Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | polo-like kinase 1 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | notch | 0.0097 | 0.0002 | 0.0002 |
Brugia malayi | Peroxidasin | 0.0299 | 0.0337 | 0.086 |
Schistosoma mansoni | laminin gamma-3 chain | 0.0097 | 0.0002 | 0.0002 |
Onchocerca volvulus | 0.0299 | 0.0337 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0299 | 0.0337 | 0.0336 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0299 | 0.0337 | 0.0336 |
Loa Loa (eye worm) | hypothetical protein | 0.0299 | 0.0337 | 0.0336 |
Schistosoma mansoni | hypothetical protein | 0.0097 | 0.0002 | 0.0002 |
Loa Loa (eye worm) | solute carrier family 8 | 0.6126 | 1 | 1 |
Echinococcus granulosus | sodium:potassium:calcium exchanger 6 | 0.0155 | 0.0098 | 0.0096 |
Schistosoma mansoni | septate junction protein | 0.0097 | 0.0002 | 0.0002 |
Schistosoma mansoni | hypothetical protein | 0.0097 | 0.0002 | 0.0002 |
Loa Loa (eye worm) | hypothetical protein | 0.0155 | 0.0098 | 0.0096 |
Onchocerca volvulus | Peroxidasin homolog | 0.0299 | 0.0337 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0155 | 0.0098 | 0.042 |
Schistosoma mansoni | potassium-dependent sodium-calcium exchanger 3 4 | 0.0155 | 0.0098 | 0.0098 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0299 | 0.0337 | 0.0336 |
Loa Loa (eye worm) | hypothetical protein | 0.0299 | 0.0337 | 0.0336 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0114 | 0.0031 | 0.0029 |
Echinococcus granulosus | sodium:potassium:calcium exchanger | 0.0155 | 0.0098 | 0.0096 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0114 | 0.0031 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0155 | 0.0098 | 0.0098 |
Loa Loa (eye worm) | hypothetical protein | 0.0299 | 0.0337 | 0.0336 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0299 | 0.0337 | 0.0336 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0114 | 0.0031 | 0.0029 |
Brugia malayi | Animal haem peroxidase family protein | 0.0299 | 0.0337 | 0.086 |
Brugia malayi | Animal haem peroxidase family protein | 0.0299 | 0.0337 | 0.086 |
Schistosoma mansoni | hypothetical protein | 0.0097 | 0.0002 | 0.0002 |
Schistosoma mansoni | peroxidasin | 0.0299 | 0.0337 | 0.0337 |
Schistosoma mansoni | notch | 0.0097 | 0.0002 | 0.0002 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0299 | 0.0337 | 0.0336 |
Schistosoma mansoni | peroxidasin | 0.0299 | 0.0337 | 0.0337 |
Mycobacterium leprae | Probable ionic transporter integral membrane protein ChaA | 0.0155 | 0.0098 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0299 | 0.0337 | 0.0336 |
Schistosoma mansoni | hypothetical protein | 0.0097 | 0.0002 | 0.0002 |
Onchocerca volvulus | 0.0299 | 0.0337 | 1 | |
Trypanosoma brucei | polo-like protein kinase | 0.0114 | 0.0031 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0299 | 0.0337 | 0.0336 |
Brugia malayi | Na/Ca eXchangers family member (ncx-4) | 0.0155 | 0.0098 | 0.0246 |
Plasmodium vivax | cation/H+ antiporter, putative | 0.0155 | 0.0098 | 0.5 |
Brugia malayi | hypothetical protein | 0.0299 | 0.0337 | 0.086 |
Onchocerca volvulus | 0.0299 | 0.0337 | 1 | |
Echinococcus multilocularis | sodium calcium exchanger | 0.6126 | 1 | 1 |
Entamoeba histolytica | sodium/calcium exchanger protein, putative | 0.0155 | 0.0098 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.245 | 0.3905 | 0.3904 |
Loa Loa (eye worm) | hypothetical protein | 0.0299 | 0.0337 | 0.0336 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0114 | 0.0031 | 0.0031 |
Onchocerca volvulus | Peroxidase homolog | 0.0299 | 0.0337 | 1 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0114 | 0.0031 | 0.5 |
Loa Loa (eye worm) | Na/Ca eXchangers family member | 0.0155 | 0.0098 | 0.0096 |
Echinococcus multilocularis | peroxidasin | 0.0299 | 0.0337 | 0.0336 |
Loa Loa (eye worm) | hypothetical protein | 0.0299 | 0.0337 | 0.0336 |
Loa Loa (eye worm) | hypothetical protein | 0.0299 | 0.0337 | 0.0336 |
Echinococcus multilocularis | sodium:potassium:calcium exchanger | 0.0155 | 0.0098 | 0.0096 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0299 | 0.0337 | 1 |
Schistosoma mansoni | notch | 0.0097 | 0.0002 | 0.0002 |
Onchocerca volvulus | Peroxidasin homolog | 0.0299 | 0.0337 | 1 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0114 | 0.0031 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0299 | 0.0337 | 0.0336 |
Loa Loa (eye worm) | hypothetical protein | 0.0299 | 0.0337 | 0.0336 |
Brugia malayi | Animal haem peroxidase family protein | 0.0299 | 0.0337 | 0.086 |
Schistosoma mansoni | lipoxygenase | 0.0137 | 0.0068 | 0.0068 |
Schistosoma mansoni | notch | 0.0097 | 0.0002 | 0.0002 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0155 | 0.0098 | 0.042 |
Schistosoma mansoni | notch | 0.0097 | 0.0002 | 0.0002 |
Brugia malayi | Animal haem peroxidase family protein | 0.0299 | 0.0337 | 0.086 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.0114 | 0.0031 | 0.0861 |
Onchocerca volvulus | Peroxidase homolog | 0.0299 | 0.0337 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0114 | 0.0031 | 0.0029 |
Toxoplasma gondii | manganese resistance 1 protein, putative | 0.0155 | 0.0098 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0155 | 0.0098 | 0.0096 |
Schistosoma mansoni | na/ca exchanger | 0.0155 | 0.0098 | 0.0098 |
Plasmodium falciparum | cation/H+ antiporter | 0.0155 | 0.0098 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0299 | 0.0337 | 0.0336 |
Schistosoma mansoni | hypothetical protein | 0.0097 | 0.0002 | 0.0002 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0137 | 0.0068 | 0.0067 |
Echinococcus granulosus | peroxidasin | 0.0299 | 0.0337 | 0.0336 |
Onchocerca volvulus | Sodium\/potassium\/calcium exchanger | 0.0155 | 0.0098 | 0.2864 |
Loa Loa (eye worm) | hypothetical protein | 0.0299 | 0.0337 | 0.0336 |
Schistosoma mansoni | potassium-dependent sodium-calcium exchanger 3 4 | 0.0155 | 0.0098 | 0.0098 |
Treponema pallidum | hypothetical protein | 0.0155 | 0.0098 | 0.5 |
Brugia malayi | K+-dependent Na+/Ca+ exchanger related-protein | 0.0155 | 0.0098 | 0.0246 |
Schistosoma mansoni | hypothetical protein | 0.0097 | 0.0002 | 0.0002 |
Brugia malayi | Sodium/calcium exchanger protein | 0.245 | 0.3905 | 1 |
Schistosoma mansoni | cell polarity protein | 0.0097 | 0.0002 | 0.0002 |
Schistosoma mansoni | notch | 0.0097 | 0.0002 | 0.0002 |
Onchocerca volvulus | Dual oxidase homolog | 0.0299 | 0.0337 | 1 |
Mycobacterium tuberculosis | Probable ionic transporter integral membrane protein ChaA | 0.0155 | 0.0098 | 0.5 |
Trichomonas vaginalis | alpha-L-fucosidase, putative | 0.108 | 0.1633 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0155 | 0.0098 | 0.042 |
Brugia malayi | Animal haem peroxidase family protein | 0.0299 | 0.0337 | 0.086 |
Schistosoma mansoni | Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] | 0.0097 | 0.0002 | 0.0002 |
Giardia lamblia | Kinase, PLK | 0.0114 | 0.0031 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0299 | 0.0337 | 0.0336 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0114 | 0.0031 | 0.0074 |
Loa Loa (eye worm) | hypothetical protein | 0.0299 | 0.0337 | 0.0336 |
Schistosoma mansoni | hypothetical protein | 0.0097 | 0.0002 | 0.0002 |
Loa Loa (eye worm) | hypothetical protein | 0.0155 | 0.0098 | 0.0096 |
Brugia malayi | Blistered cuticle protein 3 | 0.0299 | 0.0337 | 0.086 |
Trichomonas vaginalis | alpha-L-fucosidase, putative | 0.108 | 0.1633 | 1 |
Echinococcus multilocularis | sodium:potassium:calcium exchanger 6 | 0.0155 | 0.0098 | 0.0096 |
Schistosoma mansoni | sodium/calcium exchanger | 0.6126 | 1 | 1 |
Schistosoma mansoni | slit | 0.0097 | 0.0002 | 0.0002 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0137 | 0.0068 | 0.0067 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 3.7686 uM | PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 44.6684 uM | PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 2 (EPAC2): primary screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.