Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | MBOAT family protein | 0.0446 | 0.1627 | 0.1627 |
Loa Loa (eye worm) | hypothetical protein | 0.0446 | 0.1627 | 0.1627 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0054 | 0.0139 | 0.0139 |
Schistosoma mansoni | o-acyltransferase (membrane bound) domain containing protein | 0.0446 | 0.1627 | 0.1627 |
Echinococcus multilocularis | Membrane bound O acyl transferase, MBOAT | 0.0446 | 0.1627 | 0.1627 |
Trypanosoma cruzi | glycerol uptake protein, putative | 0.0446 | 0.1627 | 0.5 |
Leishmania major | glycerol uptake protein, putative | 0.0446 | 0.1627 | 0.5 |
Schistosoma mansoni | sterol O-acyltransferase 1 | 0.0446 | 0.1627 | 0.1627 |
Trichomonas vaginalis | transmembrane protein nessy, putative | 0.0446 | 0.1627 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0446 | 0.1627 | 0.1627 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0128 | 0.0423 | 0.0423 |
Brugia malayi | MBOAT family protein | 0.0446 | 0.1627 | 0.1627 |
Leishmania major | glycerol uptake protein, putative | 0.0446 | 0.1627 | 0.5 |
Echinococcus multilocularis | sterol O acyltransferase 1 | 0.0446 | 0.1627 | 0.1627 |
Echinococcus multilocularis | o acyltransferase (membrane bound) domain | 0.0446 | 0.1627 | 0.1627 |
Onchocerca volvulus | 0.0446 | 0.1627 | 0.5 | |
Echinococcus granulosus | lysophospholipid acyltransferase 7 | 0.0446 | 0.1627 | 0.1627 |
Echinococcus granulosus | membrane bound acyltransferase:hhat | 0.0446 | 0.1627 | 0.1627 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0446 | 0.1627 | 0.5 |
Echinococcus granulosus | diacylglycerol O acyltransferase 1 | 0.2653 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0446 | 0.1627 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0054 | 0.0139 | 0.0139 |
Brugia malayi | MH2 domain containing protein | 0.0128 | 0.0423 | 0.0423 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0139 | 0.0139 |
Entamoeba histolytica | membrane-bound O-acyltransferase (MBOAT ) family protein | 0.0446 | 0.1627 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0446 | 0.1627 | 0.5 |
Brugia malayi | MBOAT family protein | 0.0446 | 0.1627 | 0.1627 |
Leishmania major | glycerol uptake protein, putative | 0.0446 | 0.1627 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0446 | 0.1627 | 0.1627 |
Entamoeba histolytica | hypothetical protein | 0.0446 | 0.1627 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0037 | 0.0075 | 0.0075 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0128 | 0.0423 | 0.0423 |
Echinococcus granulosus | Membrane bound O acyl transferase MBOAT | 0.0446 | 0.1627 | 0.1627 |
Loa Loa (eye worm) | diacylglycerol acyltransferase | 0.2653 | 1 | 1 |
Echinococcus multilocularis | o acyltransferase (membrane bound) domain | 0.0446 | 0.1627 | 0.1627 |
Schistosoma mansoni | diacylglycerol O-acyltransferase 1 | 0.2653 | 1 | 1 |
Echinococcus granulosus | sterol O acyltransferase 1 | 0.0446 | 0.1627 | 0.1627 |
Trypanosoma cruzi | glycerol uptake protein, putative | 0.0446 | 0.1627 | 0.5 |
Schistosoma mansoni | o-acyltransferase (membrane bound) domain containing protein | 0.0446 | 0.1627 | 0.1627 |
Loa Loa (eye worm) | hypothetical protein | 0.0446 | 0.1627 | 0.1627 |
Trypanosoma cruzi | GUP1, putative | 0.0446 | 0.1627 | 0.5 |
Toxoplasma gondii | acyl-CoA:diacylglycerol acyltransferase 1-related enzyme | 0.2653 | 1 | 1 |
Entamoeba histolytica | vacuolar protein sorting 26 | 0.0446 | 0.1627 | 0.5 |
Plasmodium falciparum | diacylglycerol O-acyltransferase | 0.2653 | 1 | 0.5 |
Leishmania major | glycerol uptake protein, putative | 0.0446 | 0.1627 | 0.5 |
Trypanosoma cruzi | glycerol uptake protein, putative | 0.0446 | 0.1627 | 0.5 |
Loa Loa (eye worm) | MBOAT family protein | 0.0446 | 0.1627 | 0.1627 |
Trichomonas vaginalis | porcupine, putative | 0.0446 | 0.1627 | 0.5 |
Schistosoma mansoni | o-acyltransferase (membrane bound) domain containing protein | 0.0446 | 0.1627 | 0.1627 |
Echinococcus granulosus | protein cysteine N palmitoyltransferase | 0.0446 | 0.1627 | 0.1627 |
Brugia malayi | Hhat protein | 0.0446 | 0.1627 | 0.1627 |
Echinococcus multilocularis | protein cysteine N palmitoyltransferase | 0.0446 | 0.1627 | 0.1627 |
Brugia malayi | MBOAT family protein | 0.0446 | 0.1627 | 0.1627 |
Treponema pallidum | alginate O-acetylation protein (algI) | 0.0446 | 0.1627 | 0.5 |
Loa Loa (eye worm) | membrane bound O-acyltransferase domain containing 1 | 0.0446 | 0.1627 | 0.1627 |
Echinococcus multilocularis | lysophospholipid acyltransferase 7 | 0.0446 | 0.1627 | 0.1627 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0446 | 0.1627 | 0.5 |
Brugia malayi | MBOAT family protein | 0.0446 | 0.1627 | 0.1627 |
Schistosoma mansoni | leukocyte receptor cluster (lrc) member 4 protein | 0.0446 | 0.1627 | 0.1627 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0054 | 0.0139 | 0.0139 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.0075 | 0.0075 |
Echinococcus granulosus | o acyltransferase membrane bound domain | 0.0446 | 0.1627 | 0.1627 |
Brugia malayi | MBOAT family protein | 0.0446 | 0.1627 | 0.1627 |
Loa Loa (eye worm) | hhat protein | 0.0446 | 0.1627 | 0.1627 |
Plasmodium vivax | diacylglycerol O-acyltransferase, putative | 0.2653 | 1 | 0.5 |
Trypanosoma cruzi | GUP1, putative | 0.0446 | 0.1627 | 0.5 |
Schistosoma mansoni | zinc finger protein | 0.0446 | 0.1627 | 0.1627 |
Loa Loa (eye worm) | hypothetical protein | 0.2207 | 0.8308 | 0.8308 |
Entamoeba histolytica | membrane-bound O-acyltransferase (MBOAT ) family protein | 0.0446 | 0.1627 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0446 | 0.1627 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0075 | 0.0075 |
Echinococcus granulosus | o acyltransferase membrane bound domain | 0.0446 | 0.1627 | 0.1627 |
Echinococcus multilocularis | membrane bound acyltransferase:hhat | 0.0446 | 0.1627 | 0.1627 |
Echinococcus multilocularis | o acyltransferase (membrane bound) domain | 0.0446 | 0.1627 | 0.1627 |
Trypanosoma brucei | glycerol uptake protein, putative | 0.0446 | 0.1627 | 0.5 |
Toxoplasma gondii | acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha | 0.2653 | 1 | 1 |
Leishmania major | glycerol uptake protein, putative | 0.0446 | 0.1627 | 0.5 |
Echinococcus granulosus | o acyltransferase membrane bound domain | 0.0446 | 0.1627 | 0.1627 |
Loa Loa (eye worm) | MBOAT family protein | 0.0446 | 0.1627 | 0.1627 |
Trypanosoma brucei | glycerol uptake protein, putative | 0.0446 | 0.1627 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0446 | 0.1627 | 0.1627 |
Loa Loa (eye worm) | hhat protein | 0.0446 | 0.1627 | 0.1627 |
Schistosoma mansoni | membrane-bound acyltransferase/hhat | 0.0446 | 0.1627 | 0.1627 |
Echinococcus multilocularis | diacylglycerol O acyltransferase 1 | 0.2653 | 1 | 1 |
Entamoeba histolytica | membrane-bound O-acyltransferase (MBOAT ) family protein | 0.0446 | 0.1627 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CC50 (ADMET) | = 44 uM | Cytotoxicity against human HeLa CD4+ CCR5+ cells after 6 days by XTT assay | ChEMBL. | 23200249 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.