Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | kinesin family member 11 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | aspartyl protease, putative | 0.0034 | 0 | 0.5 |
Plasmodium falciparum | plasmepsin V | 0.0034 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0 | 0.5 |
Onchocerca volvulus | 0.0034 | 0 | 0.5 | |
Toxoplasma gondii | aspartyl protease ASP1 | 0.0034 | 0 | 0.5 |
Plasmodium falciparum | plasmepsin VI | 0.0034 | 0 | 0.5 |
Trichomonas vaginalis | Clan AA, family A1, cathepsin D-like aspartic peptidase | 0.0034 | 0 | 0.5 |
Toxoplasma gondii | eukaryotic aspartyl protease superfamily protein | 0.0034 | 0 | 0.5 |
Toxoplasma gondii | aspartyl protease | 0.0034 | 0 | 0.5 |
Plasmodium falciparum | plasmepsin II | 0.0034 | 0 | 0.5 |
Plasmodium vivax | plasmepsin V, putative | 0.0034 | 0 | 0.5 |
Toxoplasma gondii | aspartyl protease ASP3 | 0.0034 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0 | 0.5 |
Plasmodium falciparum | plasmepsin I | 0.0034 | 0 | 0.5 |
Loa Loa (eye worm) | aspartic protease BmAsp-2 | 0.0034 | 0 | 0.5 |
Plasmodium vivax | aspartyl protease, putative | 0.0034 | 0 | 0.5 |
Loa Loa (eye worm) | aspartic protease BmAsp-1 | 0.0034 | 0 | 0.5 |
Plasmodium falciparum | plasmepsin VII | 0.0034 | 0 | 0.5 |
Loa Loa (eye worm) | aspartyl protease 6 | 0.0034 | 0 | 0.5 |
Plasmodium vivax | aspartyl proteinase, putative | 0.0034 | 0 | 0.5 |
Plasmodium vivax | aspartyl proteinase, putative | 0.0034 | 0 | 0.5 |
Plasmodium vivax | aspartyl protease, putative | 0.0034 | 0 | 0.5 |
Echinococcus multilocularis | kinesin family 1 | 0.0247 | 0.5183 | 1 |
Brugia malayi | aspartic protease BmAsp-2, identical | 0.0034 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0034 | 0 | 0.5 |
Echinococcus granulosus | kinesin family 1 | 0.0247 | 0.5183 | 1 |
Plasmodium falciparum | plasmepsin VIII, putative | 0.0034 | 0 | 0.5 |
Toxoplasma gondii | aspartyl proteinase (eimepsin), putative | 0.0034 | 0 | 0.5 |
Plasmodium falciparum | plasmepsin IV | 0.0034 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0215 | 0.4401 | 0.4401 |
Brugia malayi | aspartic protease BmAsp-1, identical | 0.0034 | 0 | 0.5 |
Plasmodium falciparum | plasmepsin III | 0.0034 | 0 | 0.5 |
Brugia malayi | Eukaryotic aspartyl protease family protein | 0.0034 | 0 | 0.5 |
Plasmodium vivax | plasmepsin IV, putative | 0.0034 | 0 | 0.5 |
Brugia malayi | Pepsin A precursor | 0.0034 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0034 | 0 | 0.5 |
Onchocerca volvulus | 0.0034 | 0 | 0.5 | |
Plasmodium falciparum | plasmepsin X | 0.0034 | 0 | 0.5 |
Plasmodium falciparum | plasmepsin IX | 0.0034 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.65 uM | Inhibition of Eg5 (unknown origin) | ChEMBL. | 23434636 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.