Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glycogen synthase kinase 3 beta | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | neural Wiskott Aldrich syndrome protein | 0.0408 | 0.0596 | 0.0596 |
Giardia lamblia | Kinase, STE STE20 | 0.0933 | 1 | 0.5 |
Echinococcus granulosus | p21 activated protein kinase 1 Dpak1 | 0.0933 | 1 | 1 |
Loa Loa (eye worm) | STE/STE20/PAKB protein kinase | 0.0782 | 0.7302 | 0.7249 |
Entamoeba histolytica | p21-activated kinase | 0.0933 | 1 | 1 |
Echinococcus multilocularis | p21 activated protein kinase 1 Dpak1 | 0.0933 | 1 | 1 |
Loa Loa (eye worm) | STE/STE20/PAKA protein kinase | 0.0525 | 0.2698 | 0.2273 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0925 | 0.9846 | 0.9834 |
Trichomonas vaginalis | STE family protein kinase | 0.0933 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0525 | 0.2698 | 0.2235 |
Brugia malayi | p21/Cdc42/Rac1-activated kinase | 0.0525 | 0.2698 | 0.2235 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0525 | 0.2698 | 0.2235 |
Brugia malayi | serine/threonine-protein kinase PAK 7 | 0.0782 | 0.7302 | 0.713 |
Schistosoma mansoni | protein kinase | 0.0933 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0925 | 0.9846 | 1 |
Trypanosoma cruzi | STE/STE20 serine/threonine-protein kinase, putative | 0.0525 | 0.2698 | 0.5 |
Entamoeba histolytica | protein kinase, putative | 0.0416 | 0.075 | 0.0164 |
Echinococcus granulosus | neural Wiskott Aldrich syndrome protein | 0.0408 | 0.0596 | 0.0596 |
Echinococcus granulosus | 3'partial|serine:threonine protein kinase PAK 2 | 0.0408 | 0.0596 | 0.0596 |
Schistosoma mansoni | protein kinase | 0.0416 | 0.075 | 0.0164 |
Trichomonas vaginalis | mitogen-activated protein kinase kinase kinase 3, MAPKKK3, MEKK3, putative | 0.0525 | 0.2698 | 0.2106 |
Trichomonas vaginalis | STE family protein kinase | 0.0933 | 1 | 1 |
Schistosoma mansoni | protein kinase | 0.0933 | 1 | 1 |
Echinococcus granulosus | PAK box P21 Rho binding | 0.0408 | 0.0596 | 0.0596 |
Echinococcus multilocularis | serine:threonine protein kinase PAK 3 | 0.0933 | 1 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0933 | 1 | 1 |
Echinococcus multilocularis | PAK box P21 Rho binding | 0.0408 | 0.0596 | 0.0596 |
Entamoeba histolytica | protein kinase, putative | 0.0416 | 0.075 | 0.0164 |
Echinococcus granulosus | serine:threonine protein kinase PAK 3 | 0.0933 | 1 | 1 |
Trypanosoma cruzi | p21-activated kinase 3, putative | 0.0525 | 0.2698 | 0.5 |
Trichomonas vaginalis | STE family protein kinase | 0.0933 | 1 | 1 |
Echinococcus multilocularis | PAK box P21 Rho binding | 0.0416 | 0.075 | 0.075 |
Entamoeba histolytica | protein kinase, putative | 0.0416 | 0.075 | 0.0164 |
Echinococcus granulosus | serine:threonine protein kinase PAK 3 | 0.0933 | 1 | 1 |
Trichomonas vaginalis | STE family protein kinase | 0.0933 | 1 | 1 |
Echinococcus granulosus | serine:threonine protein kinase PAK 1 | 0.0517 | 0.2545 | 0.2545 |
Echinococcus multilocularis | serine:threonine protein kinase PAK 3 | 0.0933 | 1 | 1 |
Loa Loa (eye worm) | STE/STE20/PAKA protein kinase | 0.0525 | 0.2698 | 0.2273 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 74 nM | Inhibition of human recombinant GSK3beta using biotin- AAEELDSRAGS(PO3H2)PQL as substrate and [gamma32P]ATP after 20 mins by scintillation proximity assay | ChEMBL. | 22489897 |
Ki (binding) | = 24000 nM | Inhibition of CDK2/cyclin E expressed in baculovirus infected insect cells using [gamma33P]ATP after 60 mins by scintillation proximity assay | ChEMBL. | 22489897 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.