Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Acyl-CoA desaturase 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Candida albicans | one of two potential fatty acid desaturase genes similar to S. cerevisiae OLE1 (YGL055W) delta-9 fatty acid desaturase | Acyl-CoA desaturase 1 | 358 aa | 317 aa | 27.1 % |
Candida albicans | one of two potential fatty acid desaturase genes similar to S. cerevisiae OLE1 (YGL055W) delta-9 fatty acid desaturase | Acyl-CoA desaturase 1 | 358 aa | 317 aa | 27.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | fatty acid desaturase, putative | 0.0068 | 0.7358 | 0.7358 |
Mycobacterium ulcerans | linoleoyl-CoA desaturase, DesA3_2 | 0.0018 | 0 | 0.5 |
Toxoplasma gondii | sphingolipid delta 4 desaturase/c-4 hydroxylase protein des2 family protein | 0.0018 | 0 | 0.5 |
Plasmodium falciparum | stearoyl-CoA desaturase | 0.0068 | 0.7358 | 0.5 |
Echinococcus multilocularis | Peptidase M, neutral zinc metallopeptidases, zinc binding site | 0.0018 | 0 | 0.5 |
Mycobacterium tuberculosis | Possible electron transfer protein FdxB | 0.0018 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable transmembrane alkane 1-monooxygenase AlkB (alkane 1-hydroxylase) (lauric acid omega-hydroxylase) (omega-hydroxylase) (f | 0.0018 | 0 | 0.5 |
Brugia malayi | acyl-CoA desaturase | 0.0068 | 0.7358 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0018 | 0 | 0.5 |
Onchocerca volvulus | 0.0086 | 1 | 1 | |
Leishmania major | fatty-acid desaturase, putative | 0.0086 | 1 | 1 |
Loa Loa (eye worm) | acyl-CoA desaturase | 0.0068 | 0.7358 | 1 |
Onchocerca volvulus | 0.0086 | 1 | 1 | |
Mycobacterium ulcerans | linoleoyl-CoA desaturase, DesA3 | 0.0018 | 0 | 0.5 |
Trypanosoma brucei | fatty acid desaturase, putative | 0.0086 | 1 | 1 |
Echinococcus multilocularis | Fatty acid desaturase, type 1 | 0.0018 | 0 | 0.5 |
Mycobacterium ulcerans | transmembrane alkane 1-monooxygenase AlkB | 0.0018 | 0 | 0.5 |
Schistosoma mansoni | fatty acid desaturase | 0.0018 | 0 | 0.5 |
Mycobacterium ulcerans | electron transfer protein FdxB | 0.0018 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable conserved membrane protein | 0.0018 | 0 | 0.5 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.0086 | 1 | 1 |
Echinococcus granulosus | Sphingolipid delta4 desaturase DES1 | 0.0018 | 0 | 0.5 |
Plasmodium vivax | stearoyl-CoA desaturase (acyl-CoA desaturase, faty acid desaturase), putative | 0.0068 | 0.7358 | 0.5 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.0068 | 0.7358 | 0.7358 |
Echinococcus multilocularis | Peptidase M, neutral zinc metallopeptidases, zinc binding site | 0.0018 | 0 | 0.5 |
Mycobacterium ulcerans | linoleoyl-CoA desaturase, DesA3 | 0.0018 | 0 | 0.5 |
Echinococcus granulosus | Fatty acid desaturase type 1 | 0.0018 | 0 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0018 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1.6 uM | Inhibition of rat SCD1 by rat microsomal assay | ChEMBL. | 23265904 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.