Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Homo sapiens | ubiquitin specific peptidase 1 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | 3 oxo 5 alpha steroid 4 dehydrogenase, C terminal | 0.0342 | 0.5715 | 1 |
Entamoeba histolytica | steroid 5-alpha reductase, putative | 0.0556 | 1 | 1 |
Onchocerca volvulus | 0.0342 | 0.5715 | 0.5 | |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0556 | 1 | 1 |
Plasmodium vivax | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0342 | 0.5715 | 0.5 |
Echinococcus granulosus | 3 oxo 5 alpha steroid 4 dehydrogenase C terminal | 0.0342 | 0.5715 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0342 | 0.5715 | 0.5715 |
Schistosoma mansoni | synaptic glycoprotein sc2 related | 0.0342 | 0.5715 | 1 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0556 | 1 | 1 |
Giardia lamblia | Synaptic glycoprotein SC2 | 0.0342 | 0.5715 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0556 | 1 | 1 |
Echinococcus granulosus | synaptic glycoprotein sc2 | 0.0342 | 0.5715 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0556 | 1 | 0.5 |
Trypanosoma cruzi | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0556 | 1 | 1 |
Trypanosoma brucei | 3-oxo-5-alpha-steroid 4-dehydrogenase-like, putative | 0.0556 | 1 | 1 |
Echinococcus multilocularis | synaptic glycoprotein sc2 | 0.0342 | 0.5715 | 1 |
Trypanosoma cruzi | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0556 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0342 | 0.5715 | 0.5715 |
Toxoplasma gondii | 3-oxo-5-alpha-steroid 4-dehydrogenase | 0.0556 | 1 | 1 |
Schistosoma mansoni | synaptic glycoprotein sc2 related | 0.0342 | 0.5715 | 1 |
Plasmodium falciparum | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0342 | 0.5715 | 0.5 |
Plasmodium vivax | polyprenol reductase, putative | 0.0342 | 0.5715 | 0.5 |
Leishmania major | 3-oxo-5-alpha-steroid 4-dehydrogenase-like protein | 0.0556 | 1 | 0.5 |
Plasmodium falciparum | polyprenol reductase, putative | 0.0342 | 0.5715 | 0.5 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0556 | 1 | 1 |
Brugia malayi | Synaptic glycoprotein SC2 | 0.0342 | 0.5715 | 0.5715 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 7.0795 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.