TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 428.876 | Formula: C21H24ClF3N2O2
H donors: 1 H acceptors: 1 LogP: 4.13 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: O[C@@H](CN1CCN(CC1)Cc1cccc(c1)Cl)COc1ccc(cc1)C(F)(F)F
InChi: 1S/C21H24ClF3N2O2/c22-18-3-1-2-16(12-18)13-26-8-10-27(11-9-26)14-19(28)15-29-20-6-4-17(5-7-20)21(23,24)25/h1-7,12,19,28H,8-11,13-15H2/t19-/m0/s1
InChiKey: PVZHKJWRHDKDQQ-IBGZPJMESA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0041	0.0577	0.1948
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0057	0.0331
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0053	0.075	0.2555
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0041	0.0577	0.1948
Echinococcus granulosus	ferritin	0.001	0.0092	0.0289
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0013	0.0147	0.0875
Schistosoma mansoni	transcription factor LCR-F1	0.0041	0.0577	0.1967
Entamoeba histolytica	hypothetical protein	0.0013	0.0147	0.0905
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0053	0.075	0.2537
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0007	0.0057	0.0331
Echinococcus multilocularis	muscleblind protein	0.0171	0.2579	0.8789
Leishmania major	protein kinase, putative,polo-like protein kinase, putative	0.0108	0.161	1
Brugia malayi	hypothetical protein	0.008	0.117	0.2639
Entamoeba histolytica	tyrosine kinase, putative	0.0005	0.0012	0.0066
Trichomonas vaginalis	CAMK family protein kinase	0.0108	0.161	1
Entamoeba histolytica	hypothetical protein	0.0005	0.0012	0.0066
Trypanosoma brucei	beta lactamase	0.0073	0.1067	0.6286
Entamoeba histolytica	protein kinase domain containing protein	0.0005	0.0012	0.0066
Entamoeba histolytica	tyrosine kinase, putative	0.0004	0.0007	0.0033
Entamoeba histolytica	tyrosine kinase, putative	0.0005	0.0012	0.0066
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0057	0.0331
Brugia malayi	hypothetical protein	0.0291	0.4413	1
Echinococcus granulosus	kelch ECH associated protein 1	0.0108	0.161	0.5475
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0053	0.075	0.2537
Schistosoma mansoni	myst-related protein	0.0004	0.0002	0.0006
Entamoeba histolytica	protein kinase domain containing protein	0.0005	0.0012	0.0066
Schistosoma mansoni	hypothetical protein	0.0041	0.0577	0.1967
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0057	0.0331
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0057	0.0331
Onchocerca volvulus		0.0005	0.0014	0.0043
Entamoeba histolytica	hypothetical protein	0.0041	0.0577	0.3578
Entamoeba histolytica	hypothetical protein	0.0004	0.0007	0.0033
Schistosoma mansoni	ferritin light chain	0.001	0.0092	0.0312
Trichomonas vaginalis	conserved hypothetical protein	0.0013	0.0147	0.0895
Onchocerca volvulus		0.0033	0.0449	0.2758
Entamoeba histolytica	CXXC-rich protein	0.0004	0.0007	0.0033
Trichomonas vaginalis	conserved hypothetical protein	0.0009	0.0075	0.0447
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0053	0.075	0.2537
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0013	0.0147	0.0875
Echinococcus multilocularis	Kelch repeat type 1	0.0109	0.1614	0.5491
Entamoeba histolytica	hypothetical protein	0.0013	0.0147	0.0905
Entamoeba histolytica	protein kinase, putative	0.0005	0.0012	0.0066
Entamoeba histolytica	tumor susceptibility gene 101 protein, putative	0.0054	0.0777	0.4822
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0062	0.0903	1
Trichomonas vaginalis	mucin-desulfating sulfatase, putative	0.0009	0.0075	0.0447
Entamoeba histolytica	hypothetical protein	0.0004	0.0007	0.0033
Mycobacterium tuberculosis	Class a beta-lactamase BlaC	0.0152	0.2285	0.2274
Schistosoma mansoni	ferritin	0.001	0.0092	0.0312
Loa Loa (eye worm)	hypothetical protein	0.008	0.117	0.452
Plasmodium vivax	adrenodoxin reductase, putative	0.0005	0.0014	0.5
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0033	0.0449	0.1718
Echinococcus multilocularis	geminin	0.0194	0.2934	1
Entamoeba histolytica	hypothetical protein	0.0041	0.0577	0.3578
Entamoeba histolytica	tyrosine kinase, putative	0.0005	0.0012	0.0066
Entamoeba histolytica	tyrosine kinase, putative	0.0004	0.0007	0.0033
Trichomonas vaginalis	conserved hypothetical protein	0.0009	0.0075	0.0447
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0057	0.0331
Trichomonas vaginalis	conserved hypothetical protein	0.0009	0.0075	0.0447
Trichomonas vaginalis	DNA double-strand break repair Rad50 ATPase, putative	0.0004	0.0007	0.0021
Loa Loa (eye worm)	lethal protein 721	0.0005	0.0014	0.0027
Mycobacterium ulcerans	class a beta-lactamase, BlaC	0.0152	0.2285	0.2274
Entamoeba histolytica	protein kinase, putative	0.0005	0.0012	0.0066
Trichomonas vaginalis	conserved hypothetical protein	0.0004	0.0007	0.0021
Entamoeba histolytica	tyrosine kinase, putative	0.0005	0.0012	0.0066
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0595	0.2285
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0042	0.0595	0.3668
Mycobacterium tuberculosis	Possible arylsulfatase AtsD (aryl-sulfate sulphohydrolase) (arylsulphatase)	0.0009	0.0075	0.0062
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0008	0.0068	0.0208
Mycobacterium ulcerans	lipoprotein LpqF	0.0073	0.1067	0.1054
Mycobacterium tuberculosis	UDP-galactopyranose mutase Glf (UDP-GALP mutase) (NAD+-flavin adenine dinucleotide-requiring enzyme)	0.0654	1	1
Trypanosoma cruzi	polo-like protein kinase, putative	0.0108	0.161	1
Entamoeba histolytica	hypothetical protein	0.0004	0.0007	0.0033
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0057	0.0331
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0014	0.0027
Entamoeba histolytica	cysteine surface protein, putative	0.0004	0.0007	0.0033
Trichomonas vaginalis	conserved hypothetical protein	0.0009	0.0075	0.0447
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0013	0.0147	0.0875
Trichomonas vaginalis	conserved hypothetical protein	0.0009	0.0075	0.0447
Trichomonas vaginalis	conserved hypothetical protein	0.0009	0.0075	0.0447
Echinococcus multilocularis	serine:threonine protein kinase PLK1	0.0108	0.161	0.5476
Trypanosoma cruzi	Vps23 core domain containing protein, putative	0.0026	0.0335	0.2044
Trichomonas vaginalis	CAMK family protein kinase	0.0108	0.161	1
Mycobacterium tuberculosis	Bacterioferritin BfrB	0.001	0.0092	0.0078
Brugia malayi	hypothetical protein	0.0041	0.0577	0.1294
Schistosoma mansoni	ubiquitin-specific peptidase 8 (C19 family)	0.0042	0.0595	0.2027
Loa Loa (eye worm)	hypothetical protein	0.0171	0.2579	1
Schistosoma mansoni	hypothetical protein	0.0109	0.1614	0.5502
Echinococcus granulosus	cpg binding protein	0.0035	0.0478	0.1609
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0075	0.0266
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0008	0.0068	0.0231
Mycobacterium ulcerans	arylsulfatase AtsB	0.0009	0.0075	0.0062
Leishmania major	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	0.0042	0.0595	0.3668
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0042	0.0595	0.3668
Echinococcus multilocularis	prenylcysteine oxidase	0.0005	0.0014	0.0024
Schistosoma mansoni	ferritin	0.001	0.0092	0.0312
Echinococcus multilocularis	Peptidase C19, ubiquitin carboxyl terminal hydrolase 2	0.0042	0.0595	0.2009
Entamoeba histolytica	serine/threonine protein kinase, putative	0.0108	0.161	1
Trichomonas vaginalis	conserved hypothetical protein	0.0009	0.0075	0.0447
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0053	0.075	0.2887
Trichomonas vaginalis	CAMK family protein kinase	0.0108	0.161	1
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0057	0.0331
Trichomonas vaginalis	conserved hypothetical protein	0.0009	0.0075	0.0447
Plasmodium vivax	unspecified product	0.0005	0.0014	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0057	0.0331
Entamoeba histolytica	protein kinase domain containing protein	0.0005	0.0012	0.0066
Schistosoma mansoni	hypothetical protein	0.0005	0.0014	0.0047
Trichomonas vaginalis	conserved hypothetical protein	0.0009	0.0075	0.0447
Entamoeba histolytica	hypothetical protein	0.0041	0.0577	0.3578
Entamoeba histolytica	tyrosine kinase, putative	0.0004	0.0007	0.0033
Mycobacterium ulcerans	arylsulfatase, AslA	0.0009	0.0075	0.0062
Trichomonas vaginalis	conserved hypothetical protein	0.0009	0.0075	0.0447
Plasmodium vivax	lysine-specific histone demethylase 1, putative	0.0005	0.0014	0.5
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0014	0.0027
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0013	0.0147	0.0875
Mycobacterium ulcerans	arylsulfatase AtsD	0.0009	0.0075	0.0062
Entamoeba histolytica	protein kinase, putative	0.0005	0.0012	0.0066
Entamoeba histolytica	tyrosine kinase, putative	0.0005	0.0012	0.0066
Loa Loa (eye worm)	hypothetical protein	0.0171	0.2579	1
Trypanosoma brucei	polo-like protein kinase	0.0108	0.161	1
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0042	0.0595	0.3681
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0057	0.0331
Schistosoma mansoni	serine/threonine protein kinase	0.0108	0.161	0.5487
Schistosoma mansoni	ferritin	0.001	0.0092	0.0312
Entamoeba histolytica	cysteine surface protein, putative	0.0004	0.0007	0.0033
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0057	0.0331
Echinococcus granulosus	expressed protein	0.001	0.0092	0.0289
Entamoeba histolytica	hypothetical protein, conserved	0.0004	0.0007	0.0033
Trypanosoma brucei	Vps23 core domain containing protein, putative	0.0026	0.0335	0.1281
Brugia malayi	hypothetical protein	0.0009	0.0075	0.0155
Entamoeba histolytica	tyrosine kinase, putative	0.0005	0.0012	0.0066
Giardia lamblia	Hypothetical protein	0.0009	0.0075	0.0427
Entamoeba histolytica	tyrosine kinase, putative	0.0005	0.0012	0.0066
Schistosoma mansoni	cpg binding protein	0.0033	0.0449	0.153
Brugia malayi	serine/threonine-protein kinase plk-2	0.0108	0.161	0.3638
Entamoeba histolytica	protein kinase domain containing protein	0.0005	0.0012	0.0066
Schistosoma mansoni	ferritin light chain	0.001	0.0092	0.0312
Echinococcus granulosus	prenylcysteine oxidase	0.0005	0.0014	0.0024
Entamoeba histolytica	tyrosine kinase, putative	0.0005	0.0012	0.0066
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0013	0.0147	0.0875
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0008	0.0068	0.0208
Mycobacterium leprae	PROBABLE BACTERIOFERRITIN BFRA	0.001	0.0092	0.0078
Trypanosoma cruzi	electron transfer flavoprotein-ubiquinone oxidoreductase, putative	0.0005	0.0014	0.0043
Trypanosoma cruzi	electron transfer flavoprotein-ubiquinone oxidoreductase, putative	0.0005	0.0014	0.0043
Entamoeba histolytica	tyrosine kinase, putative	0.0005	0.0012	0.0066
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.001	0.0099	0.0314
Trichomonas vaginalis	conserved hypothetical protein	0.0042	0.0595	0.3681
Echinococcus multilocularis	ferritin	0.001	0.0092	0.0289
Trypanosoma cruzi	hypothetical protein, conserved	0.0013	0.0147	0.0875
Giardia lamblia	Hypothetical protein	0.0009	0.0075	0.0427
Trichomonas vaginalis	conserved hypothetical protein	0.0009	0.0075	0.0447
Mycobacterium leprae	PROBABLE CONSERVED LIPOPROTEIN LPQF	0.0073	0.1067	0.1054
Mycobacterium ulcerans	UDP-galactopyranose mutase Glf	0.0654	1	1
Toxoplasma gondii	histone lysine-specific demethylase LSD1/BHC110/KDMA1A	0.0007	0.0045	0.0348
Trichomonas vaginalis	conserved hypothetical protein	0.0009	0.0075	0.0447
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0057	0.0331
Mycobacterium tuberculosis	Probable conserved lipoprotein LpqF	0.0073	0.1067	0.1054
Entamoeba histolytica	hypothetical protein	0.0013	0.0147	0.0905
Trichomonas vaginalis	conserved hypothetical protein	0.0009	0.0075	0.0447
Trichomonas vaginalis	hypothetical protein	0.0039	0.054	0.334
Mycobacterium tuberculosis	Possible hydrolase	0.0009	0.0075	0.0062
Onchocerca volvulus	Serine\/threonine kinase homolog	0.0108	0.161	1
Trichomonas vaginalis	conserved hypothetical protein	0.0009	0.0075	0.0447
Trichomonas vaginalis	conserved hypothetical protein	0.0009	0.0075	0.0447
Entamoeba histolytica	tyrosine kinase, putative	0.0004	0.0007	0.0033
Trichomonas vaginalis	conserved hypothetical protein	0.0009	0.0075	0.0447
Trichomonas vaginalis	conserved hypothetical protein	0.0009	0.0075	0.0447
Echinococcus multilocularis	cpg binding protein	0.0035	0.0478	0.1609
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0053	0.075	0.2537
Schistosoma mansoni	tsg101-related	0.0054	0.0777	0.2649
Brugia malayi	F/Y-rich N-terminus family protein	0.001	0.0097	0.0204
Schistosoma mansoni	amine oxidase	0.0005	0.0014	0.0047
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0007	0.0057	0.0331
Wolbachia endosymbiont of Brugia malayi	bacterioferritin/cytochrome b1	0.001	0.0092	0.5
Brugia malayi	Muscleblind-like protein	0.0171	0.2579	0.5839
Entamoeba histolytica	protein kinase, putative	0.0004	0.0007	0.0033
Entamoeba histolytica	protein kinase, putative	0.0005	0.0012	0.0066
Mycobacterium tuberculosis	Probable sulfatase	0.0009	0.0075	0.0062
Trichomonas vaginalis	conserved hypothetical protein	0.0009	0.0075	0.0447
Trichomonas vaginalis	CAMK family protein kinase	0.0108	0.161	1
Schistosoma mansoni	hypothetical protein	0.0194	0.2934	1
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.0042	0.0595	0.3688
Mycobacterium ulcerans	sulfatase	0.0009	0.0075	0.0062
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0013	0.0147	0.0875
Entamoeba histolytica	tyrosine kinase, putative	0.0005	0.0012	0.0066
Entamoeba histolytica	protein kinase domain containing protein	0.0005	0.0012	0.0066
Brugia malayi	Sulfatase family protein	0.0009	0.0075	0.0155
Entamoeba histolytica	tyrosine kinase, putative	0.0005	0.0012	0.0066
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0013	0.0147	0.0875
Entamoeba histolytica	tyrosine kinase, putative	0.0004	0.0007	0.0033
Loa Loa (eye worm)	histone methyltransferase	0.001	0.0099	0.0357
Trichomonas vaginalis	conserved hypothetical protein	0.0009	0.0075	0.0447
Echinococcus multilocularis	ubiquitin specific protease 41	0.0042	0.0595	0.2009
Plasmodium vivax	unspecified product	0.0005	0.0014	0.5
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0005	0.0015	0.005
Onchocerca volvulus	GPI ethanolamine phosphate transferase 1 homolog	0.0009	0.0075	0.0427
Entamoeba histolytica	protein kinase, putative	0.0005	0.0012	0.0066
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0008	0.0068	0.0208
Brugia malayi	CXXC zinc finger family protein	0.0033	0.0449	0.1003
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0075	0.0266
Trichomonas vaginalis	conserved hypothetical protein	0.0009	0.0075	0.0447
Trichomonas vaginalis	conserved hypothetical protein	0.0009	0.0075	0.0447
Trichomonas vaginalis	conserved hypothetical protein	0.0009	0.0075	0.0447
Entamoeba histolytica	tyrosine kinase, putative	0.0004	0.0007	0.0033
Entamoeba histolytica	hypothetical protein	0.0004	0.0007	0.0033
Entamoeba histolytica	tyrosine kinase, putative	0.0005	0.0012	0.0066
Echinococcus granulosus	protoporphyrinogen oxidase	0.0005	0.0014	0.0024
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0042	0.0595	0.1334
Echinococcus multilocularis	tumor susceptibility gene 101 protein	0.008	0.117	0.3973
Entamoeba histolytica	tyrosine kinase, putative	0.0004	0.0007	0.0033
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 8	0.0042	0.0595	0.2009
Onchocerca volvulus		0.0005	0.0014	0.0043
Entamoeba histolytica	cysteine surface protein, putative	0.0004	0.0007	0.0033
Entamoeba histolytica	tyrosine kinase, putative	0.0004	0.0007	0.0033
Trichomonas vaginalis	conserved hypothetical protein	0.0013	0.0147	0.0895
Mycobacterium tuberculosis	Possible arylsulfatase AtsA (aryl-sulfate sulphohydrolase) (arylsulphatase)	0.0009	0.0075	0.0062
Entamoeba histolytica	tyrosine kinase, putative	0.0005	0.0012	0.0066
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0013	0.0147	0.0875
Schistosoma mansoni	tsg101-related	0.0066	0.0964	0.3287
Entamoeba histolytica	protein kinase, putative	0.0004	0.0007	0.0033
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 8	0.0042	0.0595	0.2009
Treponema pallidum	bacterioferrin (TpF1)	0.001	0.0092	0.5
Plasmodium vivax	unspecified product	0.0005	0.0014	0.5
Mycobacterium ulcerans	arylsulfatase AtsD	0.0009	0.0075	0.0062
Entamoeba histolytica	protein kinase domain containing protein	0.0005	0.0012	0.0066
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0013	0.0147	0.0875
Entamoeba histolytica	hypothetical protein	0.0005	0.0012	0.0066
Echinococcus multilocularis	muscleblind protein 1	0.0171	0.2579	0.8789
Schistosoma mansoni	tsg101-related	0.0066	0.0964	0.3287
Echinococcus granulosus	kelch ECH associated protein 1 like	0.0108	0.161	0.5475
Echinococcus granulosus	ubiquitin specific protease 41	0.0042	0.0595	0.2009
Trypanosoma brucei	ubiquitin carboxyl-terminal hydrolase, putative	0.0042	0.0595	0.306
Giardia lamblia	Ubiquitin carboxyl-terminal hydrolase 4	0.0042	0.0595	0.3668
Schistosoma mansoni	cpg binding protein	0.0035	0.0478	0.1629
Giardia lamblia	Kinase, PLK	0.0108	0.161	1
Entamoeba histolytica	protein kinase, putative	0.0005	0.0012	0.0066
Entamoeba histolytica	hypothetical protein	0.0013	0.0147	0.0905
Entamoeba histolytica	hypothetical protein	0.0004	0.0007	0.0033
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0013	0.0147	0.0875
Trichomonas vaginalis	CAMK family protein kinase	0.0108	0.161	1
Schistosoma mansoni	ubiquitin-specific peptidase 2 (C19 family)	0.0042	0.0595	0.2027
Mycobacterium ulcerans	bacterioferritin BfrA	0.001	0.0092	0.0078
Leishmania major	electron transfer flavoprotein-ubiquinone oxidoreductase, putative	0.0005	0.0014	0.0043
Entamoeba histolytica	hypothetical protein	0.0005	0.0012	0.0066
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0053	0.075	0.2555
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0057	0.0331
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0008	0.0068	0.0208
Entamoeba histolytica	protein kinase domain containing protein	0.0005	0.0012	0.0066
Mycobacterium ulcerans	hydrolase	0.0009	0.0075	0.0062
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0057	0.0331
Mycobacterium ulcerans	bacterioferritin BfrB	0.001	0.0092	0.0078
Entamoeba histolytica	hypothetical protein	0.0041	0.0577	0.3578
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.007	0.1017	0.3468
Mycobacterium tuberculosis	Probable bacterioferritin BfrA	0.001	0.0092	0.0078
Entamoeba histolytica	protein kinase, putative	0.0005	0.0012	0.0066
Schistosoma mansoni	kinase	0.0055	0.079	0.2691
Entamoeba histolytica	tyrosine kinase, putative	0.0005	0.0012	0.0066
Echinococcus granulosus	tumor susceptibility gene 101 protein	0.008	0.117	0.3973
Trypanosoma cruzi	polo-like protein kinase, putative	0.0108	0.161	1
Echinococcus multilocularis	expressed protein	0.001	0.0092	0.0289
Trichomonas vaginalis	CAMK family protein kinase	0.0108	0.161	1
Entamoeba histolytica	pro protein convertase subtilisin/kexinType 5 precursor, putative	0.0004	0.0007	0.0033
Entamoeba histolytica	tyrosine kinase, putative	0.0004	0.0007	0.0033
Echinococcus granulosus	Peptidase C19 ubiquitin carboxyl terminal hydrolase 2	0.0042	0.0595	0.2009
Echinococcus multilocularis	kelch ECH associated protein 1	0.0108	0.161	0.5475
Entamoeba histolytica	protein kinase, putative	0.0005	0.0012	0.0066
Plasmodium falciparum	lysine-specific histone demethylase 1, putative	0.0005	0.0014	1
Schistosoma mansoni	apoferritin-2	0.001	0.0092	0.0312
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.001	0.0099	0.0314
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0053	0.075	0.1685
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0042	0.0595	0.3681
Trichomonas vaginalis	conserved hypothetical protein	0.0009	0.0075	0.0447
Loa Loa (eye worm)	hypothetical protein	0.0123	0.1835	0.7105
Plasmodium vivax	protoporphyrinogen oxidase, putative	0.0005	0.0014	0.5
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0057	0.0331
Trichomonas vaginalis	Involucrin, putative	0.0004	0.0007	0.0021
Trichomonas vaginalis	conserved hypothetical protein	0.0009	0.0075	0.0447
Trichomonas vaginalis	conserved hypothetical protein	0.0009	0.0075	0.0447
Entamoeba histolytica	tyrosine kinase, putative	0.0005	0.0012	0.0066
Schistosoma mansoni	myst-related protein	0.0004	0.0002	0.0006
Loa Loa (eye worm)	PLK/PLK1 protein kinase	0.0108	0.161	0.623
Schistosoma mansoni	notch	0.0004	0.0007	0.0024
Echinococcus granulosus	serine:threonine protein kinase PLK1	0.0108	0.161	0.5476
Entamoeba histolytica	cysteine surface protein, putative	0.0004	0.0007	0.0033
Schistosoma mansoni	cpg binding protein	0.0035	0.0478	0.1629
Brugia malayi	all-trans-13,14-dihydroretinol saturase	0.0005	0.0014	0.0016
Trichomonas vaginalis	CAMK family protein kinase	0.0054	0.0768	0.4756
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0057	0.0331
Echinococcus granulosus	kelch ECH associated protein 1 like	0.0108	0.161	0.5475
Schistosoma mansoni	ferritin	0.001	0.0092	0.0312
Trichomonas vaginalis	conserved hypothetical protein	0.0009	0.0075	0.0447
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0053	0.075	0.2555
Trichomonas vaginalis	helicase, putative	0.0007	0.0057	0.0331
Echinococcus multilocularis	kelch ECH associated protein 1	0.0108	0.161	0.5475
Trichomonas vaginalis	conserved hypothetical protein	0.0004	0.0007	0.0021
Leishmania major	hypothetical protein, conserved	0.0026	0.0335	0.2044
Trypanosoma cruzi	hypothetical protein, conserved	0.0013	0.0147	0.0875
Trichomonas vaginalis	CAMK family protein kinase	0.0108	0.161	1
Entamoeba histolytica	tyrosine kinase, putative	0.0005	0.0012	0.0066
Trichomonas vaginalis	Phosphoglycerol transferase I, putative	0.0009	0.0075	0.0447
Trichomonas vaginalis	CAMK family protein kinase	0.0054	0.0768	0.4756
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0013	0.0147	0.0875
Trichomonas vaginalis	ferritin, putative	0.001	0.0092	0.0548
Schistosoma mansoni	apoferritin-2	0.001	0.0092	0.0312
Echinococcus granulosus	muscleblind protein	0.0171	0.2579	0.8789
Trypanosoma cruzi	UDP-galactopyranose mutase	0.0005	0.0014	0.0043
Schistosoma mansoni	hypothetical protein	0.0194	0.2934	1
Entamoeba histolytica	tyrosine kinase, putative	0.0004	0.0007	0.0033
Entamoeba histolytica	tyrosine kinase, putative	0.0005	0.0012	0.0066
Echinococcus granulosus	geminin	0.0194	0.2934	1

Activities

Activity type	Activity value	Assay description	Source	Reference
Inhibition (binding)	= 43.42 %	Inhibition of alpha-1G calcium channel in human HEK293 cells at 10 uM by whole-cell patch-clamp method	ChEMBL.	23395659

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2334272

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1732387