Detailed information for compound 1725942

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 543.455 | Formula: C21H20F7N3O4S
  • H donors: 2 H acceptors: 4 LogP: 3.28 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 2
  • SMILES: Fc1ccc(c(c1)C(F)(F)F)N1CCN([C@@H](C1)C)S(=O)(=O)c1ccc(cc1)[C@](C(F)(F)F)(C(=O)N)O
  • InChi: 1S/C21H20F7N3O4S/c1-12-11-30(17-7-4-14(22)10-16(17)20(23,24)25)8-9-31(12)36(34,35)15-5-2-13(3-6-15)19(33,18(29)32)21(26,27)28/h2-7,10,12,33H,8-9,11H2,1H3,(H2,29,32)/t12-,19-/m1/s1
  • InChiKey: XTHPPYUOTCUZNL-CWTRNNRKSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens hydroxysteroid (11-beta) dehydrogenase 1 Starlite/ChEMBL References
Mus musculus hydroxysteroid 11-beta dehydrogenase 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium tuberculosis Probable oxidoreductase Get druggable targets OG5_132866 All targets in OG5_132866
Mycobacterium ulcerans short chain dehydrogenase Get druggable targets OG5_132866 All targets in OG5_132866
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum steroid dehydrogenase, putative hydroxysteroid 11-beta dehydrogenase 1 292 aa 246 aa 25.2 %
Plasmodium falciparum steroid dehydrogenase, putative hydroxysteroid (11-beta) dehydrogenase 1 292 aa 250 aa 24.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica protein kinase domain containing protein 0.0051 0.0072 0.6345
Brugia malayi Protein kinase domain containing protein 0.007 0.0112 0.0109
Schistosoma mansoni tyrosine kinase 0.0051 0.0072 0.0125
Entamoeba histolytica protein kinase domain containing protein 0.0051 0.0072 0.6345
Schistosoma mansoni protein kinase 0.0051 0.0072 0.0125
Loa Loa (eye worm) TK protein kinase 0.0051 0.0072 0.0069
Loa Loa (eye worm) TK/ALK protein kinase 0.0051 0.0072 0.0069
Echinococcus multilocularis growth factor receptor bound protein 2 0.0032 0.0031 0.005
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0067 0.0108 0.0104
Loa Loa (eye worm) TK protein kinase 0.0051 0.0072 0.0069
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0051 0.0072 0.6345
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0051 0.0072 0.6345
Echinococcus granulosus tensin C1 domain containing phosphatase 0.0019 0.0004 0.0007
Entamoeba histolytica ankyrin repeat protein 0.0051 0.0072 0.6345
Entamoeba histolytica tyrosin kinase, putative 0.0051 0.0072 0.6345
Echinococcus granulosus SH2 motif 0.0019 0.0004 0.0007
Loa Loa (eye worm) TK/FER protein kinase 0.007 0.0112 0.0109
Echinococcus granulosus retinal guanylyl cyclase 2 0.0051 0.0072 0.0131
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0052 0.0074 0.0001
Schistosoma mansoni protein kinase 0.0051 0.0072 0.0125
Schistosoma mansoni protein kinase 0.0051 0.0072 0.0125
Entamoeba histolytica protein kinase, putative 0.0051 0.0072 0.6345
Entamoeba histolytica protein kinase, putative 0.0051 0.0072 0.6345
Echinococcus granulosus SH2 motif 0.0019 0.0004 0.0007
Entamoeba histolytica hypothetical protein 0.0051 0.0072 0.6345
Echinococcus multilocularis tyrosine protein kinase Fes:Fps 0.0051 0.0072 0.0125
Brugia malayi Protein kinase domain containing protein 0.007 0.0112 0.0109
Entamoeba histolytica hypothetical protein 0.0051 0.0072 0.6345
Brugia malayi Immunoglobulin I-set domain containing protein 0.0067 0.0108 0.0104
Entamoeba histolytica hypothetical protein 0.0051 0.0072 0.6345
Brugia malayi SH2 domain containing protein 0.007 0.0112 0.0109
Echinococcus granulosus natriuretic peptide receptor 1 0.0051 0.0072 0.0131
Entamoeba histolytica protein kinase, putative 0.0051 0.0072 0.6345
Schistosoma mansoni tyrosine kinase 0.0051 0.0072 0.0125
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0022 0.001 0.0006
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0083 0.014 0.0246
Echinococcus multilocularis insulin receptor 0.0101 0.0178 0.0316
Echinococcus multilocularis tyrosine protein kinase pr2 0.0051 0.0072 0.0125
Brugia malayi Protein kinase domain containing protein 0.0051 0.0072 0.0069
Schistosoma mansoni tyrosine protein kinase 0.0051 0.0072 0.0125
Brugia malayi Protein kinase domain containing protein 0.0051 0.0072 0.0069
Echinococcus multilocularis activated cdc42 kinase 1 0.0051 0.0072 0.0125
Loa Loa (eye worm) TK/RYK protein kinase 0.0051 0.0072 0.0069
Entamoeba histolytica tyrosine kinase, putative 0.0051 0.0072 0.6345
Echinococcus granulosus tyrosine protein kinase Fes:Fps 0.0051 0.0072 0.0131
Brugia malayi Tyrosine-protein kinase abl-1 0.0083 0.014 0.0136
Echinococcus granulosus tyrosine protein kinase Btk29A 0.048 0.0985 0.1782
Echinococcus multilocularis protein kinase 0.0051 0.0072 0.0125
Entamoeba histolytica ankyrin repeat protein 0.0051 0.0072 0.6345
Entamoeba histolytica hypothetical protein 0.0051 0.0072 0.6345
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0051 0.0072 0.6345
Brugia malayi Protein kinase domain containing protein 0.0051 0.0072 0.0069
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0051 0.0072 0.0125
Echinococcus granulosus hypothetical protein 0.0019 0.0004 0.0007
Trypanosoma brucei protein kinase, putative 0.0052 0.0074 0.0001
Entamoeba histolytica tyrosine kinase, putative 0.0051 0.0072 0.6345
Entamoeba histolytica tyrosine kinase, putative 0.0051 0.0072 0.6345
Brugia malayi Immunoglobulin I-set domain containing protein 0.0051 0.0072 0.0069
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0083 0.014 0.0246
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0019 0.0004 0.0007
Schistosoma mansoni hypothetical protein 0.0051 0.0072 0.0125
Echinococcus granulosus tyrosine protein kinase Src42A 0.0019 0.0004 0.0007
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0051 0.0072 0.0131
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0051 0.0072 0.6345
Entamoeba histolytica tyrosine kinase, putative 0.0051 0.0072 0.6345
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0051 0.0072 0.0069
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0051 0.0072 0.6345
Brugia malayi Variant SH3 domain containing protein 0.0032 0.0031 0.0028
Onchocerca volvulus 0.007 0.0112 0.0196
Echinococcus multilocularis natriuretic peptide receptor 1 0.0051 0.0072 0.0125
Entamoeba histolytica SH2-protein kinase domain containing protein 0.007 0.0112 1
Entamoeba histolytica tyrosine kinase, putative 0.0051 0.0072 0.6345
Entamoeba histolytica hypothetical protein 0.0051 0.0072 0.6345
Brugia malayi hypothetical protein 0.0051 0.0072 0.0069
Brugia malayi integrin-linked kinase 0.0051 0.0072 0.0069
Entamoeba histolytica hypothetical protein 0.0051 0.0072 0.6345
Loa Loa (eye worm) hypothetical protein 0.0051 0.0072 0.0069
Loa Loa (eye worm) TK/ACK protein kinase 0.0051 0.0072 0.0069
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0052 0.0074 1
Brugia malayi C-terminal src kinase protein 1 0.0051 0.0072 0.0069
Onchocerca volvulus 0.0051 0.0072 0.0125
Loa Loa (eye worm) hypothetical protein 0.007 0.0112 0.0109
Schistosoma mansoni tyrosine kinase 0.0084 0.0143 0.0252
Entamoeba histolytica receptor protein kinase, putative 0.0051 0.0072 0.6345
Entamoeba histolytica hypothetical protein, conserved 0.0051 0.0072 0.6345
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.007 0.0112 0.0203
Schistosoma mansoni tyrosine kinase 0.0135 0.0252 0.0449
Echinococcus multilocularis tyrosine kinase 0.007 0.0112 0.0196
Echinococcus multilocularis NCK adaptor protein 0.0032 0.0031 0.005
Echinococcus granulosus suppressor of cytokine signaling 7 0.0019 0.0004 0.0007
Onchocerca volvulus 0.0051 0.0072 0.0125
Loa Loa (eye worm) hypothetical protein 0.0051 0.0072 0.0069
Loa Loa (eye worm) TK/FER protein kinase 0.007 0.0112 0.0109
Entamoeba histolytica tyrosin kinase, putative 0.0051 0.0072 0.6345
Loa Loa (eye worm) hypothetical protein 0.0051 0.0072 0.0069
Echinococcus multilocularis ephrin type A receptor 4 A 0.0051 0.0072 0.0125
Loa Loa (eye worm) TK/DDR protein kinase 0.0051 0.0072 0.0069
Giardia lamblia Kinase, TTK 0.0077 0.0127 1
Brugia malayi Protein kinase domain containing protein 0.007 0.0112 0.0109
Echinococcus multilocularis atrial natriuretic peptide receptor 1 0.0051 0.0072 0.0125
Echinococcus multilocularis epidermal growth factor receptor 0.0208 0.0408 0.0731
Mycobacterium tuberculosis Probable oxidoreductase 0.0676 0.1402 0.5
Entamoeba histolytica protein kinase, putative 0.0051 0.0072 0.6345
Echinococcus granulosus tyrosine protein kinase csk 0.0051 0.0072 0.0131
Echinococcus granulosus vesicular acetylcholine transporter 0.2616 0.553 1
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0051 0.0072 0.0131
Loa Loa (eye worm) TK/FER protein kinase 0.007 0.0112 0.0109
Echinococcus granulosus integrin linked protein kinase 0.0051 0.0072 0.0131
Onchocerca volvulus Tyrosine kinase homolog 0.0051 0.0072 0.0125
Schistosoma mansoni growth factor receptor-bound protein 0.0032 0.0031 0.005
Loa Loa (eye worm) TK/FER protein kinase 0.0051 0.0072 0.0069
Leishmania major protein kinase, putative 0.0052 0.0074 0.0001
Schistosoma mansoni tyrosine kinase 0.0083 0.014 0.0246
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0019 0.0005 0.0096
Echinococcus granulosus tyrosine protein kinase ABL1 0.007 0.0112 0.0203
Schistosoma mansoni adapter molecule crk 0.0032 0.0031 0.005
Loa Loa (eye worm) serine/threonine protein kinase 0.0051 0.0072 0.0069
Schistosoma mansoni tyrosine kinase 0.0467 0.0958 0.1726
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0051 0.0072 0.0125
Echinococcus granulosus mitogen-activated protein kinase kinase kinase 9 0.0051 0.0072 0.0131
Schistosoma mansoni tyrosine kinase 0.0083 0.014 0.0246
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0051 0.0072 0.0125
Schistosoma mansoni tyrosine kinase 0.0083 0.014 0.0246
Loa Loa (eye worm) TK protein kinase 0.0051 0.0072 0.0069
Entamoeba histolytica protein kinase with ankyrin repeats, putative 0.0051 0.0072 0.6345
Echinococcus granulosus atrial natriuretic peptide receptor 1 0.0051 0.0072 0.0131
Echinococcus multilocularis protein KINase family member (kin 25) 0.0051 0.0072 0.0125
Echinococcus granulosus tyrosine protein kinase Lyn 0.0083 0.0141 0.0255
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0051 0.0072 0.0069
Entamoeba histolytica tyrosine kinase, putative 0.0051 0.0072 0.6345
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0051 0.0072 0.6345
Trichomonas vaginalis CAMK family protein kinase 0.0077 0.0127 1
Brugia malayi Protein kinase domain containing protein 0.0051 0.0072 0.0069
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0083 0.014 0.0246
Schistosoma mansoni tyrosine kinase 0.0051 0.0072 0.0125
Loa Loa (eye worm) hypothetical protein 0.2411 0.5093 0.5092
Loa Loa (eye worm) TK/FER protein kinase 0.007 0.0112 0.0109
Brugia malayi Variant SH3 domain containing protein 0.0022 0.001 0.0006
Brugia malayi Sex muscle abnormal protein 5 0.0032 0.0031 0.0028
Schistosoma mansoni src-type protein tyrosine kinase-related 0.0051 0.0072 0.0125
Echinococcus granulosus tyrosine kinase 0.007 0.0112 0.0203
Echinococcus granulosus SHC transforming protein 3 0.0019 0.0004 0.0007
Entamoeba histolytica protein kinase, putative 0.0051 0.0072 0.6345
Echinococcus multilocularis epidermal growth factor receptor 0.0135 0.0252 0.0449
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0083 0.014 0.0246
Brugia malayi bone morphogenetic protein type 1 receptor 0.0051 0.0072 0.0069
Echinococcus granulosus SH2 domain containing adapter protein F 0.0019 0.0004 0.0007
Loa Loa (eye worm) TKL/MLK/HH498 protein kinase 0.0051 0.0072 0.0069
Echinococcus multilocularis tyrosine protein kinase csk 0.0051 0.0072 0.0125
Onchocerca volvulus 0.007 0.0112 0.0196
Echinococcus granulosus retinal guanylyl cyclase 2 0.0051 0.0072 0.0131
Entamoeba histolytica hypothetical protein 0.0051 0.0072 0.6345
Schistosoma mansoni protein kinase 0.0051 0.0072 0.0125
Schistosoma mansoni tyrosine kinase 0.0051 0.0072 0.0125
Echinococcus granulosus epidermal growth factor receptor 0.0135 0.0252 0.0455
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0051 0.0072 0.0125
Loa Loa (eye worm) TTK protein kinase 0.0077 0.0127 0.0123
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0101 0.0178 0.0322
Schistosoma mansoni protein kinase 0.0051 0.0072 0.0125
Entamoeba histolytica protein kinase, putative 0.0051 0.0072 0.6345
Echinococcus multilocularis vesicular acetylcholine transporter 0.2616 0.553 1
Brugia malayi Protein kinase domain containing protein 0.0051 0.0072 0.0069
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0051 0.0072 0.0125
Onchocerca volvulus Tyrosine kinase receptor Cad96Ca homolog 0.0051 0.0072 0.0125
Loa Loa (eye worm) TK protein kinase 0.0051 0.0072 0.0069
Brugia malayi Protein kinase domain containing protein 0.0051 0.0072 0.0069
Schistosoma mansoni tyrosine kinase 0.0051 0.0072 0.0125
Loa Loa (eye worm) hypothetical protein 0.0051 0.0072 0.0069
Loa Loa (eye worm) TK protein kinase 0.0051 0.0072 0.0069
Brugia malayi Protein kinase domain containing protein 0.0101 0.0178 0.0175
Brugia malayi hypothetical protein 0.0051 0.0072 0.0069
Echinococcus granulosus NCK adaptor protein 0.0032 0.0031 0.0057
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0051 0.0072 0.0125
Entamoeba histolytica hypothetical protein 0.0051 0.0072 0.6345
Mycobacterium ulcerans short chain dehydrogenase 0.0676 0.1402 0.5
Loa Loa (eye worm) hypothetical protein 0.0051 0.0072 0.0069
Schistosoma mansoni tyrosine kinase 0.0051 0.0072 0.0125
Loa Loa (eye worm) TK/FER protein kinase 0.0051 0.0072 0.0069
Schistosoma mansoni tyrosine kinase 0.0083 0.014 0.0246
Schistosoma mansoni protein tyrosine kinase 0.0051 0.0072 0.0125
Schistosoma mansoni serine/threonine protein kinase 0.0051 0.0072 0.0125
Entamoeba histolytica tyrosin kinase, putative 0.0051 0.0072 0.6345
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0051 0.0072 0.6345
Echinococcus granulosus tyrosine protein kinase Src42A 0.0083 0.014 0.0253
Brugia malayi Protein kinase domain containing protein 0.0051 0.0072 0.0069
Schistosoma mansoni serine/threonine protein kinase 0.0051 0.0072 0.0125
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0083 0.014 0.0253
Loa Loa (eye worm) TK/KIN6 protein kinase 0.0051 0.0072 0.0069
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.048 0.0985 0.1776
Echinococcus multilocularis c src tyrosine kinase 0.0083 0.014 0.0246
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0051 0.0072 0.0069
Entamoeba histolytica hypothetical protein 0.0051 0.0072 0.6345
Brugia malayi Protein kinase domain containing protein 0.0051 0.0072 0.0069
Schistosoma mansoni tyrosine kinase 0.0051 0.0072 0.0125
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0032 0.0031 0.005
Brugia malayi Protein kinase domain containing protein 0.0051 0.0072 0.0069
Entamoeba histolytica protein kinase domain containing protein 0.0051 0.0072 0.6345
Loa Loa (eye worm) TK/ABL protein kinase 0.007 0.0112 0.0109
Entamoeba histolytica protein kinase domain containing protein 0.0051 0.0072 0.6345
Loa Loa (eye worm) hypothetical protein 0.0051 0.0072 0.0069
Onchocerca volvulus 0.0051 0.0072 0.0125
Loa Loa (eye worm) TK/FER protein kinase 0.0051 0.0072 0.0069
Echinococcus multilocularis tyrosine protein kinase csk 0.0051 0.0072 0.0125
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0051 0.0072 0.0131
Onchocerca volvulus 0.007 0.0112 0.0196
Echinococcus multilocularis transfer RNA-Thr 0.0051 0.0072 0.0125
Onchocerca volvulus Vesicular acetylcholine transporter homolog 0.2616 0.553 1
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0052 0.0074 0.0001
Loa Loa (eye worm) TKL/RAF/KSR protein kinase 0.0051 0.0072 0.0069
Echinococcus granulosus growth factor receptor bound protein 2 0.0032 0.0031 0.0057
Echinococcus multilocularis protein tyrosine kinase 0.0051 0.0072 0.0125
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0051 0.0072 0.6345
Entamoeba histolytica protein kinase domain containing protein 0.0051 0.0072 0.6345
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0051 0.0072 0.6345
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0051 0.0072 0.0125
Entamoeba histolytica protein kinase, putative 0.0051 0.0072 0.6345
Entamoeba histolytica tyrosine kinase, putative 0.0051 0.0072 0.6345
Brugia malayi Tyrosine-protein kinase F09A5.2 in chromosome X, putative 0.0051 0.0072 0.0069
Loa Loa (eye worm) TK/Met protein kinase 0.0051 0.0072 0.0069
Schistosoma mansoni protein kinase 0.0052 0.0074 0.0127
Onchocerca volvulus 0.0051 0.0072 0.0125
Schistosoma mansoni tyrosine kinase 0.0051 0.0072 0.0125
Brugia malayi Protein kinase domain containing protein 0.0051 0.0072 0.0069
Brugia malayi ephrin receptor 1 precursor 0.0051 0.0072 0.0069
Echinococcus multilocularis tyrosine protein kinase csk 0.0051 0.0072 0.0125
Loa Loa (eye worm) TKL/MLK/TAK1 protein kinase 0.0051 0.0072 0.0069
Schistosoma mansoni tyrosine kinase 0.0051 0.0072 0.0125
Schistosoma mansoni tyrosine kinase 0.0084 0.0143 0.0252
Echinococcus multilocularis receptor type guanylyl cyclase 0.0051 0.0072 0.0125
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0051 0.0072 0.0131
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0051 0.0072 0.0125
Onchocerca volvulus 0.0051 0.0072 0.0125
Schistosoma mansoni growth factor receptor-bound protein 0.0032 0.0031 0.005
Plasmodium vivax protein kinase, putative 0.0051 0.0072 0.5
Schistosoma mansoni serine/threonine protein kinase 0.0064 0.01 0.0175
Schistosoma mansoni protein kinase 0.0051 0.0072 0.0125
Entamoeba histolytica protein kinase, putative 0.0051 0.0072 0.6345
Loa Loa (eye worm) hypothetical protein 0.0051 0.0072 0.0069
Entamoeba histolytica tyrosine kinase, putative 0.0051 0.0072 0.6345
Schistosoma mansoni tyrosine kinase 0.0051 0.0072 0.0125
Echinococcus granulosus epidermal growth factor receptor 0.0208 0.0408 0.0737
Entamoeba histolytica serine/threonine kinase, putative 0.0051 0.0072 0.6345
Entamoeba histolytica leucine-rich repeat domain-containing protein 0.0051 0.0072 0.6345
Brugia malayi Protein kinase domain containing protein 0.0051 0.0072 0.0069
Echinococcus multilocularis heat shock protein 70 0.0051 0.0072 0.0125
Loa Loa (eye worm) protein kinase domain-containing protein 0.0051 0.0072 0.0069
Loa Loa (eye worm) hypothetical protein 0.0051 0.0072 0.0069
Echinococcus multilocularis tyrosine protein kinase Blk 0.007 0.0112 0.0196
Onchocerca volvulus 0.007 0.0112 0.0196
Echinococcus granulosus tensin 0.0019 0.0004 0.0007
Onchocerca volvulus Dual specificity protein kinase TTK homolog 0.0077 0.0127 0.0223
Schistosoma mansoni tyrosine kinase 0.0051 0.0072 0.0125
Entamoeba histolytica protein kinase domain containing protein 0.0052 0.0074 0.6441
Echinococcus granulosus tyrosine protein kinase 0.0051 0.0072 0.0131
Echinococcus multilocularis tyrosine protein kinase HCK 0.0051 0.0072 0.0125
Echinococcus granulosus activated cdc42 kinase 1 0.0051 0.0072 0.0131
Echinococcus granulosus protein tyrosine kinase 0.0051 0.0072 0.0131
Echinococcus granulosus tyrosine protein kinase Fps85D 0.007 0.0112 0.0203
Entamoeba histolytica serine/threonine kinase, putative 0.0051 0.0072 0.6345
Brugia malayi Protein kinase domain containing protein 0.0051 0.0072 0.0069
Entamoeba histolytica protein kinase domain containing protein 0.0051 0.0072 0.6345
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0051 0.0072 0.0125
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0051 0.0072 0.6345
Loa Loa (eye worm) TK/FER protein kinase 0.007 0.0112 0.0109
Entamoeba histolytica protein kinase, putative 0.0051 0.0072 0.6345
Entamoeba histolytica tyrosine kinase, putative 0.0051 0.0072 0.6345
Echinococcus multilocularis dual specificity serine:threonine tyrosine 0.0077 0.0127 0.0223
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0135 0.0252 0.0455
Loa Loa (eye worm) RGC/RGC protein kinase 0.0051 0.0072 0.0069
Loa Loa (eye worm) SRC-1 0.0083 0.014 0.0136
Echinococcus multilocularis tyrosine protein kinase shark 0.007 0.0112 0.0196
Entamoeba histolytica tyrosin kinase, putative 0.0051 0.0072 0.6345
Schistosoma mansoni protein kinase 0.0052 0.0074 0.0127
Echinococcus granulosus tyrosine protein kinase HCK 0.0051 0.0072 0.0131
Loa Loa (eye worm) TK/EPH protein kinase 0.0051 0.0072 0.0069
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.007 0.0112 0.0196
Echinococcus granulosus tyrosine protein kinase Fyn 0.0083 0.014 0.0253
Loa Loa (eye worm) TK protein kinase 0.0051 0.0072 0.0069
Brugia malayi Raf kinase 0.0051 0.0072 0.0069
Schistosoma mansoni tyrosine kinase 0.0051 0.0072 0.0125
Entamoeba histolytica protein kinase domain containing protein 0.0051 0.0072 0.6345
Echinococcus granulosus tyrosine protein kinase shark 0.007 0.0112 0.0203
Entamoeba histolytica protein kinase domain containing protein 0.0051 0.0072 0.6345
Entamoeba histolytica protein kinase domain containing protein 0.0051 0.0072 0.6345
Entamoeba histolytica serine/threonine kinase, putative 0.0051 0.0072 0.6345
Echinococcus multilocularis tyrosine protein kinase Srms 0.007 0.0112 0.0196
Echinococcus granulosus insulin receptor 0.0101 0.0178 0.0322
Echinococcus granulosus dual specificity serine:threonine tyrosine 0.0077 0.0127 0.0229
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0051 0.0072 0.0131
Loa Loa (eye worm) TK/FER protein kinase 0.007 0.0112 0.0109
Echinococcus multilocularis 0.0049 0.0068 0.0117
Echinococcus granulosus raf serine:threonine protein kinase 0.0051 0.0072 0.0131
Echinococcus granulosus ephrin type A receptor 4 A 0.0051 0.0072 0.0131
Brugia malayi Protein kinase domain containing protein 0.007 0.0112 0.0109
Trichomonas vaginalis CAMK family protein kinase 0.0077 0.0127 1
Entamoeba histolytica protein kinase, putative 0.0051 0.0072 0.6345
Loa Loa (eye worm) hypothetical protein 0.0051 0.0072 0.0069
Echinococcus granulosus tyrosine kinase 0.007 0.0112 0.0203
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0083 0.014 0.0253
Schistosoma mansoni serine/threonine protein kinase 0.0051 0.0072 0.0125
Brugia malayi Protein kinase domain containing protein 0.0051 0.0072 0.0069
Loa Loa (eye worm) TK/FER protein kinase 0.007 0.0112 0.0109
Entamoeba histolytica tyrosine kinase, putative 0.0051 0.0072 0.6345
Schistosoma mansoni tyrosine kinase 0.007 0.0112 0.0196
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0051 0.0072 0.0125
Schistosoma mansoni tyrosine kinase 0.0051 0.0072 0.0125
Echinococcus multilocularis tyrosine protein kinase ABL1 0.007 0.0112 0.0196
Echinococcus multilocularis tyrosine kinase 0.0051 0.0072 0.0125
Loa Loa (eye worm) TK/FER protein kinase 0.0051 0.0072 0.0069
Brugia malayi SH2 domain containing protein 0.007 0.0112 0.0109
Schistosoma mansoni ephrin receptor 0.0051 0.0072 0.0125
Entamoeba histolytica protein kinase domain containing protein 0.0051 0.0072 0.6345
Loa Loa (eye worm) TK protein kinase 0.0051 0.0072 0.0069
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0051 0.0072 0.0069
Plasmodium vivax tyrosine kinase-like protein, putative 0.0051 0.0072 0.5
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0051 0.0072 0.6345
Echinococcus granulosus tyrosine protein kinase Srms 0.007 0.0112 0.0203
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0051 0.0072 0.0069
Loa Loa (eye worm) TKL/MLK/ILK protein kinase 0.0051 0.0072 0.0069
Loa Loa (eye worm) RGC/RGC protein kinase 0.0051 0.0072 0.0069
Echinococcus granulosus 3'partial|retinal guanylyl cyclase 2 0.0051 0.0072 0.0131
Entamoeba histolytica protein kinase domain containing protein 0.0051 0.0072 0.6345
Entamoeba histolytica tyrosine kinase, putative 0.0051 0.0072 0.6345
Loa Loa (eye worm) hypothetical protein 0.0032 0.0031 0.0028
Loa Loa (eye worm) vesicular acetylcholine transporter unc-17 0.2616 0.553 0.5528
Brugia malayi Variant SH3 domain containing protein 0.0032 0.0031 0.0028
Echinococcus granulosus N chimaerin 0.0019 0.0004 0.0007
Loa Loa (eye worm) RGC/RGC protein kinase 0.0051 0.0072 0.0069
Entamoeba histolytica tyrosine kinase, putative 0.0051 0.0072 0.6345
Entamoeba histolytica hypothetical protein 0.0051 0.0072 0.6345
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0051 0.0072 0.0125
Brugia malayi Protein kinase domain containing protein 0.0051 0.0072 0.0069
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0052 0.0074 0.0133
Onchocerca volvulus 0.0051 0.0072 0.0125
Schistosoma mansoni nck2/grb4 0.0032 0.0031 0.005
Echinococcus multilocularis tyrosine protein kinase Fyn 0.007 0.0112 0.0196
Echinococcus granulosus suppressor of cytokine signaling 6 0.0019 0.0004 0.0007
Schistosoma mansoni tyrosine kinase 0.0051 0.0072 0.0125
Brugia malayi Protein kinase domain containing protein 0.0051 0.0072 0.0069
Schistosoma mansoni protein kinase 0.0052 0.0074 0.0127
Loa Loa (eye worm) TK protein kinase 0.0051 0.0072 0.0069
Schistosoma mansoni tyrosine kinase 0.0051 0.0072 0.0125
Loa Loa (eye worm) TK/ROR protein kinase 0.0051 0.0072 0.0069
Loa Loa (eye worm) hypothetical protein 0.0051 0.0072 0.0069
Brugia malayi vesicular acetylcholine transporter unc-17 0.2616 0.553 0.5528
Entamoeba histolytica protein kinase, putative 0.0051 0.0072 0.6345
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0019 0.0004 0.0007
Brugia malayi Protein kinase domain containing protein 0.0077 0.0127 0.0123
Entamoeba histolytica serine/threonine kinase, putative 0.0051 0.0072 0.6345
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0051 0.0072 0.6345
Onchocerca volvulus 0.0051 0.0072 0.0125
Echinococcus multilocularis FL cytokine receptor 0.0051 0.0072 0.0125
Schistosoma mansoni ephrin receptor 0.0051 0.0072 0.0125
Echinococcus granulosus fibroblast growth factor receptor 4 0.0051 0.0072 0.0131
Entamoeba histolytica receptor protein kinase, putative 0.0051 0.0072 0.6345
Echinococcus granulosus tyrosine protein kinase Fyn 0.0083 0.014 0.0253
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0051 0.0072 0.0125
Entamoeba histolytica serine/threonine kinase, putative 0.0051 0.0072 0.6345
Schistosoma mansoni tyrosine kinase 0.0101 0.0178 0.0316
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0083 0.014 0.0246
Brugia malayi Protein kinase domain containing protein 0.0051 0.0072 0.0069
Loa Loa (eye worm) TK protein kinase 0.0051 0.0072 0.0069
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0101 0.0178 0.0316
Echinococcus granulosus tyrosine protein kinase pr2 0.0051 0.0072 0.0131
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0051 0.0072 0.6345
Echinococcus granulosus tyrosine kinase 0.0051 0.0072 0.0131
Loa Loa (eye worm) TK protein kinase 0.007 0.0112 0.0109
Echinococcus granulosus receptor type guanylyl cyclase 0.0051 0.0072 0.0131
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0083 0.014 0.0246
Entamoeba histolytica protein kinase, putative 0.0051 0.0072 0.6345
Loa Loa (eye worm) TK/FER protein kinase 0.0051 0.0072 0.0069
Plasmodium vivax tyrosine kinase-like protein, putative 0.0051 0.0072 0.5
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0019 0.0004 0.0007
Entamoeba histolytica protein kinase domain containing protein 0.0051 0.0072 0.6345
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0051 0.0072 0.0131
Brugia malayi proto-oncogene tyrosine-protein kinase FER 0.0051 0.0072 0.0069
Schistosoma mansoni tyrosine kinase 0.0051 0.0072 0.0125
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0083 0.014 0.0246
Brugia malayi SRC-1 0.0083 0.014 0.0136
Entamoeba histolytica protein kinase domain containing protein 0.0051 0.0072 0.6345
Entamoeba histolytica hypothetical protein 0.0051 0.0072 0.6345
Entamoeba histolytica tyrosine kinase, putative 0.0051 0.0072 0.6345
Entamoeba histolytica protein kinase domain containing protein 0.0051 0.0072 0.6345
Entamoeba histolytica tyrosine kinase, putative 0.0051 0.0072 0.6345
Brugia malayi Protein kinase domain containing protein 0.0051 0.0072 0.0069
Brugia malayi Guanylyl cyclase protein 23 0.0051 0.0072 0.0069
Entamoeba histolytica tyrosine kinase, putative 0.0051 0.0072 0.6345
Loa Loa (eye worm) hypothetical protein 0.0051 0.0072 0.0069
Schistosoma mansoni vesicular amine transporter 0.0019 0.0004 0.0001
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0051 0.0072 0.0125
Entamoeba histolytica protein kinase, putative 0.0051 0.0072 0.6345
Schistosoma mansoni tyrosine kinase 0.0208 0.0408 0.0731
Onchocerca volvulus 0.0051 0.0072 0.0125
Schistosoma mansoni tyrosine kinase 0.0135 0.0252 0.0449
Entamoeba histolytica protein kinase domain containing protein 0.0051 0.0072 0.6345
Onchocerca volvulus 0.007 0.0112 0.0196
Echinococcus granulosus protein kinase 0.0051 0.0072 0.0131
Echinococcus granulosus signal transduction protein lnk realted 0.0019 0.0004 0.0007
Loa Loa (eye worm) TK/FER protein kinase 0.0051 0.0072 0.0069
Echinococcus granulosus tyrosine protein kinase Fyn 0.0083 0.014 0.0253
Loa Loa (eye worm) TK/FER protein kinase 0.007 0.0112 0.0109
Brugia malayi Protein kinase domain containing protein 0.0051 0.0072 0.0069
Brugia malayi Protein kinase domain containing protein 0.0051 0.0072 0.0069
Schistosoma mansoni tyrosine kinase 0.0051 0.0072 0.0125
Schistosoma mansoni tyrosine kinase 0.0051 0.0072 0.0125
Loa Loa (eye worm) TK/CSK protein kinase 0.0051 0.0072 0.0069
Schistosoma mansoni tyrosine kinase 0.0051 0.0072 0.0125
Loa Loa (eye worm) TK/FER protein kinase 0.007 0.0112 0.0109
Echinococcus granulosus retinal guanylyl cyclase 2 0.0051 0.0072 0.0131
Schistosoma mansoni tyrosine kinase 0.0051 0.0072 0.0125
Echinococcus granulosus tyrosine protein kinase csk 0.0051 0.0072 0.0131
Schistosoma mansoni serine/threonine RGC 0.0051 0.0072 0.0125
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0051 0.0072 0.0125
Entamoeba histolytica protein kinase, putative 0.0051 0.0072 0.6345
Brugia malayi Tyrosine-protein kinase PR2 0.0051 0.0072 0.0069
Loa Loa (eye worm) hypothetical protein 0.0051 0.0072 0.0069
Entamoeba histolytica protein kinase, putative 0.0051 0.0072 0.6345
Entamoeba histolytica protein kinase, putative 0.0051 0.0072 0.6345
Echinococcus multilocularis tyrosine protein kinase Abl 0.0083 0.014 0.0246
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0019 0.0004 0.0007
Entamoeba histolytica protein kinase, putative 0.0051 0.0072 0.6345
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0052 0.0074 0.0127
Echinococcus multilocularis activin receptor type 0.0052 0.0074 0.0127
Echinococcus granulosus tyrosine protein kinase csk 0.0051 0.0072 0.0131
Echinococcus multilocularis tyrosine protein kinase csk 0.0051 0.0072 0.0125
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0052 0.0074 0.0001
Echinococcus granulosus tyrosine protein kinase Src64B 0.0083 0.014 0.0253
Loa Loa (eye worm) hypothetical protein 0.0022 0.001 0.0006
Brugia malayi hypothetical protein 0.007 0.0112 0.0109
Entamoeba histolytica protein kinase domain containing protein 0.0051 0.0072 0.6345
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0032 0.0031 0.0028
Echinococcus granulosus activated cdc42 kinase 1 0.0051 0.0072 0.0131
Brugia malayi Protein kinase domain containing protein 0.0051 0.0072 0.0069
Loa Loa (eye worm) TK/INSR protein kinase 0.0101 0.0178 0.0175
Schistosoma mansoni vesicular acetylcholine transporter 0.2616 0.553 1
Loa Loa (eye worm) TK/FER protein kinase 0.0051 0.0072 0.0069
Entamoeba histolytica tyrosine kinase, putative 0.0051 0.0072 0.6345
Brugia malayi Protein kinase domain containing protein 0.0051 0.0072 0.0069
Schistosoma mansoni dual specificity serine/threonine tyrosine kinase 0.0077 0.0127 0.0223
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0083 0.014 0.0246
Entamoeba histolytica protein kinase domain containing protein 0.0051 0.0072 0.6345
Brugia malayi Protein kinase domain containing protein 0.007 0.0112 0.0109
Brugia malayi Receptor family ligand binding region containing protein 0.0051 0.0072 0.0069
Brugia malayi Protein kinase domain containing protein 0.0051 0.0072 0.0069
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0051 0.0072 0.0125
Entamoeba histolytica protein kinase, putative 0.0051 0.0072 0.6345
Schistosoma mansoni protein kinase 0.0051 0.0072 0.0125
Entamoeba histolytica protein kinase domain containing protein 0.0051 0.0072 0.6345
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0051 0.0072 0.0069
Plasmodium falciparum protein kinase, putative 0.0052 0.0074 1
Echinococcus granulosus c src tyrosine kinase 0.0083 0.014 0.0253
Onchocerca volvulus 0.0051 0.0072 0.0125
Brugia malayi Protein kinase domain containing protein 0.0051 0.0072 0.0069
Entamoeba histolytica tyrosine kinase, putative 0.0051 0.0072 0.6345
Entamoeba histolytica cysteine surface protein, putative 0.0051 0.0072 0.6345
Brugia malayi protein-tyrosine kinase 0.007 0.0112 0.0109
Schistosoma mansoni tyrosine kinase 0.0084 0.0143 0.0252
Echinococcus multilocularis raf serine:threonine protein kinase 0.0051 0.0072 0.0125
Echinococcus granulosus kinase suppressor of Ras 1 0.0051 0.0072 0.0131
Entamoeba histolytica protein kinase domain containing protein 0.0051 0.0072 0.6345
Entamoeba histolytica serine/threonine kinase, putative 0.0051 0.0072 0.6345
Entamoeba histolytica protein kinase domain containing protein 0.0051 0.0072 0.6345
Loa Loa (eye worm) TK/FER protein kinase 0.007 0.0112 0.0109
Echinococcus granulosus SH2 domain containing protein 7 0.0019 0.0004 0.0007
Loa Loa (eye worm) TK/FAK protein kinase 0.0051 0.0072 0.0069
Echinococcus multilocularis macrophage colony stimulating factor 1 receptor 0.0051 0.0072 0.0125
Loa Loa (eye worm) TK/EGFR protein kinase 0.0208 0.0408 0.0404
Entamoeba histolytica tyrosine- protein kinase 2, putative 0.0051 0.0072 0.6345
Echinococcus multilocularis integrin linked protein kinase 0.0051 0.0072 0.0125
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0032 0.0031 0.0028
Echinococcus multilocularis protein kinase 0.0051 0.0072 0.0125
Entamoeba histolytica protein kinase, putative 0.0051 0.0072 0.6345
Echinococcus multilocularis tyrosine protein kinase 0.0051 0.0072 0.0125
Schistosoma mansoni protein kinase 0.0051 0.0072 0.0125
Schistosoma mansoni tyrosine kinase 0.0101 0.0178 0.0316
Echinococcus granulosus activin receptor type 0.0052 0.0074 0.0133
Echinococcus granulosus tyrosine protein kinase Blk 0.007 0.0112 0.0203
Brugia malayi Furin-like cysteine rich region family protein 0.0208 0.0408 0.0404
Entamoeba histolytica protein kinase domain containing protein 0.0051 0.0072 0.6345
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0083 0.014 0.0246
Loa Loa (eye worm) RGC/RGC protein kinase 0.0051 0.0072 0.0069
Echinococcus granulosus expressed conserved protein 0.0019 0.0004 0.0007
Schistosoma mansoni vav2 0.0022 0.001 0.0011
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0083 0.014 0.0246
Entamoeba histolytica protein kinase, putative 0.0019 0.0005 0.0096
Brugia malayi Protein kinase domain containing protein 0.0051 0.0072 0.0069
Onchocerca volvulus 0.007 0.0112 0.0196
Echinococcus multilocularis kinase suppressor of Ras 1 0.0051 0.0072 0.0125

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.04 uM Inhibition of mouse 11beta-HSD1 expressed in CHO cells using cortisol as substrate incubated for 30 mins prior to substrate addition measured after 120 mins by chemiluminescence assay ChEMBL. 24900572
IC50 (binding) = 0.048 uM Inhibition of mouse 11beta-HSD1 expressed in CHO cells using cortisol as substrate incubated for 30 mins prior to substrate addition measured after 120 mins by chemiluminescence assay in presence of 10% human serum ChEMBL. 24900572
IC50 (binding) = 0.064 uM Inhibition of human 11beta-HSD1 expressed in CHO cells using cortisol as substrate incubated for 30 mins prior to substrate addition measured after 120 mins by chemiluminescence assay ChEMBL. 24900572
Inhibition (functional) < 10 % Ex vivo inhibition of 11beta-HSD1 in C57B16 mouse epididymal fat assessed as conversion of [3H]-cortisone to [3H]-cortisol at 10 mg/kg, po after 5 hrs by HPLC analysis relative to vehicle-treated control ChEMBL. 24900572

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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