Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | paired box 8 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Brugia malayi | Pax transcription factor protein 2 | Get druggable targets OG5_139945 | All targets in OG5_139945 |
Loa Loa (eye worm) | pax transcription factor protein 2 | Get druggable targets OG5_139945 | All targets in OG5_139945 |
Onchocerca volvulus | Get druggable targets OG5_139945 | All targets in OG5_139945 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | Protoporphyrinogen oxidase chloroplast/mitochondrial precursor | 0.0084 | 0.0284 | 0.2451 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0082 | 0.0264 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0021 | 0.01 |
Onchocerca volvulus | 0.0084 | 0.0284 | 0.1363 | |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.0284 | 0.1363 |
Echinococcus multilocularis | protoporphyrinogen oxidase | 0.0084 | 0.0284 | 0.2451 |
Mycobacterium leprae | PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) | 0.0084 | 0.0284 | 0.5 |
Schistosoma mansoni | Lysine-specific histone demethylase 1 | 0.0084 | 0.0284 | 0.2451 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.0633 | 0.5066 | 0.4922 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.0284 | 0.1363 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0084 | 0.0284 | 0.5 |
Brugia malayi | amine oxidase, flavin-containing family protein | 0.0084 | 0.0284 | 0.1363 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0084 | 0.0284 | 0.2451 |
Brugia malayi | Pax transcription factor protein 2 | 0.0291 | 0.208 | 1 |
Schistosoma mansoni | amine oxidase | 0.0084 | 0.0284 | 0.2451 |
Wolbachia endosymbiont of Brugia malayi | 3-oxoacyl-ACP synthase | 0.0633 | 0.5066 | 0.5 |
Plasmodium falciparum | beta-ketoacyl-ACP synthase III | 0.0633 | 0.5066 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.0284 | 0.1363 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0054 | 0.0019 | 0.009 |
Schistosoma mansoni | amine oxidase | 0.0084 | 0.0284 | 0.2451 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.12 | 1 | 1 |
Echinococcus multilocularis | geminin | 0.0185 | 0.1157 | 1 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0084 | 0.0284 | 0.5 |
Onchocerca volvulus | 0.0291 | 0.208 | 1 | |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0084 | 0.0284 | 0.2451 |
Brugia malayi | Cytochrome P450 family protein | 0.0054 | 0.0019 | 0.009 |
Toxoplasma gondii | histone lysine-specific demethylase | 0.0084 | 0.0284 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.0284 | 0.1363 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0054 | 0.0021 | 0.01 |
Brugia malayi | SWIRM domain containing protein | 0.0084 | 0.0284 | 0.1363 |
Mycobacterium tuberculosis | 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) | 0.0633 | 0.5066 | 0.5326 |
Mycobacterium ulcerans | beta-ketoacyl synthase-like protein | 0.0633 | 0.5066 | 0.4922 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0054 | 0.0021 | 0.01 |
Plasmodium vivax | beta-ketoacyl-acyl carrier protein synthase III precursor, putative | 0.0633 | 0.5066 | 1 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0082 | 0.0264 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0185 | 0.1157 | 1 |
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | 0.1115 | 0.9264 | 1 |
Leishmania major | UDP-galactopyranose mutase | 0.0084 | 0.0284 | 0.5 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0082 | 0.0264 | 0.5 |
Echinococcus multilocularis | 0.0084 | 0.0284 | 0.2451 | |
Loa Loa (eye worm) | pax transcription factor protein 2 | 0.0291 | 0.208 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.0284 | 0.1363 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.0633 | 0.5066 | 0.4922 |
Echinococcus multilocularis | lysine specific histone demethylase 1A | 0.0084 | 0.0284 | 0.2451 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0082 | 0.0264 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.0284 | 0.1363 |
Brugia malayi | hypothetical protein | 0.0084 | 0.0284 | 0.1363 |
Echinococcus granulosus | geminin | 0.0185 | 0.1157 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0054 | 0.0021 | 0.01 |
Schistosoma mansoni | hypothetical protein | 0.0185 | 0.1157 | 1 |
Toxoplasma gondii | histone lysine-specific demethylase LSD1/BHC110/KDMA1A | 0.0084 | 0.0284 | 0.5 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0082 | 0.0264 | 0.5 |
Chlamydia trachomatis | oxoacyl-ACP synthase III | 0.0633 | 0.5066 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
AC50 (functional) | = 7.85 uM | PubChem BioAssay. HTS for PAX8 inhibitors using PAX8 luciferase reporter gene assay in RMG-I cells Measured in Cell-Based System Using Plate Reader - 7054-01_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.