TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 460.353 | Formula: C23H23Cl2N3O3
H donors: 1 H acceptors: 2 LogP: 4.45 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: Clc1ccc(cc1Cl)Oc1cccc(c1)CN1CCC[C@@H](C1)n1cc(C)c(=O)[nH]c1=O
InChi: 1S/C23H23Cl2N3O3/c1-15-12-28(23(30)26-22(15)29)17-5-3-9-27(14-17)13-16-4-2-6-18(10-16)31-19-7-8-20(24)21(25)11-19/h2,4,6-8,10-12,17H,3,5,9,13-14H2,1H3,(H,26,29,30)/t17-/m0/s1
InChiKey: JSQCTKVQHZBGSD-KRWDZBQOSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	ectonucleotide pyrophosphatase:phosphodiesterase	0.0033	0.0094	0.0642
Schistosoma mansoni	hypothetical protein	0.004	0.0136	0.1003
Trypanosoma brucei	metallo-peptidase, Clan MA(E) Family M1	0.0041	0.0143	1
Trypanosoma cruzi	Aminopeptidase M1, putative	0.0041	0.0143	1
Echinococcus multilocularis	ectonucleotide pyrophosphatase:phosphodiesterase	0.0033	0.0094	0.0642
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0039	0.0021
Schistosoma mansoni	ornithine--oxo-acid transaminase	0.0222	0.1191	1
Brugia malayi	hypothetical protein	0.0041	0.0143	0.0125
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0098	0.0093
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0023	0.0039	0.0002
Schistosoma mansoni	paired box protein pax-1-related	0.0033	0.0098	0.0682
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0039	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0074	0.0069
Schistosoma mansoni	ectonucleotide pyrophosphatase/phosphodiesterase	0.0033	0.0094	0.0642
Mycobacterium ulcerans	L-lysine aminotransferase	0.0222	0.1191	0.1325
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0041	0.0143	0.1061
Brugia malayi	'Paired box' domain containing protein	0.0033	0.0098	0.008
Echinococcus granulosus	ectonucleotide	0.0027	0.0064	0.0389
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0059	0.0249	0.197
Mycobacterium ulcerans	4'-phosphopantetheinyl transferase	0.0023	0.0038	0.0036
Trypanosoma cruzi	metallo-peptidase, clan MA(E), family M1, putative	0.0041	0.0143	1
Schistosoma mansoni	paired box protein pax-6	0.0033	0.0098	0.0682
Toxoplasma gondii	4'-phosphopantetheinyl transferase domain-containing protein	0.0023	0.0038	0.0164
Schistosoma mansoni	cytosol alanyl aminopeptidase (M01 family)	0.0041	0.0143	0.1061
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.0039	0.0914
Schistosoma mansoni	aminoadipate-semialdehyde dehydrogenase	0.0081	0.0377	0.3055
Brugia malayi	vab-3 gene.	0.0033	0.0098	0.008
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0017	0.0005	0.0006
Schistosoma mansoni	hypothetical protein	0.004	0.0136	0.1003
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0039	0.0034
Echinococcus multilocularis	Niemann Pick C1 protein	0.0096	0.0463	0.3795
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0145	0.0139
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0023	0.0039	0.0038
Echinococcus granulosus	Aminotransferase class III	0.0222	0.1191	1
Echinococcus granulosus	ornithine aminotransferase	0.0222	0.1191	1
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0059	0.0249	0.0273
Echinococcus granulosus	ectonucleotide pyrophosphatase:phosphodiesterase	0.0033	0.0094	0.0642
Onchocerca volvulus		0.0033	0.0094	0.0054
Mycobacterium ulcerans	phosphopantetheinyl transferase, PptII	0.0023	0.0038	0.0036
Mycobacterium leprae	Probable Acetylornithine aminotransferase ArgD	0.0222	0.1191	0.1294
Echinococcus granulosus	L aminoadipate semialdehyde	0.0081	0.0377	0.3055
Echinococcus multilocularis	paired box protein pax 6	0.0033	0.0098	0.0682
Schistosoma mansoni	hypothetical protein	0.007	0.0312	0.2507
Mycobacterium tuberculosis	Probable L-lysine-epsilon aminotransferase Lat (L-lysine aminotransferase) (lysine 6-aminotransferase)	0.0222	0.1191	0.1331
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0041	0.0143	0.1061
Echinococcus granulosus	ectonucleotide pyrophosphatase:phosphodiesterase	0.0033	0.0094	0.0642
Onchocerca volvulus		0.0033	0.0094	0.0054
Leishmania major	aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1	0.0041	0.0143	0.5383
Mycobacterium ulcerans	acetylornithine aminotransferase	0.0222	0.1191	0.1325
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0041	0.0143	0.1061
Brugia malayi	CHE-14 protein	0.0041	0.0145	0.0127
Trypanosoma cruzi	aminopeptidase, putative	0.0041	0.0143	1
Onchocerca volvulus		0.0041	0.0143	0.0104
Echinococcus multilocularis	Peptidase M1, membrane alanine aminopeptidase, N terminal	0.0041	0.0143	0.1061
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0039	0.0038
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0029	0.0074	0.0477
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.0039	0.0914
Chlamydia trachomatis	glutamate-1-semialdehyde-2,1-aminomutase	0.0222	0.1191	1
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0039	0.0038
Brugia malayi	'Paired box' domain containing protein	0.0033	0.0098	0.008
Mycobacterium tuberculosis	Probable acetylornithine aminotransferase ArgD	0.0222	0.1191	0.1331
Plasmodium vivax	holo-[acyl-carrier-protein] synthase, putative	0.0023	0.0038	0.0271
Schistosoma mansoni	aldehyde dehydrogenase	0.0059	0.0249	0.197
Schistosoma mansoni	family M1 non-peptidase homologue (M01 family)	0.0027	0.0059	0.0348
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0203	0.1085	0.1081
Mycobacterium tuberculosis	holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie	0.0023	0.0038	0.0042
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0059	0.0249	0.0273
Mycobacterium leprae	Probable 4-aminobutyrate aminotransferase GabT (GAMMA-AMINO-N-BUTYRATE TRANSAMINASE) (GABA TRANSAMINASE) (GLUTAMATE:SUCCINIC SEM	0.0222	0.1191	0.1294
Brugia malayi	paired box pox-meso protein	0.0033	0.0098	0.008
Echinococcus multilocularis	ectonucleotide pyrophosphatase:phosphodiesterase	0.0033	0.0094	0.0642
Toxoplasma gondii	aldehyde dehydrogenase	0.0059	0.0249	0.197
Echinococcus multilocularis	ectonucleotide	0.0027	0.0064	0.0389
Onchocerca volvulus		0.007	0.0312	0.0274
Brugia malayi	Type I phosphodiesterase / nucleotide pyrophosphatase family protein	0.0033	0.0094	0.0075
Echinococcus granulosus	paired box protein pax 6	0.0033	0.0098	0.0682
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0059	0.0249	0.0279
Plasmodium falciparum	holo-[acyl-carrier-protein] synthase, putative	0.0023	0.0038	0.0271
Brugia malayi	Pre-SET motif family protein	0.0029	0.0074	0.0056
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0023	0.0039	0.0038
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0039	0.0038
Echinococcus multilocularis	aminopeptidase N	0.0041	0.0143	0.1061
Wolbachia endosymbiont of Brugia malayi	acetylornithine transaminase protein	0.0222	0.1191	1
Echinococcus multilocularis	ectonucleotide pyrophosphatase:phosphodiesterase	0.0033	0.0094	0.0642
Echinococcus granulosus	Niemann Pick C1 protein	0.0096	0.0463	0.3795
Echinococcus multilocularis	ectonucleotide pyrophosphatase:phosphodiesterase	0.0033	0.0094	0.0642
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0029	0.0074	0.0477
Schistosoma mansoni	ectonucleotide pyrophosphatase/phosphodiesterase	0.0033	0.0094	0.0642
Onchocerca volvulus		0.0033	0.0098	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0094	0.0088
Echinococcus multilocularis	paired box protein pax 1	0.0033	0.0098	0.0682
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0027	0.0059	0.0348
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0096	0.0463	1
Echinococcus multilocularis	paired box protein pax 6	0.0033	0.0098	0.0682
Echinococcus multilocularis	ectonucleotide pyrophosphatase:phosphodiesterase	0.0027	0.0064	0.0389
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0039	0.0021
Plasmodium vivax	ornithine aminotransferase, putative	0.0222	0.1191	1
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0059	0.0249	0.197
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0098	0.0472	0.3869
Mycobacterium ulcerans	aminopeptidase N PepN	0.0041	0.0143	0.0153
Trichomonas vaginalis	set domain proteins, putative	0.0232	0.1249	0.1256
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0023	0.0039	0.0043
Echinococcus multilocularis	sterol regulatory element binding protein	0.0041	0.0145	0.1077
Echinococcus granulosus	ectonucleotide pyrophosphatase:phosphodiesterase	0.0033	0.0094	0.0642
Echinococcus granulosus	ectonucleotide pyrophosphatase:phosphodiesterase	0.0027	0.0064	0.0389
Echinococcus granulosus	sterol regulatory element binding protein	0.0041	0.0145	0.1077
Schistosoma mansoni	aminopeptidase PILS (M01 family)	0.0041	0.0143	0.1061
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0064	0.0059
Entamoeba histolytica	acyl-coA synthetase, putative	0.0023	0.0039	0.0043
Mycobacterium tuberculosis	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA	0.1559	0.895	1
Echinococcus multilocularis	paired box protein pax 6	0.0033	0.0098	0.0682
Brugia malayi	Thrombospondin type 1 domain containing protein	0.007	0.0312	0.0294
Toxoplasma gondii	ornithine aminotransferase, mitochondrial precursor, putative	0.0222	0.1191	1
Schistosoma mansoni	paired box protein pax-6	0.0033	0.0098	0.0682
Echinococcus multilocularis	ectonucleotide pyrophosphatase:phosphodiesterase	0.0033	0.0094	0.0642
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0094	0.0088
Trypanosoma cruzi	metallo-peptidase, Clan MA(E) Family M1	0.0027	0.0059	0.328
Entamoeba histolytica	aminopeptidase, putative	0.0041	0.0143	0.2469
Brugia malayi	'Paired box' domain containing protein	0.0033	0.0098	0.008
Plasmodium falciparum	ornithine aminotransferase	0.0222	0.1191	1
Brugia malayi	Peptidase family M1 containing protein	0.0041	0.0143	0.0125
Echinococcus granulosus	ectonucleotide pyrophosphatase:phosphodiesterase	0.0033	0.0094	0.0642
Onchocerca volvulus	Retinal homeobox protein Rx homolog	0.0033	0.0098	0.0059
Brugia malayi	Gooseberry protein	0.0033	0.0098	0.008
Schistosoma mansoni	aldehyde dehydrogenase	0.0059	0.0249	0.197
Echinococcus multilocularis	L aminoadipate semialdehyde	0.0081	0.0377	0.3055
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0023	0.0039	0.0002
Echinococcus multilocularis	Aminotransferase class III	0.0222	0.1191	1
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0098	0.0093
Mycobacterium leprae	PROBABLE GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE HEML (GSA) (GLUTAMATE-1-SEMIALDEHYDE AMINOTRANSFERASE) (GSA-AT)	0.0222	0.1191	0.1294
Onchocerca volvulus		0.0041	0.0143	0.0104
Chlamydia trachomatis	holo [acyl-carrier protein] synthase	0.0023	0.0038	0.0271
Onchocerca volvulus		0.0029	0.0074	0.0035
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0039	0.0034
Echinococcus multilocularis	ectonucleotide pyrophosphatase:phosphodiesterase	0.0033	0.0094	0.0642
Onchocerca volvulus		0.0232	0.1249	0.1214
Mycobacterium tuberculosis	Probable glutamate-1-semialdehyde 2,1-aminomutase HemL (GSA) (glutamate-1-semialdehyde aminotransferase) (GSA-at)	0.0222	0.1191	0.1331
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0023	0.0039	0.0043
Mycobacterium ulcerans	adenosylmethionine-8-amino-7-oxononanoate aminotransferase	0.1559	0.895	1
Onchocerca volvulus		0.0081	0.0377	0.0338
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.0039	0.0914
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0023	0.0039	0.0044
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0041	0.0143	0.1061
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0094	0.0088
Loa Loa (eye worm)	vab-3	0.0033	0.0098	0.0093
Trypanosoma brucei	hypothetical protein, conserved	0.0023	0.0038	0.155
Echinococcus multilocularis	protein patched	0.0041	0.0145	0.1077
Brugia malayi	paired box protein	0.0033	0.0098	0.008
Brugia malayi	aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase	0.0081	0.0377	0.0359
Echinococcus granulosus	Protein patched homolog 1	0.0041	0.0145	0.1077
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0041	0.0143	0.1061
Loa Loa (eye worm)	pax transcription factor protein 2	0.174	1	1
Mycobacterium ulcerans	4-aminobutyrate aminotransferase	0.0222	0.1191	0.1325
Mycobacterium ulcerans	hypothetical protein	0.0023	0.0039	0.0038
Echinococcus multilocularis	expressed conserved protein	0.009	0.043	0.3507
Loa Loa (eye worm)	paired box protein	0.0033	0.0098	0.0093
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0059	0.0249	1
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0059	0.0054
Mycobacterium ulcerans	ornithine aminotransferase RocD1 and RocD2	0.0222	0.1191	0.1325
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0098	0.0093
Echinococcus granulosus	expressed conserved protein	0.009	0.043	0.3507
Mycobacterium tuberculosis	Probable ornithine aminotransferase (N-terminus part) RocD1 (ornithine--oxo-acid aminotransferase)	0.0222	0.1191	0.1331
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0041	0.0143	0.1061
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0023	0.0039	0.0044
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0041	0.0145	0.0139
Echinococcus granulosus	paired box protein pax 1	0.0033	0.0098	0.0682
Plasmodium vivax	SET domain protein, putative	0.0029	0.0074	0.0581
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0039	0.0021
Schistosoma mansoni	hypothetical protein	0.004	0.0136	0.1003
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0059	0.0054
Brugia malayi	Peptidase family M1 containing protein	0.0041	0.0143	0.0125
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0029	0.0074	0.0477
Echinococcus granulosus	paired box protein pax 6	0.0033	0.0098	0.0682
Echinococcus multilocularis	protein dispatched 1	0.0047	0.0179	0.1366
Onchocerca volvulus		0.174	1	1
Schistosoma mansoni	patched 1	0.0041	0.0145	0.1077
Echinococcus granulosus	aminopeptidase N	0.0041	0.0143	0.1061
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0041	0.0143	0.1061
Echinococcus granulosus	Niemann Pick C1 protein	0.0138	0.0703	0.5839
Brugia malayi	Niemann-Pick C1 protein precursor	0.0096	0.0463	0.0446
Onchocerca volvulus		0.0033	0.0098	0.0059
Loa Loa (eye worm)	aminopeptidase N	0.0041	0.0143	0.0137
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0059	0.0054
Trichomonas vaginalis	acetylornithine aminotransferase, putative	0.1559	0.895	1
Mycobacterium ulcerans	hypothetical protein	0.1559	0.895	1
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0059	0.0249	0.0273
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0029	0.0074	0.0477
Mycobacterium tuberculosis	Probable aminotransferase	0.1559	0.895	1
Trypanosoma brucei	Aminopeptidase M1, putative	0.0041	0.0143	1
Schistosoma mansoni	paired box protein pax-6	0.0033	0.0098	0.0682
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0377	0.0371
Trypanosoma brucei	Aminopeptidase M1, putative	0.0041	0.0143	1
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0199	0.0193
Schistosoma mansoni	ectonucleotide pyrophosphatase/phosphodiesterase	0.0033	0.0094	0.0642
Toxoplasma gondii	4'-phosphopantetheinyl transferase superfamily protein	0.0023	0.0038	0.0164
Echinococcus multilocularis	ornithine aminotransferase	0.0222	0.1191	1
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0098	0.0093
Schistosoma mansoni	hypothetical protein	0.004	0.0136	0.1003
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0074	0.0477
Leishmania major	aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1	0.0041	0.0143	0.5383
Loa Loa (eye worm)	hypothetical protein	0.0096	0.0463	0.0458
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0041	0.0143	0.1061
Echinococcus multilocularis	Niemann Pick C1 protein	0.0138	0.0703	0.5839
Brugia malayi	Pre-SET motif family protein	0.0203	0.1085	0.1069
Echinococcus granulosus	histone lysine methyltransferase setb	0.0029	0.0074	0.0477
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0074	0.0477
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0041	0.0143	0.1061
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0028	0.0068	0.0424
Treponema pallidum	4'-phosphopantetheinyl transferase	0.0023	0.0038	0.5
Echinococcus multilocularis	ornithine aminotransferase	0.0222	0.1191	1
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.0145	0.0002
Brugia malayi	4-aminobutyrate aminotransferase, mitochondrial precursor	0.0222	0.1191	0.1175
Leishmania major	phosphopantetheinyl transferase-like protein	0.0023	0.0038	0.0834
Mycobacterium ulcerans	4-aminobutyrate aminotransferase	0.0222	0.1191	0.1325
Loa Loa (eye worm)	thrombospondin type 1 domain-containing protein	0.007	0.0312	0.0307
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0023	0.0039	0.0038
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0074	0.0477
Schistosoma mansoni	ectonucleotide pyrophosphatase/phosphodiesterase	0.0033	0.0094	0.0642
Mycobacterium leprae	PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA	0.1559	0.895	1
Echinococcus granulosus	paired box gene 3/7 (eyeless, eyegone, twin of eyeless)	0.0033	0.0098	0.0682
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0023	0.0039	0.0038
Mycobacterium ulcerans	glutamate-1-semialdehyde aminotransferase	0.0222	0.1191	0.1325

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2179301

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1721902