TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 357.169 | Formula: C17H20BN3O5
H donors: 4 H acceptors: 6 LogP: -0.16 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: OC[C@H](C(=O)N1CCC[C@H]1B(O)O)NC(=O)c1ccnc2c1cccc2
InChi: 1S/C17H20BN3O5/c22-10-14(17(24)21-9-3-6-15(21)18(25)26)20-16(23)12-7-8-19-13-5-2-1-4-11(12)13/h1-2,4-5,7-8,14-15,22,25-26H,3,6,9-10H2,(H,20,23)/t14-,15+/m1/s1
InChiKey: LKIQQVFCAWXCIN-CABCVRRESA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	prolyl endopeptidase	Starlite/ChEMBL	References
Homo sapiens	fibroblast activation protein, alpha	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	Prolyl endopeptidase, putative	Get druggable targets OG5_129295	All targets in OG5_129295
Leishmania infantum	prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative	Get druggable targets OG5_129295	All targets in OG5_129295
Echinococcus granulosus	prolyl endopeptidase	Get druggable targets OG5_129295	All targets in OG5_129295
Trypanosoma brucei	prolyl endopeptidase	Get druggable targets OG5_129295	All targets in OG5_129295
Trypanosoma congolense	prolyl endopeptidase	Get druggable targets OG5_129295	All targets in OG5_129295
Loa Loa (eye worm)	prolyl oligopeptidase	Get druggable targets OG5_128614	All targets in OG5_128614
Leishmania donovani	prolyl endopeptidase	Get druggable targets OG5_129295	All targets in OG5_129295
Echinococcus granulosus	dipeptidyl aminopeptidaseprotein	Get druggable targets OG5_128614	All targets in OG5_128614
Trypanosoma cruzi	prolyl endopeptidase	Get druggable targets OG5_129295	All targets in OG5_129295
Candida albicans	dipeptidyl aminopeptidase B	Get druggable targets OG5_128614	All targets in OG5_128614
Candida albicans	dipeptidyl aminopeptidase B	Get druggable targets OG5_128614	All targets in OG5_128614
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_129295	All targets in OG5_129295
Echinococcus multilocularis	prolyl endopeptidase	Get druggable targets OG5_129295	All targets in OG5_129295
Echinococcus multilocularis	dipeptidyl aminopeptidaseprotein	Get druggable targets OG5_128614	All targets in OG5_128614
Schistosoma mansoni	subfamily S9B unassigned peptidase (S09 family)	Get druggable targets OG5_128614	All targets in OG5_128614
Schistosoma japonicum	ko:K01322 prolyl oligopeptidase [EC3.4.21.26], putative	Get druggable targets OG5_129295	All targets in OG5_129295
Schistosoma japonicum	ko:K01278 dipeptidyl-peptidase 4, putative	Get druggable targets OG5_128614	All targets in OG5_128614
Brugia malayi	prolyl oligopeptidase family protein	Get druggable targets OG5_128614	All targets in OG5_128614
Schistosoma mansoni	prolyl oligopeptidase (S09 family)	Get druggable targets OG5_129295	All targets in OG5_129295
Neospora caninum	Prolyl oligopeptidase (EC 3.4.21.26) (Precursor), related	Get druggable targets OG5_129295	All targets in OG5_129295
Brugia malayi	prolyl oligopeptidase family protein	Get druggable targets OG5_129295	All targets in OG5_129295
Leishmania mexicana	prolyl oligopeptidase, putative	Get druggable targets OG5_129295	All targets in OG5_129295
Onchocerca volvulus	Prolyl endopeptidase homolog	Get druggable targets OG5_129295	All targets in OG5_129295
Schistosoma mansoni	prolyl oligopeptidase (S09 family)	Get druggable targets OG5_129295	All targets in OG5_129295
Trypanosoma brucei gambiense	prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative	Get druggable targets OG5_129295	All targets in OG5_129295
Onchocerca volvulus	Dipeptidyl peptidase family member 1 homolog	Get druggable targets OG5_128614	All targets in OG5_128614
Leishmania major	prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative	Get druggable targets OG5_129295	All targets in OG5_129295
Toxoplasma gondii	prolyl endopeptidase	Get druggable targets OG5_129295	All targets in OG5_129295
Mycobacterium tuberculosis	Probable protease II PtrBa [first part] (oligopeptidase B)	Get druggable targets OG5_129295	All targets in OG5_129295

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Echinococcus multilocularis	Dipeptidyl peptidase 9	fibroblast activation protein, alpha	735 aa	597 aa	24.5 %
Trypanosoma brucei	oligopeptidase b	prolyl endopeptidase	710 aa	630 aa	27.0 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	integrin linked protein kinase	0.0751	0.5261	0.5121
Loa Loa (eye worm)	TK/Met protein kinase	0.0751	0.5261	0.5121
Echinococcus granulosus	tyrosine protein kinase csk	0.0751	0.5261	0.5121
Onchocerca volvulus		0.0751	0.5261	0.5121
Entamoeba histolytica	protein kinase domain containing protein	0.0751	0.5261	0.2688
Echinococcus granulosus	epidermal growth factor receptor	0.0751	0.5261	0.5121
Entamoeba histolytica	tyrosine kinase, putative	0.0751	0.5261	0.2688
Trichomonas vaginalis	TKL family protein kinase	0.0751	0.5261	0.5
Echinococcus multilocularis	SH2 domain containing adapter protein F	0.0549	0.3518	0.3328
Entamoeba histolytica	tyrosin kinase, putative	0.0751	0.5261	0.2688
Trichomonas vaginalis	TKL family protein kinase	0.0751	0.5261	0.5
Schistosoma mansoni	tyrosine kinase	0.0751	0.5261	0.5121
Brugia malayi	Protein kinase domain containing protein	0.0751	0.5261	0.5121
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0751	0.5261	0.5121
Loa Loa (eye worm)	hypothetical protein	0.0751	0.5261	0.5121
Entamoeba histolytica	protein kinase, putative	0.0751	0.5261	0.2688
Schistosoma mansoni	protein kinase	0.0751	0.5261	0.5121
Brugia malayi	Raf kinase	0.0751	0.5261	0.5121
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0751	0.5261	0.2688
Trichomonas vaginalis	TKL family protein kinase	0.0751	0.5261	0.5
Giardia lamblia	Kinase	0.0751	0.5261	0.5
Schistosoma mansoni	protein kinase	0.0751	0.5261	0.5121
Echinococcus granulosus	protein tyrosine kinase	0.0751	0.5261	0.5121
Brugia malayi	Protein kinase domain containing protein	0.0751	0.5261	0.5121
Loa Loa (eye worm)	hypothetical protein	0.0549	0.3518	0.3328
Onchocerca volvulus		0.1301	1	1
Brugia malayi	Protein kinase domain containing protein	0.0751	0.5261	0.5121
Schistosoma mansoni	tyrosine kinase	0.0751	0.5261	0.5121
Echinococcus granulosus	tensin C1 domain containing phosphatase	0.0549	0.3518	0.3328
Echinococcus multilocularis	SH2 domain containing protein 7	0.0549	0.3518	0.3328
Schistosoma mansoni	tyrosine kinase	0.0751	0.5261	0.5121
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0751	0.5261	1
Echinococcus granulosus	tyrosine protein kinase Blk	0.1301	1	1
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0549	0.3518	0.3328
Echinococcus granulosus	suppressor of cytokine signaling 7	0.0549	0.3518	0.3328
Trichomonas vaginalis	TKL family protein kinase	0.0751	0.5261	0.5
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.0751	0.5261	0.5121
Trichomonas vaginalis	TKL family protein kinase	0.0751	0.5261	0.5
Echinococcus granulosus	tyrosine protein kinase Fyn	0.1301	1	1
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0751	0.5261	0.5121
Trichomonas vaginalis	AGC family protein kinase	0.0751	0.5261	0.5
Entamoeba histolytica	protein kinase, putative	0.0751	0.5261	0.2688
Echinococcus multilocularis	tyrosine protein kinase csk	0.0751	0.5261	0.5121
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0751	0.5261	0.5121
Brugia malayi	SRC-1	0.1301	1	1
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0751	0.5261	0.5121
Schistosoma mansoni	hypothetical protein	0.0549	0.3518	0.3328
Schistosoma mansoni	protein kinase	0.0751	0.5261	0.5121
Brugia malayi	Protein kinase domain containing protein	0.0751	0.5261	0.5121
Schistosoma mansoni	tyrosine kinase	0.0751	0.5261	0.5121
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0751	0.5261	1
Onchocerca volvulus		0.0549	0.3518	0.3328
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0751	0.5261	0.5121
Entamoeba histolytica	leucine-rich repeat domain-containing protein	0.0751	0.5261	0.2688
Loa Loa (eye worm)	hypothetical protein	0.0549	0.3518	0.3328
Schistosoma mansoni	tyrosine kinase	0.0751	0.5261	0.5121
Brugia malayi	Variant SH3 domain containing protein	0.0549	0.3518	0.3328
Echinococcus granulosus	tyrosine protein kinase csk	0.0751	0.5261	0.5121
Loa Loa (eye worm)	TK/FER protein kinase	0.1301	1	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0751	0.5261	0.2688
Entamoeba histolytica	protein kinase domain containing protein	0.0751	0.5261	0.2688
Schistosoma mansoni	tyrosine-protein kinase zap-70	0.0549	0.3518	0.3328
Loa Loa (eye worm)	TK protein kinase	0.0751	0.5261	0.5121
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.0751	0.5261	0.5121
Trichomonas vaginalis	TKL family protein kinase	0.0751	0.5261	0.5
Schistosoma mansoni	tyrosine kinase	0.0751	0.5261	0.5121
Entamoeba histolytica	protein kinase, putative	0.0751	0.5261	0.2688
Echinococcus multilocularis	FL cytokine receptor	0.0751	0.5261	0.5121
Brugia malayi	hypothetical protein	0.0751	0.5261	0.5121
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0751	0.5261	0.5121
Onchocerca volvulus		0.0549	0.3518	0.3328
Trichomonas vaginalis	TKL family protein kinase	0.0751	0.5261	0.5
Loa Loa (eye worm)	hypothetical protein	0.0549	0.3518	0.3328
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.0751	0.5261	0.5121
Trichomonas vaginalis	STE family protein kinase	0.0751	0.5261	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0751	0.5261	0.5
Loa Loa (eye worm)	hypothetical protein	0.0549	0.3518	0.3328
Schistosoma mansoni	tyrosine kinase	0.1301	1	1
Loa Loa (eye worm)	TK/ALK protein kinase	0.0751	0.5261	0.5121
Trypanosoma brucei	protein kinase, putative	0.0751	0.5261	1
Brugia malayi	Sex muscle abnormal protein 5	0.0549	0.3518	0.3328
Trichomonas vaginalis	TKL family protein kinase	0.0751	0.5261	0.5
Schistosoma mansoni	tyrosine kinase	0.0751	0.5261	0.5121
Loa Loa (eye worm)	hypothetical protein	0.0549	0.3518	0.3328
Echinococcus granulosus	protein kinase	0.0751	0.5261	0.5121
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0751	0.5261	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0751	0.5261	0.2688
Brugia malayi	C-terminal src kinase protein 1	0.0751	0.5261	0.5121
Echinococcus granulosus	tyrosine protein kinase csk	0.0751	0.5261	0.5121
Echinococcus granulosus	natriuretic peptide receptor 1	0.0751	0.5261	0.5121
Loa Loa (eye worm)	TK protein kinase	0.0751	0.5261	0.5121
Entamoeba histolytica	tyrosine kinase, putative	0.0751	0.5261	0.2688
Entamoeba histolytica	serine/threonine kinase, putative	0.0751	0.5261	0.2688
Schistosoma mansoni	tyrosine kinase	0.0751	0.5261	0.5121
Loa Loa (eye worm)	SH2 domain-containing protein	0.0549	0.3518	0.3328
Loa Loa (eye worm)	TK/INSR protein kinase	0.0751	0.5261	0.5121
Schistosoma mansoni	signal transduction protein lnk-related	0.0549	0.3518	0.3328
Schistosoma mansoni	nck2/grb4	0.0549	0.3518	0.3328
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0751	0.5261	0.5121
Loa Loa (eye worm)	TK/FAK protein kinase	0.0751	0.5261	0.5121
Schistosoma mansoni	tensin	0.0549	0.3518	0.3328
Trypanosoma brucei	Pseudokinase, putative	0.0751	0.5261	1
Schistosoma mansoni	protein tyrosine kinase	0.0751	0.5261	0.5121
Echinococcus granulosus	N chimaerin	0.0549	0.3518	0.3328
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.0751	0.5261	0.5121
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.0751	0.5261	0.5121
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0549	0.3518	0.3328
Schistosoma mansoni	tyrosine kinase	0.0751	0.5261	0.5121
Echinococcus granulosus	phosphatidylinositol 3 kinase regulatory subunit	0.0549	0.3518	0.3328
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0751	0.5261	0.5121
Echinococcus multilocularis	tensin	0.0549	0.3518	0.3328
Schistosoma mansoni	src-type protein tyrosine kinase-related	0.0751	0.5261	0.5121
Trichomonas vaginalis	TKL family protein kinase	0.0751	0.5261	0.5
Onchocerca volvulus		0.0751	0.5261	0.5121
Loa Loa (eye worm)	hypothetical protein	0.0751	0.5261	0.5121
Echinococcus multilocularis	tyrosine protein kinase Srms	0.1301	1	1
Onchocerca volvulus		0.0549	0.3518	0.3328
Echinococcus granulosus	dipeptidyl aminopeptidaseprotein	0.0226	0.0727	0.0454
Loa Loa (eye worm)	hypothetical protein	0.0549	0.3518	0.3328
Echinococcus multilocularis	tyrosine protein kinase csk	0.0751	0.5261	0.5121
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0751	0.5261	0.5121
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0549	0.3518	0.3328
Echinococcus granulosus	signal transduction protein lnk realted	0.0549	0.3518	0.3328
Echinococcus multilocularis		0.0549	0.3518	0.3328
Schistosoma mansoni	shc transforming protein	0.0549	0.3518	0.3328
Trichomonas vaginalis	TKL family protein kinase	0.0751	0.5261	0.5
Brugia malayi	ephrin receptor 1 precursor	0.0751	0.5261	0.5121
Brugia malayi	Protein kinase domain containing protein	0.0751	0.5261	0.5121
Loa Loa (eye worm)	TK/FER protein kinase	0.1301	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0751	0.5261	0.5
Brugia malayi	Protein kinase domain containing protein	0.0751	0.5261	0.5121
Onchocerca volvulus	Dipeptidyl peptidase family member 1 homolog	0.0226	0.0727	0.0454
Loa Loa (eye worm)	TK/FER protein kinase	0.1301	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0751	0.5261	0.5
Echinococcus granulosus	tyrosine kinase	0.1301	1	1
Loa Loa (eye worm)	TK/RYK protein kinase	0.0751	0.5261	0.5121
Schistosoma mansoni	hypothetical protein	0.0549	0.3518	0.3328
Schistosoma mansoni	protein kinase	0.0751	0.5261	0.5121
Echinococcus granulosus	raf serine:threonine protein kinase	0.0751	0.5261	0.5121
Echinococcus multilocularis	phosphatidylinositol 3 kinase regulatory subunit	0.0549	0.3518	0.3328
Loa Loa (eye worm)	hypothetical protein	0.0549	0.3518	0.3328
Brugia malayi	SH2 domain containing protein	0.0549	0.3518	0.3328
Onchocerca volvulus		0.0751	0.5261	0.5121
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0549	0.3518	0.3328
Echinococcus multilocularis	heat shock protein 70	0.0751	0.5261	0.5121
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0751	0.5261	0.2688
Trichomonas vaginalis	TKL family protein kinase	0.0751	0.5261	0.5
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.0751	0.5261	0.5121
Echinococcus granulosus	epidermal growth factor receptor	0.0751	0.5261	0.5121
Entamoeba histolytica	cysteine surface protein, putative	0.0751	0.5261	0.2688
Entamoeba histolytica	ankyrin repeat protein	0.0751	0.5261	0.2688
Trichomonas vaginalis	TKL family protein kinase	0.0751	0.5261	0.5
Schistosoma mansoni	tyrosine kinase	0.0751	0.5261	0.5121
Trichomonas vaginalis	TKL family protein kinase	0.0751	0.5261	0.5
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0549	0.3518	0.3328
Echinococcus granulosus	SH2 domain containing protein 7	0.0549	0.3518	0.3328
Entamoeba histolytica	protein kinase domain containing protein	0.0751	0.5261	0.2688
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0751	0.5261	0.2688
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0751	0.5261	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0751	0.5261	0.5
Schistosoma mansoni	serine/threonine RGC	0.0751	0.5261	0.5121
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.0751	0.5261	0.5121
Echinococcus granulosus	kinase suppressor of Ras 1	0.0751	0.5261	0.5121
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.1301	1	1
Entamoeba histolytica	protein kinase domain containing protein	0.0751	0.5261	0.2688
Entamoeba histolytica	tyrosine kinase, putative	0.0751	0.5261	0.2688
Echinococcus multilocularis	dipeptidyl aminopeptidaseprotein	0.0226	0.0727	0.0454
Entamoeba histolytica	protein kinase domain containing protein	0.0751	0.5261	0.2688
Onchocerca volvulus		0.0751	0.5261	0.5121
Trichomonas vaginalis	TKL family protein kinase	0.0751	0.5261	0.5
Schistosoma mansoni	tyrosine kinase	0.0751	0.5261	0.5121
Trichomonas vaginalis	TKL family protein kinase	0.0751	0.5261	0.5
Schistosoma mansoni	tyrosine kinase	0.0751	0.5261	0.5121
Loa Loa (eye worm)	hypothetical protein	0.0751	0.5261	0.5121
Brugia malayi	Protein kinase domain containing protein	0.0751	0.5261	0.5121
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0751	0.5261	0.5121
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.0751	0.5261	0.5121
Trichomonas vaginalis	TKL family protein kinase	0.0751	0.5261	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0751	0.5261	0.5
Entamoeba histolytica	protein kinase, putative	0.0751	0.5261	0.2688
Trichomonas vaginalis	conserved hypothetical protein	0.0751	0.5261	0.5
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.1301	1	1
Brugia malayi	SH2 domain containing protein	0.0549	0.3518	0.3328
Entamoeba histolytica	tyrosine kinase, putative	0.0751	0.5261	0.2688
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0751	0.5261	0.5121
Trichomonas vaginalis	conserved hypothetical protein	0.0751	0.5261	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0751	0.5261	0.2688
Trichomonas vaginalis	TKL family protein kinase	0.0751	0.5261	0.5
Echinococcus granulosus	tyrosine protein kinase shark	0.1301	1	1
Entamoeba histolytica	protein kinase domain containing protein	0.0751	0.5261	0.2688
Plasmodium vivax	protein kinase, putative	0.0751	0.5261	0.5
Echinococcus multilocularis	insulin receptor	0.0751	0.5261	0.5121
Onchocerca volvulus		0.0549	0.3518	0.3328
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.0751	0.5261	0.5121
Loa Loa (eye worm)	TK/ROR protein kinase	0.0751	0.5261	0.5121
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0751	0.5261	0.5121
Trichomonas vaginalis	TKL family protein kinase	0.0751	0.5261	0.5
Echinococcus granulosus	activated cdc42 kinase 1	0.0751	0.5261	0.5121
Brugia malayi	SH2 domain containing protein	0.0549	0.3518	0.3328
Entamoeba histolytica	serine/threonine kinase, putative	0.0751	0.5261	0.2688
Loa Loa (eye worm)	STAT protein	0.0549	0.3518	0.3328
Trichomonas vaginalis	TKL family protein kinase	0.0751	0.5261	0.5
Schistosoma mansoni	protein kinase	0.0751	0.5261	0.5121
Loa Loa (eye worm)	hypothetical protein	0.0751	0.5261	0.5121
Loa Loa (eye worm)	SH2 domain-containing protein	0.0549	0.3518	0.3328
Echinococcus granulosus	SH2 motif	0.0549	0.3518	0.3328
Loa Loa (eye worm)	SRC-1	0.1301	1	1
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0751	0.5261	1
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0549	0.3518	0.3328
Trichomonas vaginalis	conserved hypothetical protein	0.0751	0.5261	0.5
Onchocerca volvulus		0.0751	0.5261	0.5121
Echinococcus multilocularis	natriuretic peptide receptor 1	0.0751	0.5261	0.5121
Schistosoma mansoni	tyrosine kinase	0.0751	0.5261	0.5121
Trichomonas vaginalis	TKL family protein kinase	0.0751	0.5261	0.5
Toxoplasma gondii	protein kinase domain-containing protein	0.0751	0.5261	1
Echinococcus multilocularis	SH2 motif	0.0549	0.3518	0.3328
Echinococcus multilocularis	ephrin type A receptor 4 A	0.0751	0.5261	0.5121
Entamoeba histolytica	serine/threonine kinase, putative	0.0751	0.5261	0.2688
Brugia malayi	Protein kinase domain containing protein	0.0751	0.5261	0.5121
Brugia malayi	protein-tyrosine kinase	0.1301	1	1
Loa Loa (eye worm)	prolyl oligopeptidase	0.0226	0.0727	0.0454
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0549	0.3518	0.3328
Loa Loa (eye worm)	TK protein kinase	0.0751	0.5261	0.5121
Trichomonas vaginalis	TKL family protein kinase	0.0751	0.5261	0.5
Schistosoma mansoni	suppressor of cytokine signaling	0.0549	0.3518	0.3328
Schistosoma mansoni	tyrosine kinase	0.0751	0.5261	0.5121
Loa Loa (eye worm)	TK/ABL protein kinase	0.1301	1	1
Onchocerca volvulus	Tyrosine kinase homolog	0.0751	0.5261	0.5121
Entamoeba histolytica	protein kinase domain containing protein	0.0751	0.5261	0.2688
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0549	0.3518	0.3328
Schistosoma mansoni	serine/threonine protein kinase	0.0751	0.5261	0.5121
Onchocerca volvulus		0.0549	0.3518	0.3328
Entamoeba histolytica	protein kinase domain containing protein	0.0751	0.5261	0.2688
Entamoeba histolytica	protein kinase, putative	0.0751	0.5261	0.2688
Brugia malayi	Variant SH3 domain containing protein	0.0549	0.3518	0.3328
Echinococcus granulosus	tyrosine protein kinase Src64B	0.1301	1	1
Brugia malayi	Guanylyl cyclase protein 23	0.0751	0.5261	0.5121
Brugia malayi	Variant SH3 domain containing protein	0.0549	0.3518	0.3328
Echinococcus granulosus	tyrosine protein kinase Lyn	0.1301	1	1
Schistosoma mansoni	tyrosine protein kinase	0.0751	0.5261	0.5121
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0751	0.5261	0.5121
Trichomonas vaginalis	TKL family protein kinase	0.0751	0.5261	0.5
Brugia malayi	Protein kinase domain containing protein	0.0751	0.5261	0.5121
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0549	0.3518	0.3328
Schistosoma mansoni	protein kinase	0.0751	0.5261	0.5121
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0549	0.3518	0.3328
Loa Loa (eye worm)	hypothetical protein	0.0549	0.3518	0.3328
Echinococcus multilocularis	SHC transforming protein 3	0.0549	0.3518	0.3328
Trichomonas vaginalis	TKL family protein kinase	0.0751	0.5261	0.5
Schistosoma mansoni	tyrosine kinase	0.0751	0.5261	0.5121
Echinococcus multilocularis	tyrosine kinase	0.0751	0.5261	0.5121
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0751	0.5261	0.2688
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.1301	1	1
Entamoeba histolytica	serine/threonine kinase, putative	0.0751	0.5261	0.2688
Schistosoma mansoni	serine/threonine protein kinase	0.0751	0.5261	0.5121
Schistosoma mansoni	tyrosine kinase	0.1301	1	1
Plasmodium falciparum	protein kinase, putative	0.0751	0.5261	0.5
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0751	0.5261	0.5121
Trichomonas vaginalis	TKL family protein kinase	0.0751	0.5261	0.5
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.1301	1	1
Brugia malayi	cytokine inducible SH2-containing protein 5	0.0549	0.3518	0.3328
Loa Loa (eye worm)	TK/FER protein kinase	0.1301	1	1
Onchocerca volvulus		0.1301	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0751	0.5261	0.5
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.0751	0.5261	0.5121
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.0751	0.5261	0.5121
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.1301	1	1
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0751	0.5261	0.5121
Loa Loa (eye worm)	TK/EPH protein kinase	0.0751	0.5261	0.5121
Entamoeba histolytica	protein kinase domain containing protein	0.0751	0.5261	0.2688
Echinococcus multilocularis	tyrosine protein kinase shark	0.1301	1	1
Brugia malayi	Tensin	0.0549	0.3518	0.3328
Echinococcus multilocularis	protein tyrosine kinase	0.0751	0.5261	0.5121
Brugia malayi	tRNA modification GTPase TrmE family protein	0.0549	0.3518	0.3328
Loa Loa (eye worm)	TK protein kinase	0.0751	0.5261	0.5121
Schistosoma mansoni	tyrosine kinase	0.0751	0.5261	0.5121
Trichomonas vaginalis	TKL family protein kinase	0.0751	0.5261	0.5
Plasmodium falciparum	protein kinase, putative	0.0751	0.5261	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0751	0.5261	0.2688
Echinococcus multilocularis	NCK adaptor protein	0.0549	0.3518	0.3328
Entamoeba histolytica	protein kinase domain containing protein	0.0751	0.5261	0.2688
Echinococcus granulosus	tyrosine protein kinase pr2	0.0751	0.5261	0.5121
Trichomonas vaginalis	conserved hypothetical protein	0.0751	0.5261	0.5
Entamoeba histolytica	hypothetical protein	0.0751	0.5261	0.2688
Schistosoma mansoni	adapter molecule crk	0.0549	0.3518	0.3328
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0751	0.5261	0.2688
Brugia malayi	SH2 domain containing protein	0.1301	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.1301	1	1
Onchocerca volvulus		0.0751	0.5261	0.5121
Brugia malayi	bone morphogenetic protein type 1 receptor	0.0751	0.5261	0.5121
Entamoeba histolytica	hypothetical protein	0.0751	0.5261	0.2688
Trichomonas vaginalis	TK family protein kinase	0.0751	0.5261	0.5
Loa Loa (eye worm)	TK/DDR protein kinase	0.0751	0.5261	0.5121
Schistosoma mansoni	serine/threonine protein kinase	0.0751	0.5261	0.5121
Trichomonas vaginalis	TKL family protein kinase	0.0751	0.5261	0.5
Schistosoma mansoni	suppressor of cytokine signaling	0.0549	0.3518	0.3328
Echinococcus multilocularis	tyrosine protein kinase	0.0751	0.5261	0.5121
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0751	0.5261	0.5121
Trichomonas vaginalis	TKL family protein kinase	0.0751	0.5261	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0751	0.5261	0.5
Giardia lamblia	Protein 21.1	0.0751	0.5261	0.5
Trichomonas vaginalis	CAMK family protein kinase	0.0751	0.5261	0.5
Toxoplasma gondii	protein kinase	0.0751	0.5261	1
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0751	0.5261	0.5121
Entamoeba histolytica	receptor protein kinase, putative	0.0751	0.5261	0.2688
Schistosoma mansoni	subfamily S9B unassigned peptidase (S09 family)	0.0226	0.0727	0.0454
Entamoeba histolytica	hypothetical protein	0.0751	0.5261	0.2688
Trypanosoma brucei	Flagellum attachment zone protein 20	0.0751	0.5261	1
Entamoeba histolytica	receptor protein kinase, putative	0.0751	0.5261	0.2688
Brugia malayi	Protein kinase domain containing protein	0.0751	0.5261	0.5121
Echinococcus granulosus	hypothetical protein	0.0549	0.3518	0.3328
Echinococcus multilocularis	protein kinase	0.0751	0.5261	0.5121
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0549	0.3518	0.3328
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0751	0.5261	0.2688
Brugia malayi	Protein kinase domain containing protein	0.1301	1	1
Brugia malayi	Protein kinase domain containing protein	0.0751	0.5261	0.5121
Loa Loa (eye worm)	TK protein kinase	0.0751	0.5261	0.5121
Echinococcus granulosus	expressed conserved protein	0.0549	0.3518	0.3328
Echinococcus granulosus	SH2 motif	0.0549	0.3518	0.3328
Echinococcus multilocularis	activin receptor type	0.0751	0.5261	0.5121
Brugia malayi	SH2 domain containing protein	0.1301	1	1
Echinococcus multilocularis	protein KINase family member (kin 25)	0.0751	0.5261	0.5121
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.0751	0.5261	0.5121
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0751	0.5261	1
Loa Loa (eye worm)	TK/FER protein kinase	0.1301	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0751	0.5261	0.5
Echinococcus granulosus	ephrin type A receptor 4 A	0.0751	0.5261	0.5121
Schistosoma mansoni	tensin-related	0.0549	0.3518	0.3328
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.1301	1	1
Echinococcus granulosus	NCK adaptor protein	0.0549	0.3518	0.3328
Entamoeba histolytica	protein kinase domain containing protein	0.0751	0.5261	0.2688
Loa Loa (eye worm)	cytokine inducible SH2-containing protein 5	0.0549	0.3518	0.3328
Entamoeba histolytica	protein kinase with ankyrin repeats, putative	0.0751	0.5261	0.2688
Brugia malayi	Protein kinase domain containing protein	0.0751	0.5261	0.5121
Entamoeba histolytica	protein kinase, putative	0.0751	0.5261	0.2688
Brugia malayi	Receptor family ligand binding region containing protein	0.0751	0.5261	0.5121
Brugia malayi	SH2 domain containing protein	0.0549	0.3518	0.3328
Brugia malayi	Protein kinase domain containing protein	0.0751	0.5261	0.5121
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0751	0.5261	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0751	0.5261	0.5
Brugia malayi	Protein kinase domain containing protein	0.1301	1	1
Schistosoma mansoni	tyrosine kinase	0.0751	0.5261	0.5121
Trichomonas vaginalis	TKL family protein kinase	0.0751	0.5261	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0751	0.5261	0.5
Entamoeba histolytica	hypothetical protein	0.0751	0.5261	0.2688
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0751	0.5261	0.5121
Echinococcus granulosus	SH2 domain containing adapter protein F	0.0549	0.3518	0.3328
Brugia malayi	Protein kinase domain containing protein	0.0751	0.5261	0.5121
Schistosoma mansoni	tensin-related	0.0549	0.3518	0.3328
Entamoeba histolytica	tyrosine kinase, putative	0.0751	0.5261	0.2688
Brugia malayi	Variant SH3 domain containing protein	0.0549	0.3518	0.3328
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0751	0.5261	0.5121
Loa Loa (eye worm)	hypothetical protein	0.0751	0.5261	0.5121
Trichomonas vaginalis	TKL family protein kinase	0.0751	0.5261	0.5
Loa Loa (eye worm)	hypothetical protein	0.0549	0.3518	0.3328
Loa Loa (eye worm)	TK/FER protein kinase	0.1301	1	1
Leishmania major	hypothetical protein, conserved	0.0751	0.5261	1
Schistosoma mansoni	ephrin receptor	0.0751	0.5261	0.5121
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.1301	1	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0751	0.5261	0.2688
Schistosoma mansoni	protein kinase	0.0751	0.5261	0.5121
Trichomonas vaginalis	TKL family protein kinase	0.0751	0.5261	0.5
Brugia malayi	Protein kinase domain containing protein	0.0751	0.5261	0.5121
Schistosoma mansoni	tyrosine kinase	0.0751	0.5261	0.5121
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0751	0.5261	1
Trypanosoma cruzi	protein kinase, putative	0.0751	0.5261	1
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0751	0.5261	0.5121
Entamoeba histolytica	ankyrin repeat protein	0.0751	0.5261	0.2688
Schistosoma mansoni	tyrosine kinase	0.0751	0.5261	0.5121
Brugia malayi	hypothetical protein	0.0549	0.3518	0.3328
Schistosoma mansoni	growth factor receptor-bound protein	0.0549	0.3518	0.3328
Echinococcus granulosus	tyrosine protein kinase Fyn	0.1301	1	1
Schistosoma mansoni	protein kinase	0.0751	0.5261	0.5121
Trichomonas vaginalis	TKL family protein kinase	0.0751	0.5261	0.5
Trypanosoma brucei	AGC/RSK family serine/threonine kinase, putative	0.0751	0.5261	1
Onchocerca volvulus		0.0751	0.5261	0.5121
Entamoeba histolytica	serine/threonine kinase, putative	0.0751	0.5261	0.2688
Entamoeba histolytica	tyrosine kinase, putative	0.0751	0.5261	0.2688
Entamoeba histolytica	protein kinase domain containing protein	0.0751	0.5261	0.2688
Brugia malayi	Protein kinase domain containing protein	0.0751	0.5261	0.5121
Echinococcus granulosus	suppressor of cytokine signaling 6	0.0549	0.3518	0.3328
Entamoeba histolytica	tyrosine kinase, putative	0.0751	0.5261	0.2688
Echinococcus multilocularis	transfer RNA-Thr	0.0751	0.5261	0.5121
Echinococcus granulosus	fibroblast growth factor receptor 4	0.0751	0.5261	0.5121
Schistosoma mansoni	protein kinase	0.0751	0.5261	0.5121
Loa Loa (eye worm)	TK/FER protein kinase	0.1301	1	1
Loa Loa (eye worm)	hypothetical protein	0.0549	0.3518	0.3328
Giardia lamblia	Kinase, NEK	0.0751	0.5261	0.5
Plasmodium falciparum	protein kinase, putative	0.0751	0.5261	0.5
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.1301	1	1
Brugia malayi	Furin-like cysteine rich region family protein	0.0751	0.5261	0.5121
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0751	0.5261	0.5121
Brugia malayi	hypothetical protein	0.0751	0.5261	0.5121
Loa Loa (eye worm)	hypothetical protein	0.0751	0.5261	0.5121
Trichomonas vaginalis	TKL family protein kinase	0.0751	0.5261	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0751	0.5261	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0751	0.5261	0.2688
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0751	0.5261	0.5121
Loa Loa (eye worm)	hypothetical protein	0.0751	0.5261	0.5121
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0549	0.3518	0.3328
Trichomonas vaginalis	TKL family protein kinase	0.0751	0.5261	0.5
Echinococcus multilocularis	protein kinase	0.0751	0.5261	0.5121
Entamoeba histolytica	tyrosine kinase, putative	0.0751	0.5261	0.2688
Trypanosoma cruzi	protein kinase, putative	0.0751	0.5261	1
Echinococcus granulosus	tyrosine protein kinase ABL1	0.1301	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0751	0.5261	0.5
Entamoeba histolytica	tyrosine- protein kinase 2, putative	0.0751	0.5261	0.2688
Echinococcus multilocularis	tyrosine protein kinase csk	0.0751	0.5261	0.5121
Leishmania major	protein kinase, putative	0.0751	0.5261	1
Echinococcus multilocularis	tyrosine protein kinase pr2	0.0751	0.5261	0.5121
Echinococcus granulosus	tensin	0.0549	0.3518	0.3328
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.1301	1	1
Brugia malayi	Protein kinase domain containing protein	0.0751	0.5261	0.5121
Schistosoma mansoni	tyrosine kinase	0.1301	1	1
Onchocerca volvulus		0.1301	1	1
Brugia malayi	Protein kinase domain containing protein	0.0751	0.5261	0.5121
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0751	0.5261	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0751	0.5261	0.2688
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0549	0.3518	0.3328
Leishmania major	protein kinase, putative	0.0751	0.5261	1
Loa Loa (eye worm)	hypothetical protein	0.0751	0.5261	0.5121
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.1301	1	1
Entamoeba histolytica	protein kinase, putative	0.0751	0.5261	0.2688
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0751	0.5261	0.5121
Brugia malayi	SH2 domain containing protein	0.0549	0.3518	0.3328
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.0751	0.5261	0.5121
Echinococcus granulosus	tyrosine kinase	0.1301	1	1
Schistosoma mansoni	vav2	0.0549	0.3518	0.3328
Schistosoma mansoni	protein kinase	0.0751	0.5261	0.5121
Entamoeba histolytica	protein kinase, putative	0.0751	0.5261	0.2688
Brugia malayi	STAT protein, DNA binding domain containing protein	0.0549	0.3518	0.3328
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0751	0.5261	0.5121
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.0751	0.5261	0.5121
Schistosoma mansoni	tyrosine kinase	0.0751	0.5261	0.5121
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0751	0.5261	0.5121
Schistosoma mansoni	tyrosine kinase	0.0751	0.5261	0.5121
Loa Loa (eye worm)	TK/FER protein kinase	0.0751	0.5261	0.5121
Echinococcus multilocularis	signal transduction protein lnk realted	0.0549	0.3518	0.3328
Echinococcus granulosus	tyrosine protein kinase Src42A	0.1301	1	1
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0549	0.3518	0.3328
Brugia malayi	Protein kinase domain containing protein	0.0751	0.5261	0.5121
Entamoeba histolytica	tyrosin kinase, putative	0.0751	0.5261	0.2688
Trichomonas vaginalis	TKL family protein kinase	0.0751	0.5261	0.5
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.1301	1	1
Loa Loa (eye worm)	TK protein kinase	0.0751	0.5261	0.5121
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.0751	0.5261	0.5121
Echinococcus granulosus	tyrosine protein kinase Fyn	0.1301	1	1
Brugia malayi	prolyl oligopeptidase family protein	0.0226	0.0727	0.0454
Trichomonas vaginalis	TKL family protein kinase	0.0751	0.5261	0.5
Entamoeba histolytica	protein kinase, putative	0.0751	0.5261	0.2688
Entamoeba histolytica	protein kinase, putative	0.0751	0.5261	0.2688
Loa Loa (eye worm)	protein kinase domain-containing protein	0.0751	0.5261	0.5121
Trichomonas vaginalis	conserved hypothetical protein	0.0751	0.5261	0.5
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.1301	1	1
Echinococcus multilocularis	c src tyrosine kinase	0.1301	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0751	0.5261	0.5121
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0751	0.5261	0.5121
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.0751	0.5261	0.5121
Trichomonas vaginalis	TKL family protein kinase	0.0751	0.5261	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0751	0.5261	0.5
Brugia malayi	SH2 domain containing protein	0.0549	0.3518	0.3328
Trichomonas vaginalis	TKL family protein kinase	0.0751	0.5261	0.5
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.1301	1	1
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0549	0.3518	0.3328
Loa Loa (eye worm)	TK/ACK protein kinase	0.0751	0.5261	0.5121
Entamoeba histolytica	protein kinase domain containing protein	0.0751	0.5261	0.2688
Entamoeba histolytica	protein kinase, putative	0.0751	0.5261	0.2688
Brugia malayi	Tyrosine-protein kinase PR2	0.0751	0.5261	0.5121
Entamoeba histolytica	tyrosine kinase, putative	0.0751	0.5261	0.2688
Trichomonas vaginalis	TKL family protein kinase	0.0751	0.5261	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0751	0.5261	0.5
Brugia malayi	hypothetical protein	0.1301	1	1
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0751	0.5261	0.5121
Brugia malayi	Protein kinase domain containing protein	0.0751	0.5261	0.5121
Loa Loa (eye worm)	TK/FER protein kinase	0.0751	0.5261	0.5121
Echinococcus granulosus	growth factor receptor bound protein 2	0.0549	0.3518	0.3328
Echinococcus granulosus	activin receptor type	0.0751	0.5261	0.5121
Entamoeba histolytica	tyrosine kinase, putative	0.0751	0.5261	0.2688
Loa Loa (eye worm)	hypothetical protein	0.0751	0.5261	0.5121
Echinococcus multilocularis	epidermal growth factor receptor	0.0751	0.5261	0.5121
Brugia malayi	Protein kinase domain containing protein	0.1301	1	1
Onchocerca volvulus	Atrial natriuretic peptide receptor 3 homolog	0.0751	0.5261	0.5121
Schistosoma mansoni	tyrosine kinase	0.0751	0.5261	0.5121
Loa Loa (eye worm)	SH2 domain-containing protein	0.0549	0.3518	0.3328
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0549	0.3518	0.3328
Onchocerca volvulus		0.1301	1	1
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0751	0.5261	0.5121
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0751	0.5261	1
Giardia lamblia	Kinase, NEK	0.0751	0.5261	0.5
Echinococcus granulosus	insulin receptor	0.0751	0.5261	0.5121
Entamoeba histolytica	hypothetical protein	0.0751	0.5261	0.2688
Loa Loa (eye worm)	hypothetical protein	0.1301	1	1
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0751	0.5261	0.5
Loa Loa (eye worm)	hypothetical protein	0.0751	0.5261	0.5121
Loa Loa (eye worm)	TK/FER protein kinase	0.1301	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0751	0.5261	0.5
Schistosoma mansoni	tensin	0.0549	0.3518	0.3328
Brugia malayi	Protein kinase domain containing protein	0.0751	0.5261	0.5121
Schistosoma mansoni	tyrosine kinase	0.1301	1	1
Entamoeba histolytica	hypothetical protein	0.0751	0.5261	0.2688
Brugia malayi	Protein kinase domain containing protein	0.0751	0.5261	0.5121
Loa Loa (eye worm)	TK/FER protein kinase	0.1301	1	1
Loa Loa (eye worm)	TK protein kinase	0.0751	0.5261	0.5121
Loa Loa (eye worm)	serine/threonine protein kinase	0.0751	0.5261	0.5121
Entamoeba histolytica	protein kinase, putative	0.0751	0.5261	0.2688
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0751	0.5261	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0751	0.5261	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0751	0.5261	0.2688
Loa Loa (eye worm)	hypothetical protein	0.0751	0.5261	0.5121
Onchocerca volvulus		0.1301	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0751	0.5261	0.5
Brugia malayi	Protein kinase domain containing protein	0.0751	0.5261	0.5121
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.1301	1	1
Entamoeba histolytica	hypothetical protein	0.0751	0.5261	0.2688
Entamoeba histolytica	protein kinase domain containing protein	0.0751	0.5261	0.2688
Loa Loa (eye worm)	TK protein kinase	0.0751	0.5261	0.5121
Brugia malayi	Tyrosine-protein kinase abl-1	0.1301	1	1
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0751	0.5261	0.5121
Plasmodium falciparum	tyrosine kinase-like protein	0.0751	0.5261	0.5
Entamoeba histolytica	protein kinase, putative	0.0751	0.5261	0.2688
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.1301	1	1
Trichomonas vaginalis	protein kinase atn1, putative	0.0751	0.5261	0.5
Loa Loa (eye worm)	hypothetical protein	0.0751	0.5261	0.5121
Entamoeba histolytica	tyrosine kinase, putative	0.0751	0.5261	0.2688
Trichomonas vaginalis	TKL family protein kinase	0.0751	0.5261	0.5
Onchocerca volvulus		0.0549	0.3518	0.3328
Echinococcus granulosus	c src tyrosine kinase	0.1301	1	1
Entamoeba histolytica	hypothetical protein	0.0751	0.5261	0.2688
Entamoeba histolytica	protein kinase, putative	0.0751	0.5261	0.2688
Schistosoma mansoni	tyrosine kinase	0.0751	0.5261	0.5121
Echinococcus multilocularis	integrin linked protein kinase	0.0751	0.5261	0.5121
Onchocerca volvulus	Suppressor of cytokine signaling at 36E homolog	0.0549	0.3518	0.3328
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.1301	1	1
Echinococcus multilocularis	tyrosine protein kinase csk	0.0751	0.5261	0.5121
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0549	0.3518	0.3328
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.1301	1	1
Schistosoma mansoni	protein kinase	0.0751	0.5261	0.5121
Onchocerca volvulus		0.0751	0.5261	0.5121
Echinococcus multilocularis	SH2 motif	0.0549	0.3518	0.3328
Entamoeba histolytica	tyrosin kinase, putative	0.0751	0.5261	0.2688
Trichomonas vaginalis	TKL family protein kinase	0.0751	0.5261	0.5
Schistosoma mansoni	growth factor receptor-bound protein	0.0549	0.3518	0.3328
Entamoeba histolytica	hypothetical protein	0.0751	0.5261	0.2688
Echinococcus multilocularis	tyrosine protein kinase Blk	0.1301	1	1
Entamoeba histolytica	protein kinase domain containing protein	0.0751	0.5261	0.2688
Brugia malayi	RhoGAP domain containing protein	0.0549	0.3518	0.3328
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0549	0.3518	0.3328
Loa Loa (eye worm)	TK/FER protein kinase	0.0751	0.5261	0.5121
Entamoeba histolytica	tyrosine kinase, putative	0.0751	0.5261	0.2688
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0751	0.5261	0.5
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0549	0.3518	0.3328
Entamoeba histolytica	hypothetical protein	0.0751	0.5261	0.2688
Trichomonas vaginalis	TKL family protein kinase	0.0751	0.5261	0.5
Echinococcus granulosus	tyrosine protein kinase	0.0751	0.5261	0.5121
Entamoeba histolytica	tyrosine kinase, putative	0.0751	0.5261	0.2688
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0549	0.3518	0.3328
Schistosoma mansoni	serine/threonine protein kinase	0.0751	0.5261	0.5121
Onchocerca volvulus		0.1301	1	1
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.1301	1	1
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.0751	0.5261	0.5121
Onchocerca volvulus	Tyrosine kinase receptor Cad96Ca homolog	0.0751	0.5261	0.5121
Entamoeba histolytica	tyrosine kinase, putative	0.0751	0.5261	0.2688
Brugia malayi	integrin-linked kinase	0.0751	0.5261	0.5121
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0751	0.5261	0.2688
Loa Loa (eye worm)	TK/FER protein kinase	0.0751	0.5261	0.5121
Loa Loa (eye worm)	hypothetical protein	0.0549	0.3518	0.3328
Entamoeba histolytica	protein kinase, putative	0.0751	0.5261	0.2688
Loa Loa (eye worm)	hypothetical protein	0.0549	0.3518	0.3328
Schistosoma mansoni	SH2A	0.0549	0.3518	0.3328
Echinococcus multilocularis	N chimaerin	0.0549	0.3518	0.3328
Entamoeba histolytica	serine/threonine kinase, putative	0.0751	0.5261	0.2688
Echinococcus multilocularis	tyrosine protein kinase Abl	0.1301	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0751	0.5261	0.5121
Trichomonas vaginalis	TKL family protein kinase	0.0751	0.5261	0.5
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.1301	1	1
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0751	0.5261	0.5121
Entamoeba histolytica	protein kinase domain containing protein	0.0751	0.5261	0.2688
Loa Loa (eye worm)	TK protein kinase	0.1301	1	1
Onchocerca volvulus	Suppressor of cytokine signaling 7 homolog	0.0549	0.3518	0.3328
Schistosoma mansoni	GTPase activating protein	0.0549	0.3518	0.3328
Echinococcus granulosus	tyrosine protein kinase Srms	0.1301	1	1
Entamoeba histolytica	protein kinase, putative	0.0751	0.5261	0.2688
Mycobacterium tuberculosis	Probable protease II PtrBa [first part] (oligopeptidase B)	0.0142	0	0.5
Echinococcus multilocularis	epidermal growth factor receptor	0.0751	0.5261	0.5121
Echinococcus granulosus	tyrosine protein kinase HCK	0.0751	0.5261	0.5121
Schistosoma mansoni	tyrosine kinase	0.1301	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0751	0.5261	0.5
Loa Loa (eye worm)	TK/CSK protein kinase	0.0751	0.5261	0.5121
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0751	0.5261	0.5121
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0549	0.3518	0.3328
Trichomonas vaginalis	TKL family protein kinase	0.0751	0.5261	0.5
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0751	0.5261	0.5121
Schistosoma mansoni	hypothetical protein	0.0751	0.5261	0.5121
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0751	0.5261	0.5121
Echinococcus multilocularis	kinase suppressor of Ras 1	0.0751	0.5261	0.5121
Schistosoma mansoni	tyrosine kinase	0.0751	0.5261	0.5121
Entamoeba histolytica	protein kinase domain containing protein	0.0751	0.5261	0.2688
Onchocerca volvulus		0.0751	0.5261	0.5121
Entamoeba histolytica	protein kinase, putative	0.0751	0.5261	0.2688
Entamoeba histolytica	tyrosine kinase, putative	0.0751	0.5261	0.2688
Brugia malayi	Protein kinase domain containing protein	0.1301	1	1
Entamoeba histolytica	tyrosin kinase, putative	0.0751	0.5261	0.2688
Echinococcus multilocularis	tyrosine kinase	0.1301	1	1
Loa Loa (eye worm)	hypothetical protein	0.0549	0.3518	0.3328
Trichomonas vaginalis	TKL family protein kinase	0.0751	0.5261	0.5
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0751	0.5261	0.5121
Schistosoma mansoni	ephrin receptor	0.0751	0.5261	0.5121
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.0751	0.5261	0.5121
Echinococcus multilocularis	activated cdc42 kinase 1	0.0751	0.5261	0.5121
Plasmodium falciparum	tyrosine kinase-like protein	0.0751	0.5261	0.5
Entamoeba histolytica	hypothetical protein, conserved	0.0751	0.5261	0.2688
Schistosoma mansoni	tyrosine kinase	0.1301	1	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0751	0.5261	0.2688
Echinococcus granulosus	SHC transforming protein 3	0.0549	0.3518	0.3328
Toxoplasma gondii	STE kinase	0.0751	0.5261	1
Echinococcus granulosus	activated cdc42 kinase 1	0.0751	0.5261	0.5121
Trichomonas vaginalis	TKL family protein kinase	0.0751	0.5261	0.5
Schistosoma mansoni	tyrosine kinase	0.0751	0.5261	0.5121
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.0751	0.5261	0.5121
Entamoeba histolytica	tyrosine kinase, putative	0.0751	0.5261	0.2688
Trichomonas vaginalis	TKL family protein kinase	0.0751	0.5261	0.5
Brugia malayi	Protein kinase domain containing protein	0.0751	0.5261	0.5121
Echinococcus granulosus	receptor type guanylyl cyclase	0.0751	0.5261	0.5121
Trichomonas vaginalis	TKL family protein kinase	0.0751	0.5261	0.5
Entamoeba histolytica	hypothetical protein	0.0751	0.5261	0.2688
Entamoeba histolytica	protein kinase domain containing protein	0.0751	0.5261	0.2688
Trichomonas vaginalis	conserved hypothetical protein	0.0751	0.5261	0.5
Echinococcus multilocularis	tensin	0.0549	0.3518	0.3328
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.0751	0.5261	0.5121
Echinococcus granulosus	tyrosine kinase	0.0751	0.5261	0.5121
Entamoeba histolytica	protein kinase, putative	0.0751	0.5261	0.2688
Echinococcus multilocularis	SH2 motif	0.0549	0.3518	0.3328
Echinococcus multilocularis	suppressor of cytokine signaling 6	0.0549	0.3518	0.3328
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0751	0.5261	0.5121
Loa Loa (eye worm)	hypothetical protein	0.0549	0.3518	0.3328
Entamoeba histolytica	protein kinase domain containing protein	0.0751	0.5261	0.2688
Schistosoma mansoni	tensin	0.0549	0.3518	0.3328
Trichomonas vaginalis	TKL family protein kinase	0.0751	0.5261	0.5
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0751	0.5261	0.5121
Trichomonas vaginalis	TKL family protein kinase	0.0751	0.5261	0.5
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.1301	1	1
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0751	0.5261	0.5121
Brugia malayi	SH2 domain containing protein	0.0549	0.3518	0.3328
Entamoeba histolytica	protein kinase, putative	0.0751	0.5261	0.2688
Loa Loa (eye worm)	TK protein kinase	0.0751	0.5261	0.5121
Loa Loa (eye worm)	TK/FER protein kinase	0.0751	0.5261	0.5121
Brugia malayi	Protein kinase domain containing protein	0.0751	0.5261	0.5121
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0751	0.5261	0.5121
Loa Loa (eye worm)	hypothetical protein	0.0549	0.3518	0.3328
Entamoeba histolytica	protein kinase domain containing protein	0.0751	0.5261	0.2688
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.0751	0.5261	0.5121

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 120 nM	Inhibition of human FAP using Z-Gly-Pro-AMC as substrate preincubated for 10 mins prior to substrate addition by fluorescence assay	ChEMBL.	23594271
IC50 (binding)	= 440 nM	Inhibition of human PREP using Z-Gly-Pro-AMC as substrate preincubated for 10 mins prior to substrate addition by fluorescence assay	ChEMBL.	23594271

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2332620

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1734669