TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 368.41 | Formula: C18H16N4O3S
H donors: 1 H acceptors: 2 LogP: 4.13 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc2c(c1)c(/N=N/C(=N)S)c(n2CC(=O)c1ccccc1)O
InChi: 1S/C18H16N4O3S/c1-25-12-7-8-14-13(9-12)16(20-21-18(19)26)17(24)22(14)10-15(23)11-5-3-2-4-6-11/h2-9,24H,10H2,1H3,(H2,19,26)/b21-20+
InChiKey: VHEGUUCPTADMTQ-QZQOTICOSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	APEX nuclease (multifunctional DNA repair enzyme) 1	Starlite/ChEMBL	No references
Homo sapiens	ATM serine/threonine kinase	Starlite/ChEMBL	No references
Mus musculus	RAR-related orphan receptor gamma	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Neospora caninum	hypothetical protein	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma mansoni	ataxia telangiectasia mutated (atm)	Get druggable targets OG5_128955	All targets in OG5_128955
Schistosoma japonicum	IPR000971,Globin;IPR012292,Globin-related;IPR009050,Globin-like,domain-containing	Get druggable targets OG5_128955	All targets in OG5_128955
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768
Neospora caninum	phosphatidylinositol 3- and 4-kinase domain- containing protein, putative	Get druggable targets OG5_128955	All targets in OG5_128955
Wolbachia endosymbiont of Brugia malayi	exonuclease III	Get druggable targets OG5_126768	All targets in OG5_126768
Toxoplasma gondii	FATC domain-containing protein	Get druggable targets OG5_128955	All targets in OG5_128955
Leishmania mexicana	phosphatidylinositol 3-kinase-like protein	Get druggable targets OG5_128955	All targets in OG5_128955
Trypanosoma congolense	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Entamoeba histolytica	exodeoxyribonuclease III, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Plasmodium knowlesi	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768
Candida albicans	similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma brucei	phosphatidylinositol kinase related protein, putative	Get druggable targets OG5_128955	All targets in OG5_128955
Leishmania donovani	phosphatidylinositol 3-kinase-like protein	Get druggable targets OG5_128955	All targets in OG5_128955
Echinococcus granulosus	serine protein kinase ATM	Get druggable targets OG5_128955	All targets in OG5_128955
Candida albicans	similar to putative phosphatidylinositol kinase involved in telomere length regulation	Get druggable targets OG5_128955	All targets in OG5_128955
Leishmania braziliensis	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Cryptosporidium parvum	conserved hypothetical protein	Get druggable targets OG5_126768	All targets in OG5_126768
Candida albicans	identical to the C terminus of CaP19.5580 potential phosphatidylinositol kinase	Get druggable targets OG5_128955	All targets in OG5_128955
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	Get druggable targets OG5_126768	All targets in OG5_126768
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania major	phosphatidylinositol kinase related protein, putative	Get druggable targets OG5_128955	All targets in OG5_128955
Schistosoma mansoni	ap endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Candida albicans	similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	hypothetical protein	Get druggable targets OG5_128955	All targets in OG5_128955
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128955	All targets in OG5_128955
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	DNA-(apurinic or apyrimidinic site) lyase 2, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania infantum	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768
Plasmodium berghei	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania braziliensis	phosphatidylinositol kinase related protein, putative	Get druggable targets OG5_128955	All targets in OG5_128955
Trypanosoma brucei gambiense	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania infantum	phosphatidylinositol kinase related protein, putative	Get druggable targets OG5_128955	All targets in OG5_128955
Entamoeba histolytica	hypothetical protein	Get druggable targets OG5_128955	All targets in OG5_128955
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	Get druggable targets OG5_126768	All targets in OG5_126768
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	DNA-(apurinic or apyrimidinic site) lyase 2, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma brucei gambiense	phosphatidylinositol kinase domain protein, putative	Get druggable targets OG5_128955	All targets in OG5_128955
Schistosoma japonicum	hypothetical protein	Get druggable targets OG5_128955	All targets in OG5_128955
Schistosoma japonicum	ko:K10772 AP endonuclease 2, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	Get druggable targets OG5_128955	All targets in OG5_128955
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania donovani	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	ko:K04728 ataxia telangectasia mutated family protein, putative	Get druggable targets OG5_128955	All targets in OG5_128955
Schistosoma japonicum	ko:K10771 AP endonuclease 1, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma mansoni	ap endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Cryptosporidium hominis	dna-(apurinic or apyrimidinic site) lyase	Get druggable targets OG5_126768	All targets in OG5_126768
Brugia malayi	exodeoxyribonuclease III family protein	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Theileria parva	hypothetical protein	Get druggable targets OG5_126768	All targets in OG5_126768
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	Get druggable targets OG5_126768	All targets in OG5_126768
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	Get druggable targets OG5_128955	All targets in OG5_128955
Trichomonas vaginalis	ap endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	Get druggable targets OG5_128955	All targets in OG5_128955
Plasmodium yoelii	putative AP endonuclease-related	Get druggable targets OG5_126768	All targets in OG5_126768
Toxoplasma gondii	exonuclease III APE	Get druggable targets OG5_126768	All targets in OG5_126768
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_128955	All targets in OG5_128955
Echinococcus multilocularis	serine protein kinase ATM	Get druggable targets OG5_128955	All targets in OG5_128955
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania mexicana	apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	Get druggable targets OG5_128955	All targets in OG5_128955
Candida albicans	similar to putative phosphatidylinositol kinase involved in telomere length regulation	Get druggable targets OG5_128955	All targets in OG5_128955
Treponema pallidum	exodeoxyribonuclease (exoA)	Get druggable targets OG5_126768	All targets in OG5_126768
Trichomonas vaginalis	ap endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.0022	0.6016	0.4987
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0012	0.131	0.131
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0014	0.2052	0.2052
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0012	0.131	0.131
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0023	0.6441	0.5
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0022	0.6016	0.6016
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0022	0.6016	0.6016
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0012	0.131	0.131
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0012	0.131	0.131
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0012	0.131	0.131
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0023	0.6441	0.5
Toxoplasma gondii	exonuclease III APE	0.0023	0.6441	0.5523
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0012	0.1365	0.1365
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.6016	0.6016
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.6016	0.6016
Loa Loa (eye worm)	hypothetical protein	0.0012	0.131	0.1648
Loa Loa (eye worm)	hypothetical protein	0.0012	0.131	0.1648
Echinococcus granulosus	ecdysone induced protein 78C	0.0012	0.131	0.131
Loa Loa (eye worm)	hypothetical protein	0.0012	0.131	0.1648
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.6016	0.6016
Loa Loa (eye worm)	hypothetical protein	0.0012	0.131	0.1648
Brugia malayi	nuclear receptor NHR-88	0.0012	0.131	0.131
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0012	0.131	0.5
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0023	0.6441	0.5
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0012	0.131	0.1648
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0012	0.131	0.131
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0012	0.131	0.131
Trypanosoma cruzi	target of rapamycin kinase 3	0.0022	0.6016	0.5386
Trypanosoma brucei	phosphatidylinositol kinase related protein, putative	0.003	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.6016	0.6016
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.6016	0.6016
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.6016	0.6016
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.6016	0.6016
Schistosoma mansoni	fkbp-rapamycin associated protein	0.0012	0.1365	0.1365
Toxoplasma gondii	target of rapamycin (TOR), putative	0.0022	0.6016	0.4987
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0012	0.131	0.131
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0023	0.6441	0.5
Schistosoma mansoni	ataxia telangiectasia mutated (atm)	0.003	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.6016	0.6016
Brugia malayi	photoreceptor-specific nuclear receptor	0.0012	0.131	0.131
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0022	0.6016	0.6016
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0023	0.6441	0.8105
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.0022	0.6016	0.6016
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0022	0.6016	0.5386
Echinococcus granulosus	serine:threonine protein kinase SMG1	0.0012	0.1365	0.1365
Echinococcus multilocularis	ecdysone induced protein 78C	0.0012	0.131	0.131
Loa Loa (eye worm)	phosphatidylinositol 3	0.0022	0.6016	0.7569
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0012	0.131	0.1648
Loa Loa (eye worm)	phosphatidylinositol 3	0.0022	0.6016	0.7569
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.6016	0.6016
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0012	0.1365	0.1365
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0022	0.6016	0.5386
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0012	0.1365	0.1365
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0012	0.131	0.131
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0022	0.6016	0.4987
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0012	0.131	0.1648
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.0022	0.6016	0.6016
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0012	0.131	0.1648
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.6016	0.6016
Loa Loa (eye worm)	hypothetical protein	0.0012	0.131	0.1648
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.6016	0.6016
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0012	0.131	0.131
Echinococcus multilocularis	serine protein kinase ATM	0.003	1	1
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0022	0.6016	0.4987
Entamoeba histolytica	hypothetical protein	0.003	1	1
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0012	0.131	0.131
Trichomonas vaginalis	PIKK family atypical protein kinase	0.003	1	1
Schistosoma mansoni	thyroid hormone receptor	0.0012	0.131	0.131
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.6016	0.6016
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0012	0.131	0.131
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0023	0.6441	1
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0012	0.131	0.131
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0012	0.131	0.131
Echinococcus granulosus	FTZ F1 alpha	0.0012	0.131	0.131
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.6016	0.6016
Brugia malayi	nuclear hormone receptor	0.0012	0.131	0.131
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0023	0.6441	0.6441
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0012	0.131	0.131
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0012	0.1365	0.1365
Loa Loa (eye worm)	hypothetical protein	0.0012	0.1365	0.1717
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0012	0.1365	0.1365
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0022	0.6036	0.541
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0022	0.6016	0.4987
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0023	0.6441	0.5879
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0012	0.131	0.131
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0022	0.6016	0.5386
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0012	0.131	0.131
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0012	0.131	0.131
Echinococcus granulosus	serine protein kinase ATM	0.003	1	1
Schistosoma mansoni	thyroid hormone receptor	0.0012	0.131	0.131
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.6016	0.6016
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0022	0.6016	0.5386
Schistosoma mansoni	RAR-like nuclear receptor	0.0012	0.131	0.131
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0012	0.131	0.131
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0023	0.6441	0.5879
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0012	0.131	0.1648
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.6016	0.6016
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0022	0.6016	0.6016
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0012	0.131	0.131
Onchocerca volvulus	Bile acid receptor homolog	0.0012	0.131	0.5
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0012	0.131	0.131
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0012	0.131	0.131
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0023	0.6441	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.2052	0.2052
Echinococcus multilocularis	serine:threonine protein kinase SMG1	0.0012	0.1365	0.1365
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0012	0.131	0.131
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.6016	0.6016
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0022	0.6016	0.5386
Leishmania major	phosphatidylinositol kinase related protein, putative	0.0022	0.6036	0.0485
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.6016	0.6016
Toxoplasma gondii	FATC domain-containing protein	0.003	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.6016	0.6016
Brugia malayi	steroid hormone receptor	0.0012	0.131	0.131
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0012	0.131	0.131
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.6016	0.6016
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0023	0.6441	0.5523
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.6016	0.6016
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0012	0.131	0.131
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.6016	0.6016
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0022	0.6016	0.4987
Schistosoma mansoni	nuclear hormone receptor	0.0012	0.131	0.131
Loa Loa (eye worm)	hypothetical protein	0.0012	0.131	0.1648
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0012	0.1365	0.1365
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0012	0.131	0.131
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.003	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0012	0.1365	0.1365
Brugia malayi	ecdysteroid receptor	0.0012	0.131	0.131
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.6016	0.6016
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0023	0.6441	0.5
Brugia malayi	Nuclear hormone receptor-like 1	0.0012	0.131	0.131
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0012	0.131	0.131
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0012	0.131	0.131
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.6016	0.6016
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0012	0.131	0.131
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.6016	0.6016
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.6016	0.6016
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0023	0.6441	0.5879
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0012	0.131	0.131
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0012	0.131	0.131
Trichomonas vaginalis	ap endonuclease, putative	0.0023	0.6441	0.6441
Schistosoma mansoni	retinoic acid receptor RXR	0.0012	0.131	0.131
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0012	0.131	0.131
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0023	0.6441	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0012	0.131	0.1648
Brugia malayi	Steroid receptor seven-up type 2	0.0012	0.131	0.131
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0012	0.131	0.131
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.6016	0.6016
Loa Loa (eye worm)	hypothetical protein	0.0012	0.131	0.1648
Echinococcus multilocularis	FTZ F1 alpha	0.0012	0.131	0.131
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0022	0.6016	0.5386
Onchocerca volvulus	Protein ultraspiracle homolog	0.0012	0.131	0.5
Brugia malayi	exodeoxyribonuclease III family protein	0.0023	0.6441	0.6441
Schistosoma mansoni	ap endonuclease	0.0023	0.6441	0.6441
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.6016	0.6016
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0022	0.6016	0.6016
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0026	0.7948	0.7623
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0012	0.131	0.1648
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0012	0.131	0.131
Onchocerca volvulus		0.0012	0.131	0.5
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.0022	0.6016	0.6016
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0012	0.1365	0.1365
Schistosoma mansoni	coup transcription factor	0.0012	0.131	0.131
Loa Loa (eye worm)	hypothetical protein	0.0012	0.131	0.1648
Loa Loa (eye worm)	hypothetical protein	0.0026	0.7948	1
Trichomonas vaginalis	ap endonuclease, putative	0.0023	0.6441	0.6441
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0023	0.6441	0.6441
Schistosoma mansoni	ap endonuclease	0.0023	0.6441	0.6441
Loa Loa (eye worm)	steroid hormone receptor	0.0012	0.131	0.1648
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.6016	0.6016
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.6016	0.6016
Loa Loa (eye worm)	hypothetical protein	0.0014	0.2052	0.2582

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	= 0.7079 um	PUBCHEM_BIOASSAY: qHTS Assay for Identifying a Potential Treatment of Ataxia-Telangiectasia. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 1.2589 um	PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	8.4368 uM	PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	11.6891 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2369260

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1747685