TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 384.47 | Formula: C25H24N2O2
H donors: 2 H acceptors: 2 LogP: 5.31 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: Cc1ccc(cc1Nc1ccc2c(c1)CCCCC2=O)NC(=O)c1ccccc1
InChi: 1S/C25H24N2O2/c1-17-11-12-21(27-25(29)18-7-3-2-4-8-18)16-23(17)26-20-13-14-22-19(15-20)9-5-6-10-24(22)28/h2-4,7-8,11-16,26H,5-6,9-10H2,1H3,(H,27,29)
InChiKey: MLOULFJDSFSSIC-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	mitogen-activated protein kinase 14	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Brugia malayi	P38 map kinase family protein 2	Get druggable targets OG5_128610	All targets in OG5_128610
Trypanosoma brucei gambiense	mitogen-activated protein kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Trypanosoma brucei	mitogen-activated protein kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Echinococcus multilocularis	mitogen activated protein kinase 14	Get druggable targets OG5_128610	All targets in OG5_128610
Leishmania infantum	mitogen-activated protein kinase 3, putative,map kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Leishmania braziliensis	mitogen-activated protein kinase 3, putative,map kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Trypanosoma congolense	mitogen-activated protein kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Echinococcus multilocularis	mitogen activated protein kinase 14	Get druggable targets OG5_128610	All targets in OG5_128610
Candida albicans	MAP kinase involved in osmoregulation	Get druggable targets OG5_128610	All targets in OG5_128610
Leishmania donovani	mitogen-activated protein kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Schistosoma japonicum	ko:K04441 p38 MAP kinase, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Echinococcus granulosus	mitogen activated protein kinase 11	Get druggable targets OG5_128610	All targets in OG5_128610
Loa Loa (eye worm)	CMGC/MAPK/P38 protein kinase	Get druggable targets OG5_128610	All targets in OG5_128610
Echinococcus granulosus	mitogen activated protein kinase 14	Get druggable targets OG5_128610	All targets in OG5_128610
Echinococcus multilocularis	mitogen activated protein kinase 11	Get druggable targets OG5_128610	All targets in OG5_128610
Echinococcus multilocularis	mitogen activated protein kinase 11	Get druggable targets OG5_128610	All targets in OG5_128610
Leishmania major	mitogen-activated protein kinase 3, putative,map kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Leishmania mexicana	mitogen-activated protein kinase 3, putative,map kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Trypanosoma cruzi	mitogen-activated protein kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Candida albicans	MAP kinase involved in osmoregulation	Get druggable targets OG5_128610	All targets in OG5_128610
Trypanosoma cruzi	mitogen-activated protein kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Trypanosoma brucei	mitogen-activated protein kinase 5	mitogen-activated protein kinase 14	360 aa	336 aa	33.3 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Cam kinase protein 1	0.0033	0.0496	0.0511
Leishmania major	protein kinase, putative	0.0033	0.0496	0.129
Trichomonas vaginalis	CAMK family protein kinase	0.0033	0.0496	0.0495
Echinococcus granulosus	General substrate transporter	0.009	0.1818	0.5501
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0084	0.0033
Plasmodium vivax	ataxin-2 like protein, putative	0.0028	0.0383	0.0374
Echinococcus granulosus	BRK domain containing protein	0.0013	0.0039	0.0025
Plasmodium falciparum	protein kinase 7	0.0298	0.6576	0.6572
Plasmodium falciparum	calcium-dependent protein kinase 4	0.0033	0.0496	0.0487
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.0033	0.0496	0.0511
Plasmodium falciparum	hexose transporter	0.0105	0.2158	0.215
Plasmodium vivax	hexose transporter	0.0105	0.2158	0.215
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 2 LysX	0.002	0.0202	0.0195
Schistosoma mansoni	sugar transporter	0.0015	0.0084	0.0248
Trypanosoma cruzi	hexose transporter, putative	0.0033	0.0493	0.128
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0084	0.0033
Giardia lamblia	DNA repair protein RAD52	0.0384	0.8558	0.9527
Brugia malayi	Major Facilitator Superfamily protein	0.0015	0.0084	0.005
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0105	0.2158	0.6545
Entamoeba histolytica	protein kinase, putative	0.0033	0.0496	0.0245
Echinococcus multilocularis	BRK domain	0.0013	0.0039	0.0025
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.0402	0.8979	1
Trypanosoma brucei	glucose transporter, putative	0.0033	0.0493	0.128
Mycobacterium ulcerans	integral membrane transport protein	0.0015	0.0084	0.0093
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0084	0.0033
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0084	0.005
Giardia lamblia	Low molecular weight protein-tyrosine-phosphatase	0.0402	0.8979	1
Schistosoma mansoni	lysyl-tRNA synthetase	0.0023	0.0283	0.1185
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0015	0.0084	0.005
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0084	0.0033
Echinococcus multilocularis	lysyl tRNA synthetase	0.0023	0.0283	0.0776
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0084	0.0033
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0084	0.0033
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0084	0.0033
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0055	0.1008	0.1084
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0021	0.0217	0.0182
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0017	0.0144	0.0349
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0608	0.0637
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0402	0.8979	1
Schistosoma mansoni	hypothetical protein	0.0105	0.2158	1
Trypanosoma brucei	glucose transporter, putative	0.0033	0.0493	0.128
Schistosoma mansoni	hypothetical protein	0.0017	0.0144	0.0533
Brugia malayi	BRM protein	0.0074	0.1447	0.1575
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0033	0.0493	0.128
Trichomonas vaginalis	sugar transporter, putative	0.0033	0.0493	0.0491
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0033	0.0496	0.1432
Mycobacterium leprae	Probable prolyl tRNA synthetase ProS	0.0032	0.0468	1
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0033	0.0493	0.128
Echinococcus granulosus	global transcription activator snf2l2	0.0074	0.1447	0.4359
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0084	0.005
Trichomonas vaginalis	conserved hypothetical protein	0.0105	0.2158	0.2357
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0402	0.8979	1
Echinococcus multilocularis	mitogen activated protein kinase 14	0.0154	0.328	1
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0084	0.0033
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0124	0.2591	0.2842
Schistosoma mansoni	glucose transport protein	0.0105	0.2158	1
Echinococcus granulosus	solute carrier family 22	0.0015	0.0084	0.0162
Brugia malayi	hypothetical protein	0.0015	0.0084	0.005
Mycobacterium ulcerans	sugar-transport integral membrane protein SugI	0.0015	0.0084	0.0093
Brugia malayi	Latrophilin receptor protein 2	0.0017	0.0144	0.0117
Mycobacterium ulcerans	phosphotyrosine protein phosphatase PtpA	0.0402	0.8979	1
Trypanosoma cruzi	mitogen-activated protein kinase 3, putative	0.0154	0.328	1
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0084	0.0033
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0105	0.2158	0.6545
Brugia malayi	major facilitator superfamily protein	0.0015	0.0084	0.005
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0084	0.0033
Trypanosoma brucei	glucose transporter, putative	0.0033	0.0493	0.128
Echinococcus multilocularis	BRK domain containing protein	0.0013	0.0039	0.0025
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0017	0.0144	0.0117
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0084	0.005
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0084	0.0033
Schistosoma mansoni	protein kinase	0.0033	0.0496	0.2187
Echinococcus multilocularis	solute carrier family 22	0.0015	0.0084	0.0162
Echinococcus granulosus	solute carrier family 22	0.0015	0.0084	0.0162
Echinococcus granulosus	solute carrier family 22	0.0015	0.0084	0.0162
Schistosoma mansoni	protein kinase	0.0033	0.0496	0.2187
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0084	0.005
Onchocerca volvulus		0.0402	0.8979	1
Entamoeba histolytica	Rad52/22 family double-strand break repair protein, putative	0.0109	0.2252	0.2264
Echinococcus multilocularis	chromodomain helicase DNA binding protein 7	0.0013	0.0039	0.0025
Trichomonas vaginalis	glucose transporter, putative	0.0015	0.0084	0.0033
Plasmodium falciparum	calcium-dependent protein kinase 5	0.0033	0.0496	0.0487
Trypanosoma brucei	mitogen-activated protein kinase 3, putative	0.0154	0.328	1
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0084	0.005
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	0.0033	0.0496	0.0742
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0084	0.0033
Trichomonas vaginalis	glucose transporter, putative	0.0033	0.0493	0.0491
Brugia malayi	hypothetical protein	0.0018	0.0157	0.0132
Echinococcus multilocularis	Chromo domain	0.0013	0.0039	0.0026
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0017	0.0144	0.0349
Mycobacterium ulcerans	sugar transporter	0.0015	0.0084	0.0093
Toxoplasma gondii	transporter, major facilitator family protein	0.0015	0.0084	0.0113
Echinococcus granulosus	mitogen activated protein kinase 14	0.0154	0.328	1
Schistosoma mansoni	sugar transporter	0.0015	0.0084	0.0248
Plasmodium falciparum	calcium-dependent protein kinase 1	0.0033	0.0496	0.0487
Plasmodium falciparum	calcium-dependent protein kinase 2	0.0033	0.0496	0.0487
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0084	0.0033
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0084	0.0033
Trichomonas vaginalis	conserved hypothetical protein	0.0033	0.0493	0.0491
Schistosoma mansoni	hypothetical protein	0.0013	0.0039	0.0039
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0017	0.0144	0.0349
Mycobacterium ulcerans	fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT	0.0015	0.0084	0.0093
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0084	0.0033
Leishmania major	glucose transporter, lmgt1	0.0033	0.0493	0.128
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0468	0.048
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0084	0.005
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	0.0033	0.0496	0.0742
Plasmodium vivax	lysine--tRNA ligase, putative	0.0023	0.0283	0.0274
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.002	0.0202	0.0195
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.0033	0.0496	0.0487
Toxoplasma gondii	prolyl-tRNA synthetase (ProRS)	0.0037	0.0588	0.0881
Plasmodium vivax	CDK-related protein kinase 6, putative	0.0447	1	1
Echinococcus granulosus	calcium dependent protein kinase	0.003	0.0438	0.1252
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0084	0.005
Schistosoma mansoni	glucose transport protein	0.0105	0.2158	1
Echinococcus multilocularis	solute carrier family 22	0.0015	0.0084	0.0162
Schistosoma mansoni	glucose transport protein	0.0105	0.2158	1
Echinococcus multilocularis	BRK domain containing protein	0.0013	0.0039	0.0025
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.0023	0.0283	0.0624
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0084	0.0033
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0084	0.0033
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0084	0.0033
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0084	0.0033
Trypanosoma cruzi	hypothetical protein, conserved	0.0124	0.2591	0.7844
Mycobacterium leprae	Possible lysyl-tRNA synthetase 2 LysX	0.0023	0.0283	0.3046
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0033	0.0496	0.0511
Leishmania major	lysyl-tRNA synthetase, putative	0.0023	0.0283	0.0624
Trypanosoma cruzi	hexose transporter, putative	0.0033	0.0493	0.128
Leishmania major	hypothetical protein, conserved	0.0124	0.2591	0.7844
Plasmodium vivax	mitogen-activated protein kinase 2, putative	0.017	0.3657	0.3651
Trichomonas vaginalis	conserved hypothetical protein	0.0033	0.0493	0.0491
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0033	0.0496	0.1432
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.0402	0.8979	1
Toxoplasma gondii	protein kinase, putative	0.0298	0.6576	1
Trypanosoma brucei	glucose transporter 1E	0.0033	0.0493	0.128
Trypanosoma brucei	glucose transporter, putative	0.0033	0.0493	0.128
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0023	0.0283	0.0315
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0017	0.0144	0.0118
Toxoplasma gondii	LsmAD domain-containing protein	0.0028	0.0383	0.0569
Plasmodium vivax	proline--tRNA ligase, putative	0.0037	0.0588	0.0579
Schistosoma mansoni	hypothetical protein	0.0038	0.0608	0.2715
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0084	0.0033
Loa Loa (eye worm)	hypothetical protein	0.0055	0.1008	0.1084
Trypanosoma cruzi	hexose transporter	0.0033	0.0493	0.128
Entamoeba histolytica	hypothetical protein	0.0109	0.2252	0.2264
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0015	0.0084	0.005
Toxoplasma gondii	lysine-tRNA ligase	0.0023	0.0283	0.0416
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0084	0.0033
Echinococcus multilocularis	global transcription activator snf2l2	0.0074	0.1447	0.4359
Toxoplasma gondii	cell-cycle-associated protein kinase MAPK, putative	0.017	0.3657	0.5555
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0023	0.0283	0.0256
Trichomonas vaginalis	prolyl-tRNA synthetase, putative	0.0032	0.0468	0.0464
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0084	0.0033
Trypanosoma brucei	glucose transporter, putative	0.0033	0.0493	0.128
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0084	0.0033
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0084	0.005
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0084	0.005
Brugia malayi	lysyl-tRNA synthetase	0.0023	0.0283	0.0273
Schistosoma mansoni	glucose transporter	0.0015	0.0084	0.0248
Plasmodium falciparum	ataxin-2 like protein, putative	0.0028	0.0383	0.0374
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0084	0.005
Schistosoma mansoni	lysyl-tRNA synthetase	0.0023	0.0283	0.1185
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0033	0.0496	0.1432
Schistosoma mansoni	hypothetical protein	0.0013	0.0039	0.0038
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0033	0.0493	0.128
Loa Loa (eye worm)	bifunctional aminoacyl-tRNA synthetase	0.0013	0.0041	0.0003
Schistosoma mansoni	nuclear transcription factor X-box binding 1 (nfx1)	0.0015	0.0084	0.0248
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0496	0.0511
Plasmodium falciparum	proline--tRNA ligase	0.0037	0.0588	0.0579
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0333	0.0328
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0084	0.0033
Echinococcus granulosus	lysyl tRNA synthetase	0.0023	0.0283	0.0776
Schistosoma mansoni	sugar transporter	0.0015	0.0084	0.0248
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0383	0.0385
Treponema pallidum	prolyl-tRNA synthetase	0.0011	0	0.5
Echinococcus granulosus	GPCR family 2	0.0017	0.0144	0.0349
Brugia malayi	hypothetical protein	0.0015	0.0084	0.005
Trichomonas vaginalis	glucose transporter, putative	0.0033	0.0493	0.0491
Chlamydia trachomatis	lysine--tRNA ligase	0.0023	0.0283	1
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0084	0.0033
Echinococcus multilocularis	calcium dependent protein kinase	0.003	0.0438	0.1252
Giardia lamblia	Lysyl-tRNA synthetase	0.0023	0.0283	0.0224
Brugia malayi	hypothetical protein	0.0015	0.0084	0.005
Loa Loa (eye worm)	sugar transporter	0.0015	0.0084	0.005
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0084	0.005
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0084	0.0033
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0084	0.005
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0084	0.0033
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0037	0.0588	0.1579
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0105	0.2158	0.6545
Trypanosoma brucei	glucose transporter, putative	0.0033	0.0493	0.128
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0084	0.0033
Echinococcus multilocularis	BRK domain containing protein	0.0013	0.0039	0.0025
Schistosoma mansoni	hypothetical protein	0.0017	0.0144	0.0533
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0033	0.0496	0.0487
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0105	0.2158	0.6545
Brugia malayi	Sugar transporter family protein	0.0015	0.0084	0.005
Echinococcus multilocularis	BRK domain containing protein	0.0013	0.0039	0.0025
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0084	0.0033
Plasmodium falciparum	calcium-dependent protein kinase 3	0.0033	0.0496	0.0487
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0023	0.0283	0.0624
Entamoeba histolytica	prolyl-tRNA synthetase, putative	0.0032	0.0468	0.0213
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0033	0.0496	0.1432
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0084	0.0033
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	0.0033	0.0496	0.129
Toxoplasma gondii	sugar transporter ST1	0.0015	0.0084	0.0113
Trypanosoma cruzi	hypothetical protein, conserved	0.0124	0.2591	0.7844
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0402	0.8979	1
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0105	0.2158	0.6545
Toxoplasma gondii	sugar transporter ST2	0.0015	0.0084	0.0113
Brugia malayi	latrophilin 2 splice variant baaae	0.0038	0.0608	0.0637
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0037	0.0588	0.1579
Trichomonas vaginalis	sugar transporter, putative	0.0033	0.0493	0.0491
Echinococcus multilocularis	Sugar transporter ERD6 protein	0.0015	0.0084	0.0162
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0084	0.0033
Trichomonas vaginalis	sugar transporter, putative	0.0033	0.0493	0.0491
Loa Loa (eye worm)	BRM protein	0.0038	0.0625	0.0655
Trypanosoma brucei	low molecular weight protein tyrosine phosphatase, putative	0.0124	0.2591	0.7844
Plasmodium vivax	calcium-dependent protein kinase, putative	0.0033	0.0496	0.0487
Echinococcus multilocularis	mitogen activated protein kinase 14	0.0154	0.328	1
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0037	0.0588	0.1579
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0032	0.0468	0.2057
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	0.0033	0.0496	0.0742
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0033	0.0496	0.1432
Echinococcus multilocularis	GPCR, family 2	0.0017	0.0144	0.0349
Echinococcus multilocularis	BRK domain containing protein	0.0013	0.0039	0.0025
Echinococcus multilocularis	mitogen activated protein kinase 11	0.0154	0.328	1
Brugia malayi	hypothetical protein	0.0028	0.0383	0.0385
Leishmania major	hypothetical protein, conserved	0.0028	0.0383	0.0938
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0084	0.0033
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0468	0.048
Echinococcus granulosus	Chromo domain	0.0013	0.0039	0.0026
Plasmodium falciparum	ataxin-2 like protein, putative	0.0028	0.0383	0.0374
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0033	0.0496	0.1432
Echinococcus multilocularis	General substrate transporter	0.009	0.1818	0.5501
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0105	0.2158	0.6545
Schistosoma mansoni	serine/threonine protein kinase	0.0033	0.0496	0.2187
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0084	0.0033
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0144	0.0118
Brugia malayi	Low molecular weight phosphotyrosine protein phosphatase containing protein	0.0402	0.8979	1
Brugia malayi	major facilitator superfamily protein	0.0015	0.0084	0.005
Schistosoma mansoni	protein kinase	0.0033	0.0496	0.2187
Trypanosoma cruzi	PAB1-binding protein , putative	0.0028	0.0383	0.0938
Trypanosoma cruzi	PAB1-binding protein , putative	0.0028	0.0383	0.0938
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0084	0.005
Echinococcus granulosus	mitogen activated protein kinase 11	0.0154	0.328	1
Plasmodium falciparum	lysine--tRNA ligase	0.0023	0.0283	0.0274
Brugia malayi	Major Facilitator Superfamily protein	0.0015	0.0084	0.005
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.0033	0.0496	0.0487
Plasmodium vivax	sugar transporter, putative	0.0015	0.0084	0.0074
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.0402	0.8979	1
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0037	0.0588	0.1579
Trypanosoma cruzi	hexose transporter, putative	0.0018	0.0153	0.0218
Toxoplasma gondii	SWI2/SNF2 Brahma-like putative	0.0014	0.0055	0.0069
Brugia malayi	Major Facilitator Superfamily protein	0.0015	0.0084	0.005
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0283	0.0273
Brugia malayi	Bifunctional aminoacyl-tRNA synthetase	0.0032	0.0468	0.048
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0084	0.0033
Trichomonas vaginalis	myo-inositol transporter, putative	0.0015	0.0084	0.0033
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0124	0.2591	0.2842
Mycobacterium tuberculosis	Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase)	0.0278	0.6132	1
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.0033	0.0496	0.1432
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0084	0.0033
Loa Loa (eye worm)	sugar transporter	0.0105	0.2158	0.237
Brugia malayi	Sugar transporter family protein	0.0015	0.0084	0.005
Echinococcus multilocularis	mitogen activated protein kinase 11	0.0154	0.328	1
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0023	0.0283	0.0315
Leishmania major	glucose transporter, lmgt2	0.0033	0.0493	0.128
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0017	0.0144	0.0349
Schistosoma mansoni	hypothetical protein	0.0017	0.0144	0.0533
Entamoeba histolytica	protein kinase, putative	0.0033	0.0496	0.0245
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0033	0.0496	0.1432
Wolbachia endosymbiont of Brugia malayi	major facilitator superfamily permease	0.0015	0.0084	0.5
Plasmodium falciparum	mitogen-activated protein kinase 2	0.017	0.3657	0.3651
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0055	0.1008	0.1084
Trypanosoma cruzi	mitogen-activated protein kinase 3, putative	0.0154	0.328	1
Echinococcus granulosus	glutamyl tRNA synthetase cytoplasmic	0.0032	0.0468	0.1346
Trichomonas vaginalis	sugar transport protein, putative	0.0015	0.0084	0.0033
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.0033	0.0496	0.0511
Brugia malayi	Sugar transporter family protein	0.0105	0.2158	0.237
Trypanosoma brucei	glucose transporter, putative	0.0033	0.0493	0.128
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0402	0.8979	1
Trypanosoma brucei	glucose transporter, putative	0.0033	0.0493	0.128
Echinococcus multilocularis	synaptic vesicle 2 protein	0.0015	0.0084	0.0162
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0402	0.8979	1
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0084	0.0033
Echinococcus multilocularis	solute carrier family 22	0.0015	0.0084	0.0162
Loa Loa (eye worm)	phosphotyrosine protein phosphatase	0.0402	0.8979	1
Trypanosoma cruzi	hexose transporter, putative	0.0033	0.0493	0.128
Schistosoma mansoni	sugar transporter	0.0015	0.0084	0.0248
Plasmodium falciparum	major facilitator superfamily domain-containing protein, putative	0.0015	0.0084	0.0074
Echinococcus granulosus	Sugar transporter ERD6 protein	0.0015	0.0084	0.0162
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0055	0.1008	0.1084
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0084	0.005
Schistosoma mansoni	hypothetical protein	0.0017	0.0144	0.0533
Trypanosoma brucei	PAB1-binding protein , putative	0.0028	0.0383	0.0938
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0084	0.005
Trypanosoma brucei	glucose transporter 2A	0.0033	0.0493	0.128
Echinococcus multilocularis	glutamyl tRNA synthetase cytoplasmic	0.0032	0.0468	0.1346
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0105	0.2158	0.6545
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0105	0.2158	0.6545
Giardia lamblia	Prolyl-tRNA synthetase	0.0032	0.0468	0.0432
Echinococcus granulosus	synaptic vesicle 2 protein	0.0015	0.0084	0.0162
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0033	0.0493	0.128
Leishmania major	mitogen-activated protein kinase 3, putative,map kinase 3, putative	0.0154	0.328	1
Toxoplasma gondii	sugar transporter ST3	0.0015	0.0084	0.0113
Toxoplasma gondii	facilitative glucose transporter GT1	0.0105	0.2158	0.3272
Echinococcus multilocularis	BRK domain containing protein	0.0013	0.0039	0.0025
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0084	0.0033
Brugia malayi	P38 map kinase family protein 2	0.0154	0.328	0.3625
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0084	0.0033
Loa Loa (eye worm)	CMGC/MAPK/P38 protein kinase	0.0154	0.328	0.3625
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0084	0.0033
Echinococcus granulosus	solute carrier family 22	0.0015	0.0084	0.0162
Loa Loa (eye worm)	BRM protein	0.0047	0.0832	0.0887
Leishmania major	glucose transporter, lmgt3	0.0033	0.0493	0.128
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.0032	0.0468	0.048
Schistosoma mansoni	helicase	0.0074	0.1447	0.6659
Trypanosoma brucei	bifunctional aminoacyl-tRNA synthetase, putative	0.0037	0.0588	0.1579
Entamoeba histolytica	DNA repair and recombination protein RAD52, putative	0.0384	0.8558	0.9516
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0032	0.0468	0.2057
Echinococcus multilocularis	solute carrier family 22	0.0015	0.0084	0.0162
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0084	0.0033

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.014 uM	Inhibition of MAP kinase p38alpha assessed as phosphorylation of ATF-2	ChEMBL.	22897496

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2177217

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1721473