Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | spleen tyrosine kinase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma mansoni | tyrosine kinase | Get druggable targets OG5_131855 | All targets in OG5_131855 |
Echinococcus granulosus | tyrosine protein kinase shark | Get druggable targets OG5_131855 | All targets in OG5_131855 |
Schistosoma japonicum | ko:K08253 non-specific protein-tyrosine kinase [EC2.7.10.2], putative | Get druggable targets OG5_131855 | All targets in OG5_131855 |
Echinococcus multilocularis | tyrosine protein kinase shark | Get druggable targets OG5_131855 | All targets in OG5_131855 |
Schistosoma mansoni | tyrosine kinase | Get druggable targets OG5_131855 | All targets in OG5_131855 |
Schistosoma japonicum | ko:K05855 spleen tyrosine kinase, putative | Get druggable targets OG5_131855 | All targets in OG5_131855 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | tyrosine protein kinase Lyn | 0.0012 | 0.0015 | 0.0015 |
Echinococcus granulosus | tyrosine protein kinase shark | 0.0264 | 0.0962 | 0.0962 |
Onchocerca volvulus | 0.0008 | 0 | 0.5 | |
Onchocerca volvulus | 0.0008 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.267 | 0.9985 | 1 |
Loa Loa (eye worm) | STE/STE11/ASK protein kinase | 0.0809 | 0.3006 | 0.301 |
Schistosoma mansoni | protein kinase | 0.2674 | 1 | 1 |
Onchocerca volvulus | 0.0008 | 0 | 0.5 | |
Onchocerca volvulus | 0.0008 | 0 | 0.5 | |
Echinococcus multilocularis | mitogen activated protein kinase kinase kinase | 0.2674 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0264 | 0.0962 | 0.0962 |
Trypanosoma cruzi | STE/STE11 serine/threonine-protein kinase, putative | 0.0809 | 0.3006 | 0.5 |
Schistosoma mansoni | protein kinase | 0.2674 | 1 | 1 |
Onchocerca volvulus | 0.0008 | 0 | 0.5 | |
Trypanosoma cruzi | STE/STE11 serine/threonine-protein kinase, putative | 0.0809 | 0.3006 | 0.5 |
Echinococcus granulosus | mitogen activated protein kinase kinase kinase | 0.2674 | 1 | 1 |
Onchocerca volvulus | 0.0008 | 0 | 0.5 | |
Entamoeba histolytica | protein kinase, putative | 0.001 | 0.0009 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0258 | 0.0939 | 0.0939 |
Echinococcus multilocularis | tyrosine protein kinase shark | 0.0264 | 0.0962 | 0.0962 |
Loa Loa (eye worm) | hypothetical protein | 0.0805 | 0.2991 | 0.2995 |
Entamoeba histolytica | SH2-protein kinase domain containing protein | 0.001 | 0.0009 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 850 nM | Inhibitory activity against human Syk protein tyrosine kinase expressed in yeast Klyveromyces lactis | ChEMBL. | 12941345 |
IC50 (binding) | = 850 nM | Inhibition of recombinant Syk | ChEMBL. | 19254842 |
S | = 70 mg l-1 | Solubility | ChEMBL. | 12941345 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.