Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | mitogen-activated protein kinase 14 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | mitogen-activated protein kinase 5 | mitogen-activated protein kinase 14 | 360 aa | 336 aa | 33.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0019 | 0.0644 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase 11 | 0.0152 | 0.8728 | 0.8728 |
Plasmodium vivax | cyclin dependent kinase 7 (cdk7), putative | 0.0118 | 0.6664 | 1 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0019 | 0.0644 | 0.5 |
Brugia malayi | P38 map kinase family protein 2 | 0.0152 | 0.8728 | 1 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0019 | 0.0644 | 0.0738 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0019 | 0.0644 | 0.0644 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0019 | 0.0644 | 0.0738 |
Trypanosoma cruzi | mitogen-activated protein kinase 3, putative | 0.0152 | 0.8728 | 1 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0019 | 0.0644 | 1 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0019 | 0.0644 | 0.0738 |
Toxoplasma gondii | cell-cycle-associated protein kinase, putative | 0.0111 | 0.6193 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase 11 | 0.0152 | 0.8728 | 0.8728 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0.0644 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase 14 | 0.0152 | 0.8728 | 0.8728 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0019 | 0.0644 | 0.0738 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0019 | 0.0644 | 0.0644 |
Schistosoma mansoni | ap endonuclease | 0.0019 | 0.0644 | 0.0644 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0.0644 | 0.0967 |
Echinococcus granulosus | mitogen activated protein kinase 14 | 0.0152 | 0.8728 | 0.8728 |
Schistosoma mansoni | ap endonuclease | 0.0019 | 0.0644 | 0.0644 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0019 | 0.0644 | 0.0738 |
Echinococcus multilocularis | geminin | 0.0173 | 1 | 1 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0019 | 0.0644 | 0.5 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0019 | 0.0644 | 0.0738 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0019 | 0.0644 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0173 | 1 | 1 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0019 | 0.0644 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0173 | 1 | 1 |
Loa Loa (eye worm) | CMGC/MAPK/P38 protein kinase | 0.0152 | 0.8728 | 1 |
Echinococcus granulosus | mitogen activated protein kinase 11 | 0.0152 | 0.8728 | 0.8728 |
Trypanosoma brucei | mitogen-activated protein kinase 3, putative | 0.0152 | 0.8728 | 1 |
Plasmodium falciparum | MO15-related protein kinase | 0.0118 | 0.6664 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0.0644 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase 14 | 0.0152 | 0.8728 | 0.8728 |
Trypanosoma cruzi | mitogen-activated protein kinase 3, putative | 0.0152 | 0.8728 | 1 |
Leishmania major | mitogen-activated protein kinase 3, putative,map kinase 3, putative | 0.0152 | 0.8728 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.012 uM | Inhibition of MAP kinase p38alpha assessed as phosphorylation of ATF-2 | ChEMBL. | 22897496 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.