Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ubiquitin specific peptidase 1 | Starlite/ChEMBL | No references |
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0342 | 0.5715 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0342 | 0.5715 | 0.5715 |
Schistosoma mansoni | synaptic glycoprotein sc2 related | 0.0342 | 0.5715 | 1 |
Trypanosoma brucei | 3-oxo-5-alpha-steroid 4-dehydrogenase-like, putative | 0.0556 | 1 | 1 |
Brugia malayi | Synaptic glycoprotein SC2 | 0.0342 | 0.5715 | 0.5715 |
Loa Loa (eye worm) | hypothetical protein | 0.0556 | 1 | 1 |
Giardia lamblia | Synaptic glycoprotein SC2 | 0.0342 | 0.5715 | 0.5 |
Toxoplasma gondii | 3-oxo-5-alpha-steroid 4-dehydrogenase | 0.0556 | 1 | 1 |
Echinococcus granulosus | synaptic glycoprotein sc2 | 0.0342 | 0.5715 | 1 |
Echinococcus granulosus | 3 oxo 5 alpha steroid 4 dehydrogenase C terminal | 0.0342 | 0.5715 | 1 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0556 | 1 | 1 |
Plasmodium vivax | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0342 | 0.5715 | 0.5 |
Schistosoma mansoni | synaptic glycoprotein sc2 related | 0.0342 | 0.5715 | 1 |
Echinococcus multilocularis | synaptic glycoprotein sc2 | 0.0342 | 0.5715 | 1 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0556 | 1 | 1 |
Plasmodium vivax | polyprenol reductase, putative | 0.0342 | 0.5715 | 0.5 |
Entamoeba histolytica | steroid 5-alpha reductase, putative | 0.0556 | 1 | 1 |
Trypanosoma cruzi | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0556 | 1 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0556 | 1 | 0.5 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0556 | 1 | 1 |
Plasmodium falciparum | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0342 | 0.5715 | 0.5 |
Plasmodium falciparum | polyprenol reductase, putative | 0.0342 | 0.5715 | 0.5 |
Trypanosoma cruzi | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0556 | 1 | 1 |
Echinococcus multilocularis | 3 oxo 5 alpha steroid 4 dehydrogenase, C terminal | 0.0342 | 0.5715 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0342 | 0.5715 | 0.5715 |
Leishmania major | 3-oxo-5-alpha-steroid 4-dehydrogenase-like protein | 0.0556 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 7.0795 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.