Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | Protoporphyrinogen oxidase chloroplast/mitochondrial precursor | 0.0084 | 0.0284 | 0.2451 |
Echinococcus multilocularis | lysine specific histone demethylase 1A | 0.0084 | 0.0284 | 0.2451 |
Brugia malayi | SWIRM domain containing protein | 0.0084 | 0.0284 | 0.1363 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0054 | 0.0019 | 0.009 |
Echinococcus multilocularis | geminin | 0.0185 | 0.1157 | 1 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0082 | 0.0264 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0021 | 0.01 |
Onchocerca volvulus | 0.0291 | 0.208 | 1 | |
Onchocerca volvulus | 0.0084 | 0.0284 | 0.1363 | |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0084 | 0.0284 | 0.2451 |
Brugia malayi | Pax transcription factor protein 2 | 0.0291 | 0.208 | 1 |
Leishmania major | UDP-galactopyranose mutase | 0.0084 | 0.0284 | 0.5 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.0633 | 0.5066 | 0.4922 |
Brugia malayi | Cytochrome P450 family protein | 0.0054 | 0.0019 | 0.009 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.0284 | 0.1363 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0084 | 0.0284 | 0.2451 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.0284 | 0.1363 |
Echinococcus multilocularis | protoporphyrinogen oxidase | 0.0084 | 0.0284 | 0.2451 |
Schistosoma mansoni | hypothetical protein | 0.0185 | 0.1157 | 1 |
Mycobacterium leprae | PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) | 0.0084 | 0.0284 | 0.5 |
Toxoplasma gondii | histone lysine-specific demethylase | 0.0084 | 0.0284 | 0.5 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.0633 | 0.5066 | 0.4922 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0054 | 0.0021 | 0.01 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0084 | 0.0284 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.0284 | 0.1363 |
Echinococcus multilocularis | 0.0084 | 0.0284 | 0.2451 | |
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | 0.1115 | 0.9264 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0054 | 0.0021 | 0.01 |
Toxoplasma gondii | histone lysine-specific demethylase LSD1/BHC110/KDMA1A | 0.0084 | 0.0284 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.0284 | 0.1363 |
Plasmodium falciparum | beta-ketoacyl-ACP synthase III | 0.0633 | 0.5066 | 1 |
Brugia malayi | hypothetical protein | 0.0084 | 0.0284 | 0.1363 |
Schistosoma mansoni | amine oxidase | 0.0084 | 0.0284 | 0.2451 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.12 | 1 | 1 |
Chlamydia trachomatis | oxoacyl-ACP synthase III | 0.0633 | 0.5066 | 1 |
Mycobacterium ulcerans | beta-ketoacyl synthase-like protein | 0.0633 | 0.5066 | 0.4922 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.0284 | 0.1363 |
Plasmodium vivax | beta-ketoacyl-acyl carrier protein synthase III precursor, putative | 0.0633 | 0.5066 | 1 |
Echinococcus granulosus | geminin | 0.0185 | 0.1157 | 1 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0082 | 0.0264 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.0284 | 0.1363 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0054 | 0.0021 | 0.01 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0082 | 0.0264 | 0.5 |
Schistosoma mansoni | Lysine-specific histone demethylase 1 | 0.0084 | 0.0284 | 0.2451 |
Mycobacterium tuberculosis | 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) | 0.0633 | 0.5066 | 0.5326 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0082 | 0.0264 | 0.5 |
Loa Loa (eye worm) | pax transcription factor protein 2 | 0.0291 | 0.208 | 1 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0082 | 0.0264 | 0.5 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0084 | 0.0284 | 0.5 |
Schistosoma mansoni | amine oxidase | 0.0084 | 0.0284 | 0.2451 |
Schistosoma mansoni | hypothetical protein | 0.0185 | 0.1157 | 1 |
Wolbachia endosymbiont of Brugia malayi | 3-oxoacyl-ACP synthase | 0.0633 | 0.5066 | 0.5 |
Brugia malayi | amine oxidase, flavin-containing family protein | 0.0084 | 0.0284 | 0.1363 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.