Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | nicastrin | References | |
Homo sapiens | APH1B gamma secretase subunit | Starlite/ChEMBL | References |
Homo sapiens | presenilin enhancer gamma secretase subunit | References | |
Homo sapiens | presenilin 1 | References | |
Homo sapiens | APH1A gamma secretase subunit | References | |
Homo sapiens | presenilin 2 | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | oxalate:formate antiporter | presenilin enhancer gamma secretase subunit | 101 aa | 98 aa | 29.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | presenilin enhancer 2 | 0.0233 | 0.2892 | 0.2378 |
Loa Loa (eye worm) | gamma-secretase subunit pen-2 | 0.0233 | 0.2892 | 0.2892 |
Toxoplasma gondii | hypothetical protein | 0.0087 | 0 | 0.5 |
Leishmania major | presenilin-like aspartic peptidase, putative,presenilin-like aspartic peptidase, clan AD, family A22A, putative | 0.0248 | 0.3194 | 0.5 |
Entamoeba histolytica | presenilin 1 peptidase, putative | 0.0248 | 0.3194 | 0.5 |
Brugia malayi | hypothetical protein | 0.0121 | 0.0674 | 0.0674 |
Trichomonas vaginalis | Clan AD, family A22, presenilin-like aspartic peptidase | 0.0248 | 0.3194 | 1 |
Echinococcus granulosus | gamma secretase subunit aph 1 | 0.0592 | 1 | 1 |
Trypanosoma cruzi | presenilin-like aspartic peptidase, putative | 0.0248 | 0.3194 | 1 |
Echinococcus multilocularis | presenilin enhancer 2 | 0.0233 | 0.2892 | 0.2378 |
Trypanosoma brucei | presenilin-like aspartic peptidase, putative | 0.0248 | 0.3194 | 1 |
Echinococcus multilocularis | gamma secretase subunit aph 1 | 0.0592 | 1 | 1 |
Schistosoma mansoni | subfamily A22A unassigned peptidase (A22 family) | 0.0248 | 0.3194 | 0.2702 |
Echinococcus multilocularis | presenilin | 0.0248 | 0.3194 | 0.2702 |
Loa Loa (eye worm) | gamma-secretase subunit aph-1 | 0.0592 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0121 | 0.0674 | 0.0674 |
Schistosoma mansoni | gamma-secretase subunit aph-1 | 0.0592 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0121 | 0.0674 | 0.0674 |
Echinococcus granulosus | presenilin | 0.0248 | 0.3194 | 0.2702 |
Trypanosoma cruzi | presenilin-like aspartic peptidase, putative | 0.0248 | 0.3194 | 1 |
Trichomonas vaginalis | Clan AD, family A22, presenilin-like aspartic peptidase | 0.0248 | 0.3194 | 1 |
Brugia malayi | gamma-secretase subunit pen-2 | 0.0233 | 0.2892 | 0.2892 |
Brugia malayi | Presenilin family protein | 0.0248 | 0.3194 | 0.3194 |
Trichomonas vaginalis | Clan AD, family A22, presenilin-like aspartic peptidase | 0.0248 | 0.3194 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | Reduction in total amyloid beta level in CD1 mouse at 30 mg/kg, po at 4 hrs by ELISA relative to control | ChEMBL. | 22650177 | |
IC50 (binding) | = 2113 nM | Modulation of gamma-secretase in human SK-N-BE(2) cells expressing wild type APP 695 assessed as reduction in amyloid beta 42 level after overnight incubation by sandwich immunoassay | ChEMBL. | 22650177 |
Inhibition (binding) | Inhibition of beta-secretase in human SK-N-BE(2) cells expressing wild type APP 695 assessed as reduction in total amyloid beta level up to 10 uM after overnight incubation by sandwich immunoassay | ChEMBL. | 22650177 | |
Inhibition (binding) | Inhibition of gamma-secretase in human SK-N-BE(2) cells expressing wild type APP 695 assessed as reduction in total amyloid beta level up to 10 uM after overnight incubation by sandwich immunoassay | ChEMBL. | 22650177 | |
Inhibition (functional) | Antialzheimer activity in CD1 mouse assessed as reduction in amyloid beta 42 level in brain at 30 mg/kg, po at 4 hrs by ELISA relative to control | ChEMBL. | 22650177 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.