TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 473.928 | Formula: C23H25ClFN5O3
H donors: 3 H acceptors: 4 LogP: 3.48 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: OC[C@H]1O[C@H](CC[C@@H]1NC(=O)Nc1ccc(cc1)Cl)CCn1nnc(c1)c1ccccc1F
InChi: 1S/C23H25ClFN5O3/c24-15-5-7-16(8-6-15)26-23(32)27-20-10-9-17(33-22(20)14-31)11-12-30-13-21(28-29-30)18-3-1-2-4-19(18)25/h1-8,13,17,20,22,31H,9-12,14H2,(H2,26,27,32)/t17-,20+,22-/m1/s1
InChiKey: DFXHLBQSDWHRLL-PIPMEXSNSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	glucagon-like peptide 1 receptor	Starlite/ChEMBL	No references
Homo sapiens	TAR DNA binding protein	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	TAR DNA-binding protein 43, putative	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma japonicum	TAR DNA-binding protein 43, putative	Get druggable targets OG5_132461	All targets in OG5_132461
Loa Loa (eye worm)	TAR-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Brugia malayi	RNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Echinococcus granulosus	tar DNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Brugia malayi	TAR-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Loa Loa (eye worm)	RNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Echinococcus multilocularis	tar DNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	Get druggable targets OG5_132461	All targets in OG5_132461
Brugia malayi	RNA recognition motif domain containing protein	Get druggable targets OG5_132461	All targets in OG5_132461

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Loa Loa (eye worm)	pigment dispersing factor receptor c	glucagon-like peptide 1 receptor	463 aa	388 aa	25.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0084	0.0199
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.006	0.1193	0.5343
Loa Loa (eye worm)	hypothetical protein	0.003	0.0469	0.2017
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0084	0.0199
Trypanosoma brucei	glucose transporter 1E	0.0031	0.0493	0.8107
Echinococcus granulosus	General substrate transporter	0.0086	0.1821	0.8364
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0084	0.0199
Onchocerca volvulus		0.0014	0.0084	0.5
Plasmodium vivax	CDK-related protein kinase 6, putative	0.0426	1	1
Brugia malayi	Bifunctional aminoacyl-tRNA synthetase	0.003	0.0469	0.1855
Treponema pallidum	prolyl-tRNA synthetase	0.0011	0	0.5
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.1586	0.7233
Trichomonas vaginalis	conserved hypothetical protein	0.01	0.216	1
Mycobacterium ulcerans	fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT	0.0014	0.0084	0.2954
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.0031	0.0484	0.2088
Trypanosoma brucei	glucose transporter, putative	0.0031	0.0493	0.8107
Giardia lamblia	Prolyl-tRNA synthetase	0.003	0.0469	1
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.003	0.0469	0.1855
Schistosoma mansoni	protein kinase	0.0031	0.0484	0.1927
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.003	0.0469	0.1855
Schistosoma mansoni	hypothetical protein	0.01	0.216	1
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.1586	0.7233
Plasmodium falciparum	lysine--tRNA ligase	0.0022	0.0283	0.0201
Onchocerca volvulus		0.0014	0.0084	0.5
Trypanosoma brucei	glucose transporter, putative	0.0031	0.0493	0.8107
Plasmodium falciparum	mitogen-activated protein kinase 2	0.0162	0.3649	0.3595
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0084	0.0199
Onchocerca volvulus		0.0014	0.0084	0.5
Echinococcus granulosus	GPCR family 2	0.0019	0.0203	0.0572
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0333	0.1375
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 2 LysX	0.0019	0.0202	1
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0035	0.0589	1
Leishmania major	lysyl-tRNA synthetase, putative	0.0022	0.0283	0.395
Brugia malayi	Latrophilin receptor protein 2	0.0019	0.0203	0.0572
Schistosoma mansoni	glucose transport protein	0.01	0.216	1
Entamoeba histolytica	protein kinase, putative	0.0031	0.0484	1
Onchocerca volvulus	Putative transporter	0.0014	0.0084	0.5
Schistosoma mansoni	hypothetical protein	0.0019	0.0203	0.0572
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0019	0.0203	0.076
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0031	0.0484	0.1927
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.01	0.216	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.006	0.1193	0.5436
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	0.0031	0.0484	0.7919
Entamoeba histolytica	protein kinase, putative	0.0031	0.0484	1
Schistosoma mansoni	serine/threonine protein kinase	0.0031	0.0484	0.1927
Plasmodium falciparum	proline--tRNA ligase	0.0035	0.0589	0.051
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.0031	0.0484	0.1927
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0014	0.0084	0.0199
Trypanosoma brucei	bifunctional aminoacyl-tRNA synthetase, putative	0.0035	0.0589	1
Schistosoma mansoni	hypothetical protein	0.0019	0.0203	0.0572
Plasmodium falciparum	calcium-dependent protein kinase 1	0.0031	0.0484	0.0404
Onchocerca volvulus		0.0014	0.0084	0.5
Plasmodium vivax	lysine--tRNA ligase, putative	0.0022	0.0283	0.0201
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	0.0031	0.0484	0.0617
Plasmodium falciparum	calcium-dependent protein kinase 5	0.0031	0.0484	0.0404
Schistosoma mansoni	protein kinase	0.0031	0.0484	0.1927
Leishmania major	glucose transporter, lmgt2	0.0031	0.0493	0.8107
Onchocerca volvulus		0.0014	0.0084	0.5
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	0.0031	0.0484	0.0617
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0031	0.0493	0.8107
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0022	0.0283	1
Brugia malayi	RNA binding protein	0.0076	0.1586	0.7233
Loa Loa (eye worm)	hypothetical protein	0.003	0.0469	0.2017
Mycobacterium leprae	Possible lysyl-tRNA synthetase 2 LysX	0.0022	0.0283	0.3046
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	0.0031	0.0484	0.0617
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0014	0.0084	0.0199
Brugia malayi	RNA recognition motif domain containing protein	0.0076	0.1586	0.7233
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0283	0.1141
Trypanosoma cruzi	hexose transporter, putative	0.0031	0.0493	0.8107
Onchocerca volvulus		0.0014	0.0084	0.5
Mycobacterium ulcerans	sugar transporter	0.0014	0.0084	0.2954
Plasmodium falciparum	calcium-dependent protein kinase 2	0.0031	0.0484	0.0404
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0019	0.0203	0.0572
Toxoplasma gondii	lysine-tRNA ligase	0.0022	0.0283	0.0308
Trypanosoma brucei	glucose transporter 2A	0.0031	0.0493	0.8107
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0735	0.3272
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0084	0.0199
Onchocerca volvulus		0.0014	0.0084	0.5
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0031	0.0484	0.0404
Wolbachia endosymbiont of Brugia malayi	major facilitator superfamily permease	0.0014	0.0084	0.5
Mycobacterium ulcerans	sugar-transport integral membrane protein SugI	0.0014	0.0084	0.2954
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0022	0.0283	0.395
Trypanosoma brucei	glucose transporter, putative	0.0031	0.0493	0.8107
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0084	0.0199
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0035	0.0589	1
Toxoplasma gondii	prolyl-tRNA synthetase (ProRS)	0.0035	0.0589	0.0779
Onchocerca volvulus		0.0014	0.0084	0.5
Plasmodium vivax	calcium-dependent protein kinase, putative	0.0031	0.0484	0.0404
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0084	0.0199
Onchocerca volvulus		0.0014	0.0084	0.5
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.0031	0.0484	0.0404
Schistosoma mansoni	lysyl-tRNA synthetase	0.0022	0.0283	0.0961
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0.0493	0.1973
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.002	0.0217	0.0641
Mycobacterium ulcerans	integral membrane transport protein	0.0014	0.0084	0.2954
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0084	0.0199
Echinococcus granulosus	glutamyl tRNA synthetase cytoplasmic	0.003	0.0469	0.1855
Plasmodium falciparum	calcium-dependent protein kinase 4	0.0031	0.0484	0.0404
Plasmodium falciparum	hexose transporter	0.01	0.216	0.2094
Plasmodium falciparum	calcium-dependent protein kinase 3	0.0031	0.0484	0.0404
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0031	0.0484	0.1927
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0031	0.0484	0.1927
Echinococcus multilocularis	GPCR, family 2	0.0019	0.0203	0.0572
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0084	0.0199
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.01	0.216	1
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0022	0.0283	0.0961
Schistosoma mansoni	protein kinase	0.0031	0.0484	0.1927
Brugia malayi	Sugar transporter family protein	0.01	0.216	1
Trypanosoma brucei	glucose transporter, putative	0.0031	0.0493	0.8107
Schistosoma mansoni	hypothetical protein	0.0019	0.0203	0.0572
Onchocerca volvulus		0.0014	0.0084	0.5
Echinococcus granulosus	calcium dependent protein kinase	0.0029	0.0438	0.1707
Entamoeba histolytica	prolyl-tRNA synthetase, putative	0.003	0.0469	0.9253
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0084	0.0199
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0022	0.0283	1
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.1586	0.7233
Echinococcus multilocularis	General substrate transporter	0.0086	0.1821	0.8364
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0019	0.0202	1
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0019	0.0203	0.0572
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0084	0.0199
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0076	0.1586	0.7288
Trypanosoma cruzi	hexose transporter, putative	0.0031	0.0493	0.8107
Onchocerca volvulus		0.0014	0.0084	0.5
Schistosoma mansoni	glucose transport protein	0.01	0.216	1
Brugia malayi	Calcitonin receptor-like protein seb-1	0.006	0.1193	0.5343
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.01	0.216	1
Plasmodium vivax	hexose transporter	0.01	0.216	0.2094
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0031	0.0493	0.8107
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0084	0.0199
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0031	0.0484	0.1927
Loa Loa (eye worm)	sugar transporter	0.0014	0.0084	0.0199
Brugia malayi	TAR-binding protein	0.0076	0.1586	0.7233
Toxoplasma gondii	cell-cycle-associated protein kinase MAPK, putative	0.0162	0.3649	0.5495
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0084	0.0199
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0031	0.0493	0.8107
Brugia malayi	latrophilin 2 splice variant baaae	0.0041	0.0735	0.3135
Toxoplasma gondii	protein kinase, putative	0.0284	0.6571	1
Toxoplasma gondii	facilitative glucose transporter GT1	0.01	0.216	0.3201
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0035	0.0589	1
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.0031	0.0484	0.2088
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0493	0.1973
Schistosoma mansoni	glucose transport protein	0.01	0.216	1
Plasmodium falciparum	protein kinase 7	0.0284	0.6571	0.6542
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0493	0.1973
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0203	0.076
Echinococcus multilocularis	tar DNA binding protein	0.0076	0.1586	0.7233
Trichomonas vaginalis	glucose transporter, putative	0.0031	0.0493	0.1973
Trichomonas vaginalis	prolyl-tRNA synthetase, putative	0.003	0.0469	0.1855
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0084	0.0199
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0019	0.0203	0.0572
Chlamydia trachomatis	lysine--tRNA ligase	0.0022	0.0283	1
Onchocerca volvulus		0.0014	0.0084	0.5
Schistosoma mansoni	lysyl-tRNA synthetase	0.0022	0.0283	0.0961
Loa Loa (eye worm)	sugar transporter	0.01	0.216	1
Giardia lamblia	Lysyl-tRNA synthetase	0.0022	0.0283	0.5182
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0084	0.0199
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0493	0.1973
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0.0493	0.1973
Trypanosoma cruzi	hexose transporter	0.0031	0.0493	0.8107
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0031	0.0484	0.1927
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0019	0.0203	0.0572
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.01	0.216	1
Plasmodium vivax	mitogen-activated protein kinase 2, putative	0.0162	0.3649	0.3595
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.01	0.216	1
Schistosoma mansoni	hypothetical protein	0.0019	0.0203	0.0572
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0035	0.0589	1
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.003	0.0469	0.1855
Plasmodium vivax	proline--tRNA ligase, putative	0.0035	0.0589	0.051
Trichomonas vaginalis	CAMK family protein kinase	0.0031	0.0484	0.1927
Loa Loa (eye worm)	hypothetical protein	0.006	0.1193	0.5436
Mycobacterium leprae	Probable prolyl tRNA synthetase ProS	0.003	0.0469	1
Trypanosoma brucei	glucose transporter, putative	0.0031	0.0493	0.8107
Echinococcus granulosus	lysyl tRNA synthetase	0.0022	0.0283	0.0961
Onchocerca volvulus		0.0014	0.0084	0.5
Onchocerca volvulus		0.0014	0.0084	0.5
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0031	0.0484	0.1927
Onchocerca volvulus		0.0014	0.0084	0.5
Trichomonas vaginalis	glucose transporter, putative	0.0031	0.0493	0.1973
Leishmania major	glucose transporter, lmgt1	0.0031	0.0493	0.8107
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.01	0.216	1
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.01	0.216	1
Schistosoma mansoni	hypothetical protein	0.0041	0.0735	0.3135
Brugia malayi	lysyl-tRNA synthetase	0.0022	0.0283	0.0961
Leishmania major	glucose transporter, lmgt3	0.0031	0.0493	0.8107
Loa Loa (eye worm)	TAR-binding protein	0.0076	0.1586	0.7288
Trypanosoma brucei	glucose transporter, putative	0.0031	0.0493	0.8107
Trypanosoma brucei	glucose transporter, putative	0.0031	0.0493	0.8107
Echinococcus multilocularis	lysyl tRNA synthetase	0.0022	0.0283	0.0961
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.1586	0.7233
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0031	0.0484	0.1927
Trypanosoma brucei	glucose transporter, putative	0.0031	0.0493	0.8107
Echinococcus multilocularis	calcium dependent protein kinase	0.0029	0.0438	0.1707
Loa Loa (eye worm)	RNA binding protein	0.0076	0.1586	0.7288
Echinococcus multilocularis	glutamyl tRNA synthetase cytoplasmic	0.003	0.0469	0.1855
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.0031	0.0484	0.0404
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0031	0.0484	0.1927
Brugia malayi	Cam kinase protein 1	0.0031	0.0484	0.1927
Echinococcus granulosus	tar DNA binding protein	0.0076	0.1586	0.7233
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0031	0.0493	0.8107
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.1586	0.7233
Onchocerca volvulus		0.0014	0.0084	0.5
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.0022	0.0283	0.395
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0484	0.2088
Trypanosoma cruzi	hexose transporter, putative	0.0017	0.0154	0.1383
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.01	0.216	1
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0019	0.0203	0.0572
Leishmania major	protein kinase, putative	0.0031	0.0484	0.7919
Trypanosoma cruzi	hexose transporter, putative	0.0031	0.0493	0.8107

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	0.3162 uM	PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	12.5893 uM	PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2136287

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1712593