Detailed information for compound 170418

Basic information

Technical information
  • TDR Targets ID: 170418
  • Name: 7-methyl-6-[4-[methyl(phenethyl)amino]piperid ine-1-carbonyl]-3,4-dihydro-1H-quinolin-2-one ; oxalic acid
  • MW: 495.567 | Formula: C27H33N3O6
  • H donors: 3 H acceptors: 6 LogP: 0.91 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)C(=O)O.O=C1CCc2c(N1)cc(c(c2)C(=O)N1CCC(CC1)N(CCc1ccccc1)C)C
  • InChi: 1S/C25H31N3O2.C2H2O4/c1-18-16-23-20(8-9-24(29)26-23)17-22(18)25(30)28-14-11-21(12-15-28)27(2)13-10-19-6-4-3-5-7-19;3-1(4)2(5)6/h3-7,16-17,21H,8-15H2,1-2H3,(H,26,29);(H,3,4)(H,5,6)
  • InChiKey: FPYPMJHXLLWAMC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 7-methyl-6-[[4-[methyl(phenethyl)amino]-1-piperidinyl]-oxomethyl]-3,4-dihydro-1H-quinolin-2-one; oxalic acid
  • ethanedioic acid; 7-methyl-6-[4-[methyl(phenethyl)amino]piperidin-1-yl]carbonyl-3,4-dihydro-1H-quinolin-2-one
  • 7-methyl-6-[4-[methyl(phenethyl)amino]piperidine-1-carbonyl]-3,4-dihydrocarbostyril; oxalic acid
  • 2-hydroxy-2-oxoacetate; methyl-[1-(7-methyl-2-oxo-3,4-dihydro-1H-quinoline-6-carbonyl)piperidin-4-yl]-phenethylazanium
  • 2-hydroxy-2-oxo-acetate; methyl-[1-(7-methyl-2-oxo-3,4-dihydro-1H-quinoline-6-carbonyl)-4-piperidyl]-phenethyl-ammonium
  • 2-hydroxy-2-oxoacetate; methyl-[1-[(7-methyl-2-oxo-3,4-dihydro-1H-quinolin-6-yl)-oxomethyl]-4-piperidinyl]-phenethylammonium
  • 2-hydroxy-2-oxo-ethanoate; methyl-[1-[(7-methyl-2-oxo-3,4-dihydro-1H-quinolin-6-yl)carbonyl]piperidin-4-yl]-phenethyl-azanium
  • [1-(2-keto-7-methyl-3,4-dihydro-1H-quinoline-6-carbonyl)-4-piperidyl]-methyl-phenethyl-ammonium binoxalate
  • 7-methyl-6-[4-(methyl-(2-phenylethyl)amino)piperidine-1-carbonyl]-3,4-dihydro-1H-quinolin-2-one; oxalic acid
  • 7-methyl-6-[[4-(methyl-(2-phenylethyl)amino)-1-piperidinyl]-oxomethyl]-3,4-dihydro-1H-quinolin-2-one; oxalic acid
  • 7-methyl-6-[4-(methyl-(2-phenylethyl)amino)piperidine-1-carbonyl]-3,4-dihydrocarbostyril; oxalic acid
  • ethanedioic acid; 7-methyl-6-[4-(methyl-(2-phenylethyl)amino)piperidin-1-yl]carbonyl-3,4-dihydro-1H-quinolin-2-one
  • 2-hydroxy-2-oxoacetate; methyl-[1-(7-methyl-2-oxo3,4-dihydro-1H-quinoline-6-carbonyl)piperidin-4-yl]-(2-phenylethyl)azanium
  • 2-hydroxy-2-oxo-acetate; methyl-[1-(7-methyl-2-oxo-3,4-dihydro-1H-quinoline-6-carbonyl)-4-piperidyl]-(2-phenylethyl)ammonium
  • 2-hydroxy-2-oxoacetate; methyl-[1-[(7-methyl-2-oxo-3,4-dihydro-1H-quinolin-6-yl)-oxomethyl]-4-piperidinyl]-(2-phenylethyl)ammonium
  • [1-(2-keto-7-methyl-3,4-dihydro-1H-quinoline-6-carbonyl)-4-piperidyl]-methyl-(2-phenylethyl)ammonium bioxalate
  • 2-hydroxy-2-oxo-ethanoate; methyl-[1-[(7-methyl-2-oxo-3,4-dihydro-1H-quinolin-6-yl)carbonyl]piperidin-4-yl]-(2-phenylethyl)azanium

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0037 0.6458 1
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.005 1 1
Brugia malayi Protein kinase domain containing protein 0.0037 0.6458 0.6319
Echinococcus multilocularis c src tyrosine kinase 0.0037 0.6458 0.6458
Onchocerca volvulus 0.0037 0.6458 1
Schistosoma mansoni tyrosine kinase 0.0037 0.6458 0.618
Loa Loa (eye worm) hypothetical protein 0.0037 0.6458 0.6458
Loa Loa (eye worm) TK/FER protein kinase 0.0037 0.6458 0.6458
Schistosoma mansoni tyrosine kinase 0.0037 0.6458 0.618
Brugia malayi Furin-like cysteine rich region family protein 0.0037 0.6458 0.6319
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0037 0.6458 0.6458
Echinococcus granulosus retinal guanylyl cyclase 2 0.0037 0.6458 0.6458
Echinococcus multilocularis tyrosine protein kinase Srms 0.0037 0.6458 0.6458
Echinococcus multilocularis ephrin type A receptor 4 A 0.0037 0.6458 0.6458
Brugia malayi Protein kinase domain containing protein 0.0037 0.6458 0.6319
Schistosoma mansoni tyrosine kinase 0.0037 0.6458 0.618
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 1 1
Echinococcus granulosus fibroblast growth factor receptor 4 0.0037 0.6458 0.6458
Echinococcus granulosus tyrosine protein kinase ABL1 0.0037 0.6458 0.6458
Echinococcus granulosus mitogen activated protein kinase 3 0.005 1 1
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0037 0.6458 0.6458
Schistosoma mansoni tyrosine kinase 0.0037 0.6458 0.618
Brugia malayi SH2 domain containing protein 0.0037 0.6458 0.6319
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0037 0.6458 1
Schistosoma mansoni serine/threonine protein kinase 0.0037 0.6458 0.618
Loa Loa (eye worm) protein kinase domain-containing protein 0.0037 0.6458 0.6458
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0037 0.6458 0.6458
Echinococcus granulosus activin receptor type 0.0037 0.6579 0.6579
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0037 0.6579 0.0343
Echinococcus granulosus kinase suppressor of Ras 1 0.0037 0.6458 0.6458
Onchocerca volvulus 0.0037 0.6458 1
Loa Loa (eye worm) TK/ABL protein kinase 0.0037 0.6458 0.6458
Brugia malayi hypothetical protein 0.0037 0.6458 0.6319
Schistosoma mansoni protein tyrosine kinase 0.0037 0.6458 0.618
Schistosoma mansoni serine/threonine protein kinase 0.0037 0.6458 0.618
Loa Loa (eye worm) hypothetical protein 0.0037 0.6458 0.6458
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0037 0.6458 0.6458
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0037 0.6458 0.618
Echinococcus granulosus activated cdc42 kinase 1 0.0037 0.6458 0.6458
Echinococcus granulosus lamin dm0 0.0026 0.3678 0.3678
Echinococcus multilocularis activin receptor type 0.0037 0.6579 0.6579
Echinococcus granulosus atrial natriuretic peptide receptor 1 0.0037 0.6458 0.6458
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.005 1 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.6458 0.6458
Loa Loa (eye worm) hypothetical protein 0.0037 0.6458 0.6458
Onchocerca volvulus 0.0037 0.6458 1
Onchocerca volvulus 0.0037 0.6458 1
Echinococcus granulosus ephrin type A receptor 4 A 0.0037 0.6458 0.6458
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0037 0.6458 0.6458
Schistosoma mansoni tyrosine kinase 0.0037 0.6458 0.618
Loa Loa (eye worm) TK/ACK protein kinase 0.0037 0.6458 0.6458
Loa Loa (eye worm) hypothetical protein 0.0026 0.3678 0.3678
Echinococcus multilocularis epidermal growth factor receptor 0.0037 0.6458 0.6458
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0037 0.6458 0.6319
Brugia malayi Protein kinase domain containing protein 0.0037 0.6458 0.6319
Echinococcus granulosus protein kinase 0.0037 0.6458 0.6458
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0037 0.6458 0.6458
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0037 0.6579 0.0343
Schistosoma mansoni protein kinase 0.0037 0.6458 0.618
Echinococcus multilocularis macrophage colony stimulating factor 1 receptor 0.0037 0.6458 0.6458
Loa Loa (eye worm) TK protein kinase 0.0037 0.6458 0.6458
Brugia malayi Protein kinase domain containing protein 0.0037 0.6458 0.6319
Echinococcus granulosus tyrosine protein kinase 0.0037 0.6458 0.6458
Loa Loa (eye worm) hypothetical protein 0.0033 0.5552 0.5552
Schistosoma mansoni protein kinase 0.0037 0.6579 0.6311
Brugia malayi Immunoglobulin I-set domain containing protein 0.0037 0.6458 0.6319
Schistosoma mansoni lamin 0.0026 0.3678 0.3182
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0037 0.6458 0.618
Schistosoma mansoni ephrin receptor 0.0037 0.6458 0.618
Echinococcus multilocularis protein KINase family member (kin 25) 0.0037 0.6458 0.6458
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0037 0.6458 0.6458
Echinococcus granulosus tyrosine protein kinase csk 0.0037 0.6458 0.6458
Plasmodium falciparum protein kinase, putative 0.0037 0.6579 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0037 0.6458 0.6319
Echinococcus granulosus receptor type guanylyl cyclase 0.0037 0.6458 0.6458
Loa Loa (eye worm) intermediate filament protein 0.0026 0.3678 0.3678
Loa Loa (eye worm) TK protein kinase 0.0037 0.6458 0.6458
Loa Loa (eye worm) TK protein kinase 0.0037 0.6458 0.6458
Echinococcus granulosus tyrosine kinase 0.0037 0.6458 0.6458
Echinococcus granulosus tyrosine protein kinase Lyn 0.0037 0.6579 0.6579
Echinococcus multilocularis kinase suppressor of Ras 1 0.0037 0.6458 0.6458
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0037 0.6458 0.618
Loa Loa (eye worm) hypothetical protein 0.0037 0.6458 0.6458
Brugia malayi integrin-linked kinase 0.0037 0.6458 0.6319
Brugia malayi Protein kinase domain containing protein 0.0037 0.6458 0.6319
Loa Loa (eye worm) hypothetical protein 0.0037 0.6458 0.6458
Brugia malayi SH2 domain containing protein 0.0037 0.6458 0.6319
Brugia malayi Protein kinase domain containing protein 0.0037 0.6458 0.6319
Loa Loa (eye worm) hypothetical protein 0.0037 0.6458 0.6458
Loa Loa (eye worm) TK/FER protein kinase 0.0037 0.6458 0.6458
Loa Loa (eye worm) TK/FER protein kinase 0.0037 0.6458 0.6458
Schistosoma mansoni tyrosine kinase 0.0037 0.6458 0.618
Echinococcus multilocularis activated cdc42 kinase 1 0.0037 0.6458 0.6458
Giardia lamblia Kinase, CMGC MAPK 0.005 1 1
Brugia malayi SRC-1 0.0037 0.6458 0.6319
Loa Loa (eye worm) TK/FER protein kinase 0.0037 0.6458 0.6458
Echinococcus granulosus raf serine:threonine protein kinase 0.0037 0.6458 0.6458
Echinococcus multilocularis lamin 0.0026 0.3678 0.3678
Brugia malayi Protein kinase domain containing protein 0.0037 0.6458 0.6319
Brugia malayi Protein kinase domain containing protein 0.0037 0.6458 0.6319
Onchocerca volvulus 0.0037 0.6458 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0727 0.0727
Echinococcus multilocularis tyrosine protein kinase csk 0.0037 0.6458 0.6458
Loa Loa (eye worm) TK/ROR protein kinase 0.0037 0.6458 0.6458
Brugia malayi Protein kinase domain containing protein 0.0037 0.6458 0.6319
Echinococcus granulosus 3'partial|retinal guanylyl cyclase 2 0.0037 0.6458 0.6458
Echinococcus granulosus tyrosine protein kinase Fyn 0.0037 0.6458 0.6458
Loa Loa (eye worm) TK/FAK protein kinase 0.0037 0.6458 0.6458
Schistosoma mansoni tyrosine kinase 0.0037 0.6458 0.618
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0037 0.6458 0.618
Schistosoma mansoni protein kinase 0.0037 0.6458 0.618
Echinococcus multilocularis tyrosine protein kinase csk 0.0037 0.6458 0.6458
Loa Loa (eye worm) TKL/MLK/HH498 protein kinase 0.0037 0.6458 0.6458
Entamoeba histolytica protein kinase domain containing protein 0.0037 0.6579 1
Echinococcus multilocularis tyrosine kinase 0.0037 0.6458 0.6458
Echinococcus granulosus integrin linked protein kinase 0.0037 0.6458 0.6458
Echinococcus granulosus intermediate filament protein 0.0026 0.3678 0.3678
Schistosoma mansoni protein kinase 0.0037 0.6458 0.618
Echinococcus multilocularis mitogen activated protein kinase 3 0.005 1 1
Schistosoma mansoni tyrosine kinase 0.0037 0.6458 0.618
Loa Loa (eye worm) TK/EPH protein kinase 0.0037 0.6458 0.6458
Loa Loa (eye worm) hypothetical protein 0.0049 0.9709 0.9709
Leishmania major protein kinase, putative 0.0037 0.6579 0.0343
Onchocerca volvulus 0.0037 0.6458 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.6458 0.6458
Echinococcus granulosus GPCR family 2 0.0015 0.0727 0.0727
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0037 0.6458 0.6458
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0037 0.6458 0.6458
Schistosoma mansoni tyrosine kinase 0.0037 0.6458 0.618
Schistosoma mansoni tyrosine kinase 0.0037 0.6458 0.618
Schistosoma mansoni protein kinase 0.0037 0.6458 0.618
Echinococcus multilocularis epidermal growth factor receptor 0.0037 0.6458 0.6458
Echinococcus multilocularis mitogen activated protein kinase 0.005 1 1
Echinococcus multilocularis protein kinase 0.0037 0.6458 0.6458
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0037 0.6458 0.6458
Onchocerca volvulus 0.0037 0.6458 1
Schistosoma mansoni tyrosine kinase 0.0037 0.6458 0.618
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0037 0.6458 0.6458
Echinococcus granulosus protein tyrosine kinase 0.0037 0.6458 0.6458
Loa Loa (eye worm) TK protein kinase 0.0037 0.6458 0.6458
Onchocerca volvulus Tyrosine kinase homolog 0.0037 0.6458 1
Trichomonas vaginalis CMGC family protein kinase 0.005 1 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.6458 0.6458
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0037 0.6458 0.6458
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0727 0.0727
Brugia malayi Guanylyl cyclase protein 23 0.0037 0.6458 0.6319
Brugia malayi Protein kinase domain containing protein 0.0037 0.6458 0.6319
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0037 0.6458 0.618
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0037 0.6458 0.6458
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0037 0.6458 0.6458
Trichomonas vaginalis CMGC family protein kinase 0.005 1 1
Schistosoma mansoni tyrosine kinase 0.0037 0.6458 0.618
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0037 0.6458 0.6319
Loa Loa (eye worm) TKL/MLK/TAK1 protein kinase 0.0037 0.6458 0.6458
Schistosoma mansoni tyrosine kinase 0.0037 0.6458 0.618
Brugia malayi Protein kinase domain containing protein 0.0037 0.6458 0.6319
Echinococcus multilocularis tyrosine protein kinase csk 0.0037 0.6458 0.6458
Schistosoma mansoni hypothetical protein 0.0037 0.6458 0.618
Echinococcus multilocularis integrin linked protein kinase 0.0037 0.6458 0.6458
Schistosoma mansoni tyrosine kinase 0.0037 0.6458 0.618
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0727 0.0727
Onchocerca volvulus 0.0037 0.6458 1
Loa Loa (eye worm) TK/INSR protein kinase 0.0037 0.6458 0.6458
Trypanosoma brucei protein kinase, putative 0.005 1 1
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0037 0.6458 0.6458
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0037 0.6458 0.6319
Trichomonas vaginalis CMGC family protein kinase 0.005 1 1
Echinococcus granulosus insulin receptor 0.0037 0.6458 0.6458
Loa Loa (eye worm) TK/FER protein kinase 0.0037 0.6458 0.6458
Loa Loa (eye worm) TK/FER protein kinase 0.0037 0.6458 0.6458
Echinococcus multilocularis FL cytokine receptor 0.0037 0.6458 0.6458
Schistosoma mansoni tyrosine kinase 0.0037 0.6458 0.618
Loa Loa (eye worm) TK/EGFR protein kinase 0.0037 0.6458 0.6458
Loa Loa (eye worm) TK/FER protein kinase 0.0037 0.6458 0.6458
Brugia malayi Protein kinase domain containing protein 0.0037 0.6458 0.6319
Echinococcus multilocularis tyrosine kinase 0.0037 0.6458 0.6458
Brugia malayi Protein kinase domain containing protein 0.0037 0.6458 0.6319
Schistosoma mansoni protein kinase 0.0037 0.6579 0.6311
Loa Loa (eye worm) TK protein kinase 0.0037 0.6458 0.6458
Loa Loa (eye worm) TK/KIN6 protein kinase 0.0037 0.6458 0.6458
Brugia malayi Protein kinase domain containing protein 0.0037 0.6458 0.6319
Loa Loa (eye worm) RGC/RGC protein kinase 0.0037 0.6458 0.6458
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0037 0.6458 0.6458
Echinococcus granulosus tyrosine protein kinase Src42A 0.0037 0.6458 0.6458
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.9709 0.9709
Loa Loa (eye worm) TK/DDR protein kinase 0.0037 0.6458 0.6458
Plasmodium vivax protein kinase, putative 0.0037 0.6458 0.5
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.005 1 1
Loa Loa (eye worm) TK/FER protein kinase 0.0037 0.6458 0.6458
Echinococcus multilocularis heat shock protein 70 0.0037 0.6458 0.6458
Brugia malayi Protein kinase domain containing protein 0.0037 0.6458 0.6319
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0037 0.6458 0.6458
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0037 0.6458 0.6458
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0037 0.6458 0.6458
Schistosoma mansoni tyrosine kinase 0.0037 0.6458 0.618
Loa Loa (eye worm) hypothetical protein 0.0015 0.0727 0.0727
Brugia malayi Protein kinase domain containing protein 0.0037 0.6458 0.6319
Echinococcus granulosus c src tyrosine kinase 0.0037 0.6458 0.6458
Schistosoma mansoni tyrosine kinase 0.0037 0.6458 0.618
Schistosoma mansoni serine/threonine protein kinase 0.0037 0.6458 0.618
Loa Loa (eye worm) TK/FER protein kinase 0.0037 0.6458 0.6458
Schistosoma mansoni tyrosine kinase 0.0037 0.6458 0.618
Echinococcus multilocularis GPCR, family 2 0.0015 0.0727 0.0727
Onchocerca volvulus 0.0037 0.6458 1
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0037 0.6458 0.6458
Echinococcus multilocularis tyrosine protein kinase Blk 0.0037 0.6458 0.6458
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0037 0.6458 0.6458
Loa Loa (eye worm) TK/ALK protein kinase 0.0037 0.6458 0.6458
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0037 0.6579 0.6579
Loa Loa (eye worm) TK/FER protein kinase 0.0037 0.6458 0.6458
Loa Loa (eye worm) TK protein kinase 0.0037 0.6458 0.6458
Brugia malayi Protein kinase domain containing protein 0.0037 0.6458 0.6319
Schistosoma mansoni ephrin receptor 0.0037 0.6458 0.618
Echinococcus granulosus tyrosine protein kinase HCK 0.0037 0.6458 0.6458
Echinococcus granulosus tyrosine protein kinase csk 0.0037 0.6458 0.6458
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0037 0.6458 0.6458
Echinococcus multilocularis protein tyrosine kinase 0.0037 0.6458 0.6458
Echinococcus granulosus tyrosine kinase 0.0037 0.6458 0.6458
Echinococcus granulosus activated cdc42 kinase 1 0.0037 0.6458 0.6458
Brugia malayi Raf kinase 0.0037 0.6458 0.6319
Schistosoma mansoni tyrosine kinase 0.0037 0.6458 0.618
Echinococcus multilocularis tyrosine protein kinase HCK 0.0037 0.6458 0.6458
Echinococcus granulosus tyrosine protein kinase Fes:Fps 0.0037 0.6458 0.6458
Loa Loa (eye worm) TK/FER protein kinase 0.0037 0.6458 0.6458
Brugia malayi C-terminal src kinase protein 1 0.0037 0.6458 0.6319
Loa Loa (eye worm) TK/Met protein kinase 0.0037 0.6458 0.6458
Schistosoma mansoni hypothetical protein 0.0033 0.5552 0.5203
Echinococcus multilocularis atrial natriuretic peptide receptor 1 0.0037 0.6458 0.6458
Loa Loa (eye worm) serine/threonine protein kinase 0.0037 0.6458 0.6458
Schistosoma mansoni tyrosine kinase 0.0037 0.6458 0.618
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.5552 0.5377
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0037 0.6458 0.6458
Schistosoma mansoni serine/threonine protein kinase 0.005 1 1
Brugia malayi Protein kinase domain containing protein 0.0037 0.6458 0.6319
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.9709 0.9698
Onchocerca volvulus Tyrosine kinase receptor Cad96Ca homolog 0.0037 0.6458 1
Brugia malayi Protein kinase domain containing protein 0.0037 0.6458 0.6319
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0037 0.6458 0.6458
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0037 0.6458 0.618
Echinococcus granulosus mitogen activated protein kinase 0.005 1 1
Echinococcus granulosus retinal guanylyl cyclase 2 0.0037 0.6458 0.6458
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.005 1 1
Brugia malayi Protein kinase domain containing protein 0.0037 0.6458 0.6319
Echinococcus multilocularis tyrosine protein kinase shark 0.0037 0.6458 0.6458
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0037 0.6458 0.6458
Echinococcus multilocularis insulin receptor 0.0037 0.6458 0.6458
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 1 1
Echinococcus granulosus natriuretic peptide receptor 1 0.0037 0.6458 0.6458
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0037 0.6458 0.6458
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0037 0.6458 0.6458
Loa Loa (eye worm) TK/FER protein kinase 0.0037 0.6458 0.6458
Loa Loa (eye worm) RGC/RGC protein kinase 0.0037 0.6458 0.6458
Brugia malayi Protein kinase domain containing protein 0.0037 0.6458 0.6319
Loa Loa (eye worm) SRC-1 0.0037 0.6458 0.6458
Echinococcus granulosus tyrosine protein kinase Fyn 0.0037 0.6458 0.6458
Brugia malayi Protein kinase domain containing protein 0.0037 0.6458 0.6319
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.005 1 1
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0037 0.6458 0.6458
Echinococcus multilocularis tyrosine protein kinase csk 0.0037 0.6458 0.6458
Schistosoma mansoni serine/threonine RGC 0.0037 0.6458 0.618
Echinococcus granulosus epidermal growth factor receptor 0.0037 0.6458 0.6458
Brugia malayi Protein kinase domain containing protein 0.0037 0.6458 0.6319
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0037 0.6579 0.0343
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.3678 0.3678
Loa Loa (eye worm) hypothetical protein 0.0037 0.6458 0.6458
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0037 0.6579 0.0343
Schistosoma mansoni tyrosine kinase 0.0037 0.6458 0.618
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0727 0.0727
Loa Loa (eye worm) TK/FER protein kinase 0.0037 0.6458 0.6458
Loa Loa (eye worm) TKL/MLK/ILK protein kinase 0.0037 0.6458 0.6458
Brugia malayi Protein kinase domain containing protein 0.0037 0.6458 0.6319
Loa Loa (eye worm) hypothetical protein 0.0037 0.6458 0.6458
Schistosoma mansoni tyrosine kinase 0.0037 0.6458 0.618
Schistosoma mansoni src-type protein tyrosine kinase-related 0.0037 0.6458 0.618
Loa Loa (eye worm) TK protein kinase 0.0037 0.6458 0.6458
Echinococcus granulosus tyrosine protein kinase Srms 0.0037 0.6458 0.6458
Echinococcus multilocularis tyrosine protein kinase pr2 0.0037 0.6458 0.6458
Brugia malayi hypothetical protein 0.0037 0.6458 0.6319
Loa Loa (eye worm) TK/FER protein kinase 0.0037 0.6458 0.6458
Echinococcus multilocularis tyrosine protein kinase Abl 0.0037 0.6458 0.6458
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.3678 0.343
Echinococcus granulosus tyrosine protein kinase Blk 0.0037 0.6458 0.6458
Brugia malayi Protein kinase domain containing protein 0.0037 0.6458 0.6319
Brugia malayi protein-tyrosine kinase 0.0037 0.6458 0.6319
Schistosoma mansoni serine/threonine protein kinase 0.0037 0.6458 0.618
Echinococcus granulosus tyrosine protein kinase shark 0.0037 0.6458 0.6458
Brugia malayi Protein kinase domain containing protein 0.0037 0.6458 0.6319
Schistosoma mansoni tyrosine kinase 0.0037 0.6458 0.618
Loa Loa (eye worm) TK/RYK protein kinase 0.0037 0.6458 0.6458
Echinococcus multilocularis lamin dm0 0.0026 0.3678 0.3678
Loa Loa (eye worm) TK protein kinase 0.0037 0.6458 0.6458
Loa Loa (eye worm) TK/FER protein kinase 0.0037 0.6458 0.6458
Onchocerca volvulus 0.0037 0.6458 1
Brugia malayi bone morphogenetic protein type 1 receptor 0.0037 0.6458 0.6319
Schistosoma mansoni tyrosine protein kinase 0.0037 0.6458 0.618
Echinococcus granulosus epidermal growth factor receptor 0.0037 0.6458 0.6458
Echinococcus multilocularis tyrosine protein kinase 0.0037 0.6458 0.6458
Loa Loa (eye worm) RGC/RGC protein kinase 0.0037 0.6458 0.6458
Schistosoma mansoni tyrosine kinase 0.0037 0.6458 0.618
Echinococcus granulosus retinal guanylyl cyclase 2 0.0037 0.6458 0.6458
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0377 0.0377
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0037 0.6458 0.6458
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0037 0.6458 0.6458
Echinococcus multilocularis tyrosine protein kinase Fes:Fps 0.0037 0.6458 0.6458
Brugia malayi ephrin receptor 1 precursor 0.0037 0.6458 0.6319
Brugia malayi Protein kinase domain containing protein 0.0037 0.6458 0.6319
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0037 0.6579 0.6579
Loa Loa (eye worm) hypothetical protein 0.0037 0.6458 0.6458
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0037 0.6458 0.6458
Schistosoma mansoni protein kinase 0.0037 0.6458 0.618
Schistosoma mansoni protein kinase 0.0037 0.6458 0.618
Brugia malayi Protein kinase domain containing protein 0.0037 0.6458 0.6319
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0037 0.6458 0.6458
Brugia malayi Receptor family ligand binding region containing protein 0.0037 0.6458 0.6319
Plasmodium vivax tyrosine kinase-like protein, putative 0.0037 0.6458 0.5
Brugia malayi proto-oncogene tyrosine-protein kinase FER 0.0037 0.6458 0.6319
Schistosoma mansoni intermediate filament proteins 0.0026 0.3678 0.3182
Brugia malayi Protein kinase domain containing protein 0.0037 0.6458 0.6319
Brugia malayi Tyrosine-protein kinase F09A5.2 in chromosome X, putative 0.0037 0.6458 0.6319
Loa Loa (eye worm) TK/FER protein kinase 0.0037 0.6458 0.6458
Brugia malayi hypothetical protein 0.0037 0.6458 0.6319
Echinococcus granulosus tyrosine kinase 0.0037 0.6458 0.6458
Schistosoma mansoni tyrosine kinase 0.0037 0.6458 0.618
Schistosoma mansoni tyrosine kinase 0.0037 0.6458 0.618
Brugia malayi intermediate filament protein 0.0026 0.3678 0.343
Trichomonas vaginalis CMGC family protein kinase 0.005 1 1
Loa Loa (eye worm) TKL/RAF/KSR protein kinase 0.0037 0.6458 0.6458
Schistosoma mansoni tyrosine kinase 0.0037 0.6458 0.618
Schistosoma mansoni protein kinase 0.0037 0.6579 0.6311
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0037 0.6458 0.6458
Loa Loa (eye worm) TK protein kinase 0.0037 0.6458 0.6458
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0037 0.6458 0.6458
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0037 0.6458 0.6458
Trypanosoma brucei protein kinase, putative 0.0037 0.6579 0.0343
Loa Loa (eye worm) TK protein kinase 0.0037 0.6458 0.6458
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0037 0.6458 0.6319
Onchocerca volvulus 0.0037 0.6458 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0727 0.0363
Loa Loa (eye worm) TK/CSK protein kinase 0.0037 0.6458 0.6458
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.005 1 1
Schistosoma mansoni tyrosine kinase 0.0037 0.6458 0.618
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0037 0.6458 0.6458
Brugia malayi Tyrosine-protein kinase abl-1 0.0037 0.6458 0.6319
Echinococcus granulosus lamin 0.0026 0.3678 0.3678
Echinococcus granulosus tyrosine protein kinase csk 0.0037 0.6458 0.6458
Schistosoma mansoni protein kinase 0.0037 0.6458 0.618
Echinococcus multilocularis musashi 0.0026 0.3678 0.3678
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.9709 0.9698
Schistosoma mansoni tyrosine kinase 0.0037 0.6458 0.618
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0037 0.6458 0.6458
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0727 0.0727
Onchocerca volvulus 0.0037 0.6458 1
Brugia malayi Protein kinase domain containing protein 0.0037 0.6458 0.6319
Loa Loa (eye worm) RGC/RGC protein kinase 0.0037 0.6458 0.6458
Schistosoma mansoni tyrosine kinase 0.0037 0.6458 0.618
Loa Loa (eye worm) hypothetical protein 0.0026 0.3548 0.3548
Loa Loa (eye worm) hypothetical protein 0.0037 0.6458 0.6458
Schistosoma mansoni lamin 0.0026 0.3678 0.3182
Loa Loa (eye worm) TK/FER protein kinase 0.0037 0.6458 0.6458
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0037 0.6458 0.6458
Echinococcus granulosus tyrosine protein kinase pr2 0.0037 0.6458 0.6458
Echinococcus granulosus tyrosine protein kinase Fyn 0.0037 0.6458 0.6458
Echinococcus multilocularis raf serine:threonine protein kinase 0.0037 0.6458 0.6458
Echinococcus multilocularis natriuretic peptide receptor 1 0.0037 0.6458 0.6458
Echinococcus multilocularis protein kinase 0.0037 0.6458 0.6458
Plasmodium vivax tyrosine kinase-like protein, putative 0.0037 0.6458 0.5
Brugia malayi Tyrosine-protein kinase PR2 0.0037 0.6458 0.6319
Echinococcus multilocularis transfer RNA-Thr 0.0037 0.6458 0.6458
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0727 0.0363
Echinococcus granulosus tyrosine protein kinase Src64B 0.0037 0.6458 0.6458
Echinococcus multilocularis receptor type guanylyl cyclase 0.0037 0.6458 0.6458
Onchocerca volvulus 0.0037 0.6458 1
Schistosoma mansoni protein kinase 0.0037 0.6458 0.618
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0037 0.6458 0.6458
Echinococcus granulosus mitogen-activated protein kinase kinase kinase 9 0.0037 0.6458 0.6458
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.005 1 1
Schistosoma mansoni tyrosine kinase 0.0037 0.6458 0.618
Onchocerca volvulus 0.0037 0.6458 1

Activities

Activity type Activity value Assay description Source Reference
BP (functional) = -13 mmHg Cardiovascular effect upon blood pressure(BP) in anesthetized open-chest dogs at a dose of 10 ug/ kg adminitesterd intravenously ChEMBL. 12825942
CBF Ratio (functional) = 0.02 Vasodilatory activity of the compound (at 100 nmol) relative to nifedipine (at 10 nmol) by coronary artery blood flow (CBF) in isolated blood perfused canine heart preparations. ChEMBL. 12825942
CBF Ratio (functional) = 11 Cardiovascular effect upon coronary artery blood flow(CBF) in anesthetized open-chest dogs at a dose of 10 ug/ kg adminitesterd intravenously ChEMBL. 12825942
FBF Ratio (functional) = 3.01 Vasodilatory activity (at 10 nmol) relative to nifedipine (at 1 nmol) by femoral artery blood flow (FBF) in autoperfused canine femoral artery preparations. ChEMBL. 12825942
FBF Ratio (functional) = 41 Cardiovascular effect upon femoral artery blood flow(FBF) in anesthetized open-chest dogs at a dose of 10 ug/ kg adminitesterd intravenously ChEMBL. 12825942

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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