Detailed information for compound 1705306

Basic information

Technical information
  • TDR Targets ID: 1705306
  • Name: 2-methoxy-N-[(Z)-1-(1-methylindol-3-yl)-3-(2- morpholin-4-ylethylamino)-3-oxoprop-1-en-2-yl ]benzamide
  • MW: 462.541 | Formula: C26H30N4O4
  • H donors: 2 H acceptors: 2 LogP: 2.38 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccccc1C(=O)N/C(=C\c1cn(c2c1cccc2)C)/C(=O)NCCN1CCOCC1
  • InChi: 1S/C26H30N4O4/c1-29-18-19(20-7-3-5-9-23(20)29)17-22(26(32)27-11-12-30-13-15-34-16-14-30)28-25(31)21-8-4-6-10-24(21)33-2/h3-10,17-18H,11-16H2,1-2H3,(H,27,32)(H,28,31)/b22-17-
  • InChiKey: MJKFGAQOAJFCAH-XLNRJJMWSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-methoxy-N-[(Z)-2-(1-methylindol-3-yl)-1-(2-morpholinoethylcarbamoyl)vinyl]benzamide
  • 2-methoxy-N-[(Z)-2-(1-methyl-3-indolyl)-1-[(2-morpholinoethylamino)-oxomethyl]vinyl]benzamide
  • 2-methoxy-N-[(Z)-1-(1-methylindol-3-yl)-3-(2-morpholin-4-ylethylamino)-3-oxo-prop-1-en-2-yl]benzamide
  • STOCK3S-78569

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens GNAS complex locus Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi cathepsin Z-like cysteine proteinase 0.0053 0.0266 0.0266
Brugia malayi Cathepsin L-like precursor 0.0232 0.4693 0.4693
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0232 0.4693 0.4693
Brugia malayi fibroinase precursor 0.0053 0.0266 0.0266
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0325 0.0325
Trypanosoma cruzi cysteine peptidase, putative 0.0126 0.2061 0.1844
Schistosoma mansoni cathepsin s 0.0073 0.0758 0.0758
Plasmodium vivax vivapain-2 0.0232 0.4693 1
Loa Loa (eye worm) fibroinase 0.0232 0.4693 0.4693
Brugia malayi cathepsin L-like precursor 0.016 0.2898 0.2898
Entamoeba histolytica cysteine protease, putative 0.0126 0.2061 0.4054
Trypanosoma cruzi cruzipain precursor, putative 0.0073 0.0758 0.0505
Entamoeba histolytica cysteine protease, putative 0.0126 0.2061 0.4054
Entamoeba histolytica cysteine proteinase 2 0.0126 0.2061 0.4054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0232 0.4693 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.016 0.2898 0.5946
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0232 0.4693 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0232 0.4693 1
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0145 0.2543 0.2543
Loa Loa (eye worm) hypothetical protein 0.0053 0.0266 0.0266
Loa Loa (eye worm) hypothetical protein 0.0053 0.0266 0.0266
Echinococcus multilocularis cathepsin L 0.0126 0.2061 0.2061
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0175 0.3276 0.68
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0232 0.4693 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0136 0.2307 0.461
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0073 0.0758 0.0758
Brugia malayi cathepsin Z-like cysteine proteinase 0.0053 0.0266 0.0266
Onchocerca volvulus Cathepsin F homolog 0.0232 0.4693 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0175 0.3276 0.3276
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0073 0.0758 0.0758
Entamoeba histolytica cysteine protease, putative 0.0126 0.2061 0.4054
Brugia malayi cathepsin L-like cysteine proteinase 0.0053 0.0266 0.0266
Loa Loa (eye worm) hypothetical protein 0.0053 0.0266 0.0266
Entamoeba histolytica cysteine protease, putative 0.0126 0.2061 0.4054
Brugia malayi Cathepsin L-like precursor 0.0232 0.4693 0.4693
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0232 0.4693 1
Leishmania major cathepsin L-like protease 0.0232 0.4693 1
Schistosoma mansoni voltage-gated potassium channel 0.0158 0.2871 0.2871
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0232 0.4693 1
Echinococcus granulosus cathepsin L cysteine protease 0.0126 0.2061 0.2061
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0232 0.4693 1
Trypanosoma brucei cysteine peptidase C (CPC) 0.0175 0.3276 0.4618
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0232 0.4693 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0232 0.4693 0.4693
Onchocerca volvulus 0.016 0.2898 0.5946
Entamoeba histolytica cysteine proteinase, putative 0.016 0.2898 0.5946
Brugia malayi Papain family cysteine protease containing protein 0.0232 0.4693 0.4693
Brugia malayi cathepsin L precursor 0.0053 0.0266 0.0266
Echinococcus granulosus cathepsin L 0.0053 0.0266 0.0266
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0232 0.4693 1
Onchocerca volvulus 0.0232 0.4693 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0232 0.4693 0.4693
Echinococcus multilocularis cathepsin L cysteine protease 0.0232 0.4693 0.4693
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0232 0.4693 1
Leishmania major cathepsin L-like protease 0.0232 0.4693 1
Entamoeba histolytica cysteine protease, putative 0.0126 0.2061 0.4054
Onchocerca volvulus 0.0232 0.4693 1
Plasmodium vivax vivapain-1 0.0126 0.2061 0.4054
Echinococcus granulosus cathepsin b 0.0448 1 1
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0126 0.2061 0.1844
Echinococcus granulosus cathepsin l1 0.0232 0.4693 0.4693
Schistosoma mansoni cathepsin F (C01 family) 0.0232 0.4693 0.4693
Entamoeba histolytica cysteine protease, putative 0.0126 0.2061 0.4054
Echinococcus multilocularis cathepsin b 0.0448 1 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0136 0.2307 0.461
Leishmania major cysteine peptidase A (CPA) 0.0232 0.4693 1
Entamoeba histolytica cysteine proteinase, putative 0.0126 0.2061 0.4054
Leishmania major cathepsin L-like protease 0.0232 0.4693 1
Loa Loa (eye worm) hypothetical protein 0.0126 0.207 0.207
Loa Loa (eye worm) cysteine protease 0.0232 0.4693 0.4693
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0232 0.4693 1
Loa Loa (eye worm) hypothetical protein 0.016 0.2898 0.2898
Loa Loa (eye worm) hypothetical protein 0.0053 0.0266 0.0266
Echinococcus granulosus cathepsin b 0.0448 1 1
Brugia malayi Cathepsin L-like precursor 0.0073 0.0758 0.0758
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0325 0.0325
Entamoeba histolytica cysteine protease, putative 0.0126 0.2061 0.4054
Trypanosoma cruzi cysteine peptidase, putative 0.0232 0.4693 0.4548
Entamoeba histolytica cysteine protease, putative 0.0126 0.2061 0.4054
Leishmania major cathepsin L-like protease 0.0232 0.4693 1
Plasmodium falciparum cysteine proteinase falcipain 1 0.0126 0.2061 0.4054
Echinococcus multilocularis cathepsin b 0.0448 1 1
Onchocerca volvulus 0.0232 0.4693 1
Brugia malayi Papain family cysteine protease containing protein 0.0126 0.2061 0.2061
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0448 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0232 0.4693 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0053 0.0266 0.0266
Trypanosoma cruzi cysteine protease, putative 0.0126 0.2061 0.1844
Onchocerca volvulus 0.0232 0.4693 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0232 0.4693 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0232 0.4693 1
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0053 0.0266 0.0266
Brugia malayi Cathepsin L-like precursor 0.0232 0.4693 0.4693
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0325 0.0325
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0126 0.2061 0.2061
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0232 0.4693 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0053 0.0266 0.0266
Trypanosoma cruzi cysteine proteinase, putative 0.0126 0.2061 0.1844
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0232 0.4693 1
Toxoplasma gondii cathepsin B 0.0175 0.3276 0.68
Giardia lamblia Cathepsin B precursor 0.0175 0.3276 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0232 0.4693 1
Loa Loa (eye worm) hypothetical protein 0.0448 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0232 0.4693 1
Giardia lamblia Cathepsin B precursor 0.0175 0.3276 1
Onchocerca volvulus 0.0232 0.4693 1
Schistosoma mansoni cathepsin S (C01 family) 0.0053 0.0266 0.0266
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0053 0.0266 0.0266
Trypanosoma cruzi cysteine peptidase, putative 0.0232 0.4693 0.4548
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0232 0.4693 1
Entamoeba histolytica cysteine proteinase, putative 0.0126 0.2061 0.4054
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0053 0.0266 0.0266
Schistosoma mansoni cathepsin F (C01 family) 0.016 0.2898 0.2898
Brugia malayi Cathepsin L-like cysteine proteinase 0.016 0.2898 0.2898
Loa Loa (eye worm) hypothetical protein 0.0053 0.0266 0.0266
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0232 0.4693 1
Trypanosoma cruzi cysteine peptidase, putative 0.0232 0.4693 0.4548
Onchocerca volvulus Cathepsin L homolog 0.0232 0.4693 1
Loa Loa (eye worm) hypothetical protein 0.016 0.2898 0.2898
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0232 0.4693 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0232 0.4693 1
Brugia malayi Papain family cysteine protease containing protein 0.0053 0.0266 0.0266
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0053 0.0266 0.0266
Brugia malayi cathepsin F-like cysteine proteinase 0.0073 0.0758 0.0758
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0232 0.4693 1
Loa Loa (eye worm) hypothetical protein 0.0232 0.4693 0.4693
Brugia malayi Papain family cysteine protease containing protein 0.0053 0.0266 0.0266
Echinococcus granulosus cathepsin L cysteine proteinase 0.0232 0.4693 0.4693
Echinococcus granulosus cathepsin l cysteine peptidase 0.0232 0.4693 0.4693
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0325 0.0325
Entamoeba histolytica cysteine proteinase, putative 0.0232 0.4693 1
Echinococcus granulosus cathepsin L 0.0126 0.2061 0.2061
Trypanosoma cruzi cruzipain precursor, putative 0.0232 0.4693 0.4548
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0232 0.4693 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0232 0.4693 1
Trypanosoma cruzi cysteine peptidase, putative 0.0232 0.4693 0.4548
Leishmania major cathepsin L-like protease 0.0232 0.4693 1
Loa Loa (eye worm) hypothetical protein 0.0053 0.0266 0.0266
Schistosoma mansoni cathepsin B (C01 family) 0.0053 0.0266 0.0266
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0145 0.2543 0.2543
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0232 0.4693 1
Onchocerca volvulus 0.0232 0.4693 1
Onchocerca volvulus 0.0232 0.4693 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0325 0.0325
Entamoeba histolytica cysteine protease, putative 0.0126 0.2061 0.4054
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0325 0.0325
Entamoeba histolytica cysteine protease, putative 0.0126 0.2061 0.4054
Echinococcus granulosus cysteine protease 0.0126 0.2061 0.2061
Echinococcus multilocularis cathepsin L 0.0053 0.0266 0.0266
Brugia malayi Cathepsin L-like precursor 0.016 0.2898 0.2898
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0232 0.4693 1
Toxoplasma gondii cathepsin CPL 0.0232 0.4693 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0325 0.0325
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0053 0.0266 0.0266
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0053 0.0266 0.0266
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0053 0.0266 0.0266
Trypanosoma cruzi cysteine peptidase, putative 0.0073 0.0758 0.0505
Loa Loa (eye worm) hypothetical protein 0.016 0.2898 0.2898
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0145 0.2543 0.2543
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0053 0.0266 0.0266
Entamoeba histolytica cysteine proteinase, putative 0.0126 0.2061 0.4054
Leishmania major cathepsin L-like protease 0.0232 0.4693 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0232 0.4693 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.016 0.2898 0.5946
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0232 0.4693 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0232 0.4693 1
Loa Loa (eye worm) cathepsin B 0.0175 0.3276 0.3276
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0232 0.4693 1
Plasmodium falciparum cysteine proteinase falcipain 3 0.0232 0.4693 1
Schistosoma mansoni cathepsin F (C01 family) 0.0232 0.4693 0.4693
Plasmodium vivax vivapain-2 0.0232 0.4693 1
Loa Loa (eye worm) ctsf protein 0.0232 0.4693 0.4693
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0232 0.4693 1
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0053 0.0266 0.0266
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0448 1 1
Schistosoma mansoni cathepsin C 0.0053 0.0266 0.0266
Brugia malayi cathepsin F-like cysteine proteinase 0.0053 0.0266 0.0266
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0232 0.4693 1
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0448 1 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0325 0.0325
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0126 0.2061 0.4054
Echinococcus multilocularis cysteine protease 0.0232 0.4693 0.4693
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0053 0.0266 0.0266
Echinococcus granulosus cathepsin l1 0.016 0.2898 0.2898
Entamoeba histolytica cysteine protease, putative 0.0126 0.2061 0.4054
Loa Loa (eye worm) hypothetical protein 0.0073 0.0758 0.0758
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0232 0.4693 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0232 0.4693 1
Giardia lamblia Cathepsin B precursor 0.0175 0.3276 1
Entamoeba histolytica cysteine protease, putative 0.0126 0.2061 0.4054
Entamoeba histolytica cysteine proteinase 1, putative 0.0126 0.2061 0.4054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0232 0.4693 1
Brugia malayi Papain family cysteine protease containing protein 0.0126 0.2061 0.2061
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0232 0.4693 1
Onchocerca volvulus Cathepsin L homolog 0.0232 0.4693 1
Entamoeba histolytica cysteine protease, putative 0.0232 0.4693 1
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0145 0.2543 0.2543
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.016 0.2898 0.2704
Loa Loa (eye worm) hypothetical protein 0.0073 0.0758 0.0758
Plasmodium vivax vivapain-3 0.0126 0.2061 0.4054
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0448 1 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0126 0.2061 0.2061
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0448 1 1
Brugia malayi Cathepsin L-like precursor 0.016 0.2898 0.2898
Brugia malayi Cathepsin L-like precursor 0.0232 0.4693 0.4693
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0232 0.4693 0.4693
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0126 0.2061 0.4054
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0126 0.2061 0.2061
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0325 0.0325
Trypanosoma cruzi cysteine proteinase, putative 0.0126 0.2061 0.1844
Loa Loa (eye worm) hypothetical protein 0.0073 0.0758 0.0758
Leishmania major cathepsin L-like protease 0.0232 0.4693 1
Plasmodium vivax unspecified product 0.0073 0.0758 0.1111
Schistosoma mansoni voltage-gated potassium channel 0.0158 0.2871 0.2871
Brugia malayi Cathepsin L-like precursor 0.0232 0.4693 0.4693
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0232 0.4693 1
Entamoeba histolytica cysteine proteinase, putative 0.0232 0.4693 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0053 0.0266 0.0266
Entamoeba histolytica cysteine protease, putative 0.0126 0.2061 0.4054
Plasmodium vivax unspecified product 0.0126 0.2061 0.4054
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0232 0.4693 0.4693
Entamoeba histolytica cysteine proteinase, putative 0.0126 0.2061 0.4054
Brugia malayi Papain family cysteine protease containing protein 0.0053 0.0266 0.0266
Echinococcus multilocularis cysteine protease 0.0232 0.4693 0.4693
Brugia malayi Cathepsin L-like precursor 0.0232 0.4693 0.4693
Leishmania major cathepsin L-like protease 0.0232 0.4693 1
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0175 0.3276 0.3093

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.8913 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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