Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ubiquitin specific peptidase 1 | Starlite/ChEMBL | No references |
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0342 | 0.5715 | 0.5 |
Plasmodium vivax | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0342 | 0.5715 | 0.5 |
Plasmodium vivax | polyprenol reductase, putative | 0.0342 | 0.5715 | 0.5 |
Echinococcus multilocularis | synaptic glycoprotein sc2 | 0.0342 | 0.5715 | 1 |
Echinococcus granulosus | synaptic glycoprotein sc2 | 0.0342 | 0.5715 | 1 |
Leishmania major | 3-oxo-5-alpha-steroid 4-dehydrogenase-like protein | 0.0556 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0556 | 1 | 1 |
Trypanosoma cruzi | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0556 | 1 | 1 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0556 | 1 | 1 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0556 | 1 | 1 |
Echinococcus granulosus | 3 oxo 5 alpha steroid 4 dehydrogenase C terminal | 0.0342 | 0.5715 | 1 |
Schistosoma mansoni | synaptic glycoprotein sc2 related | 0.0342 | 0.5715 | 1 |
Trypanosoma brucei | 3-oxo-5-alpha-steroid 4-dehydrogenase-like, putative | 0.0556 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0342 | 0.5715 | 0.5715 |
Plasmodium falciparum | polyprenol reductase, putative | 0.0342 | 0.5715 | 0.5 |
Schistosoma mansoni | synaptic glycoprotein sc2 related | 0.0342 | 0.5715 | 1 |
Trypanosoma cruzi | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0556 | 1 | 1 |
Brugia malayi | Synaptic glycoprotein SC2 | 0.0342 | 0.5715 | 0.5715 |
Mycobacterium ulcerans | hypothetical protein | 0.0556 | 1 | 0.5 |
Toxoplasma gondii | 3-oxo-5-alpha-steroid 4-dehydrogenase | 0.0556 | 1 | 1 |
Giardia lamblia | Synaptic glycoprotein SC2 | 0.0342 | 0.5715 | 0.5 |
Entamoeba histolytica | steroid 5-alpha reductase, putative | 0.0556 | 1 | 1 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0556 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0342 | 0.5715 | 0.5715 |
Onchocerca volvulus | 0.0342 | 0.5715 | 0.5 | |
Echinococcus multilocularis | 3 oxo 5 alpha steroid 4 dehydrogenase, C terminal | 0.0342 | 0.5715 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 7.0795 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.