0.0153 |
Loa Loa (eye worm) | hypothetical protein | 0.016 | 0.6275 | 0.627 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.013 | 0.013 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.002 | 0.0659 | 1 |
Trypanosoma cruzi | ubiquitin-conjugating enzyme E2, putative | 0.0253 | 1 | 1 |
Entamoeba histolytica | ubiquitin-conjugating enzyme family protein | 0.0253 | 1 | 1 |
Echinococcus granulosus | ubiquitin conjugating enzyme E2 N | 0.0253 | 1 | 1 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.002 | 0.0659 | 0.0646 |
Trypanosoma cruzi | ubiquitin-conjugating enzyme E2, putative | 0.0253 | 1 | 1 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.002 | 0.0659 | 0.0646 |
Schistosoma mansoni | smad1 5 8 and | 0.0008 | 0.0166 | 0.0153 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0008 | 0.0166 | 0.0153 |
Toxoplasma gondii | ubiquitin-conjugating enzyme subfamily protein | 0.0253 | 1 | 1 |
Echinococcus granulosus | mothers against decapentaplegic 5 | 0.0008 | 0.0166 | 0.0153 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.002 | 0.0659 | 0.5 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.002 | 0.0659 | 0.0646 |
Brugia malayi | Muscleblind-like protein | 0.016 | 0.6275 | 0.627 |
Echinococcus multilocularis | muscleblind protein | 0.016 | 0.6275 | 0.627 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.002 | 0.0659 | 0.0646 |
Echinococcus multilocularis | Smad4 | 0.0008 | 0.0166 | 0.0153 |
Loa Loa (eye worm) | ubiquitin conjugating enzyme protein 13 | 0.0253 | 1 | 1 |
Echinococcus granulosus | muscleblind protein | 0.016 | 0.6275 | 0.627 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.013 | 0.013 |
Trypanosoma brucei | ubiquitin-protein ligase, putative | 0.0253 | 1 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0116 | 0.4484 | 0.4477 |
Schistosoma mansoni | hypothetical protein | 0.0182 | 0.7138 | 0.7134 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.0008 | 0.0166 | 0.0153 |
Echinococcus granulosus | TGF beta signal transducer SmadC | 0.0008 | 0.0166 | 0.0153 |
Schistosoma mansoni | cpg binding protein | 0.0033 | 0.1156 | 0.1144 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.013 | 0.013 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0008 | 0.0157 | 0.0144 |
Trichomonas vaginalis | Phospholipase C precursor, putative | 0.0004 | 0.0013 | 0.0013 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.013 | 0.013 |
Trichomonas vaginalis | ap endonuclease, putative | 0.002 | 0.0659 | 0.0659 |
Echinococcus multilocularis | ubiquitin conjugating enzyme E2 N | 0.0253 | 1 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.013 | 0.013 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Contraction (functional) | 0 % | Agonism of Muscarinic acetylcholine receptor M3 was determined as maximal contraction rate of isolated guinea pig ileum | ChEMBL. | 15149637 |
Relaxation (functional) | = 10 % | Agonism of endothelin A receptor was determined as maximal rate of vascular endothelium-dependent relaxation at the concentration of 10E-5 M/L; 0-10% | ChEMBL. | 15149637 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.