Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) | 0.0633 | 0.5066 | 0.5326 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0054 | 0.0021 | 0.01 |
Mycobacterium ulcerans | beta-ketoacyl synthase-like protein | 0.0633 | 0.5066 | 0.4922 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0082 | 0.0264 | 0.5 |
Plasmodium vivax | beta-ketoacyl-acyl carrier protein synthase III precursor, putative | 0.0633 | 0.5066 | 1 |
Brugia malayi | SWIRM domain containing protein | 0.0084 | 0.0284 | 0.1363 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0054 | 0.0021 | 0.01 |
Schistosoma mansoni | hypothetical protein | 0.0185 | 0.1157 | 1 |
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | 0.1115 | 0.9264 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.0284 | 0.1363 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.0633 | 0.5066 | 0.4922 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0082 | 0.0264 | 0.5 |
Leishmania major | UDP-galactopyranose mutase | 0.0084 | 0.0284 | 0.5 |
Echinococcus multilocularis | 0.0084 | 0.0284 | 0.2451 | |
Loa Loa (eye worm) | pax transcription factor protein 2 | 0.0291 | 0.208 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.0284 | 0.1363 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0082 | 0.0264 | 0.5 |
Echinococcus multilocularis | lysine specific histone demethylase 1A | 0.0084 | 0.0284 | 0.2451 |
Brugia malayi | hypothetical protein | 0.0084 | 0.0284 | 0.1363 |
Echinococcus granulosus | geminin | 0.0185 | 0.1157 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0185 | 0.1157 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0054 | 0.0021 | 0.01 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0082 | 0.0264 | 0.5 |
Chlamydia trachomatis | oxoacyl-ACP synthase III | 0.0633 | 0.5066 | 1 |
Toxoplasma gondii | histone lysine-specific demethylase LSD1/BHC110/KDMA1A | 0.0084 | 0.0284 | 0.5 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0082 | 0.0264 | 0.5 |
Schistosoma mansoni | Protoporphyrinogen oxidase chloroplast/mitochondrial precursor | 0.0084 | 0.0284 | 0.2451 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0021 | 0.01 |
Echinococcus multilocularis | protoporphyrinogen oxidase | 0.0084 | 0.0284 | 0.2451 |
Onchocerca volvulus | 0.0084 | 0.0284 | 0.1363 | |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.0284 | 0.1363 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0084 | 0.0284 | 0.5 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.0633 | 0.5066 | 0.4922 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.0284 | 0.1363 |
Brugia malayi | amine oxidase, flavin-containing family protein | 0.0084 | 0.0284 | 0.1363 |
Brugia malayi | Pax transcription factor protein 2 | 0.0291 | 0.208 | 1 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0084 | 0.0284 | 0.2451 |
Mycobacterium leprae | PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) | 0.0084 | 0.0284 | 0.5 |
Schistosoma mansoni | Lysine-specific histone demethylase 1 | 0.0084 | 0.0284 | 0.2451 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0054 | 0.0019 | 0.009 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.0284 | 0.1363 |
Schistosoma mansoni | amine oxidase | 0.0084 | 0.0284 | 0.2451 |
Wolbachia endosymbiont of Brugia malayi | 3-oxoacyl-ACP synthase | 0.0633 | 0.5066 | 0.5 |
Plasmodium falciparum | beta-ketoacyl-ACP synthase III | 0.0633 | 0.5066 | 1 |
Schistosoma mansoni | amine oxidase | 0.0084 | 0.0284 | 0.2451 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.12 | 1 | 1 |
Onchocerca volvulus | 0.0291 | 0.208 | 1 | |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0084 | 0.0284 | 0.5 |
Echinococcus multilocularis | geminin | 0.0185 | 0.1157 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0054 | 0.0019 | 0.009 |
Toxoplasma gondii | histone lysine-specific demethylase | 0.0084 | 0.0284 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.0284 | 0.1363 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0084 | 0.0284 | 0.2451 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.