Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Cryptosporidium parvum | inosine-5-monophosphate dehydrogenase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | GMP reductase | 0.0136355 | 0.291506 | 0.5 |
Brugia malayi | inosine-5'-monophosphate dehydrogenase family protein | 0.0136355 | 0.291506 | 0.813405 |
Entamoeba histolytica | hypothetical protein | 0.0167409 | 0.358378 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.000108061 | 0.000208378 | 0.000208378 |
Plasmodium falciparum | inosine-5'-monophosphate dehydrogenase | 0.0136355 | 0.291506 | 0.5 |
Trypanosoma cruzi | GMP reductase | 0.0136355 | 0.291506 | 0.5 |
Echinococcus granulosus | kelch protein 10 | 0.000107916 | 0.000205258 | 0.000205694 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0167409 | 0.358378 | 0.359139 |
Brugia malayi | Kelch motif family protein | 0.000108061 | 0.000208378 | 0.000581449 |
Echinococcus multilocularis | kelch protein 12 | 0.000108061 | 0.000208378 | 0.000208378 |
Brugia malayi | inosine-5'-monophosphate dehydrogenase | 0.00617284 | 0.130806 | 0.364995 |
Echinococcus granulosus | kelch protein 12 | 0.000108061 | 0.000208378 | 0.000208821 |
Echinococcus multilocularis | kelch protein 10 | 0.000107916 | 0.000205258 | 0.000205258 |
Leishmania major | inosine-5-monophosphate dehydrogenase | 0.0136355 | 0.291506 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0167409 | 0.358378 | 0.358378 |
Schistosoma mansoni | hypothetical protein | 0.000108061 | 0.000208378 | 0.000208378 |
Loa Loa (eye worm) | kelch domain-containing protein family protein | 0.000108061 | 0.000208378 | 0.000714834 |
Loa Loa (eye worm) | IMP dehydrogenase 1 | 0.0136355 | 0.291506 | 1 |
Onchocerca volvulus | Putative GMP reductase | 0.00617284 | 0.130806 | 1 |
Echinococcus granulosus | kelch protein 3 | 0.000108061 | 0.000208378 | 0.000208821 |
Plasmodium vivax | inosine-5'-monophosphate dehydrogenase, putative | 0.0136355 | 0.291506 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0167409 | 0.358378 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.000107916 | 0.000205258 | 0.000205258 |
Brugia malayi | GMP reductase | 0.00617284 | 0.130806 | 0.364995 |
Schistosoma mansoni | hypothetical protein | 0.000108061 | 0.000208378 | 0.000208378 |
Mycobacterium leprae | Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena | 0.00746269 | 0.158581 | 0.172839 |
Entamoeba histolytica | hypothetical protein | 0.0167409 | 0.358378 | 0.5 |
Brugia malayi | inosine-5'-monophosphate dehydrogenase | 0.00617284 | 0.130806 | 0.364995 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0136355 | 0.291506 | 0.5 |
Echinococcus multilocularis | kelch protein 3 | 0.000108061 | 0.000208378 | 0.000208378 |
Schistosoma mansoni | hypothetical protein | 0.000107916 | 0.000205258 | 0.000205258 |
Wolbachia endosymbiont of Brugia malayi | IMP dehydrogenase | 0.0136355 | 0.291506 | 0.5 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0167409 | 0.358378 | 0.358378 |
Trypanosoma cruzi | GMP reductase | 0.0136355 | 0.291506 | 0.5 |
Schistosoma mansoni | inosine-5-monophosphate dehydrogenase | 0.0136355 | 0.291506 | 0.291506 |
Brugia malayi | BTB/POZ domain containing protein | 0.000108061 | 0.000208378 | 0.000581449 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0136355 | 0.291506 | 0.5 |
Brugia malayi | Kelch motif family protein | 0.000108061 | 0.000208378 | 0.000581449 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0136355 | 0.291506 | 0.5 |
Mycobacterium tuberculosis | Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase | 0.0136355 | 0.291506 | 1 |
Echinococcus granulosus | kelch ECH associated protein 1 | 0.0464386 | 0.997881 | 1 |
Loa Loa (eye worm) | ring canal kelch protein | 0.000108061 | 0.000208378 | 0.000714834 |
Schistosoma mansoni | hypothetical protein | 0.000107916 | 0.000205258 | 0.000205258 |
Loa Loa (eye worm) | GMP reductase | 0.00617284 | 0.130806 | 0.448725 |
Brugia malayi | Kelch-like protein X | 0.000108061 | 0.000208378 | 0.000581449 |
Echinococcus multilocularis | inosine 5' monophosphate dehydrogenase 2 | 0.0136355 | 0.291506 | 0.291506 |
Echinococcus multilocularis | ectoderm neural cortex protein 1 | 0.000108061 | 0.000208378 | 0.000208378 |
Loa Loa (eye worm) | Klhl5 protein | 0.000108061 | 0.000208378 | 0.000714834 |
Mycobacterium ulcerans | inosine 5'-monophosphate dehydrogenase | 0.0136355 | 0.291506 | 1 |
Echinococcus granulosus | kelch ECH associated protein 1 like | 0.0464386 | 0.997881 | 1 |
Brugia malayi | hypothetical protein | 0.0167409 | 0.358378 | 1 |
Echinococcus granulosus | kelch ECH associated protein 1 like | 0.0464386 | 0.997881 | 1 |
Echinococcus multilocularis | kelch ECH associated protein 1 | 0.0464386 | 0.997881 | 0.997881 |
Echinococcus granulosus | ectoderm neural cortex protein 1 | 0.000108061 | 0.000208378 | 0.000208821 |
Echinococcus multilocularis | kelch protein 18 | 0.000108061 | 0.000208378 | 0.000208378 |
Leishmania major | guanosine monophosphate reductase | 0.0136355 | 0.291506 | 0.5 |
Mycobacterium leprae | Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) | 0.0136355 | 0.291506 | 1 |
Mycobacterium ulcerans | inosine 5-monophosphate dehydrogenase | 0.0136355 | 0.291506 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0167409 | 0.358378 | 0.358378 |
Entamoeba histolytica | hypothetical protein | 0.0167409 | 0.358378 | 0.5 |
Echinococcus granulosus | inosine 5' monophosphate dehydrogenase 2 | 0.0136355 | 0.291506 | 0.292125 |
Trypanosoma brucei | inosine-5'-monophosphate dehydrogenase | 0.0136355 | 0.291506 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.000108061 | 0.000208378 | 0.000208378 |
Echinococcus multilocularis | Kelch repeat type 1 | 0.046537 | 1 | 1 |
Echinococcus granulosus | kelch protein 18 | 0.000108061 | 0.000208378 | 0.000208821 |
Schistosoma mansoni | hypothetical protein | 0.046537 | 1 | 1 |
Echinococcus multilocularis | kelch ECH associated protein 1 | 0.0464386 | 0.997881 | 0.997881 |
Toxoplasma gondii | IMP dehydrogenas | 0.0136355 | 0.291506 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 0.2 uM | Antiparasitic activity against Toxoplasma gondii expressing Cryptosporidium parvum IMPDH and co-expressing yellow fluorescent protein infected to human TERT immobilized human foreskin fibroblasts assessed as parasite growth inhibition for 6 to 7 days by fluorescence based assay | ChEMBL. | 22950983 |
EC50 (ADMET) | > 25 uM | Toxicity against wild type Toxoplasma gondii expressing yellow fluorescent protein infected in human TERT immobilized human foreskin fibroblasts assessed as parasite growth inhibition for 6 to 7 days by fluorescence based assay | ChEMBL. | 22950983 |
IC50 (binding) | = 5 nM | Inhibition of Cryptosporidium parvum recombinant IMPDH expressed in Escherichia coli assessed as production of NADH in presence of 0.05% fatty acid free BSA incubated for 5 mins by fluorescence based assay | ChEMBL. | 22950983 |
IC50 (binding) | = 5 nM | Inhibition of Cryptosporidium parvum recombinant IMPDH expressed in Escherichia coli assessed as production of NADH incubated for 5 mins by fluorescence based assay | ChEMBL. | 22950983 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Toxoplasma gondii | ChEMBL23 | 22950983 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.