Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0107 | 0.0124 | 0.0623 |
Echinococcus granulosus | receptor type tyrosine protein phosphatase | 0.0107 | 0.0124 | 0.0124 |
Echinococcus multilocularis | transfer RNA-Phe | 0.0107 | 0.0124 | 0.0124 |
Schistosoma mansoni | cell adhesion molecule | 0.0107 | 0.0124 | 0.1093 |
Echinococcus granulosus | titin | 0.0111 | 0.0133 | 0.0133 |
Loa Loa (eye worm) | vesicular acetylcholine transporter unc-17 | 0.0502 | 0.1133 | 0.5703 |
Onchocerca volvulus | 0.0107 | 0.0124 | 0.1093 | |
Schistosoma mansoni | cell adhesion molecule | 0.0107 | 0.0124 | 0.1093 |
Loa Loa (eye worm) | hypothetical protein | 0.0107 | 0.0124 | 0.0623 |
Schistosoma mansoni | myosin-binding protein-related | 0.0107 | 0.0124 | 0.1093 |
Echinococcus granulosus | nephrin | 0.0107 | 0.0124 | 0.0124 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0107 | 0.0124 | 0.0623 |
Onchocerca volvulus | Vesicular acetylcholine transporter homolog | 0.0502 | 0.1133 | 1 |
Echinococcus multilocularis | contactin neuroglian septate junction protein | 0.0107 | 0.0124 | 0.0124 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0107 | 0.0124 | 0.0623 |
Loa Loa (eye worm) | hypothetical protein | 0.0107 | 0.0124 | 0.0623 |
Loa Loa (eye worm) | CAMK/MLCK protein kinase | 0.0111 | 0.0133 | 0.0671 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0107 | 0.0124 | 0.0623 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0107 | 0.0124 | 0.0623 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0107 | 0.0124 | 0.0623 |
Onchocerca volvulus | 0.0111 | 0.0133 | 0.1177 | |
Echinococcus multilocularis | vesicular acetylcholine transporter | 0.0502 | 0.1133 | 0.1133 |
Echinococcus granulosus | roundabout 2 | 0.0107 | 0.0124 | 0.0124 |
Schistosoma mansoni | titin | 0.0111 | 0.0133 | 0.1177 |
Echinococcus multilocularis | titin | 0.0111 | 0.0133 | 0.0133 |
Schistosoma mansoni | neuroglian | 0.0107 | 0.0124 | 0.1093 |
Schistosoma mansoni | vesicular acetylcholine transporter | 0.0502 | 0.1133 | 1 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0107 | 0.0124 | 0.0623 |
Echinococcus granulosus | receptor type tyrosine protein phosphatase | 0.0107 | 0.0124 | 0.0124 |
Brugia malayi | vesicular acetylcholine transporter unc-17 | 0.0502 | 0.1133 | 0.5703 |
Echinococcus multilocularis | roundabout 2 | 0.0107 | 0.0124 | 0.0124 |
Echinococcus multilocularis | roundabout 2 | 0.0107 | 0.0124 | 0.0124 |
Echinococcus multilocularis | roundabout 2 | 0.0107 | 0.0124 | 0.0124 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0107 | 0.0124 | 0.0623 |
Echinococcus granulosus | roundabout 2 | 0.0107 | 0.0124 | 0.0124 |
Schistosoma mansoni | hypothetical protein | 0.0107 | 0.0124 | 0.1093 |
Loa Loa (eye worm) | hypothetical protein | 0.0107 | 0.0124 | 0.0623 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0107 | 0.0124 | 0.0623 |
Schistosoma mansoni | nephrin | 0.0107 | 0.0124 | 0.1093 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase | 0.0107 | 0.0124 | 0.0124 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0111 | 0.0133 | 0.1177 |
Echinococcus granulosus | roundabout 2 | 0.0107 | 0.0124 | 0.0124 |
Loa Loa (eye worm) | hypothetical protein | 0.0427 | 0.0943 | 0.4743 |
Echinococcus multilocularis | myosin light chain kinase, smooth muscle | 0.3971 | 1 | 1 |
Brugia malayi | protein unc-22 | 0.0111 | 0.0133 | 0.0671 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0836 | 0.1988 | 1 |
Echinococcus granulosus | serine:threonine protein kinase | 0.3971 | 1 | 1 |
Schistosoma mansoni | cell adhesion molecule | 0.0107 | 0.0124 | 0.1093 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0836 | 0.1988 | 1 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0836 | 0.1988 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase | 0.3971 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0836 | 0.1988 | 1 |
Echinococcus granulosus | vesicular acetylcholine transporter | 0.0502 | 0.1133 | 0.1133 |
Loa Loa (eye worm) | CAMK protein kinase | 0.0111 | 0.0133 | 0.0671 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0107 | 0.0124 | 0.0623 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase | 0.0107 | 0.0124 | 0.0124 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0107 | 0.0124 | 0.0623 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0111 | 0.0133 | 0.0671 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase F | 0.0107 | 0.0124 | 0.0124 |
Loa Loa (eye worm) | CAMK/MLCK protein kinase | 0.0111 | 0.0133 | 0.0671 |
Echinococcus granulosus | neuroglian | 0.0107 | 0.0124 | 0.0124 |
Echinococcus granulosus | contactin | 0.0107 | 0.0124 | 0.0124 |
Schistosoma mansoni | receptor tyrosine phosphatase type r2a | 0.0107 | 0.0124 | 0.1093 |
Schistosoma mansoni | nephrin | 0.0107 | 0.0124 | 0.1093 |
Schistosoma mansoni | hemicentin | 0.0107 | 0.0124 | 0.1093 |
Echinococcus granulosus | titin | 0.0111 | 0.0133 | 0.0133 |
Schistosoma mansoni | titin | 0.0107 | 0.0124 | 0.1093 |
Schistosoma mansoni | cell adhesion molecule | 0.0107 | 0.0124 | 0.1093 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0107 | 0.0124 | 0.0623 |
Loa Loa (eye worm) | projectin | 0.0107 | 0.0124 | 0.0623 |
Brugia malayi | ERG2 and Sigma1 receptor like protein | 0.0836 | 0.1988 | 1 |
Echinococcus multilocularis | neuroglian | 0.0107 | 0.0124 | 0.0124 |
Onchocerca volvulus | 0.0107 | 0.0124 | 0.1093 | |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0107 | 0.0124 | 0.0623 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 49.3 % | Antiproliferative activity against human Jurkat cells assessed as 5th generation cell population at 10 uM after 24 hrs using CFSE staining by flow cytometry (Rvb = 18.43 %) | ChEMBL. | 23063518 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.