Detailed information for compound 1704957

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 605.744 | Formula: C33H39N3O6S
  • H donors: 2 H acceptors: 4 LogP: 3.63 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 2
  • SMILES: COCCNC(=O)c1cc2CN([C@H](c2c(n1)c1cccc(c1)C#Cc1ccc(c(c1)OC)OC)CCO)S(=O)C(C)(C)C
  • InChi: 1S/C33H39N3O6S/c1-33(2,3)43(39)36-21-25-20-26(32(38)34-15-17-40-4)35-31(30(25)27(36)14-16-37)24-9-7-8-22(18-24)10-11-23-12-13-28(41-5)29(19-23)42-6/h7-9,12-13,18-20,27,37H,14-17,21H2,1-6H3,(H,34,38)/t27-,43?/m0/s1
  • InChiKey: LNDCZUBYGBTLEJ-LANXFFHOSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi ecdysteroid receptor 0.001 0.0014 0.0141
Mycobacterium leprae PROBABLE METHYLTRANSFERASE 0.0386 0.1026 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.0075 0.0729
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0014 0.0141
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0006 0.0029
Entamoeba histolytica hypothetical protein 0.0038 0.009 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0295 0.0781 0.7136
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0014 0.0141
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0111 0.1014
Loa Loa (eye worm) hypothetical protein 0.0037 0.0086 0.0838
Toxoplasma gondii pyruvate kinase PyK1 0.0037 0.0086 0.0648
Loa Loa (eye worm) hypothetical protein 0.0026 0.0056 0.0546
Loa Loa (eye worm) hypothetical protein 0.0295 0.0781 0.7609
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.0075 0.0343
Echinococcus multilocularis pyruvate kinase 0.0019 0.0038 0.0173
Trichomonas vaginalis D-aminoacylase, putative 0.0295 0.0781 1
Echinococcus granulosus pyruvate kinase 0.0019 0.0038 0.0346
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0152 0.1389
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0014 0.0141
Loa Loa (eye worm) hypothetical protein 0.001 0.0014 0.0141
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0111 0.0508
Trypanosoma cruzi hypothetical protein, conserved 0.0295 0.0781 1
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0014 0.0141
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0014 0.0066
Loa Loa (eye worm) pyruvate kinase 0.0037 0.0086 0.0838
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.0075 0.0729
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0014 0.0066
Loa Loa (eye worm) hypothetical protein 0.0005 0.0002 0.0015
Trichomonas vaginalis pyruvate kinase, putative 0.0037 0.0086 0.1047
Schistosoma mansoni o-methyltransferase 0.0386 0.1026 0.9378
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.0075 0.0684
Loa Loa (eye worm) hypothetical protein 0.0103 0.0264 0.2576
Brugia malayi Nuclear hormone receptor-like 1 0.0005 0.0002 0.0015
Brugia malayi beta-lactamase 0.0295 0.0781 0.7609
Echinococcus granulosus pyruvate kinase 0.0019 0.0038 0.0346
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0014 0.0066
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0014 0.0132
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0014 0.0141
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0014 0.0132
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0014 0.0141
Loa Loa (eye worm) pyruvate kinase-PB 0.0026 0.0056 0.0546
Schistosoma mansoni pyruvate kinase 0.0037 0.0086 0.0786
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0014 0.0066
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0005 0.0002 0.0014
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.009 0.0821
Loa Loa (eye worm) hypothetical protein 0.0386 0.1026 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0111 0.1081
Loa Loa (eye worm) hypothetical protein 0.0005 0.0002 0.0015
Schistosoma mansoni thyroid hormone receptor 0.001 0.0014 0.0132
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0111 0.1014
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0014 0.0141
Mycobacterium tuberculosis Probable lipase LipD 0.0295 0.0781 0.0783
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0014 0.0132
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0295 0.0781 0.0701
Onchocerca volvulus Pyruvate kinase homolog 0.0037 0.0086 0.0838
Brugia malayi Latrophilin receptor protein 2 0.0033 0.0075 0.0729
Trichomonas vaginalis pyruvate kinase, putative 0.0037 0.0086 0.1047
Plasmodium vivax hypothetical protein, conserved 0.0295 0.0781 1
Brugia malayi O-methyltransferase 0.0386 0.1026 1
Entamoeba histolytica hypothetical protein 0.0038 0.009 1
Brugia malayi O-methyltransferase family protein 0.0386 0.1026 1
Schistosoma mansoni cpg binding protein 0.003 0.0069 0.0633
Loa Loa (eye worm) pyruvate kinase 0.0037 0.0086 0.0838
Mycobacterium ulcerans beta-lactamase 0.0295 0.0781 0.0701
Mycobacterium leprae Probable lipase LipE 0.0295 0.0781 0.739
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0014 0.0132
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0014 0.0141
Giardia lamblia Pyruvate kinase 0.0037 0.0086 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0014 0.0141
Echinococcus multilocularis pyruvate kinase 0.0019 0.0038 0.0173
Onchocerca volvulus 0.0295 0.0781 0.7609
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0103 0.0264 0.2576
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0014 0.0141
Echinococcus granulosus GPCR family 2 0.0033 0.0075 0.0684
Schistosoma mansoni cpg binding protein 0.003 0.0069 0.0633
Mycobacterium tuberculosis Conserved protein 0.0295 0.0781 0.0783
Onchocerca volvulus Pyruvate kinase homolog 0.0037 0.0086 0.0838
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0014 0.0066
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0065 0.0632
Loa Loa (eye worm) hypothetical protein 0.0005 0.0002 0.0015
Schistosoma mansoni hypothetical protein 0.007 0.0177 0.1614
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0014 0.0132
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.009 0.0412
Loa Loa (eye worm) hypothetical protein 0.0295 0.0781 0.7609
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0014 0.0141
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0014 0.0141
Schistosoma mansoni pyruvate kinase 0.0019 0.0038 0.0346
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0014 0.0141
Schistosoma mansoni hypothetical protein 0.0038 0.009 0.0821
Brugia malayi Pyruvate kinase, muscle isozyme 0.0037 0.0086 0.0838
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0111 0.1014
Trichomonas vaginalis penicillin-binding protein, putative 0.0295 0.0781 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0014 0.0132
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0103 0.0264 0.2576
Schistosoma mansoni cpg binding protein 0.0029 0.0065 0.0592
Brugia malayi Pyruvate kinase, M2 isozyme 0.0037 0.0086 0.0838
Onchocerca volvulus 0.0029 0.0065 0.0632
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0111 0.1014
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0014 0.0132
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0014 0.0141
Brugia malayi beta-lactamase family protein 0.0295 0.0781 0.7609
Brugia malayi hypothetical protein 0.0005 0.0002 0.0015
Echinococcus granulosus pyruvate kinase 0.0019 0.0038 0.0346
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0005 0.0002 0.0007
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0014 0.0132
Loa Loa (eye worm) hypothetical protein 0.0295 0.0781 0.7609
Loa Loa (eye worm) hypothetical protein 0.001 0.0014 0.0141
Brugia malayi Calcitonin receptor-like protein seb-1 0.0103 0.0264 0.2576
Onchocerca volvulus 0.0295 0.0781 0.7609
Mycobacterium ulcerans methyltransferase 0.0386 0.1026 0.0948
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0014 0.0132
Echinococcus granulosus pyruvate kinase 0.0037 0.0086 0.0786
Echinococcus multilocularis pyruvate kinase 0.0037 0.0086 0.0394
Loa Loa (eye worm) pyruvate kinase 0.0008 0.0008 0.0077
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0014 0.0141
Schistosoma mansoni o-methyltransferase 0.0386 0.1026 0.9378
Loa Loa (eye worm) hypothetical protein 0.001 0.0014 0.0141
Echinococcus multilocularis pyruvate kinase 0.0019 0.0038 0.0173
Mycobacterium tuberculosis Probable lipase LipE 0.0295 0.0781 0.0783
Brugia malayi nuclear receptor NHR-88 0.001 0.0014 0.0141
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0011 0.0106
Leishmania major hypothetical protein, conserved 0.0295 0.0781 1
Schistosoma mansoni hypothetical protein 0.0033 0.0075 0.0684
Echinococcus multilocularis beta LACTamase domain containing family member 0.0295 0.0781 0.3578
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0014 0.0141
Trypanosoma cruzi hypothetical protein, conserved 0.0295 0.0781 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0295 0.0781 0.0783
Schistosoma mansoni hypothetical protein 0.0411 0.1094 1
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0005 0.0002 0.0014
Echinococcus multilocularis GPCR, family 2 0.0033 0.0075 0.0343
Echinococcus multilocularis cpg binding protein 0.003 0.0069 0.0317
Brugia malayi nuclear hormone receptor 0.001 0.0014 0.0141
Echinococcus multilocularis pyruvate kinase 0.0029 0.0065 0.0299
Brugia malayi hypothetical protein 0.0005 0.0002 0.0015
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0014 0.0066
Mycobacterium tuberculosis Probable catechol-O-methyltransferase 0.333 0.8961 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0014 0.0141
Mycobacterium tuberculosis Probable esterase LipL 0.0295 0.0781 0.0783
Wolbachia endosymbiont of Brugia malayi O-methyltransferase 0.0386 0.1026 0.5
Brugia malayi CXXC zinc finger family protein 0.0029 0.0065 0.0632
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0014 0.0141
Loa Loa (eye worm) hypothetical protein 0.0295 0.0781 0.7609
Onchocerca volvulus 0.0386 0.1026 1
Trypanosoma brucei hypothetical protein, conserved 0.0295 0.0781 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0014 0.0132
Loa Loa (eye worm) hypothetical protein 0.0295 0.0781 0.7609
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0295 0.0781 0.0783
Brugia malayi pyruvate kinase 0.0008 0.0008 0.0077
Mycobacterium tuberculosis Probable methyltransferase 0.0386 0.1026 0.106
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0014 0.0132
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.0011 0.0017 0.0166
Echinococcus granulosus beta LACTamase domain containing family member 0.0295 0.0781 0.7136
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0014 0.0141
Onchocerca volvulus 0.0295 0.0781 0.7609
Mycobacterium tuberculosis Conserved protein 0.0295 0.0781 0.0783
Trichomonas vaginalis D-aminoacylase, putative 0.0295 0.0781 1
Loa Loa (eye worm) beta-lactamase 0.0295 0.0781 0.7609
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0014 0.0066
Loa Loa (eye worm) hypothetical protein 0.001 0.0014 0.0141
Brugia malayi latrophilin 2 splice variant baaae 0.007 0.0177 0.1721
Entamoeba histolytica hypothetical protein 0.0038 0.009 1
Brugia malayi pyruvate kinase, muscle isozyme 0.0008 0.0008 0.0077
Plasmodium falciparum pyruvate kinase 0.0037 0.0086 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0011 0.0102
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0111 0.1014
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0295 0.0781 0.7609
Onchocerca volvulus Pyruvate kinase homolog 0.0037 0.0086 0.0838
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0014 0.0141
Schistosoma mansoni hypothetical protein 0.0033 0.0075 0.0684
Loa Loa (eye worm) pyruvate kinase 0.0037 0.0086 0.0838
Mycobacterium ulcerans lipase LipD 0.0295 0.0781 0.0701
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0014 0.0066
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.0075 0.0684
Loa Loa (eye worm) hypothetical protein 0.0005 0.0002 0.0015
Loa Loa (eye worm) hypothetical protein 0.007 0.0177 0.1721
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0011 0.0109
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.0006 0.0029
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0295 0.0781 0.0783
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0005 0.0002 0.0014
Loa Loa (eye worm) hypothetical protein 0.0033 0.0075 0.0729
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0014 0.0141
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0011 0.0051
Brugia malayi Nuclear hormone receptor-like 1 0.0005 0.0002 0.0015
Echinococcus granulosus pyruvate kinase 0.0037 0.0086 0.0786
Schistosoma mansoni o-methyltransferase 0.0386 0.1026 0.9378
Brugia malayi nuclear receptor RXR 0.0005 0.0002 0.0015
Schistosoma mansoni hypothetical protein 0.0033 0.0075 0.0684
Schistosoma mansoni pyruvate kinase 0.0037 0.0086 0.0786
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0014 0.0141
Brugia malayi O-methyltransferase family protein 0.0386 0.1026 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0014 0.0141
Brugia malayi beta-lactamase family protein 0.0295 0.0781 0.7609
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0014 0.0141
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0014 0.0132
Echinococcus multilocularis dnaJ subfamily B 0.0411 0.1094 0.5015
Mycobacterium tuberculosis Possible penicillin-binding protein 0.1882 0.5059 0.5603
Schistosoma mansoni o-methyltransferase 0.0386 0.1026 0.9378
Echinococcus multilocularis pyruvate kinase 0.0037 0.0086 0.0394
Brugia malayi steroid hormone receptor 0.001 0.0014 0.0141
Echinococcus granulosus FTZ F1 alpha 0.001 0.0014 0.0132
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0111 0.0508
Mycobacterium leprae conserved hypothetical protein 0.0295 0.0781 0.739
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0014 0.0141
Loa Loa (eye worm) hypothetical protein 0.001 0.0014 0.0141
Mycobacterium tuberculosis Conserved protein 0.0295 0.0781 0.0783
Loa Loa (eye worm) hypothetical protein 0.0295 0.0781 0.7609
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0295 0.0781 0.7609
Brugia malayi hypothetical protein 0.0038 0.009 0.0875
Trichomonas vaginalis penicillin-binding protein, putative 0.0295 0.0781 1
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0815 0.2182 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0111 0.1081
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0295 0.0781 0.7136
Trichomonas vaginalis esterase, putative 0.0295 0.0781 1
Echinococcus granulosus dnaJ subfamily B 0.0411 0.1094 1
Mycobacterium tuberculosis Probable hydrolase 0.0295 0.0781 0.0783
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0006 0.0059
Chlamydia trachomatis pyruvate kinase 0.0037 0.0086 0.5
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0014 0.0141
Toxoplasma gondii ABC1 family protein 0.0295 0.0781 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0006 0.0059
Onchocerca volvulus 0.0386 0.1026 1
Schistosoma mansoni coup transcription factor 0.001 0.0014 0.0132
Echinococcus granulosus cpg binding protein 0.003 0.0069 0.0633
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0005 0.0002 0.0015
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0014 0.0141
Loa Loa (eye worm) O-methyltransferase 0.0386 0.1026 1
Brugia malayi O-methyltransferase family protein 0.0386 0.1026 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.009 0.0821
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0014 0.0066
Schistosoma mansoni hypothetical protein 0.0033 0.0075 0.0684
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.0134 0.1299
Trichomonas vaginalis D-aminoacylase, putative 0.0295 0.0781 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0014 0.0132
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0014 0.0132
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0014 0.0132
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0014 0.0141
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.0075 0.0343
Onchocerca volvulus 0.001 0.0014 0.0141
Plasmodium vivax pyruvate kinase, putative 0.0037 0.0086 0.0648
Mycobacterium ulcerans esterase/lipase LipP 0.0295 0.0781 0.0701
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0014 0.0141
Schistosoma mansoni nuclear hormone receptor 0.001 0.0014 0.0132
Loa Loa (eye worm) hypothetical protein 0.001 0.0014 0.0141
Mycobacterium ulcerans hypothetical protein 0.0295 0.0781 0.0701
Schistosoma mansoni thyroid hormone receptor 0.001 0.0014 0.0132
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.0006 0.0059
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0014 0.0132
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0014 0.0132
Entamoeba histolytica hypothetical protein 0.0038 0.009 1
Loa Loa (eye worm) hypothetical protein 0.0005 0.0002 0.0015

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 39.8107 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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