Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ubiquitin specific peptidase 1 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Choline O-acetyltransferase | 0.0252 | 0.0553 | 0.0469 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.0383 | 0.6932 |
Trypanosoma brucei | carnitine O-palmitoyltransferase, putative | 0.0252 | 0.0553 | 0.5 |
Onchocerca volvulus | 0.0252 | 0.0553 | 0.5 | |
Onchocerca volvulus | 0.0252 | 0.0553 | 0.5 | |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.1372 | 0.4605 | 1 |
Trypanosoma brucei | carnitine O-palmitoyltransferase II, putative | 0.0252 | 0.0553 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.0489 | 0.1412 | 0.293 |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.0252 | 0.0553 | 0.0469 |
Loa Loa (eye worm) | hypothetical protein | 0.2863 | 1 | 1 |
Loa Loa (eye worm) | carnitine O-palmitoyltransferase I isoform | 0.0252 | 0.0553 | 0.0469 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.0383 | 0.6932 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 1, liver | 0.1372 | 0.4605 | 1 |
Loa Loa (eye worm) | choline/Carnitine O-acyltransferase | 0.0252 | 0.0553 | 0.0469 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.1372 | 0.4605 | 1 |
Leishmania major | choline/Carnitine o-acyltransferase-like protein | 0.1372 | 0.4605 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0252 | 0.0553 | 0.0469 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0252 | 0.0553 | 0.5 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 2 | 0.0252 | 0.0553 | 0.1029 |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.0252 | 0.0553 | 0.0469 |
Trypanosoma brucei | carnitine O-acetyltransferase, putative | 0.0252 | 0.0553 | 0.5 |
Onchocerca volvulus | 0.0252 | 0.0553 | 0.5 | |
Brugia malayi | Choline O-acetyltransferase | 0.0252 | 0.0553 | 0.0469 |
Loa Loa (eye worm) | choline O-acetyltransferase | 0.0252 | 0.0553 | 0.0469 |
Echinococcus granulosus | carnitine O palmitoyltransferase 2 | 0.0252 | 0.0553 | 0.1029 |
Onchocerca volvulus | 0.0252 | 0.0553 | 0.5 | |
Trypanosoma brucei | carnitine O-palmitoyltransferase II, putative | 0.0252 | 0.0553 | 0.5 |
Echinococcus granulosus | choline O acetyltransferase | 0.0252 | 0.0553 | 0.1029 |
Echinococcus multilocularis | geminin | 0.0205 | 0.0383 | 0.0653 |
Echinococcus multilocularis | choline O acetyltransferase | 0.0252 | 0.0553 | 0.1029 |
Echinococcus granulosus | geminin | 0.0205 | 0.0383 | 0.0653 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0123 | 0.0088 | 0.1596 |
Schistosoma mansoni | choline o-acyltransferase | 0.0252 | 0.0553 | 1 |
Echinococcus granulosus | carnitine O palmitoyltransferase 1 liver | 0.1372 | 0.4605 | 1 |
Schistosoma mansoni | choline o-acyltransferase | 0.0252 | 0.0553 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.1259 uM | PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.