TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 487.863 | Formula: C17H9ClF3N5O3S2
H donors: 2 H acceptors: 5 LogP: 3.99 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: Fc1cc(c(cc1Oc1cc(Cl)c(cc1c1c[nH]nc1)F)F)S(=O)(=O)Nc1ncns1
InChi: 1S/C17H9ClF3N5O3S2/c18-10-2-14(9(1-11(10)19)8-5-23-24-6-8)29-15-3-13(21)16(4-12(15)20)31(27,28)26-17-22-7-25-30-17/h1-7H,(H,23,24)(H,22,25,26)
InChiKey: WOQOGHLAUSUSDQ-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	sodium channel, voltage-gated, type IX, alpha subunit	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Leishmania mexicana	calcium channel protein, putative,ion transporter, putative	Get druggable targets OG5_126819	All targets in OG5_126819
Leishmania donovani	calcium channel protein, putative	Get druggable targets OG5_126819	All targets in OG5_126819
Echinococcus granulosus	sodium channel protein	Get druggable targets OG5_126819	All targets in OG5_126819
Leishmania infantum	calcium channel protein, putative,ion transporter, putative	Get druggable targets OG5_126819	All targets in OG5_126819
Leishmania braziliensis	calcium channel protein, putative,ion transporter, putative	Get druggable targets OG5_126819	All targets in OG5_126819
Leishmania major	calcium channel protein, putative,ion transporter, putative	Get druggable targets OG5_126819	All targets in OG5_126819
Echinococcus granulosus	voltage gated sodium channel Nav1 alpha subunit	Get druggable targets OG5_126819	All targets in OG5_126819
Echinococcus multilocularis	sodium channel protein	Get druggable targets OG5_126819	All targets in OG5_126819

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	jun protein	0.0088	0.061	0.1298
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0015	0.0008	0.0051
Echinococcus granulosus	Tubulin alpha 1 chain	0.0018	0.0031	0.0066
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0015	0.0008	0.0065
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0008	0.0065
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0015	0.0008	0.0065
Leishmania major	calcium channel protein, putative,ion transporter, putative	0.0045	0.0257	0.0558
Mycobacterium ulcerans	carbonic anhydrase	0.0511	0.4076	0.3983
Schistosoma mansoni	loxhd1	0.0164	0.1232	0.2621
Brugia malayi	Nuclear hormone receptor-like 1	0.0015	0.0008	0.0065
Schistosoma mansoni	thyroid hormone receptor	0.0015	0.0008	0.0017
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.0264	0.0562
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0015	0.0008	0.0065
Echinococcus granulosus	FTZ F1 alpha	0.0015	0.0008	0.0017
Schistosoma mansoni	tyrosine kinase	0.0066	0.0424	0.0902
Brugia malayi	bZIP transcription factor family protein	0.0088	0.061	0.4953
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0015	0.0008	0.0017
Schistosoma mansoni	tyrosine kinase	0.0144	0.107	0.2278
Schistosoma mansoni	alpha tubulin	0.0018	0.0031	0.0066
Entamoeba histolytica	hypothetical protein	0.0036	0.0183	0.0376
Brugia malayi	Doublecortin family protein	0.0164	0.1232	1
Echinococcus multilocularis	tubulin alpha 3 chain	0.0018	0.0031	0.0066
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0008	0.0065
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0015	0.0008	0.0017
Echinococcus granulosus	tar DNA binding protein	0.0064	0.041	0.0873
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0015	0.0008	0.0065
Echinococcus granulosus	peroxisome assembly protein 26	0.0018	0.0031	0.0066
Loa Loa (eye worm)	hypothetical protein	0.0156	0.1163	0.9443
Brugia malayi	Furin-like cysteine rich region family protein	0.0066	0.0424	0.3442
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0015	0.0008	0.0065
Brugia malayi	alpha-tubulin	0.0018	0.0031	0.0252
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.0264	0.0562
Schistosoma mansoni	tubulin subunit alpha	0.0018	0.0031	0.0066
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0036	0.0183	0.039
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.041	0.0873
Plasmodium falciparum	LCCL domain-containing protein	0.0164	0.1232	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0015	0.0008	0.0017
Echinococcus granulosus	tubulin alpha chain	0.0018	0.0031	0.0066
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0264	0.0562
Schistosoma mansoni	tyrosine kinase	0.0065	0.0414	0.0882
Echinococcus granulosus	ankyrin repeat and death domain containing protein	0.0014	0.0000000066822	0.00000001422
Echinococcus multilocularis	tubulin alpha 1C chain	0.0018	0.0031	0.0066
Schistosoma mansoni	hypothetical protein	0.0036	0.0183	0.039
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0008	0.0065
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0008	0.0065
Echinococcus multilocularis	tubulin subunit TubB	0.0018	0.0031	0.0066
Giardia lamblia	Alpha-tubulin	0.0018	0.0031	0.5
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0066	0.0424	0.0902
Echinococcus multilocularis	epidermal growth factor receptor	0.0066	0.0424	0.0902
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0015	0.0008	0.0017
Schistosoma mansoni	ankyrin 23/unc44	0.0014	0.0000000066822	0.00000001422
Echinococcus granulosus	Basic leucine zipper bZIP transcription factor	0.0088	0.061	0.1298
Echinococcus multilocularis	tubulin alpha chain	0.0018	0.0031	0.0066
Plasmodium vivax	multidomain scavenger receptor, putative	0.0164	0.1232	1
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0008	0.0065
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0015	0.0008	0.0065
Brugia malayi	Steroid receptor seven-up type 2	0.0015	0.0008	0.0065
Entamoeba histolytica	hypothetical protein	0.0036	0.0183	0.0376
Chlamydia trachomatis	sulfate transporter	0.0033	0.0155	0.5
Mycobacterium ulcerans	hypothetical protein	0.011	0.0786	0.0641
Echinococcus granulosus	Polycystic kidney disease protein	0.0164	0.1232	0.2621
Loa Loa (eye worm)	tubulin alpha chain	0.0018	0.0031	0.0252
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.0264	0.0562
Giardia lamblia	Alpha-tubulin	0.0018	0.0031	0.5
Onchocerca volvulus		0.0206	0.1579	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0264	0.0562
Echinococcus granulosus	lipoxygenase domain containing protein	0.0164	0.1232	0.2621
Brugia malayi	nuclear hormone receptor	0.0015	0.0008	0.0065
Loa Loa (eye worm)	hypothetical protein	0.0164	0.1232	1
Entamoeba histolytica	hypothetical protein	0.0036	0.0183	0.0376
Schistosoma mansoni	jun-related protein	0.0072	0.048	0.102
Brugia malayi	RNA binding protein	0.0064	0.041	0.3331
Echinococcus multilocularis	ankyrin repeat and death domain containing protein	0.0014	0.0000000066822	0.00000001422
Mycobacterium tuberculosis	Beta-carbonic anhydrase CanB	0.0261	0.2032	0.031
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0046	0.0264	0.2145
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0015	0.0008	0.0017
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.041	0.0873
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0015	0.0008	0.0017
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0015	0.0008	0.0017
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0015	0.0008	0.0065
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0015	0.0008	0.0065
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0015	0.0008	0.0065
Entamoeba histolytica	hypothetical protein	0.0036	0.0183	0.0376
Echinococcus granulosus	tubulin alpha 3 chain	0.0018	0.0031	0.0066
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0562	0.4565
Onchocerca volvulus	Bile acid receptor homolog	0.0015	0.0008	0.0051
Echinococcus multilocularis	ecdysone induced protein 78C	0.0015	0.0008	0.0017
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0015	0.0008	0.0065
Echinococcus granulosus	alpha tubulin	0.0018	0.0031	0.0066
Echinococcus multilocularis	epidermal growth factor receptor	0.0066	0.0424	0.0902
Schistosoma mansoni	retinoblastoma-binding protein 4 (rbbp4)	0.0014	0.0001	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0001	0.0008
Echinococcus multilocularis		0.0019	0.004	0.0084
Brugia malayi	Tubulin alpha chain	0.0018	0.0031	0.0252
Schistosoma mansoni	lipoxygenase	0.0291	0.2275	0.484
Brugia malayi	tubulin alpha-2 chain	0.0018	0.0031	0.0252
Brugia malayi	hypothetical protein	0.0036	0.0183	0.1487
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0015	0.0008	0.0017
Schistosoma mansoni	RAR-like nuclear receptor	0.0015	0.0008	0.0017
Plasmodium vivax	sulfate transporter, putative	0.0033	0.0155	0.103
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0064	0.041	0.3331
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0164	0.1232	0.2621
Echinococcus granulosus	Tubulin alpha 1 chain	0.0018	0.0031	0.0066
Brugia malayi	Tubulin alpha-2 chain	0.0018	0.0031	0.0252
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0015	0.0008	0.0065
Echinococcus multilocularis	jun protein	0.0088	0.061	0.1298
Echinococcus multilocularis	tar DNA binding protein	0.0064	0.041	0.0873
Echinococcus granulosus	tubulin alpha chain	0.0018	0.0031	0.0066
Echinococcus multilocularis	tubulin alpha chain	0.0018	0.0031	0.0066
Onchocerca volvulus		0.0156	0.1163	0.7366
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0036	0.0183	0.039
Echinococcus multilocularis	tubulin alpha chain	0.0018	0.0031	0.0066
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.041	0.0873
Schistosoma mansoni	transcription factor LCR-F1	0.0036	0.0183	0.039
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0264	0.0562
Brugia malayi	hypothetical protein	0.0156	0.1163	0.9443
Schistosoma mansoni	tubulin subunit alpha	0.0018	0.0031	0.0066
Loa Loa (eye worm)	tubulin alpha-2 chain	0.0018	0.0031	0.0252
Onchocerca volvulus	Putative sulfate transporter	0.0206	0.1579	1
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0015	0.0008	0.0017
Schistosoma mansoni	coup transcription factor	0.0015	0.0008	0.0017
Brugia malayi	ecdysteroid receptor	0.0015	0.0008	0.0065
Schistosoma mansoni	nuclear hormone receptor	0.0015	0.0008	0.0017
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0015	0.0008	0.0017
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0015	0.0008	0.0017
Echinococcus granulosus	Ankyrin	0.0014	0.0001	0.0002
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.0264	0.0562
Echinococcus granulosus	RUN	0.0164	0.1232	0.2621
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0015	0.0008	0.0065
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription factor	0.0088	0.061	0.1298
Schistosoma mansoni	retinoic acid receptor RXR	0.0015	0.0008	0.0017
Echinococcus multilocularis	tubulin alpha chain	0.0018	0.0031	0.0066
Echinococcus granulosus	Tubulin alpha 1 chain	0.0018	0.0031	0.0066
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0015	0.0008	0.0017
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0015	0.0008	0.0017
Toxoplasma gondii	inorganic anion transporter, sulfate permease (SulP) family protein	0.0033	0.0155	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0015	0.0008	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0031	0.0252
Schistosoma mansoni	thyroid hormone receptor	0.0015	0.0008	0.0017
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0015	0.0008	0.0065
Echinococcus multilocularis	insulin receptor	0.0144	0.107	0.2278
Brugia malayi	RNA recognition motif domain containing protein	0.0064	0.041	0.3331
Schistosoma mansoni	tubulin subunit alpha	0.0018	0.0031	0.0066
Loa Loa (eye worm)	RNA binding protein	0.0064	0.041	0.3331
Brugia malayi	Tubulin alpha-2 chain	0.0018	0.0031	0.0252
Echinococcus granulosus	lipoxygenase domain containing protein	0.0164	0.1232	0.2621
Echinococcus granulosus	ecdysone induced protein 78C	0.0015	0.0008	0.0017
Schistosoma mansoni	rab6-interacting	0.0164	0.1232	0.2621
Echinococcus multilocularis	hypothetical protein	0.0018	0.0031	0.0066
Mycobacterium tuberculosis	Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase)	0.0487	0.3887	0.3344
Schistosoma mansoni	polycystin 1-related	0.0164	0.1232	0.2621
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0015	0.0008	0.0017
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0018	0.0031	0.0066
Brugia malayi	steroid hormone receptor	0.0015	0.0008	0.0065
Echinococcus granulosus	voltage gated sodium channel Nav1 alpha subunit	0.0045	0.0257	0.0546
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0015	0.0008	0.0017
Brugia malayi	hypothetical protein	0.0067	0.0432	0.3506
Onchocerca volvulus	Protein ultraspiracle homolog	0.0015	0.0008	0.0051
Loa Loa (eye worm)	TAR-binding protein	0.0064	0.041	0.3331
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0144	0.107	0.2278
Onchocerca volvulus		0.0164	0.1232	0.78
Mycobacterium leprae	CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE)	0.0511	0.4076	1
Loa Loa (eye worm)	TK/INSR protein kinase	0.0144	0.107	0.8689
Schistosoma mansoni	lipoxygenase	0.0586	0.4699	1
Loa Loa (eye worm)	doublecortin family protein	0.0164	0.1232	1
Echinococcus multilocularis	Polycystic kidney disease protein	0.0164	0.1232	0.2621
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.041	0.0873
Echinococcus granulosus	tubulin alpha chain	0.0018	0.0031	0.0066
Onchocerca volvulus		0.0164	0.1232	0.78
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.041	0.0873
Schistosoma mansoni	hypothetical protein	0.0072	0.048	0.102
Echinococcus granulosus	tubulin alpha 1C chain	0.0018	0.0031	0.0066
Schistosoma mansoni	alpha tubulin	0.0018	0.0031	0.0066
Trypanosoma cruzi	Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative	0.0033	0.0155	1
Brugia malayi	photoreceptor-specific nuclear receptor	0.0015	0.0008	0.0065
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0586	0.4699	1
Echinococcus multilocularis	nuclear factor of activated T cells 5	0.0072	0.0475	0.1011
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0018	0.0031	0.0066
Brugia malayi	nuclear receptor NHR-88	0.0015	0.0008	0.0065
Leishmania major	carbonic anhydrase family protein, putative	0.0511	0.4076	1
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0586	0.4699	1
Schistosoma mansoni	alpha tubulin	0.0018	0.0031	0.0066
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0164	0.1232	0.2621
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0015	0.0008	0.0017
Brugia malayi	Death domain containing protein	0.0014	0.0000000066822	0.00000005425
Echinococcus granulosus	sodium channel protein	0.0045	0.0257	0.0546
Schistosoma mansoni	carbonic anhydrase	0.0511	0.4076	0.8674
Brugia malayi	Protein kinase domain containing protein	0.0014	0.0000000066822	0.00000005425
Plasmodium falciparum	inorganic anion exchanger, inorganic anion antiporter	0.0033	0.0155	0.103
Echinococcus multilocularis	tubulin alpha chain	0.0018	0.0031	0.0066
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0015	0.0008	0.0017
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0015	0.0008	0.0065
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0018	0.0031	0.0066
Echinococcus multilocularis	Ankyrin	0.0014	0.0001	0.0002
Brugia malayi	tubulin alpha chain - mouse	0.0018	0.0031	0.0252
Echinococcus granulosus	tubulin alpha 3 chain	0.0018	0.0031	0.0066
Schistosoma mansoni	tyrosine kinase	0.0066	0.0424	0.0902
Schistosoma mansoni	tyrosine kinase	0.0065	0.0414	0.0882
Loa Loa (eye worm)	steroid hormone receptor	0.0015	0.0008	0.0065
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0015	0.0008	0.0017
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0015	0.0008	0.0065
Loa Loa (eye worm)	hypothetical protein	0.0164	0.1232	1
Loa Loa (eye worm)	alpha-tubulin	0.0018	0.0031	0.0252
Echinococcus multilocularis	sodium channel protein	0.0045	0.0257	0.0546
Brugia malayi	TAR-binding protein	0.0064	0.041	0.3331
Echinococcus multilocularis	RUN	0.0164	0.1232	0.2621
Trypanosoma cruzi	Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative	0.0033	0.0155	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0015	0.0008	0.0065
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0008	0.0065
Trypanosoma brucei	Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative	0.0033	0.0155	1
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0008	0.0065
Schistosoma mansoni	tyrosine kinase	0.0065	0.0414	0.0882
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0015	0.0008	0.0017
Onchocerca volvulus		0.0015	0.0008	0.0051
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0046	0.0264	0.2145
Echinococcus granulosus	insulin receptor	0.0144	0.107	0.2278
Schistosoma mansoni	tyrosine kinase	0.0144	0.107	0.2278
Echinococcus granulosus	tubulin alpha 1C chain	0.0018	0.0031	0.0066
Echinococcus multilocularis	peroxisome assembly protein 26	0.0018	0.0031	0.0066
Schistosoma mansoni	rab6-interacting	0.0164	0.1232	0.2621
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0015	0.0008	0.0065
Brugia malayi	hypothetical protein	0.0164	0.1232	1
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0144	0.107	0.2278
Echinococcus granulosus	epidermal growth factor receptor	0.0066	0.0424	0.0902
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0066	0.0424	0.3442
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0015	0.0008	0.0065
Brugia malayi	hypothetical protein	0.0164	0.1232	1
Echinococcus granulosus	tubulin subunit TubB	0.0018	0.0031	0.0066
Schistosoma mansoni	hypothetical protein	0.0164	0.1232	0.2621
Brugia malayi	Protein kinase domain containing protein	0.0144	0.107	0.8689
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0015	0.0008	0.0065
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0015	0.0008	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0156	0.1163	0.9443
Echinococcus granulosus	epidermal growth factor receptor	0.0066	0.0424	0.0902
Echinococcus granulosus	tubulin alpha chain	0.0018	0.0031	0.0066
Mycobacterium tuberculosis	Beta-carbonic anhydrase	0.0983	0.7955	1
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0531	0.4311
Echinococcus multilocularis	FTZ F1 alpha	0.0015	0.0008	0.0017
Loa Loa (eye worm)	tubulin alpha chain	0.0018	0.0031	0.0252
Echinococcus multilocularis	tubulin alpha 1C chain	0.0018	0.0031	0.0066
Brugia malayi	Uncoordinated protein 44	0.0014	0.0000000066822	0.00000005425
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0008	0.0065
Entamoeba histolytica	carbonic anhydrase, putative	0.0511	0.4076	1
Loa Loa (eye worm)	alpha-tubulin	0.0018	0.0031	0.0252
Echinococcus granulosus	tubulin alpha chain	0.0018	0.0031	0.0066
Brugia malayi	Protein kinase domain containing protein	0.008	0.0541	0.4389
Echinococcus granulosus	nuclear factor of activated T cells 5	0.0072	0.0475	0.1011
Onchocerca volvulus		0.0067	0.0432	0.2734
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0015	0.0008	0.0065
Schistosoma mansoni	tyrosine kinase	0.0066	0.0424	0.0902
Echinococcus multilocularis	tubulin alpha 3 chain	0.0018	0.0031	0.0066

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 8.6778	Inhibition of NaV1.7 ion channel (unknown origin)	ChEMBL.	23177785

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2325611

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1726655