TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 373.257 | Formula: C9H20N5O9P
H donors: 7 H acceptors: 7 LogP: -9.23 Rotable bonds: 4
Rule of 5 violations (Lipinski): 2
SMILES: O[C@@H]1[C@H](O)[C@H](O[C@H]1n1ccc([n+](c1=O)[O-])N)COP(=O)(O)O.N.N
InChi: 1S/C9H14N3O9P.2H3N/c10-5-1-2-11(9(15)12(5)16)8-7(14)6(13)4(21-8)3-20-22(17,18)19;;/h1-2,4,6-8,13-14H,3,10H2,(H2,17,18,19);2*1H3/t4-,6-,7-,8-;;/m1../s1
InChiKey: YFWCPDLWULUBAP-WFIJOQBCSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Methanobacterium thermoautotrophicum	Orotidine 5'-phosphate decarboxylase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Wolbachia endosymbiont of Brugia malayi	orotidine-5'-phosphate decarboxylase	Get druggable targets OG5_133087	All targets in OG5_133087
Onchocerca volvulus		Get druggable targets OG5_133087	All targets in OG5_133087

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Plasmodium yoelii	putative orotidine-monophosphate-decarboxylase	Orotidine 5'-phosphate decarboxylase	228 aa	237 aa	19.8 %
Dictyostelium discoideum	UMP synthase	Orotidine 5'-phosphate decarboxylase	228 aa	193 aa	28.0 %
Brugia malayi	metallo-beta-lactamase superfamily protein	Orotidine 5'-phosphate decarboxylase	228 aa	212 aa	23.6 %
Plasmodium knowlesi	orotidine 5'-phosphate decarboxylase, putative	Orotidine 5'-phosphate decarboxylase	228 aa	232 aa	23.7 %
Loa Loa (eye worm)	orotate phosphoribosyltransferase	Orotidine 5'-phosphate decarboxylase	228 aa	235 aa	22.6 %
Babesia bovis	orotidine 5'-phosphate decarboxylase, putative	Orotidine 5'-phosphate decarboxylase	228 aa	222 aa	26.6 %
Schistosoma japonicum	ko:K01168 pancreatic ribonuclease [EC3.1.27.5], putative	Orotidine 5'-phosphate decarboxylase	228 aa	224 aa	25.4 %
Babesia bovis	hypothetical protein	Orotidine 5'-phosphate decarboxylase	228 aa	196 aa	26.0 %
Leishmania major	orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative,OMPDCase-OPRTase, putative	Orotidine 5'-phosphate decarboxylase	228 aa	186 aa	25.8 %
Plasmodium vivax	orotidine 5'-phosphate decarboxylase, putative	Orotidine 5'-phosphate decarboxylase	228 aa	232 aa	22.4 %
Leishmania donovani	orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative	Orotidine 5'-phosphate decarboxylase	228 aa	186 aa	25.8 %
Plasmodium berghei	orotidine 5'-phosphate decarboxylase, putative	Orotidine 5'-phosphate decarboxylase	228 aa	237 aa	20.3 %
Plasmodium falciparum	orotidine 5'-phosphate decarboxylase	Orotidine 5'-phosphate decarboxylase	228 aa	192 aa	19.8 %
Leishmania infantum	orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative,OMPDCase-OPRTase, putative	Orotidine 5'-phosphate decarboxylase	228 aa	186 aa	25.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0039	0.0282	0.3575
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0017	0.0017	0.006
Schistosoma mansoni	hypothetical protein	0.0036	0.0246	0.0271
Leishmania major	cathepsin L-like protease	0.0067	0.062	0.8331
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0067	0.062	0.7458
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0038	0.0273	0.9591
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0038	0.0273	0.9591
Brugia malayi	Cathepsin L-like precursor	0.0018	0.0029	0.0103
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0018	0.0029	0.0012
Plasmodium vivax	orotidine 5'-phosphate decarboxylase, putative	0.0077	0.0738	1
Echinococcus multilocularis	Peptidase C19, ubiquitin carboxyl terminal hydrolase 2	0.0039	0.0283	0.0267
Schistosoma mansoni	ubiquitin-specific peptidase 2 (C19 family)	0.0039	0.0283	0.0314
Loa Loa (eye worm)	fibroinase	0.0018	0.0029	0.0103
Onchocerca volvulus	Huntingtin homolog	0.0129	0.1357	0.1636
Loa Loa (eye worm)	hypothetical protein	0.0213	0.237	0.8502
Trichomonas vaginalis	alpha-glucosidase, putative	0.0038	0.0273	0.9591
Echinococcus granulosus	inositol monophosphatase 1	0.0039	0.0282	0.0314
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0067	0.062	0.7458
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0029	0.0103
Echinococcus multilocularis	tar DNA binding protein	0.0067	0.0614	0.0598
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0067	0.062	0.7458
Echinococcus multilocularis	lamin	0.0028	0.0157	0.0141
Schistosoma mansoni	tar DNA-binding protein	0.0067	0.0614	0.0706
Schistosoma mansoni	tar DNA-binding protein	0.0067	0.0614	0.0706
Brugia malayi	RNA binding protein	0.0067	0.0614	0.2202
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0051	0.0424	0.1522
Leishmania major	orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative,OMPDCase-OPRTase, putative	0.0077	0.0738	1
Schistosoma mansoni	lamin	0.0028	0.0157	0.0166
Schistosoma mansoni	inositol monophosphatase	0.0039	0.0282	0.0314
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0038	0.0273	0.9591
Onchocerca volvulus		0.0028	0.0157	0.0158
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0067	0.062	0.7458
Loa Loa (eye worm)	cysteine protease	0.0018	0.0029	0.0103
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0039	0.0283	1
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0178	0.1942	0.1929
Echinococcus multilocularis	neuropeptide s receptor	0.0486	0.5625	0.5617
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 8	0.0039	0.0283	0.0314
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0039	0.0283	0.3583
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0052	0.0445	0.1595
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0028	0.0157	0.0564
Schistosoma mansoni	cathepsin F (C01 family)	0.0018	0.0029	0.0014
Echinococcus multilocularis	inositol monophosphatase 1	0.0039	0.0282	0.0266
Brugia malayi	latrophilin 2 splice variant baaae	0.0036	0.0246	0.0884
Loa Loa (eye worm)	RNA binding protein	0.0067	0.0614	0.2202
Echinococcus multilocularis	uridine 5' monophosphate synthase	0.0077	0.0738	0.0722
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0039	0.0282	0.9978
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0067	0.062	0.7458
Echinococcus multilocularis	musashi	0.0028	0.0157	0.0141
Loa Loa (eye worm)	hypothetical protein	0.0129	0.1357	0.4867
Trypanosoma cruzi	major cysteine proteinase, putative	0.0053	0.0448	0.5914
Schistosoma mansoni	cathepsin F (C01 family)	0.0018	0.0029	0.0014
Schistosoma mansoni	intermediate filament proteins	0.0028	0.0157	0.0166
Schistosoma mansoni	ubiquitin-specific peptidase 8 (C19 family)	0.0039	0.0283	0.0314
Echinococcus multilocularis	lamin dm0	0.0028	0.0157	0.0141
Loa Loa (eye worm)	orotate phosphoribosyltransferase	0.0077	0.0738	0.2647
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0038	0.0273	0.0978
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.0039	0.0282	0.3575
Echinococcus multilocularis	survival motor neuron protein 1	0.0248	0.2788	0.2776
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0038	0.0273	0.9591
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0151	0.0542
Trichomonas vaginalis	alpha-glucosidase, putative	0.0038	0.0273	0.9591
Leishmania major	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	0.0039	0.0283	0.3583
Brugia malayi	Latrophilin receptor protein 2	0.0017	0.0017	0.006
Echinococcus multilocularis	cysteine protease	0.0018	0.0029	0.0012
Echinococcus multilocularis	ubiquitin specific protease 41	0.0039	0.0283	0.0267
Trypanosoma cruzi	orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative	0.0077	0.0738	1
Brugia malayi	Cathepsin L-like precursor	0.0018	0.0029	0.0103
Leishmania major	alpha glucosidase II subunit, putative	0.0038	0.0273	0.3437
Echinococcus granulosus	survival motor neuron protein 1	0.0248	0.2788	0.3273
Brugia malayi	Inositol-1	0.0039	0.0282	0.1013
Schistosoma mansoni	survival motor neuron protein	0.0051	0.0424	0.0481
Schistosoma mansoni	tar DNA-binding protein	0.0067	0.0614	0.0706
Onchocerca volvulus		0.0051	0.0424	0.0487
Brugia malayi	Cathepsin L-like precursor	0.0018	0.0029	0.0103
Loa Loa (eye worm)	hypothetical protein	0.0248	0.2788	1
Trichomonas vaginalis	conserved hypothetical protein	0.0039	0.0283	1
Loa Loa (eye worm)	inositol-1	0.0039	0.0282	0.1013
Onchocerca volvulus	Huntingtin homolog	0.0129	0.1357	0.1636
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0213	0.237	0.8502
Trichomonas vaginalis	inositol monophosphatase, putative	0.0039	0.0282	0.9978
Giardia lamblia	Ubiquitin carboxyl-terminal hydrolase 4	0.0039	0.0283	0.5
Echinococcus multilocularis	neutral alpha glucosidase AB	0.0038	0.0273	0.0256
Mycobacterium ulcerans	orotidine 5'-phosphate decarboxylase	0.0077	0.0738	1
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0039	0.0282	0.3575
Loa Loa (eye worm)	intermediate filament protein	0.0028	0.0157	0.0564
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0018	0.0029	0.0012
Echinococcus multilocularis	cathepsin L cysteine protease	0.0018	0.0029	0.0012
Schistosoma mansoni	tar DNA-binding protein	0.0067	0.0614	0.0706
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0067	0.062	0.7458
Brugia malayi	Papain family cysteine protease containing protein	0.0018	0.0029	0.0103
Onchocerca volvulus		0.0028	0.0157	0.0158
Echinococcus granulosus	ubiquitin specific protease 41	0.0039	0.0283	0.0314
Schistosoma mansoni	alpha-glucosidase	0.0147	0.1579	0.1846
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.0039	0.0282	0.9978
Brugia malayi	orotate phosphoribosyltransferase family protein	0.0077	0.0738	0.2647
Schistosoma mansoni	microtubule-associated protein tau	0.0725	0.8483	1
Schistosoma mansoni	orotidine 5'-phosphate decarboxylase	0.0077	0.0738	0.0852
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0067	0.062	0.7458
Schistosoma mansoni	lamin	0.0028	0.0157	0.0166
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.0039	0.0283	1
Brugia malayi	Cathepsin L-like precursor	0.0018	0.0029	0.0103
Trypanosoma cruzi	orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative	0.0077	0.0738	1
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0017	0.0017	0.006
Trypanosoma cruzi	cysteine peptidase, putative	0.0067	0.062	0.8331
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0039	0.0282	0.3575
Mycobacterium leprae	Probable orotidine 5'-phosphate decarboxylase PyrF (OMP decarboxylase) (OMPDCase) (OMPdecase)	0.0077	0.0738	1
Plasmodium falciparum	orotidine 5'-phosphate decarboxylase	0.0077	0.0738	1
Onchocerca volvulus		0.0697	0.8148	1
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 8	0.0039	0.0283	0.0267
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0018	0.0029	0.0014
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0178	0.1942	0.2274
Trichomonas vaginalis	sucrase-isomaltase, putative	0.0038	0.0273	0.9591
Trypanosoma cruzi	hypothetical protein, conserved	0.0038	0.0273	0.3437
Schistosoma mansoni	inositol monophosphatase	0.0039	0.0282	0.0314
Echinococcus granulosus	neuropeptide receptor A26	0.0486	0.5625	0.6624
Trypanosoma brucei	ubiquitin carboxyl-terminal hydrolase, putative	0.0039	0.0283	0.0223
Brugia malayi	Intermediate filament tail domain containing protein	0.0028	0.0157	0.0564
Echinococcus multilocularis	microtubule associated protein 2	0.0725	0.8483	0.848
Echinococcus granulosus	neuropeptide s receptor	0.0486	0.5625	0.6624
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0067	0.062	0.7458
Echinococcus granulosus	microtubule associated protein 2	0.0725	0.8483	1
Echinococcus granulosus	cathepsin l1	0.0018	0.0029	0.0014
Trypanosoma cruzi	hypothetical protein, conserved	0.0038	0.0273	0.3437
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0039	0.0283	0.1015
Loa Loa (eye worm)	ctsf protein	0.0018	0.0029	0.0103
Echinococcus multilocularis	cysteine protease	0.0018	0.0029	0.0012
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0039	0.0282	0.9978
Brugia malayi	Cathepsin L-like precursor	0.0018	0.0029	0.0103
Echinococcus multilocularis	cathepsin L cysteine protease	0.0018	0.0029	0.0012
Loa Loa (eye worm)	TAR-binding protein	0.0067	0.0614	0.2202
Brugia malayi	hypothetical protein	0.0129	0.1357	0.4867
Echinococcus granulosus	lysosomal alpha glucosidase	0.0171	0.1864	0.2182
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0018	0.0029	0.0014
Trichomonas vaginalis	maltase-glucoamylase, putative	0.0038	0.0273	0.9591
Brugia malayi	hypothetical protein	0.0248	0.2788	1
Loa Loa (eye worm)	hypothetical protein	0.0129	0.1357	0.4867
Echinococcus granulosus	neutral alpha glucosidase AB	0.0038	0.0273	0.0302
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0052	0.0445	0.1595
Echinococcus granulosus	tar DNA binding protein	0.0067	0.0614	0.0706
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0171	0.1864	0.1851
Echinococcus granulosus	lamin	0.0028	0.0157	0.0166
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0283	0.1015
Leishmania major	cathepsin L-like protease	0.0067	0.062	0.8331
Toxoplasma gondii	orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase	0.0077	0.0738	1
Mycobacterium tuberculosis	Inositol-1-monophosphatase SuhB	0.0035	0.0234	0.5
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0171	0.1864	0.6687
Echinococcus granulosus	uridine 5' monophosphate synthase	0.0077	0.0738	0.0852
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0171	0.1864	0.6687
Schistosoma mansoni	tar DNA-binding protein	0.0067	0.0614	0.0706
Wolbachia endosymbiont of Brugia malayi	orotidine-5'-phosphate decarboxylase	0.0774	0.9067	1
Echinococcus granulosus	lamin dm0	0.0028	0.0157	0.0166
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0067	0.062	0.7458
Brugia malayi	RNA recognition motif domain containing protein	0.0067	0.0614	0.2202
Schistosoma mansoni	alpha-glucosidase	0.0147	0.1579	0.1846
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0157	0.0564
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0171	0.1864	0.1851
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0018	0.0029	0.0103
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0067	0.062	0.7458
Trypanosoma cruzi	cruzipain precursor, putative	0.0067	0.062	0.8331
Trypanosoma cruzi	cysteine peptidase, putative	0.0067	0.062	0.8331
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0067	0.0614	0.2202
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0067	0.062	0.7458
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0038	0.0273	0.0978
Trypanosoma cruzi	cysteine peptidase, putative	0.0067	0.062	0.8331
Echinococcus granulosus	intermediate filament protein	0.0028	0.0157	0.0166
Brugia malayi	Cathepsin L-like precursor	0.0018	0.0029	0.0103
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0246	0.0884
Trichomonas vaginalis	alpha-glucosidase, putative	0.0038	0.0273	0.9591
Trichomonas vaginalis	alpha-glucosidase, putative	0.0038	0.0273	0.9591
Echinococcus multilocularis	neuropeptide receptor A26	0.0486	0.5625	0.5617
Trypanosoma brucei	orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative	0.0077	0.0738	1
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0039	0.0283	0.3583
Schistosoma mansoni	alpha glucosidase	0.0038	0.0273	0.0302
Trichomonas vaginalis	alpha-glucosidase, putative	0.0038	0.0273	0.9591
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0061	0.055	0.7351
Leishmania major	cathepsin L-like protease	0.0067	0.062	0.8331
Brugia malayi	intermediate filament protein	0.0028	0.0157	0.0564
Toxoplasma gondii	glycosyl hydrolase, family 31 protein	0.0038	0.0273	0.3437
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0039	0.0283	1
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0017	0.006
Brugia malayi	TAR-binding protein	0.0067	0.0614	0.2202
Trypanosoma cruzi	orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative	0.0077	0.0738	1
Echinococcus granulosus	Peptidase C19 ubiquitin carboxyl terminal hydrolase 2	0.0039	0.0283	0.0314
Onchocerca volvulus		0.0099	0.1002	0.1198
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0018	0.0029	0.0103
Schistosoma mansoni	hypothetical protein	0.0051	0.0424	0.0481
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0039	0.0282	0.0211

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 11.1 uM	Inhibition of Methanobacterium thermoautotrophicum ODCase by isothermal titration calorimetry	ChEMBL.	22991951
Ki (binding)	= 22.1 uM	Inhibition of Plasmodium falciparum ODCase by isothermal titration calorimetry	ChEMBL.	22991951
Ki (binding)	= 28.3 uM	Inhibition of human ODCase by isothermal titration calorimetry	ChEMBL.	22991951
Ratio Ki (binding)	= 100	Ratio of Ki for CMP to Ki for compound against Methanobacterium thermoautotrophicum ODCase by isothermal titration calorimetry	ChEMBL.	22991951

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2178721

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1719533