TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 485.514 | Formula: C25H19N5O4S
H donors: 2 H acceptors: 4 LogP: 3.81 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccccc1n1nc(C(=O)NCC(=O)Nc2nc3c(s2)cccc3)c2c(c1=O)cccc2
InChi: 1S/C25H19N5O4S/c1-34-19-12-6-5-11-18(19)30-24(33)16-9-3-2-8-15(16)22(29-30)23(32)26-14-21(31)28-25-27-17-10-4-7-13-20(17)35-25/h2-13H,14H2,1H3,(H,26,32)(H,27,28,31)
InChiKey: QCHBOHCUGYHCNK-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Mus musculus	porcupine homolog (Drosophila)	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	protein cysteine N palmitoyltransferase	Get druggable targets OG5_133309	All targets in OG5_133309
Loa Loa (eye worm)	MBOAT family protein	Get druggable targets OG5_133309	All targets in OG5_133309
Schistosoma japonicum	ko:K00181 porcupine, putative	Get druggable targets OG5_133309	All targets in OG5_133309
Echinococcus granulosus	protein cysteine N palmitoyltransferase	Get druggable targets OG5_133309	All targets in OG5_133309
Echinococcus multilocularis	zinc finger protein	Get druggable targets OG5_133309	All targets in OG5_133309
Schistosoma mansoni	zinc finger protein	Get druggable targets OG5_133309	All targets in OG5_133309
Brugia malayi	MBOAT family protein	Get druggable targets OG5_133309	All targets in OG5_133309
Echinococcus granulosus	zinc finger protein	Get druggable targets OG5_133309	All targets in OG5_133309

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	tyrosine kinase	0.0038	0.018	0.0186
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0038	0.018	0.018
Schistosoma mansoni	dual specificity serine/threonine tyrosine kinase	0.0073	0.1029	0.1061
Schistosoma mansoni	protein kinase	0.0038	0.018	0.0186
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0038	0.018	0.0279
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0056	0.0607	0.0607
Brugia malayi	Protein kinase domain containing protein	0.0038	0.018	0.0279
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0038	0.018	0.0186
Brugia malayi	Protein kinase domain containing protein	0.0038	0.018	0.0279
Echinococcus granulosus	dual specificity serine:threonine tyrosine	0.0073	0.1029	0.1029
Echinococcus granulosus	tyrosine protein kinase	0.0038	0.018	0.018
Brugia malayi	Protein kinase domain containing protein	0.0056	0.0607	0.0942
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0038	0.018	0.018
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0038	0.0191	1
Schistosoma mansoni	zinc finger protein	0.0299	0.6444	0.6641
Brugia malayi	Protein kinase domain containing protein	0.0038	0.018	0.0279
Entamoeba histolytica	protein kinase domain containing protein	0.0038	0.0191	0.0262
Schistosoma mansoni	protein kinase	0.0038	0.018	0.0186
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0068	0.0904	0.0904
Schistosoma mansoni	tyrosine kinase	0.0068	0.0904	0.0932
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0068	0.0904	0.0904
Loa Loa (eye worm)	TK/FER protein kinase	0.0038	0.018	0.0279
Schistosoma mansoni	serine/threonine RGC	0.0038	0.018	0.0186
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.0038	0.018	0.0279
Brugia malayi	Protein kinase domain containing protein	0.0085	0.1318	0.2045
Echinococcus granulosus	natriuretic peptide receptor 1	0.0038	0.018	0.018
Schistosoma mansoni	tyrosine kinase	0.0068	0.0904	0.0932
Loa Loa (eye worm)	TK protein kinase	0.0038	0.018	0.0279
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0068	0.0904	0.0904
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.0038	0.018	0.0279
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0085	0.1318	0.1318
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0068	0.0904	0.0904
Brugia malayi	hypothetical protein	0.0038	0.018	0.0279
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0038	0.018	0.0186
Loa Loa (eye worm)	TK/FER protein kinase	0.0056	0.0607	0.0942
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0068	0.0904	0.0904
Echinococcus granulosus	protein kinase	0.0038	0.018	0.018
Schistosoma mansoni	tyrosine kinase	0.0068	0.0904	0.0932
Echinococcus granulosus	tyrosine protein kinase Blk	0.0056	0.0607	0.0607
Brugia malayi	Tyrosine-protein kinase PR2	0.0038	0.018	0.0279
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.0038	0.018	0.018
Loa Loa (eye worm)	TK/FER protein kinase	0.0056	0.0607	0.0942
Schistosoma mansoni	tyrosine kinase	0.0038	0.018	0.0186
Echinococcus multilocularis	protein tyrosine kinase	0.0038	0.018	0.018
Brugia malayi	Protein kinase domain containing protein	0.0038	0.018	0.0279
Schistosoma mansoni	tyrosine kinase	0.008	0.1203	0.124
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0038	0.018	0.0279
Brugia malayi	Protein kinase domain containing protein	0.0038	0.018	0.0279
Brugia malayi	Protein kinase domain containing protein	0.0038	0.018	0.0279
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.0038	0.018	0.0279
Loa Loa (eye worm)	hypothetical protein	0.0038	0.018	0.0279
Leishmania major	protein kinase, putative	0.0038	0.0191	1
Schistosoma mansoni	protein kinase	0.0038	0.018	0.0186
Schistosoma mansoni	protein kinase	0.0038	0.018	0.0186
Echinococcus granulosus	activin receptor type	0.0038	0.0191	0.0191
Schistosoma mansoni	protein kinase	0.0038	0.018	0.0186
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0038	0.018	0.018
Loa Loa (eye worm)	TK/Met protein kinase	0.0038	0.018	0.0279
Echinococcus multilocularis	natriuretic peptide receptor 1	0.0038	0.018	0.018
Echinococcus multilocularis	tyrosine protein kinase csk	0.0038	0.018	0.018
Echinococcus granulosus	tyrosine protein kinase pr2	0.0038	0.018	0.018
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.0038	0.018	0.0279
Plasmodium falciparum	protein kinase, putative	0.0038	0.0191	1
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0038	0.018	0.018
Echinococcus granulosus	tyrosine protein kinase csk	0.0038	0.018	0.018
Brugia malayi	Protein kinase domain containing protein	0.0038	0.018	0.0279
Loa Loa (eye worm)	MBOAT family protein	0.0299	0.6444	1
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0038	0.018	0.0279
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0068	0.0904	0.0904
Echinococcus granulosus	protein cysteine N palmitoyltransferase	0.0299	0.6444	0.6444
Brugia malayi	Protein kinase domain containing protein	0.0038	0.018	0.0279
Echinococcus multilocularis	zinc finger protein	0.0273	0.5826	0.5826
Loa Loa (eye worm)	hypothetical protein	0.0038	0.018	0.0279
Echinococcus multilocularis	epidermal growth factor receptor	0.0118	0.2107	0.2107
Brugia malayi	SH2 domain containing protein	0.0056	0.0607	0.0942
Echinococcus multilocularis	epidermal growth factor receptor	0.0188	0.3784	0.3784
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0038	0.0191	1
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0038	0.0191	1
Echinococcus multilocularis	tyrosine kinase	0.0038	0.018	0.018
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.0038	0.018	0.018
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0038	0.0191	0.0191
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0038	0.018	0.0186
Loa Loa (eye worm)	TK/FER protein kinase	0.0056	0.0607	0.0942
Echinococcus multilocularis	protein cysteine N palmitoyltransferase	0.0299	0.6444	0.6444
Brugia malayi	Protein kinase domain containing protein	0.0073	0.1029	0.1597
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0068	0.0904	0.0904
Schistosoma mansoni	tyrosine kinase	0.0038	0.018	0.0186
Loa Loa (eye worm)	SRC-1	0.0068	0.0904	0.1403
Echinococcus multilocularis	insulin receptor	0.0085	0.1318	0.1318
Trichomonas vaginalis	CAMK family protein kinase	0.0073	0.1029	1
Brugia malayi	MBOAT family protein	0.0299	0.6444	1
Trichomonas vaginalis	CAMK family protein kinase	0.0073	0.1029	1
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0038	0.018	0.0279
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0038	0.018	0.0186
Loa Loa (eye worm)	TK protein kinase	0.0038	0.018	0.0279
Brugia malayi	Protein kinase domain containing protein	0.0038	0.018	0.0279
Brugia malayi	Protein kinase domain containing protein	0.0038	0.018	0.0279
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0038	0.018	0.0279
Loa Loa (eye worm)	TK protein kinase	0.0038	0.018	0.0279
Loa Loa (eye worm)	TK/FER protein kinase	0.0038	0.018	0.0279
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0056	0.0607	0.0607
Schistosoma mansoni	tyrosine kinase	0.0038	0.018	0.0186
Loa Loa (eye worm)	TK/FER protein kinase	0.0038	0.018	0.0279
Brugia malayi	Protein kinase domain containing protein	0.0038	0.018	0.0279
Schistosoma mansoni	tyrosine kinase	0.0038	0.018	0.0186
Echinococcus multilocularis	tyrosine protein kinase shark	0.0056	0.0607	0.0607
Trypanosoma brucei	protein kinase, putative	0.0038	0.0191	1
Echinococcus granulosus	tyrosine protein kinase Srms	0.0056	0.0607	0.0607
Schistosoma mansoni	ephrin receptor	0.0038	0.018	0.0186
Loa Loa (eye worm)	TK/FER protein kinase	0.0056	0.0607	0.0942
Echinococcus granulosus	tyrosine kinase	0.0056	0.0607	0.0607
Brugia malayi	Protein kinase domain containing protein	0.0056	0.0607	0.0942
Brugia malayi	integrin-linked kinase	0.0038	0.018	0.0279
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.0038	0.018	0.018
Brugia malayi	SH2 domain containing protein	0.0056	0.0607	0.0942
Schistosoma mansoni	src-type protein tyrosine kinase-related	0.0038	0.018	0.0186
Loa Loa (eye worm)	TK protein kinase	0.0038	0.018	0.0279
Schistosoma mansoni	tyrosine kinase	0.008	0.1203	0.124
Loa Loa (eye worm)	TK/FER protein kinase	0.0056	0.0607	0.0942
Echinococcus granulosus	tyrosine protein kinase shark	0.0056	0.0607	0.0607
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0068	0.0904	0.0904
Brugia malayi	Protein kinase domain containing protein	0.0038	0.018	0.0279
Loa Loa (eye worm)	hypothetical protein	0.0038	0.018	0.0279
Echinococcus multilocularis	tyrosine protein kinase csk	0.0038	0.018	0.018
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.0038	0.018	0.018
Brugia malayi	SRC-1	0.0068	0.0904	0.1403
Brugia malayi	C-terminal src kinase protein 1	0.0038	0.018	0.0279
Loa Loa (eye worm)	TK/DDR protein kinase	0.0038	0.018	0.0279
Onchocerca volvulus		0.0056	0.0607	0.5029
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0607	0.0942
Brugia malayi	Protein kinase domain containing protein	0.0056	0.0607	0.0942
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0038	0.018	0.0186
Schistosoma mansoni	tyrosine kinase	0.0038	0.018	0.0186
Loa Loa (eye worm)	TK protein kinase	0.0038	0.018	0.0279
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0068	0.0916	0.0916
Schistosoma mansoni	tyrosine kinase	0.0038	0.018	0.0186
Echinococcus granulosus	zinc finger protein	0.0273	0.5826	0.5826
Brugia malayi	bone morphogenetic protein type 1 receptor	0.0038	0.018	0.0279
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0038	0.0191	1
Schistosoma mansoni	tyrosine kinase	0.0118	0.2107	0.2172
Brugia malayi	Protein kinase domain containing protein	0.0038	0.018	0.0279
Schistosoma mansoni	tyrosine kinase	0.0038	0.018	0.0186
Echinococcus granulosus	c src tyrosine kinase	0.0068	0.0904	0.0904
Onchocerca volvulus		0.0056	0.0607	0.5029
Echinococcus multilocularis	tyrosine kinase	0.0056	0.0607	0.0607
Loa Loa (eye worm)	hypothetical protein	0.0038	0.018	0.0279
Brugia malayi	Protein kinase domain containing protein	0.0038	0.018	0.0279
Onchocerca volvulus	Dual specificity protein kinase TTK homolog	0.0073	0.1029	1
Brugia malayi	hypothetical protein	0.0038	0.018	0.0279
Schistosoma mansoni	tyrosine kinase	0.0038	0.018	0.0186
Echinococcus multilocularis	activin receptor type	0.0038	0.0191	0.0191
Loa Loa (eye worm)	TK protein kinase	0.0038	0.018	0.0279
Loa Loa (eye worm)	TK protein kinase	0.0038	0.018	0.0279
Echinococcus granulosus	epidermal growth factor receptor	0.0118	0.2107	0.2107
Echinococcus granulosus	protein tyrosine kinase	0.0038	0.018	0.018
Echinococcus multilocularis	dual specificity serine:threonine tyrosine	0.0073	0.1029	0.1029
Schistosoma mansoni	protein kinase	0.0038	0.0191	0.0197
Loa Loa (eye worm)	TK/FER protein kinase	0.0056	0.0607	0.0942
Loa Loa (eye worm)	hypothetical protein	0.0038	0.018	0.0279
Echinococcus multilocularis	tyrosine protein kinase pr2	0.0038	0.018	0.018
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.0038	0.018	0.0279
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0038	0.018	0.018
Brugia malayi	hypothetical protein	0.0056	0.0607	0.0942
Loa Loa (eye worm)	TK/FER protein kinase	0.0056	0.0607	0.0942
Echinococcus multilocularis		0.0047	0.0398	0.0398
Schistosoma mansoni	protein tyrosine kinase	0.0038	0.018	0.0186
Loa Loa (eye worm)	TK/FER protein kinase	0.0038	0.018	0.0279
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.0038	0.018	0.0279
Loa Loa (eye worm)	TK protein kinase	0.0056	0.0607	0.0942
Echinococcus granulosus	receptor type guanylyl cyclase	0.0038	0.018	0.018
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0068	0.0904	0.0904
Echinococcus granulosus	activated cdc42 kinase 1	0.0038	0.018	0.018
Schistosoma mansoni	tyrosine kinase	0.0038	0.018	0.0186
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.0038	0.018	0.018
Schistosoma mansoni	tyrosine kinase	0.0038	0.018	0.0186
Schistosoma mansoni	tyrosine kinase	0.0038	0.018	0.0186
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0038	0.018	0.018
Echinococcus multilocularis	integrin linked protein kinase	0.0038	0.018	0.018
Brugia malayi	Protein kinase domain containing protein	0.0038	0.018	0.0279
Brugia malayi	Protein kinase domain containing protein	0.0038	0.018	0.0279
Schistosoma mansoni	tyrosine kinase	0.0056	0.0607	0.0626
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0056	0.0607	0.0607
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0038	0.018	0.018
Echinococcus granulosus	fibroblast growth factor receptor 4	0.0038	0.018	0.018
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0038	0.018	0.018
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.0038	0.018	0.018
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.0038	0.018	0.018
Loa Loa (eye worm)	TK/FER protein kinase	0.0038	0.018	0.0279
Echinococcus multilocularis	protein kinase	0.0038	0.018	0.018
Loa Loa (eye worm)	TK protein kinase	0.0038	0.018	0.0279
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.0038	0.018	0.0279
Schistosoma mansoni	serine/threonine protein kinase	0.0038	0.018	0.0186
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0068	0.0904	0.0904
Loa Loa (eye worm)	TK/ABL protein kinase	0.0056	0.0607	0.0942
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0068	0.0904	0.0904
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0085	0.1318	0.1318
Echinococcus granulosus	kinase suppressor of Ras 1	0.0038	0.018	0.018
Schistosoma mansoni	tyrosine kinase	0.0038	0.018	0.0186
Schistosoma mansoni	protein kinase	0.0038	0.018	0.0186
Schistosoma mansoni	tyrosine kinase	0.0085	0.1318	0.1358
Echinococcus granulosus	raf serine:threonine protein kinase	0.0038	0.018	0.018
Schistosoma mansoni	protein kinase	0.0038	0.018	0.0186
Schistosoma mansoni	tyrosine kinase	0.0435	0.9703	1
Loa Loa (eye worm)	hypothetical protein	0.0038	0.018	0.0279
Brugia malayi	Protein kinase domain containing protein	0.0038	0.018	0.0279
Loa Loa (eye worm)	TK/FAK protein kinase	0.0038	0.018	0.0279
Echinococcus granulosus	ephrin type A receptor 4 A	0.0038	0.018	0.018
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0068	0.0904	0.0932
Schistosoma mansoni	protein kinase	0.0038	0.0191	0.0197
Loa Loa (eye worm)	TK/INSR protein kinase	0.0085	0.1318	0.2045
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.0038	0.018	0.018
Schistosoma mansoni	tyrosine kinase	0.0118	0.2107	0.2172
Brugia malayi	Furin-like cysteine rich region family protein	0.0188	0.3784	0.5873
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0038	0.018	0.0279
Brugia malayi	Protein kinase domain containing protein	0.0038	0.018	0.0279
Echinococcus multilocularis	tyrosine protein kinase	0.0038	0.018	0.018
Brugia malayi	Protein kinase domain containing protein	0.0056	0.0607	0.0942
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0038	0.018	0.018
Schistosoma mansoni	tyrosine kinase	0.0085	0.1318	0.1358
Loa Loa (eye worm)	TK/EPH protein kinase	0.0038	0.018	0.0279
Schistosoma mansoni	tyrosine protein kinase	0.0038	0.018	0.0186
Loa Loa (eye worm)	serine/threonine protein kinase	0.0038	0.018	0.0279
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.0038	0.018	0.018
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0038	0.018	0.5
Schistosoma mansoni	tyrosine kinase	0.0068	0.0904	0.0932
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0038	0.018	0.018
Loa Loa (eye worm)	TK/RYK protein kinase	0.0038	0.018	0.0279
Brugia malayi	Guanylyl cyclase protein 23	0.0038	0.018	0.0279
Echinococcus multilocularis	heat shock protein 70	0.0038	0.018	0.018
Loa Loa (eye worm)	TK/ACK protein kinase	0.0038	0.018	0.0279
Loa Loa (eye worm)	hypothetical protein	0.0038	0.018	0.0279
Schistosoma mansoni	serine/threonine protein kinase	0.0038	0.018	0.0186
Brugia malayi	Protein kinase domain containing protein	0.0038	0.018	0.0279
Echinococcus granulosus	tyrosine kinase	0.0038	0.018	0.018
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.0038	0.018	0.018
Echinococcus granulosus	tyrosine protein kinase HCK	0.0038	0.018	0.018
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0038	0.018	0.018
Schistosoma mansoni	tyrosine kinase	0.0038	0.018	0.0186
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0038	0.018	0.018
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0068	0.0904	0.0904
Brugia malayi	Protein kinase domain containing protein	0.0056	0.0607	0.0942
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0038	0.018	0.0279
Brugia malayi	Protein kinase domain containing protein	0.0038	0.018	0.0279
Loa Loa (eye worm)	TK/FER protein kinase	0.0056	0.0607	0.0942
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0056	0.0607	0.0607
Echinococcus multilocularis	protein kinase	0.0038	0.018	0.018
Echinococcus multilocularis	c src tyrosine kinase	0.0068	0.0904	0.0904
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.0038	0.018	0.018
Loa Loa (eye worm)	hypothetical protein	0.0038	0.018	0.0279
Onchocerca volvulus		0.0056	0.0607	0.5029
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0068	0.0904	0.0904
Echinococcus granulosus	integrin linked protein kinase	0.0038	0.018	0.018
Echinococcus granulosus	tyrosine protein kinase csk	0.0038	0.018	0.018
Brugia malayi	Protein kinase domain containing protein	0.0038	0.018	0.0279
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0038	0.018	0.018
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.0038	0.018	0.0279
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0038	0.018	0.0279
Schistosoma mansoni	tyrosine kinase	0.0038	0.018	0.0186
Brugia malayi	protein-tyrosine kinase	0.0056	0.0607	0.0942
Echinococcus granulosus	insulin receptor	0.0085	0.1318	0.1318
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0056	0.0607	0.0607
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0038	0.018	0.018
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0118	0.2107	0.2107
Giardia lamblia	Kinase, TTK	0.0073	0.1029	1
Onchocerca volvulus		0.0056	0.0607	0.5029
Schistosoma mansoni	protein kinase	0.0038	0.018	0.0186
Brugia malayi	Receptor family ligand binding region containing protein	0.0038	0.018	0.0279
Schistosoma mansoni	tyrosine kinase	0.0038	0.018	0.0186
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0068	0.0904	0.0904
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0188	0.3784	0.5873
Loa Loa (eye worm)	TK/ALK protein kinase	0.0038	0.018	0.0279
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0038	0.018	0.018
Schistosoma mansoni	tyrosine kinase	0.0038	0.018	0.0186
Echinococcus granulosus	tyrosine protein kinase csk	0.0038	0.018	0.018
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0053	0.0557	0.0864
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0068	0.0904	0.0904
Echinococcus multilocularis	tyrosine protein kinase csk	0.0038	0.018	0.018
Schistosoma mansoni	tyrosine kinase	0.0038	0.018	0.0186
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.0038	0.018	0.0279
Loa Loa (eye worm)	hypothetical protein	0.0038	0.018	0.0279
Schistosoma mansoni	tyrosine kinase	0.0188	0.3784	0.39
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0038	0.0191	0.0191
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.0038	0.018	0.018
Brugia malayi	Protein kinase domain containing protein	0.0038	0.018	0.0279
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0038	0.018	0.0279
Echinococcus granulosus	epidermal growth factor receptor	0.0188	0.3784	0.3784
Echinococcus multilocularis	protein KINase family member (kin 25)	0.0038	0.018	0.018
Echinococcus multilocularis	ephrin type A receptor 4 A	0.0038	0.018	0.018
Schistosoma mansoni	serine/threonine protein kinase	0.005	0.0477	0.0492
Echinococcus granulosus	activated cdc42 kinase 1	0.0038	0.018	0.018
Echinococcus multilocularis	tyrosine protein kinase csk	0.0038	0.018	0.018
Loa Loa (eye worm)	hypothetical protein	0.0038	0.018	0.0279
Loa Loa (eye worm)	TTK protein kinase	0.0073	0.1029	0.1597
Onchocerca volvulus		0.0056	0.0607	0.5029
Echinococcus multilocularis	kinase suppressor of Ras 1	0.0038	0.018	0.018
Echinococcus multilocularis	FL cytokine receptor	0.0038	0.018	0.018
Loa Loa (eye worm)	hypothetical protein	0.0038	0.018	0.0279
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0056	0.0607	1
Loa Loa (eye worm)	protein kinase domain-containing protein	0.0038	0.018	0.0279
Loa Loa (eye worm)	TK/CSK protein kinase	0.0038	0.018	0.0279
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0038	0.018	0.018
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0056	0.0607	0.0607
Schistosoma mansoni	tyrosine kinase	0.0038	0.018	0.0186
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0056	0.0607	0.0607
Brugia malayi	ephrin receptor 1 precursor	0.0038	0.018	0.0279
Echinococcus multilocularis	activated cdc42 kinase 1	0.0038	0.018	0.018
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0068	0.0904	0.0904
Loa Loa (eye worm)	TK/FER protein kinase	0.0056	0.0607	0.0942
Schistosoma mansoni	serine/threonine protein kinase	0.0038	0.018	0.0186
Plasmodium vivax	protein kinase, putative	0.0038	0.018	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0038	0.018	0.0279
Loa Loa (eye worm)	TK/FER protein kinase	0.0056	0.0607	0.0942
Brugia malayi	Protein kinase domain containing protein	0.0038	0.018	0.0279
Echinococcus multilocularis	transfer RNA-Thr	0.0038	0.018	0.018
Brugia malayi	Tyrosine-protein kinase abl-1	0.0068	0.0904	0.1403
Schistosoma mansoni	protein kinase	0.0038	0.0191	0.0197
Loa Loa (eye worm)	TK/FER protein kinase	0.0038	0.018	0.0279
Brugia malayi	Protein kinase domain containing protein	0.0038	0.018	0.0279
Schistosoma mansoni	tyrosine kinase	0.008	0.1203	0.124
Onchocerca volvulus		0.0056	0.0607	0.5029
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0068	0.0904	0.0904
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0053	0.0557	0.0864
Schistosoma mansoni	hypothetical protein	0.0038	0.018	0.0186
Loa Loa (eye worm)	TK protein kinase	0.0038	0.018	0.0279
Schistosoma mansoni	tyrosine kinase	0.0038	0.018	0.0186
Loa Loa (eye worm)	TK/ROR protein kinase	0.0038	0.018	0.0279
Schistosoma mansoni	ephrin receptor	0.0038	0.018	0.0186
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0056	0.0607	0.0607
Echinococcus granulosus	tyrosine kinase	0.0056	0.0607	0.0607
Brugia malayi	Raf kinase	0.0038	0.018	0.0279
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0038	0.018	0.5
Loa Loa (eye worm)	hypothetical protein	0.0038	0.018	0.0279

Activities

Activity type	Activity value	Assay description	Source	Reference
EC50 (binding)	= 10000 nM	Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay	ChEMBL.	23477365

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2324270

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1725939