Detailed information for compound 173956

Basic information

Technical information
  • TDR Targets ID: 173956
  • Name: 1-[3-[(2-amino-1,6-dimethylpyrimidin-1-ium-4- yl)amino]-5-(1-hydroxyethyl)phenyl]ethanol
  • MW: 303.379 | Formula: C16H23N4O2+
  • H donors: 4 H acceptors: 3 LogP: 1.29 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(c1cc(Nc2cc(C)[n+](c(n2)N)C)cc(c1)C(O)C)O
  • InChi: 1S/C16H22N4O2/c1-9-5-15(19-16(17)20(9)4)18-14-7-12(10(2)21)6-13(8-14)11(3)22/h5-8,10-11,21-22H,1-4H3,(H2,17,18,19)/p+1
  • InChiKey: QNQYVCHCPNDLAT-UHFFFAOYSA-O  


Substructure search Similarity search

Network

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Synonyms

  • 1-[3-[(2-amino-1,6-dimethyl-pyrimidin-1-ium-4-yl)amino]-5-(1-hydroxyethyl)phenyl]ethanol
  • 1-[3-[(2-amino-1,6-dimethyl-4-pyrimidin-1-iumyl)amino]-5-(1-hydroxyethyl)phenyl]ethanol
  • 1-[3-[(2-azanyl-1,6-dimethyl-pyrimidin-1-ium-4-yl)amino]-5-(1-hydroxyethyl)phenyl]ethanol
  • AIDS-154360
  • AIDS154360
  • ITI-H0299
  • Pyrimidinium, 2-amino-4-[[3,5-bis(1-hydroxyethyl)phenyl]amino]-1,6-dimethyl-

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi nuclear hormone receptor 0.0014 0.0151 0.0177
Onchocerca volvulus Suppressor of cytokine signaling at 36E homolog 0.0076 0.2735 0.5357
Loa Loa (eye worm) serine/threonine protein kinase 0.0053 0.1784 0.2097
Echinococcus granulosus tyrosine protein kinase Lyn 0.0129 0.4975 0.5847
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0076 0.2735 0.3215
Onchocerca volvulus 0.0129 0.4975 1
Onchocerca volvulus 0.0076 0.2735 0.5357
Brugia malayi Protein kinase domain containing protein 0.0053 0.1784 0.2097
Echinococcus granulosus activin receptor type 0.0053 0.1784 0.2097
Leishmania major hypothetical protein, conserved 0.0053 0.1784 1
Schistosoma mansoni suppressor of cytokine signaling 0.0076 0.2735 0.5498
Entamoeba histolytica protein kinase, putative 0.0053 0.1784 0.1784
Schistosoma mansoni thyroid hormone receptor 0.0014 0.0151 0.0303
Brugia malayi Sex muscle abnormal protein 5 0.0076 0.2735 0.3215
Onchocerca volvulus 0.0129 0.4975 1
Echinococcus granulosus atrial natriuretic peptide receptor 1 0.0053 0.1784 0.2097
Schistosoma mansoni tyrosine kinase 0.0129 0.4975 1
Trichomonas vaginalis TKL family protein kinase 0.0053 0.1784 0.1784
Echinococcus granulosus tyrosine protein kinase Fyn 0.0129 0.4975 0.5847
Loa Loa (eye worm) TK/FER protein kinase 0.0129 0.4975 0.5847
Loa Loa (eye worm) hypothetical protein 0.0213 0.8509 1
Onchocerca volvulus Suppressor of cytokine signaling 7 homolog 0.0076 0.2735 0.5357
Schistosoma mansoni tyrosine kinase 0.0053 0.1784 0.3586
Trichomonas vaginalis TKL family protein kinase 0.0053 0.1784 0.1784
Trichomonas vaginalis TKL family protein kinase 0.0053 0.1784 0.1784
Echinococcus multilocularis receptor type guanylyl cyclase 0.0053 0.1784 0.2097
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0129 0.4975 0.5847
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0014 0.0151 0.0177
Schistosoma mansoni src-type protein tyrosine kinase-related 0.0053 0.1784 0.3586
Entamoeba histolytica serine/threonine kinase, putative 0.0053 0.1784 0.1784
Brugia malayi Latrophilin receptor protein 2 0.0013 0.0108 0.0127
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0249 1 1
Echinococcus granulosus SH2 domain containing adapter protein F 0.0076 0.2735 0.3215
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0076 0.2735 0.3215
Schistosoma mansoni tyrosine kinase 0.0053 0.1784 0.3586
Brugia malayi photoreceptor-specific nuclear receptor 0.0014 0.0151 0.0177
Trypanosoma brucei AGC/RSK family serine/threonine kinase, putative 0.0053 0.1784 1
Echinococcus granulosus natriuretic peptide receptor 1 0.0053 0.1784 0.2097
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0014 0.0151 0.0177
Brugia malayi Immunoglobulin I-set domain containing protein 0.0053 0.1784 0.2097
Echinococcus granulosus expressed conserved protein 0.0076 0.2735 0.3215
Trichomonas vaginalis TKL family protein kinase 0.0053 0.1784 0.1784
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0053 0.1784 0.2097
Trichomonas vaginalis TKL family protein kinase 0.0053 0.1784 0.1784
Onchocerca volvulus 0.0053 0.1784 0.3385
Entamoeba histolytica protein kinase domain containing protein 0.0053 0.1784 0.1784
Trichomonas vaginalis br serine/threonine-protein kinase, putative 0.0053 0.1784 0.1784
Schistosoma mansoni tyrosine kinase 0.0053 0.1784 0.3586
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0129 0.4975 0.5847
Echinococcus multilocularis tensin 0.0076 0.2735 0.3215
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0053 0.1784 0.2097
Brugia malayi steroid hormone receptor 0.0014 0.0151 0.0177
Entamoeba histolytica protein kinase, putative 0.0053 0.1784 0.1784
Toxoplasma gondii protein kinase 0.0053 0.1784 1
Brugia malayi RhoGAP domain containing protein 0.0076 0.2735 0.3215
Entamoeba histolytica tyrosine kinase, putative 0.0053 0.1784 0.1784
Echinococcus multilocularis signal transduction protein lnk realted 0.0076 0.2735 0.3215
Schistosoma mansoni tyrosine kinase 0.0053 0.1784 0.3586
Schistosoma mansoni tensin 0.0076 0.2735 0.5498
Loa Loa (eye worm) SH2 domain-containing protein 0.0076 0.2735 0.3215
Schistosoma mansoni tyrosine kinase 0.0129 0.4975 1
Echinococcus multilocularis protein kinase 0.0053 0.1784 0.2097
Schistosoma mansoni tyrosine kinase 0.0053 0.1784 0.3586
Onchocerca volvulus 0.0076 0.2735 0.5357
Schistosoma mansoni tyrosine kinase 0.0053 0.1784 0.3586
Trichomonas vaginalis TKL family protein kinase 0.0053 0.1784 0.1784
Echinococcus granulosus tyrosine protein kinase 0.0053 0.1784 0.2097
Echinococcus multilocularis transfer RNA-Thr 0.0053 0.1784 0.2097
Schistosoma mansoni hypothetical protein 0.0013 0.0108 0.0218
Trichomonas vaginalis TKL family protein kinase 0.0053 0.1784 0.1784
Trichomonas vaginalis TKL family protein kinase 0.0053 0.1784 0.1784
Brugia malayi Receptor family ligand binding region containing protein 0.0053 0.1784 0.2097
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0053 0.1784 0.1784
Brugia malayi SH2 domain containing protein 0.0076 0.2735 0.3215
Loa Loa (eye worm) hypothetical protein 0.0053 0.1784 0.2097
Schistosoma mansoni ephrin receptor 0.0053 0.1784 0.3586
Loa Loa (eye worm) hypothetical protein 0.0053 0.1784 0.2097
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0014 0.0151 0.0177
Brugia malayi Protein kinase domain containing protein 0.0053 0.1784 0.2097
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0129 0.4975 0.5847
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0053 0.1784 0.1784
Entamoeba histolytica protein kinase domain containing protein 0.0053 0.1784 0.1784
Entamoeba histolytica protein kinase, putative 0.0053 0.1784 0.1784
Entamoeba histolytica protein kinase domain containing protein 0.0053 0.1784 0.1784
Echinococcus granulosus NCK adaptor protein 0.0076 0.2735 0.3215
Schistosoma mansoni hypothetical protein 0.0013 0.0108 0.0218
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0053 0.1784 0.2097
Entamoeba histolytica hypothetical protein 0.0053 0.1784 0.1784
Trichomonas vaginalis TKL family protein kinase 0.0053 0.1784 0.1784
Brugia malayi Protein kinase domain containing protein 0.0053 0.1784 0.2097
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0053 0.1784 0.2097
Echinococcus granulosus tyrosine kinase 0.0129 0.4975 0.5847
Trichomonas vaginalis TKL family protein kinase 0.0053 0.1784 0.1784
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.1784 0.3586
Loa Loa (eye worm) TK/FER protein kinase 0.0129 0.4975 0.5847
Brugia malayi nuclear receptor NHR-88 0.0014 0.0151 0.0177
Echinococcus granulosus tyrosine protein kinase csk 0.0053 0.1784 0.2097
Loa Loa (eye worm) TK protein kinase 0.0053 0.1784 0.2097
Brugia malayi ephrin receptor 1 precursor 0.0053 0.1784 0.2097
Loa Loa (eye worm) hypothetical protein 0.0042 0.1328 0.156
Echinococcus multilocularis tyrosine kinase 0.0129 0.4975 0.5847
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0076 0.2735 0.3215
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0053 0.1784 0.2097
Schistosoma mansoni hypothetical protein 0.0076 0.2735 0.5498
Entamoeba histolytica ankyrin repeat protein 0.0053 0.1784 0.1784
Loa Loa (eye worm) TK/FER protein kinase 0.0129 0.4975 0.5847
Giardia lamblia Kinase, NEK 0.0053 0.1784 0.1784
Entamoeba histolytica tyrosine kinase, putative 0.0053 0.1784 0.1784
Brugia malayi tRNA modification GTPase TrmE family protein 0.0076 0.2735 0.3215
Echinococcus multilocularis tensin 0.0076 0.2735 0.3215
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0076 0.2735 0.3215
Plasmodium falciparum tyrosine kinase-like protein 0.0053 0.1784 1
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0053 0.1784 0.1784
Entamoeba histolytica protein kinase domain containing protein 0.0053 0.1784 0.1784
Echinococcus granulosus hypothetical protein 0.0076 0.2735 0.3215
Echinococcus multilocularis protein tyrosine kinase 0.0053 0.1784 0.2097
Echinococcus multilocularis SHC transforming protein 3 0.0076 0.2735 0.3215
Loa Loa (eye worm) hypothetical protein 0.0076 0.2735 0.3215
Echinococcus granulosus protein kinase 0.0053 0.1784 0.2097
Entamoeba histolytica protein kinase domain containing protein 0.0053 0.1784 0.1784
Trichomonas vaginalis TKL family protein kinase 0.0053 0.1784 0.1784
Echinococcus multilocularis tyrosine protein kinase csk 0.0053 0.1784 0.2097
Entamoeba histolytica hypothetical protein 0.0053 0.1784 0.1784
Trichomonas vaginalis CAMK family protein kinase 0.0053 0.1784 0.1784
Echinococcus granulosus insulin receptor 0.0053 0.1784 0.2097
Trichomonas vaginalis TKL family protein kinase 0.0053 0.1784 0.1784
Loa Loa (eye worm) cytokine inducible SH2-containing protein 5 0.0076 0.2735 0.3215
Echinococcus multilocularis tyrosine protein kinase Srms 0.0129 0.4975 0.5847
Entamoeba histolytica protein kinase, putative 0.0053 0.1784 0.1784
Trichomonas vaginalis TKL family protein kinase 0.0053 0.1784 0.1784
Trichomonas vaginalis TKL family protein kinase 0.0053 0.1784 0.1784
Loa Loa (eye worm) protein kinase domain-containing protein 0.0053 0.1784 0.2097
Schistosoma mansoni tensin 0.0076 0.2735 0.5498
Onchocerca volvulus 0.0076 0.2735 0.5357
Echinococcus multilocularis SH2 motif 0.0076 0.2735 0.3215
Echinococcus granulosus N chimaerin 0.0076 0.2735 0.3215
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0053 0.1784 0.2097
Entamoeba histolytica serine/threonine kinase, putative 0.0053 0.1784 0.1784
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0076 0.2735 0.3215
Echinococcus granulosus fibroblast growth factor receptor 4 0.0053 0.1784 0.2097
Echinococcus granulosus c src tyrosine kinase 0.0129 0.4975 0.5847
Entamoeba histolytica protein kinase, putative 0.0053 0.1784 0.1784
Echinococcus granulosus tensin 0.0076 0.2735 0.3215
Entamoeba histolytica protein kinase, putative 0.0053 0.1784 0.1784
Giardia lamblia Protein 21.1 0.0053 0.1784 0.1784
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0053 0.1784 0.3385
Onchocerca volvulus 0.0053 0.1784 0.3385
Entamoeba histolytica tyrosin kinase, putative 0.0053 0.1784 0.1784
Echinococcus multilocularis SH2 motif 0.0076 0.2735 0.3215
Plasmodium falciparum tyrosine kinase-like protein 0.0053 0.1784 1
Echinococcus multilocularis NCK adaptor protein 0.0076 0.2735 0.3215
Echinococcus granulosus 3'partial|retinal guanylyl cyclase 2 0.0053 0.1784 0.2097
Brugia malayi Immunoglobulin I-set domain containing protein 0.0053 0.1784 0.2097
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0129 0.4975 1
Echinococcus granulosus SH2 domain containing protein 7 0.0076 0.2735 0.3215
Entamoeba histolytica tyrosin kinase, putative 0.0053 0.1784 0.1784
Schistosoma mansoni tyrosine kinase 0.0053 0.1784 0.3586
Echinococcus multilocularis epidermal growth factor receptor 0.0053 0.1784 0.2097
Loa Loa (eye worm) hypothetical protein 0.0014 0.0151 0.0177
Loa Loa (eye worm) MH2 domain-containing protein 0.0069 0.2438 0.2865
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0076 0.2735 0.3215
Echinococcus granulosus GPCR family 2 0.0013 0.0108 0.0127
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0129 0.4975 0.5847
Trichomonas vaginalis TKL family protein kinase 0.0053 0.1784 0.1784
Echinococcus granulosus epidermal growth factor receptor 0.0053 0.1784 0.2097
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0014 0.0151 0.0177
Entamoeba histolytica serine/threonine kinase, putative 0.0053 0.1784 0.1784
Trypanosoma cruzi protein kinase, putative 0.0053 0.1784 1
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.1784 0.1784
Schistosoma mansoni protein kinase 0.0053 0.1784 0.3586
Loa Loa (eye worm) TK/FER protein kinase 0.0129 0.4975 0.5847
Trichomonas vaginalis TKL family protein kinase 0.0053 0.1784 0.1784
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0053 0.1784 0.1784
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0053 0.1784 0.2097
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0014 0.0151 0.0177
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.1784 0.1784
Loa Loa (eye worm) hypothetical protein 0.0053 0.1784 0.2097
Trichomonas vaginalis TKL family protein kinase 0.0053 0.1784 0.1784
Loa Loa (eye worm) TKL/MLK/HH498 protein kinase 0.0053 0.1784 0.2097
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0249 1 1
Entamoeba histolytica tyrosine kinase, putative 0.0053 0.1784 0.1784
Trichomonas vaginalis TKL family protein kinase 0.0053 0.1784 0.1784
Echinococcus multilocularis tyrosine protein kinase 0.0053 0.1784 0.2097
Echinococcus granulosus integrin linked protein kinase 0.0053 0.1784 0.2097
Echinococcus multilocularis activated cdc42 kinase 1 0.0053 0.1784 0.2097
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0122 0.4652 0.5
Schistosoma mansoni tyrosine kinase 0.0053 0.1784 0.3586
Brugia malayi Nuclear hormone receptor-like 1 0.0014 0.0151 0.0177
Echinococcus granulosus tyrosine protein kinase Fes:Fps 0.0053 0.1784 0.2097
Trichomonas vaginalis TKL family protein kinase 0.0053 0.1784 0.1784
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0122 0.4652 1
Trichomonas vaginalis TKL family protein kinase 0.0053 0.1784 0.1784
Schistosoma mansoni ephrin receptor 0.0053 0.1784 0.3586
Trichomonas vaginalis TKL family protein kinase 0.0053 0.1784 0.1784
Echinococcus multilocularis SH2 motif 0.0076 0.2735 0.3215
Loa Loa (eye worm) hypothetical protein 0.0129 0.4975 0.5847
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0129 0.4975 0.5847
Onchocerca volvulus Tyrosine kinase homolog 0.0053 0.1784 0.3385
Schistosoma mansoni protein kinase 0.0053 0.1784 0.3586
Schistosoma mansoni tensin-related 0.0076 0.2735 0.5498
Echinococcus multilocularis protein kinase 0.0053 0.1784 0.2097
Echinococcus multilocularis c src tyrosine kinase 0.0129 0.4975 0.5847
Trichomonas vaginalis TKL family protein kinase 0.0053 0.1784 0.1784
Brugia malayi Tyrosine-protein kinase abl-1 0.0129 0.4975 0.5847
Trichomonas vaginalis TKL family protein kinase 0.0053 0.1784 0.1784
Trichomonas vaginalis TKL family protein kinase 0.0053 0.1784 0.1784
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0053 0.1784 0.2097
Brugia malayi SH2 domain containing protein 0.0076 0.2735 0.3215
Trichomonas vaginalis TK family protein kinase 0.0053 0.1784 0.1784
Loa Loa (eye worm) TK/FER protein kinase 0.0129 0.4975 0.5847
Trichomonas vaginalis TKL family protein kinase 0.0053 0.1784 0.1784
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0014 0.0151 0.0177
Echinococcus multilocularis epidermal growth factor receptor 0.0053 0.1784 0.2097
Brugia malayi Protein kinase domain containing protein 0.0053 0.1784 0.2097
Trichomonas vaginalis TKL family protein kinase 0.0053 0.1784 0.1784
Loa Loa (eye worm) TK/KIN6 protein kinase 0.0053 0.1784 0.2097
Entamoeba histolytica protein kinase with ankyrin repeats, putative 0.0053 0.1784 0.1784
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0076 0.2735 0.3215
Brugia malayi Protein kinase domain containing protein 0.0053 0.1784 0.2097
Schistosoma mansoni vav2 0.0076 0.2735 0.5498
Loa Loa (eye worm) hypothetical protein 0.0076 0.2735 0.3215
Entamoeba histolytica protein kinase, putative 0.0053 0.1784 0.1784
Plasmodium vivax tyrosine kinase-like protein, putative 0.0053 0.1784 1
Echinococcus granulosus tyrosine protein kinase Src42A 0.0129 0.4975 0.5847
Brugia malayi Protein kinase domain containing protein 0.0129 0.4975 0.5847
Schistosoma mansoni thyroid hormone receptor 0.0014 0.0151 0.0303
Brugia malayi proto-oncogene tyrosine-protein kinase FER 0.0053 0.1784 0.2097
Loa Loa (eye worm) TK protein kinase 0.0053 0.1784 0.2097
Schistosoma mansoni tyrosine kinase 0.0053 0.1784 0.3586
Schistosoma mansoni tyrosine-protein kinase zap-70 0.0076 0.2735 0.5498
Trichomonas vaginalis TKL family protein kinase 0.0053 0.1784 0.1784
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0014 0.0151 0.0303
Echinococcus granulosus muscleblind protein 0.0213 0.8509 1
Echinococcus multilocularis tyrosine protein kinase csk 0.0053 0.1784 0.2097
Entamoeba histolytica tyrosine kinase, putative 0.0053 0.1784 0.1784
Trichomonas vaginalis TKL family protein kinase 0.0053 0.1784 0.1784
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0076 0.2735 0.3215
Brugia malayi SH2 domain containing protein 0.0076 0.2735 0.3215
Toxoplasma gondii STE kinase 0.0053 0.1784 1
Brugia malayi Protein kinase domain containing protein 0.0053 0.1784 0.2097
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0014 0.0151 0.0177
Echinococcus granulosus SHC transforming protein 3 0.0076 0.2735 0.3215
Brugia malayi Steroid receptor seven-up type 2 0.0014 0.0151 0.0177
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0053 0.1784 0.2097
Trichomonas vaginalis TKL family protein kinase 0.0053 0.1784 0.1784
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0053 0.1784 0.2097
Schistosoma mansoni tyrosine kinase 0.0053 0.1784 0.3586
Brugia malayi bone morphogenetic protein type 1 receptor 0.0053 0.1784 0.2097
Echinococcus multilocularis suppressor of cytokine signaling 6 0.0076 0.2735 0.3215
Entamoeba histolytica protein kinase domain containing protein 0.0053 0.1784 0.1784
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0249 1 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0014 0.0151 0.0177
Loa Loa (eye worm) TK/EGFR protein kinase 0.0053 0.1784 0.2097
Entamoeba histolytica protein kinase, putative 0.0053 0.1784 0.1784
Entamoeba histolytica protein kinase domain containing protein 0.0053 0.1784 0.1784
Echinococcus multilocularis tyrosine protein kinase shark 0.0129 0.4975 0.5847
Entamoeba histolytica protein kinase, putative 0.0053 0.1784 0.1784
Schistosoma mansoni tensin-related 0.0076 0.2735 0.5498
Trichomonas vaginalis TKL family protein kinase 0.0053 0.1784 0.1784
Trichomonas vaginalis TKL family protein kinase 0.0053 0.1784 0.1784
Brugia malayi Protein kinase domain containing protein 0.0129 0.4975 0.5847
Loa Loa (eye worm) hypothetical protein 0.0053 0.1784 0.2097
Brugia malayi Protein kinase domain containing protein 0.0053 0.1784 0.2097
Schistosoma mansoni protein tyrosine kinase 0.0053 0.1784 0.3586
Trichomonas vaginalis AGC family protein kinase 0.0053 0.1784 0.1784
Echinococcus granulosus retinal guanylyl cyclase 2 0.0053 0.1784 0.2097
Trichomonas vaginalis TKL family protein kinase 0.0053 0.1784 0.1784
Loa Loa (eye worm) TK/Met protein kinase 0.0053 0.1784 0.2097
Echinococcus multilocularis heat shock protein 70 0.0053 0.1784 0.2097
Entamoeba histolytica receptor protein kinase, putative 0.0053 0.1784 0.1784
Schistosoma mansoni suppressor of cytokine signaling 0.0076 0.2735 0.5498
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0076 0.2735 0.3215
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0053 0.1784 0.2097
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0042 0.1328 0.156
Loa Loa (eye worm) hypothetical protein 0.0213 0.8509 1
Trichomonas vaginalis TKL family protein kinase 0.0053 0.1784 0.1784
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0014 0.0151 0.0177
Echinococcus multilocularis macrophage colony stimulating factor 1 receptor 0.0053 0.1784 0.2097
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0014 0.0151 0.0177
Brugia malayi Variant SH3 domain containing protein 0.0076 0.2735 0.3215
Echinococcus granulosus tyrosine protein kinase pr2 0.0053 0.1784 0.2097
Onchocerca volvulus 0.0053 0.1784 0.3385
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0053 0.1784 0.2097
Brugia malayi Tyrosine-protein kinase F09A5.2 in chromosome X, putative 0.0053 0.1784 0.2097
Entamoeba histolytica protein kinase, putative 0.0053 0.1784 0.1784
Entamoeba histolytica protein kinase, putative 0.0053 0.1784 0.1784
Loa Loa (eye worm) hypothetical protein 0.0076 0.2735 0.3215
Giardia lamblia Kinase, NEK 0.0053 0.1784 0.1784
Loa Loa (eye worm) hypothetical protein 0.0053 0.1784 0.2097
Schistosoma mansoni coup transcription factor 0.0014 0.0151 0.0303
Entamoeba histolytica tyrosine kinase, putative 0.0053 0.1784 0.1784
Entamoeba histolytica hypothetical protein 0.0053 0.1784 0.1784
Brugia malayi Protein kinase domain containing protein 0.0129 0.4975 0.5847
Entamoeba histolytica tyrosin kinase, putative 0.0053 0.1784 0.1784
Loa Loa (eye worm) RGC/RGC protein kinase 0.0053 0.1784 0.2097
Entamoeba histolytica protein kinase domain containing protein 0.0053 0.1784 0.1784
Echinococcus granulosus tensin C1 domain containing phosphatase 0.0076 0.2735 0.3215
Schistosoma mansoni RAR-like nuclear receptor 0.0014 0.0151 0.0303
Echinococcus granulosus retinal guanylyl cyclase 2 0.0053 0.1784 0.2097
Loa Loa (eye worm) hypothetical protein 0.0076 0.2735 0.3215
Trichomonas vaginalis serine-threonine protein kinase, putative 0.0053 0.1784 0.1784
Loa Loa (eye worm) hypothetical protein 0.0076 0.2735 0.3215
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0014 0.0151 0.0177
Entamoeba histolytica hypothetical protein 0.0053 0.1784 0.1784
Echinococcus granulosus tyrosine kinase 0.0053 0.1784 0.2097
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0014 0.0151 0.0177
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0014 0.0151 0.0177
Giardia lamblia Fructose-bisphosphate aldolase 0.0249 1 1
Schistosoma mansoni tyrosine protein kinase 0.0053 0.1784 0.3586
Echinococcus granulosus tyrosine protein kinase Fyn 0.0129 0.4975 0.5847
Trichomonas vaginalis TKL family protein kinase 0.0053 0.1784 0.1784
Brugia malayi Protein kinase domain containing protein 0.0053 0.1784 0.2097
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0014 0.0151 0.0177
Entamoeba histolytica protein kinase domain containing protein 0.0053 0.1784 0.1784
Schistosoma mansoni shc transforming protein 0.0076 0.2735 0.5498
Entamoeba histolytica protein kinase domain containing protein 0.0053 0.1784 0.1784
Loa Loa (eye worm) TK protein kinase 0.0053 0.1784 0.2097
Entamoeba histolytica hypothetical protein 0.0053 0.1784 0.1784
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0053 0.1784 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0014 0.0151 0.0177
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0129 0.4975 0.5847
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0053 0.1784 0.2097
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0053 0.1784 0.1784
Brugia malayi Protein kinase domain containing protein 0.0053 0.1784 0.2097
Loa Loa (eye worm) hypothetical protein 0.0014 0.0151 0.0177
Trichomonas vaginalis TKL family protein kinase 0.0053 0.1784 0.1784
Entamoeba histolytica tyrosin kinase, putative 0.0053 0.1784 0.1784
Entamoeba histolytica tyrosine kinase, putative 0.0053 0.1784 0.1784
Onchocerca volvulus 0.0053 0.1784 0.3385
Trichomonas vaginalis TKL family protein kinase 0.0053 0.1784 0.1784
Entamoeba histolytica serine/threonine kinase, putative 0.0053 0.1784 0.1784
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0014 0.0151 0.0177
Plasmodium falciparum protein kinase, putative 0.0053 0.1784 1
Schistosoma mansoni tyrosine kinase 0.0053 0.1784 0.3586
Trichomonas vaginalis TKL family protein kinase 0.0053 0.1784 0.1784
Loa Loa (eye worm) TK protein kinase 0.0129 0.4975 0.5847
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0129 0.4975 0.5847
Brugia malayi SH2 domain containing protein 0.0129 0.4975 0.5847
Brugia malayi cytokine inducible SH2-containing protein 5 0.0076 0.2735 0.3215
Loa Loa (eye worm) SH2 domain-containing protein 0.0076 0.2735 0.3215
Echinococcus granulosus kinase suppressor of Ras 1 0.0053 0.1784 0.2097
Entamoeba histolytica hypothetical protein 0.0053 0.1784 0.1784
Schistosoma mansoni tyrosine kinase 0.0053 0.1784 0.3586
Echinococcus multilocularis ephrin type A receptor 4 A 0.0053 0.1784 0.2097
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0014 0.0151 0.0177
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0129 0.4975 0.5847
Echinococcus granulosus tyrosine protein kinase csk 0.0053 0.1784 0.2097
Trichomonas vaginalis TKL family protein kinase 0.0053 0.1784 0.1784
Trichomonas vaginalis TKL family protein kinase 0.0053 0.1784 0.1784
Trichomonas vaginalis TKL family protein kinase 0.0053 0.1784 0.1784
Schistosoma mansoni hypothetical protein 0.0076 0.2735 0.5498
Entamoeba histolytica cysteine surface protein, putative 0.0053 0.1784 0.1784
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0053 0.1784 0.3586
Trichomonas vaginalis TKL family protein kinase 0.0053 0.1784 0.1784
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0053 0.1784 0.1784
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0129 0.4975 0.5847
Brugia malayi SH2 domain containing protein 0.0076 0.2735 0.3215
Entamoeba histolytica protein kinase domain containing protein 0.0053 0.1784 0.1784
Schistosoma mansoni tyrosine kinase 0.0129 0.4975 1
Brugia malayi hypothetical protein 0.0053 0.1784 0.2097
Echinococcus granulosus growth factor receptor bound protein 2 0.0076 0.2735 0.3215
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0053 0.1784 0.2097
Loa Loa (eye worm) hypothetical protein 0.0014 0.0151 0.0177
Loa Loa (eye worm) TK/ACK protein kinase 0.0053 0.1784 0.2097
Onchocerca volvulus 0.0053 0.1784 0.3385
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0014 0.0151 0.0303
Echinococcus granulosus tyrosine protein kinase ABL1 0.0129 0.4975 0.5847
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0053 0.1784 0.2097
Echinococcus granulosus ecdysone induced protein 78C 0.0014 0.0151 0.0177
Entamoeba histolytica tyrosine kinase, putative 0.0053 0.1784 0.1784
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0053 0.1784 0.1784
Entamoeba histolytica tyrosine kinase, putative 0.0053 0.1784 0.1784
Loa Loa (eye worm) TK/FER protein kinase 0.0129 0.4975 0.5847
Entamoeba histolytica protein kinase domain containing protein 0.0053 0.1784 0.1784
Trichomonas vaginalis TKL family protein kinase 0.0053 0.1784 0.1784
Schistosoma mansoni hypothetical protein 0.0013 0.0108 0.0218
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0053 0.1784 0.1784
Echinococcus granulosus FTZ F1 alpha 0.0014 0.0151 0.0177
Echinococcus granulosus mitogen-activated protein kinase kinase kinase 9 0.0053 0.1784 0.2097
Brugia malayi C-terminal src kinase protein 1 0.0053 0.1784 0.2097
Echinococcus multilocularis 0.0076 0.2735 0.3215
Schistosoma mansoni tyrosine kinase 0.0053 0.1784 0.3586
Echinococcus multilocularis tyrosine protein kinase csk 0.0053 0.1784 0.2097
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0053 0.1784 1
Entamoeba histolytica protein kinase domain containing protein 0.0053 0.1784 0.1784
Trichomonas vaginalis TKL family protein kinase 0.0053 0.1784 0.1784
Entamoeba histolytica hypothetical protein 0.0053 0.1784 0.1784
Schistosoma mansoni tyrosine kinase 0.0053 0.1784 0.3586
Echinococcus granulosus protein tyrosine kinase 0.0053 0.1784 0.2097
Brugia malayi Protein kinase domain containing protein 0.0053 0.1784 0.2097
Brugia malayi Protein kinase domain containing protein 0.0053 0.1784 0.2097
Schistosoma mansoni protein kinase 0.0053 0.1784 0.3586
Entamoeba histolytica tyrosine kinase, putative 0.0053 0.1784 0.1784
Schistosoma mansoni protein kinase 0.0053 0.1784 0.3586
Entamoeba histolytica protein kinase, putative 0.0053 0.1784 0.1784
Echinococcus multilocularis protein KINase family member (kin 25) 0.0053 0.1784 0.2097
Onchocerca volvulus 0.0053 0.1784 0.3385
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0014 0.0151 0.0177
Echinococcus granulosus tyrosine kinase 0.0129 0.4975 0.5847
Schistosoma mansoni tensin 0.0076 0.2735 0.5498
Trichomonas vaginalis TKL family protein kinase 0.0053 0.1784 0.1784
Brugia malayi Protein kinase domain containing protein 0.0129 0.4975 0.5847
Brugia malayi Protein kinase domain containing protein 0.0053 0.1784 0.2097
Loa Loa (eye worm) latrophilin receptor protein 2 0.0013 0.0108 0.0127
Onchocerca volvulus 0.0053 0.1784 0.3385
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0053 0.1784 0.2097
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0013 0.0108 0.0127
Echinococcus multilocularis insulin receptor 0.0053 0.1784 0.2097
Entamoeba histolytica tyrosine kinase, putative 0.0053 0.1784 0.1784
Loa Loa (eye worm) TK/FER protein kinase 0.0129 0.4975 0.5847
Brugia malayi SH2 domain containing protein 0.0076 0.2735 0.3215
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.1784 0.3586
Trichomonas vaginalis serine/threonine-protein kinase wnk, putative 0.0053 0.1784 0.1784
Schistosoma mansoni tyrosine kinase 0.0053 0.1784 0.3586
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.1784 0.1784
Entamoeba histolytica hypothetical protein 0.0053 0.1784 0.1784
Echinococcus multilocularis tyrosine protein kinase HCK 0.0053 0.1784 0.2097
Brugia malayi STAT protein, DNA binding domain containing protein 0.0076 0.2735 0.3215
Loa Loa (eye worm) SRC-1 0.0129 0.4975 0.5847
Schistosoma mansoni serine/threonine RGC 0.0053 0.1784 0.3586
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0053 0.1784 0.3586
Trichomonas vaginalis TKL family protein kinase 0.0053 0.1784 0.1784
Schistosoma mansoni tyrosine kinase 0.0129 0.4975 1
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0053 0.1784 0.3586
Brugia malayi Protein kinase domain containing protein 0.0053 0.1784 0.2097
Schistosoma mansoni protein kinase 0.0053 0.1784 0.3586
Echinococcus multilocularis activin receptor type 0.0053 0.1784 0.2097
Echinococcus multilocularis FTZ F1 alpha 0.0014 0.0151 0.0177
Schistosoma mansoni tyrosine kinase 0.0053 0.1784 0.3586
Onchocerca volvulus 0.0129 0.4975 1
Plasmodium falciparum protein kinase, putative 0.0053 0.1784 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0013 0.0108 0.0127
Echinococcus granulosus ephrin type A receptor 4 A 0.0053 0.1784 0.2097
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0053 0.1784 0.1784
Leishmania major protein kinase, putative 0.0053 0.1784 1
Trichomonas vaginalis TKL family protein kinase 0.0053 0.1784 0.1784
Entamoeba histolytica protein kinase, putative 0.0053 0.1784 0.1784
Brugia malayi Protein kinase domain containing protein 0.0053 0.1784 0.2097
Entamoeba histolytica hypothetical protein 0.0053 0.1784 0.1784
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0042 0.1328 0.156
Loa Loa (eye worm) hypothetical protein 0.0053 0.1784 0.2097
Loa Loa (eye worm) hypothetical protein 0.0076 0.2735 0.3215
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0076 0.2735 0.5498
Trichomonas vaginalis TKL family protein kinase 0.0053 0.1784 0.1784
Trichomonas vaginalis TKL family protein kinase 0.0053 0.1784 0.1784
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0014 0.0151 0.0177
Echinococcus multilocularis thyroid hormone receptor alpha 0.0014 0.0151 0.0177
Loa Loa (eye worm) hypothetical protein 0.0076 0.2735 0.3215
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0053 0.1784 0.1784
Schistosoma mansoni hypothetical protein 0.0013 0.0108 0.0218
Brugia malayi Protein kinase domain containing protein 0.0053 0.1784 0.2097
Echinococcus multilocularis muscleblind protein 1 0.0213 0.8509 1
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0076 0.2735 0.3215
Entamoeba histolytica ankyrin repeat protein 0.0053 0.1784 0.1784
Brugia malayi Guanylyl cyclase protein 23 0.0053 0.1784 0.2097
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0076 0.2735 0.5498
Trypanosoma brucei Pseudokinase, putative 0.0053 0.1784 1
Entamoeba histolytica protein kinase, putative 0.0076 0.2735 0.2735
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0053 0.1784 1
Loa Loa (eye worm) STAT protein 0.0076 0.2735 0.3215
Trichomonas vaginalis protein kinase atn1, putative 0.0053 0.1784 0.1784
Onchocerca volvulus 0.0076 0.2735 0.5357
Brugia malayi Muscleblind-like protein 0.0213 0.8509 1
Giardia lamblia Kinase 0.0053 0.1784 0.1784
Brugia malayi Variant SH3 domain containing protein 0.0076 0.2735 0.3215
Plasmodium falciparum protein kinase, putative 0.0053 0.1784 1
Echinococcus multilocularis tyrosine kinase 0.0053 0.1784 0.2097
Loa Loa (eye worm) hypothetical protein 0.0076 0.2735 0.3215
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0053 0.1784 0.2097
Entamoeba histolytica protein kinase, putative 0.0053 0.1784 0.1784
Loa Loa (eye worm) TK/FER protein kinase 0.0129 0.4975 0.5847
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0053 0.1784 0.2097
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0249 1 1
Loa Loa (eye worm) hypothetical protein 0.0076 0.2735 0.3215
Loa Loa (eye worm) TK/ALK protein kinase 0.0053 0.1784 0.2097
Loa Loa (eye worm) TK protein kinase 0.0053 0.1784 0.2097
Entamoeba histolytica protein kinase, putative 0.0053 0.1784 0.1784
Echinococcus granulosus retinal guanylyl cyclase 2 0.0053 0.1784 0.2097
Schistosoma mansoni tyrosine kinase 0.0129 0.4975 1
Echinococcus multilocularis kinase suppressor of Ras 1 0.0053 0.1784 0.2097
Echinococcus multilocularis tyrosine protein kinase Fes:Fps 0.0053 0.1784 0.2097
Schistosoma mansoni steroid hormone receptor ad4bp 0.0014 0.0151 0.0303
Loa Loa (eye worm) TK/EPH protein kinase 0.0053 0.1784 0.2097
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0014 0.0151 0.0177
Trichomonas vaginalis TKL family protein kinase 0.0053 0.1784 0.1784
Echinococcus multilocularis ecdysone induced protein 78C 0.0014 0.0151 0.0177
Entamoeba histolytica protein kinase domain containing protein 0.0053 0.1784 0.1784
Brugia malayi hypothetical protein 0.0053 0.1784 0.2097
Loa Loa (eye worm) hypothetical protein 0.0053 0.1784 0.2097
Brugia malayi Protein kinase domain containing protein 0.0053 0.1784 0.2097
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0014 0.0151 0.0177
Echinococcus multilocularis GPCR, family 2 0.0013 0.0108 0.0127
Entamoeba histolytica protein kinase, putative 0.0053 0.1784 0.1784
Loa Loa (eye worm) TK/FER protein kinase 0.0053 0.1784 0.2097
Brugia malayi Raf kinase 0.0053 0.1784 0.2097
Schistosoma mansoni tyrosine kinase 0.0053 0.1784 0.3586
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0013 0.0108 0.0127
Loa Loa (eye worm) hypothetical protein 0.0053 0.1784 0.2097
Entamoeba histolytica protein kinase domain containing protein 0.0053 0.1784 0.1784
Echinococcus granulosus tyrosine protein kinase HCK 0.0053 0.1784 0.2097
Echinococcus multilocularis raf serine:threonine protein kinase 0.0053 0.1784 0.2097
Schistosoma mansoni hypothetical protein 0.0053 0.1784 0.3586
Brugia malayi ecdysteroid receptor 0.0014 0.0151 0.0177
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0076 0.2735 0.3215
Loa Loa (eye worm) TKL/MLK/TAK1 protein kinase 0.0053 0.1784 0.2097
Echinococcus granulosus tyrosine protein kinase shark 0.0129 0.4975 0.5847
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0053 0.1784 0.2097
Loa Loa (eye worm) TK/FAK protein kinase 0.0053 0.1784 0.2097
Trichomonas vaginalis TKL family protein kinase 0.0053 0.1784 0.1784
Schistosoma mansoni protein kinase 0.0053 0.1784 0.3586
Echinococcus multilocularis SH2 domain containing protein 7 0.0076 0.2735 0.3215
Loa Loa (eye worm) TK/FER protein kinase 0.0053 0.1784 0.2097
Brugia malayi Protein kinase domain containing protein 0.0053 0.1784 0.2097
Treponema pallidum fructose-bisphosphate aldolase 0.0249 1 1
Loa Loa (eye worm) TK/FER protein kinase 0.0053 0.1784 0.2097
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0249 1 1
Echinococcus multilocularis SH2 domain containing adapter protein F 0.0076 0.2735 0.3215
Schistosoma mansoni tyrosine kinase 0.0053 0.1784 0.3586
Onchocerca volvulus 0.0129 0.4975 1
Echinococcus multilocularis tyrosine protein kinase Blk 0.0129 0.4975 0.5847
Loa Loa (eye worm) hypothetical protein 0.0013 0.0108 0.0127
Schistosoma mansoni adapter molecule crk 0.0076 0.2735 0.5498
Schistosoma mansoni retinoic acid receptor RXR 0.0014 0.0151 0.0303
Loa Loa (eye worm) TK/DDR protein kinase 0.0053 0.1784 0.2097
Loa Loa (eye worm) hypothetical protein 0.0076 0.2735 0.3215
Loa Loa (eye worm) TK/FER protein kinase 0.0053 0.1784 0.2097
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0076 0.2735 0.2735
Loa Loa (eye worm) TK/CSK protein kinase 0.0053 0.1784 0.2097
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0053 0.1784 0.2097
Trichomonas vaginalis protein tyrosine kinase, putative 0.0053 0.1784 0.1784
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0129 0.4975 0.5847
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0053 0.1784 0.3586
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0013 0.0108 0.0127
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0014 0.0151 0.0177
Brugia malayi hypothetical protein 0.0129 0.4975 0.5847
Brugia malayi Protein kinase domain containing protein 0.0053 0.1784 0.2097
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0249 1 1
Entamoeba histolytica tyrosine kinase, putative 0.0053 0.1784 0.1784
Entamoeba histolytica protein kinase domain containing protein 0.0053 0.1784 0.1784
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0053 0.1784 0.2097
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0249 1 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0014 0.0151 0.0303
Loa Loa (eye worm) hypothetical protein 0.0053 0.1784 0.2097
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0076 0.2735 0.5498
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0076 0.2735 0.3215
Loa Loa (eye worm) hypothetical protein 0.0053 0.1784 0.2097
Schistosoma mansoni protein kinase 0.0053 0.1784 0.3586
Schistosoma mansoni tyrosine kinase 0.0053 0.1784 0.3586
Schistosoma mansoni signal transduction protein lnk-related 0.0076 0.2735 0.5498
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0129 0.4975 0.5847
Echinococcus multilocularis tyrosine protein kinase csk 0.0053 0.1784 0.2097
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0129 0.4975 0.5847
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0129 0.4975 0.5847
Echinococcus granulosus tyrosine protein kinase Src64B 0.0129 0.4975 0.5847
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0014 0.0151 0.0177
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0053 0.1784 0.2097
Echinococcus granulosus activated cdc42 kinase 1 0.0053 0.1784 0.2097
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0014 0.0151 0.0177
Echinococcus multilocularis natriuretic peptide receptor 1 0.0053 0.1784 0.2097
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0249 1 1
Schistosoma mansoni SH2A 0.0076 0.2735 0.5498
Echinococcus multilocularis FL cytokine receptor 0.0053 0.1784 0.2097
Entamoeba histolytica tyrosine kinase, putative 0.0053 0.1784 0.1784
Loa Loa (eye worm) hypothetical protein 0.0029 0.0763 0.0897
Loa Loa (eye worm) hypothetical protein 0.0076 0.2735 0.3215
Entamoeba histolytica serine/threonine kinase, putative 0.0053 0.1784 0.1784
Brugia malayi protein-tyrosine kinase 0.0129 0.4975 0.5847
Plasmodium vivax protein kinase, putative 0.0053 0.1784 1
Trichomonas vaginalis TKL family protein kinase 0.0053 0.1784 0.1784
Entamoeba histolytica protein kinase domain containing protein 0.0053 0.1784 0.1784
Entamoeba histolytica protein kinase, putative 0.0053 0.1784 0.1784
Brugia malayi hypothetical protein 0.0076 0.2735 0.3215
Loa Loa (eye worm) TK/INSR protein kinase 0.0053 0.1784 0.2097
Loa Loa (eye worm) TK protein kinase 0.0053 0.1784 0.2097
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0249 1 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0014 0.0151 0.0177
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0053 0.1784 0.3586
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.1784 0.3586
Trichomonas vaginalis TKL family protein kinase 0.0053 0.1784 0.1784
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.1784 0.1784
Loa Loa (eye worm) hypothetical protein 0.0014 0.0151 0.0177
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0053 0.1784 1
Brugia malayi SH2 domain containing protein 0.0129 0.4975 0.5847
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.1784 0.1784
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0014 0.0151 0.0177
Echinococcus granulosus tyrosine protein kinase Srms 0.0129 0.4975 0.5847
Loa Loa (eye worm) RGC/RGC protein kinase 0.0053 0.1784 0.2097
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0014 0.0151 0.0177
Entamoeba histolytica protein kinase domain containing protein 0.0053 0.1784 0.1784
Trichomonas vaginalis TKL family protein kinase 0.0053 0.1784 0.1784
Plasmodium vivax tyrosine kinase-like protein, putative 0.0053 0.1784 1
Onchocerca volvulus 0.0076 0.2735 0.5357
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0129 0.4975 0.5847
Brugia malayi Protein kinase domain containing protein 0.0053 0.1784 0.2097
Schistosoma mansoni nuclear hormone receptor 0.0014 0.0151 0.0303
Echinococcus granulosus SH2 motif 0.0076 0.2735 0.3215
Entamoeba histolytica protein kinase, putative 0.0053 0.1784 0.1784
Echinococcus granulosus activated cdc42 kinase 1 0.0053 0.1784 0.2097
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0014 0.0151 0.0303
Entamoeba histolytica tyrosine kinase, putative 0.0053 0.1784 0.1784
Loa Loa (eye worm) SH2 domain-containing protein 0.0076 0.2735 0.3215
Loa Loa (eye worm) RGC/RGC protein kinase 0.0053 0.1784 0.2097
Echinococcus granulosus suppressor of cytokine signaling 7 0.0076 0.2735 0.3215
Onchocerca volvulus 0.0076 0.2735 0.5357
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0014 0.0151 0.0303
Loa Loa (eye worm) hypothetical protein 0.0076 0.2735 0.3215
Onchocerca volvulus 0.0053 0.1784 0.3385
Trichomonas vaginalis TKL family protein kinase 0.0053 0.1784 0.1784
Schistosoma mansoni tyrosine kinase 0.0053 0.1784 0.3586
Entamoeba histolytica protein kinase domain containing protein 0.0053 0.1784 0.1784
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0122 0.4652 1
Trichomonas vaginalis TKL family protein kinase 0.0053 0.1784 0.1784
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0129 0.4975 0.4975
Entamoeba histolytica tyrosine kinase, putative 0.0053 0.1784 0.1784
Leishmania major protein kinase, putative 0.0053 0.1784 1
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0129 0.4975 0.5847
Loa Loa (eye worm) TK/FER protein kinase 0.0053 0.1784 0.2097
Echinococcus granulosus suppressor of cytokine signaling 6 0.0076 0.2735 0.3215
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0053 0.1784 0.2097
Trichomonas vaginalis TKL family protein kinase 0.0053 0.1784 0.1784
Brugia malayi Tensin 0.0076 0.2735 0.3215
Entamoeba histolytica tyrosine kinase, putative 0.0053 0.1784 0.1784
Schistosoma mansoni protein kinase 0.0053 0.1784 0.3586
Loa Loa (eye worm) hypothetical protein 0.0014 0.0151 0.0177
Entamoeba histolytica tyrosine kinase, putative 0.0053 0.1784 0.1784
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0053 0.1784 0.1784
Loa Loa (eye worm) TKL/MLK/ILK protein kinase 0.0053 0.1784 0.2097
Loa Loa (eye worm) hypothetical protein 0.0053 0.1784 0.2097
Schistosoma mansoni tyrosine kinase 0.0053 0.1784 0.3586
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0053 0.1784 0.1784
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0014 0.0151 0.0177
Brugia malayi SRC-1 0.0129 0.4975 0.5847
Trichomonas vaginalis TKL family protein kinase 0.0053 0.1784 0.1784
Brugia malayi Variant SH3 domain containing protein 0.0076 0.2735 0.3215
Brugia malayi latrophilin 2 splice variant baaae 0.0029 0.0763 0.0897
Echinococcus granulosus tyrosine protein kinase csk 0.0053 0.1784 0.2097
Onchocerca volvulus Tyrosine kinase receptor Cad96Ca homolog 0.0053 0.1784 0.3385
Brugia malayi SH2 domain containing protein 0.0076 0.2735 0.3215
Trichomonas vaginalis TKL family protein kinase 0.0053 0.1784 0.1784
Entamoeba histolytica hypothetical protein 0.0053 0.1784 0.1784
Loa Loa (eye worm) TK protein kinase 0.0053 0.1784 0.2097
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.1784 0.3586
Entamoeba histolytica hypothetical protein, conserved 0.0053 0.1784 0.1784
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0129 0.4975 0.5847
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0053 0.1784 1
Entamoeba histolytica tyrosine kinase, putative 0.0053 0.1784 0.1784
Trypanosoma cruzi protein kinase, putative 0.0053 0.1784 1
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0011 0 0.5
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0014 0.0151 0.0177
Trichomonas vaginalis TKL family protein kinase 0.0053 0.1784 0.1784
Loa Loa (eye worm) TK protein kinase 0.0053 0.1784 0.2097
Loa Loa (eye worm) transcription factor SMAD2 0.0069 0.2438 0.2865
Schistosoma mansoni growth factor receptor-bound protein 0.0076 0.2735 0.5498
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0053 0.1784 0.1784
Schistosoma mansoni protein kinase 0.0053 0.1784 0.3586
Brugia malayi Calcitonin receptor-like protein seb-1 0.0042 0.1328 0.156
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0053 0.1784 0.2097
Brugia malayi Protein kinase domain containing protein 0.0053 0.1784 0.2097
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0076 0.2735 0.3215
Loa Loa (eye worm) hypothetical protein 0.0076 0.2735 0.3215
Entamoeba histolytica protein kinase, putative 0.0053 0.1784 0.1784
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0129 0.4975 0.5847
Loa Loa (eye worm) TK protein kinase 0.0053 0.1784 0.2097
Brugia malayi Tyrosine-protein kinase PR2 0.0053 0.1784 0.2097
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0076 0.2735 0.3215
Schistosoma mansoni tyrosine kinase 0.0053 0.1784 0.3586
Onchocerca volvulus 0.0129 0.4975 1
Loa Loa (eye worm) TK/RYK protein kinase 0.0053 0.1784 0.2097
Brugia malayi Protein kinase domain containing protein 0.0053 0.1784 0.2097
Trichomonas vaginalis STE family protein kinase 0.0053 0.1784 0.1784
Loa Loa (eye worm) TK/FER protein kinase 0.0053 0.1784 0.2097
Brugia malayi SH2 domain containing protein 0.0076 0.2735 0.3215
Brugia malayi MH2 domain containing protein 0.0069 0.2438 0.2865
Loa Loa (eye worm) TK/FER protein kinase 0.0129 0.4975 0.5847
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0076 0.2735 0.3215
Trichomonas vaginalis TKL family protein kinase 0.0053 0.1784 0.1784
Entamoeba histolytica protein kinase domain containing protein 0.0053 0.1784 0.1784
Brugia malayi integrin-linked kinase 0.0053 0.1784 0.2097
Trichomonas vaginalis TKL family protein kinase 0.0053 0.1784 0.1784
Echinococcus granulosus epidermal growth factor receptor 0.0053 0.1784 0.2097
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0076 0.2735 0.3215
Echinococcus granulosus tyrosine protein kinase Src42A 0.0076 0.2735 0.3215
Loa Loa (eye worm) TK/ABL protein kinase 0.0129 0.4975 0.5847
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0014 0.0151 0.0303
Echinococcus granulosus tyrosine protein kinase Fyn 0.0129 0.4975 0.5847
Schistosoma mansoni tyrosine kinase 0.0053 0.1784 0.3586
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0053 0.1784 0.2097
Loa Loa (eye worm) hypothetical protein 0.0014 0.0151 0.0177
Echinococcus multilocularis atrial natriuretic peptide receptor 1 0.0053 0.1784 0.2097
Trypanosoma brucei Flagellum attachment zone protein 20 0.0053 0.1784 1
Echinococcus multilocularis N chimaerin 0.0076 0.2735 0.3215
Loa Loa (eye worm) hypothetical protein 0.0014 0.0151 0.0177
Loa Loa (eye worm) steroid hormone receptor 0.0014 0.0151 0.0177
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0013 0.0108 0.0127
Schistosoma mansoni protein kinase 0.0053 0.1784 0.3586
Trichomonas vaginalis TKL family protein kinase 0.0053 0.1784 0.1784
Echinococcus granulosus receptor type guanylyl cyclase 0.0053 0.1784 0.2097
Loa Loa (eye worm) TK/FER protein kinase 0.0129 0.4975 0.5847
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0014 0.0151 0.0177
Schistosoma mansoni nck2/grb4 0.0076 0.2735 0.5498
Echinococcus multilocularis muscleblind protein 0.0213 0.8509 1
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.1784 0.1784
Loa Loa (eye worm) hypothetical protein 0.0053 0.1784 0.2097
Trichomonas vaginalis TKL family protein kinase 0.0053 0.1784 0.1784
Echinococcus multilocularis tyrosine protein kinase pr2 0.0053 0.1784 0.2097
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0076 0.2735 0.5498
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0076 0.2735 0.3215
Brugia malayi Protein kinase domain containing protein 0.0129 0.4975 0.5847
Entamoeba histolytica receptor protein kinase, putative 0.0053 0.1784 0.1784
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.1784 0.1784
Loa Loa (eye worm) TK protein kinase 0.0053 0.1784 0.2097
Brugia malayi Variant SH3 domain containing protein 0.0076 0.2735 0.3215
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0129 0.4975 0.5847
Onchocerca volvulus 0.0053 0.1784 0.3385
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0014 0.0151 0.0177
Echinococcus multilocularis integrin linked protein kinase 0.0053 0.1784 0.2097
Echinococcus granulosus tyrosine protein kinase Blk 0.0129 0.4975 0.5847
Schistosoma mansoni GTPase activating protein 0.0076 0.2735 0.5498
Echinococcus multilocularis tyrosine protein kinase Abl 0.0129 0.4975 0.5847
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0053 0.1784 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0014 0.0151 0.0177
Loa Loa (eye worm) hypothetical protein 0.0076 0.2735 0.3215
Loa Loa (eye worm) hypothetical protein 0.0014 0.0151 0.0177
Trichomonas vaginalis TKL family protein kinase 0.0053 0.1784 0.1784
Schistosoma mansoni tyrosine kinase 0.0053 0.1784 0.3586
Schistosoma mansoni tyrosine kinase 0.0129 0.4975 1
Brugia malayi Protein kinase domain containing protein 0.0053 0.1784 0.2097
Entamoeba histolytica protein kinase domain containing protein 0.0053 0.1784 0.1784
Entamoeba histolytica leucine-rich repeat domain-containing protein 0.0053 0.1784 0.1784
Schistosoma mansoni tyrosine kinase 0.0053 0.1784 0.3586
Onchocerca volvulus 0.0129 0.4975 1
Echinococcus granulosus signal transduction protein lnk realted 0.0076 0.2735 0.3215
Loa Loa (eye worm) hypothetical protein 0.0076 0.2735 0.3215
Loa Loa (eye worm) TKL/RAF/KSR protein kinase 0.0053 0.1784 0.2097
Entamoeba histolytica tyrosine- protein kinase 2, putative 0.0053 0.1784 0.1784
Toxoplasma gondii protein kinase domain-containing protein 0.0053 0.1784 1
Brugia malayi Protein kinase domain containing protein 0.0053 0.1784 0.2097
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0053 0.1784 0.2097
Entamoeba histolytica hypothetical protein 0.0053 0.1784 0.1784
Echinococcus granulosus raf serine:threonine protein kinase 0.0053 0.1784 0.2097
Schistosoma mansoni growth factor receptor-bound protein 0.0076 0.2735 0.5498
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0053 0.1784 0.1784
Schistosoma mansoni hypothetical protein 0.0029 0.0763 0.1534
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0053 0.1784 0.2097
Echinococcus granulosus SH2 motif 0.0076 0.2735 0.3215
Entamoeba histolytica SH2 domain containing protein 0.0076 0.2735 0.2735
Schistosoma mansoni protein kinase 0.0053 0.1784 0.3586
Trichomonas vaginalis TKL family protein kinase 0.0053 0.1784 0.1784
Brugia malayi Furin-like cysteine rich region family protein 0.0053 0.1784 0.2097
Brugia malayi Protein kinase domain containing protein 0.0053 0.1784 0.2097
Trichomonas vaginalis TKL family protein kinase 0.0053 0.1784 0.1784
Loa Loa (eye worm) TK/FER protein kinase 0.0053 0.1784 0.2097
Loa Loa (eye worm) TK/ROR protein kinase 0.0053 0.1784 0.2097
Echinococcus multilocularis growth factor receptor bound protein 2 0.0076 0.2735 0.3215
Brugia malayi Protein kinase domain containing protein 0.0053 0.1784 0.2097
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0014 0.0151 0.0177
Trypanosoma brucei protein kinase, putative 0.0053 0.1784 1
Entamoeba histolytica serine/threonine kinase, putative 0.0053 0.1784 0.1784
Entamoeba histolytica protein kinase domain containing protein 0.0053 0.1784 0.1784
Loa Loa (eye worm) RGC/RGC protein kinase 0.0053 0.1784 0.2097

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) 0 nM Concentration of the compound required to block the Nuclear translocation of HIV-1 pre-integration complex with Reverse Transcriptase protein; NA : Not Active ChEMBL. 12372514

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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